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The map label for this gene is hmuU [H]

Identifier: 148653309

GI number: 148653309

Start: 1844304

End: 1845281

Strand: Direct

Name: hmuU [H]

Synonym: PsycPRwf_1509

Alternate gene names: 148653309

Gene position: 1844304-1845281 (Clockwise)

Preceding gene: 148653308

Following gene: 148653310

Centisome position: 61.91

GC content: 50.92

Gene sequence:

>978_bases
ATGTCCAATTTTGTGCACCCACATAAGCGATTCTTGTCTACAACCGTAATCAGCTATGGCGCTGCTGTCTTGGTATCTGC
CCTATTGATTTGGTTGAGCTTGGGCGTGGGATTTGGTCAGTGGTCTAGCCCCTCACAACTTGATGCCACCTTATGGCAGC
TGCGCTATCCTCGGGTAGTCACCGCCTTATTGGTGGGCTTAGCACTATCAGTGAGTGGCGCTGCACTACAAGCTTTATTC
GAAAATCCATTGGCCGATCCGAGCTTAATTGGTACCTCTGGTGGCGCAGCCTTAGGGGTGGTATTGATACTGGCTCTGGG
CATCTCTGGCATTGGGGTGCCACTGGCCGCCTTCATAGGCAGCTTAGTGGTATGTCTGTTGGTGCTGGGTTGTCACCGAT
TTTTGGGTGGTGGTCAGATGGGGCTGCTTATCTTAGGCTTTGTGATCAGCGCCTTTTGTGGCGCTTTGGTGAGTTTAATT
TTGTTTTTGTCCAATGACATGGTGCTGCGCAGTGCCACCAATTGGCTGGCAGGTAGTATGGCTGAGGCAGGCTTTGTACC
ACTGCGCTATGCCTTGATAAGCATTGCTTTGGGATTGGCCATTATTTTACCATTCGGACGGCAATTGGATGGACTAATGC
TGGGGGAAACCACCGCGCTGTCTTTGGGTATAAAAGTCGGTCAGGTTCGGGCACTGGTCATCATTGCGTGCGCCCTACTG
ACTGGGGCAGCGGTATCTATGTCTGGGGTGATTGGATTTATTGGAATGATGATTCCCAATTTACTCAGCCTATTGTTTGG
CGGTGGTCGAATGCGCATTATGTTTTGGTCCGGCTGGTTTGGGGCCTTGTTTTTATTGGTCATAGACAGTCTGGCGCGCC
ATGTGGCCTACCCCGTGGATGTGCCCATTGGCATCGTTTTGGCCTTAATCGGCGGCCCATTTTTTATTTGGTTATTTATT
CGCAGCACCCGTAGCTGA

Upstream 100 bases:

>100_bases
TTTGGGATGCCGATGAGTTCTTACGCTACGGACTCGCCTCACCTCAAGTAGTCGATAAGCTACATAAGCTGGCCAATTAG
CAACTTGACTGAGATCTATT

Downstream 100 bases:

>100_bases
CCAAGTGAGTTTTTTGTACTGGCTAGCGCTGCTCTAATCTTTTTTATGGCGGGCAGCTGGTCTTTTTGTGCTTAGTTATT
ATGCACTCTTTTCTCTTAAG

Product: transport system permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSNFVHPHKRFLSTTVISYGAAVLVSALLIWLSLGVGFGQWSSPSQLDATLWQLRYPRVVTALLVGLALSVSGAALQALF
ENPLADPSLIGTSGGAALGVVLILALGISGIGVPLAAFIGSLVVCLLVLGCHRFLGGGQMGLLILGFVISAFCGALVSLI
LFLSNDMVLRSATNWLAGSMAEAGFVPLRYALISIALGLAIILPFGRQLDGLMLGETTALSLGIKVGQVRALVIIACALL
TGAAVSMSGVIGFIGMMIPNLLSLLFGGGRMRIMFWSGWFGALFLLVIDSLARHVAYPVDVPIGIVLALIGGPFFIWLFI
RSTRS

Sequences:

>Translated_325_residues
MSNFVHPHKRFLSTTVISYGAAVLVSALLIWLSLGVGFGQWSSPSQLDATLWQLRYPRVVTALLVGLALSVSGAALQALF
ENPLADPSLIGTSGGAALGVVLILALGISGIGVPLAAFIGSLVVCLLVLGCHRFLGGGQMGLLILGFVISAFCGALVSLI
LFLSNDMVLRSATNWLAGSMAEAGFVPLRYALISIALGLAIILPFGRQLDGLMLGETTALSLGIKVGQVRALVIIACALL
TGAAVSMSGVIGFIGMMIPNLLSLLFGGGRMRIMFWSGWFGALFLLVIDSLARHVAYPVDVPIGIVLALIGGPFFIWLFI
RSTRS
>Mature_324_residues
SNFVHPHKRFLSTTVISYGAAVLVSALLIWLSLGVGFGQWSSPSQLDATLWQLRYPRVVTALLVGLALSVSGAALQALFE
NPLADPSLIGTSGGAALGVVLILALGISGIGVPLAAFIGSLVVCLLVLGCHRFLGGGQMGLLILGFVISAFCGALVSLIL
FLSNDMVLRSATNWLAGSMAEAGFVPLRYALISIALGLAIILPFGRQLDGLMLGETTALSLGIKVGQVRALVIIACALLT
GAAVSMSGVIGFIGMMIPNLLSLLFGGGRMRIMFWSGWFGALFLLVIDSLARHVAYPVDVPIGIVLALIGGPFFIWLFIR
STRS

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790741, Length=289, Percent_Identity=35.2941176470588, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788004, Length=292, Percent_Identity=34.9315068493151, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1790740, Length=287, Percent_Identity=33.1010452961672, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786805, Length=277, Percent_Identity=35.7400722021661, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1786347, Length=314, Percent_Identity=30.2547770700637, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1786804, Length=288, Percent_Identity=30.9027777777778, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 33966; Mature: 33835

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFVHPHKRFLSTTVISYGAAVLVSALLIWLSLGVGFGQWSSPSQLDATLWQLRYPRVV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
TALLVGLALSVSGAALQALFENPLADPSLIGTSGGAALGVVLILALGISGIGVPLAAFIG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
SLVVCLLVLGCHRFLGGGQMGLLILGFVISAFCGALVSLILFLSNDMVLRSATNWLAGSM
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AEAGFVPLRYALISIALGLAIILPFGRQLDGLMLGETTALSLGIKVGQVRALVIIACALL
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHCCHHHHHHHHHHHHHHHH
TGAAVSMSGVIGFIGMMIPNLLSLLFGGGRMRIMFWSGWFGALFLLVIDSLARHVAYPVD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCC
VPIGIVLALIGGPFFIWLFIRSTRS
CHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNFVHPHKRFLSTTVISYGAAVLVSALLIWLSLGVGFGQWSSPSQLDATLWQLRYPRVV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
TALLVGLALSVSGAALQALFENPLADPSLIGTSGGAALGVVLILALGISGIGVPLAAFIG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
SLVVCLLVLGCHRFLGGGQMGLLILGFVISAFCGALVSLILFLSNDMVLRSATNWLAGSM
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AEAGFVPLRYALISIALGLAIILPFGRQLDGLMLGETTALSLGIKVGQVRALVIIACALL
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHCCHHHHHHHHHHHHHHHH
TGAAVSMSGVIGFIGMMIPNLLSLLFGGGRMRIMFWSGWFGALFLLVIDSLARHVAYPVD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCC
VPIGIVLALIGGPFFIWLFIRSTRS
CHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]