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The map label for this gene is acsA [H]

Identifier: 148652671

GI number: 148652671

Start: 1019488

End: 1021152

Strand: Direct

Name: acsA [H]

Synonym: PsycPRwf_0862

Alternate gene names: 148652671

Gene position: 1019488-1021152 (Clockwise)

Preceding gene: 148652670

Following gene: 148652672

Centisome position: 34.22

GC content: 47.63

Gene sequence:

>1665_bases
ATGTCACTTACTACCCCCACATCACTGAACTCTATCAGTTACGCTGAATTTTATCAGCAGTTTGACCAACAAGACCTACT
AAAACAAATATTCCAAGATCATCCTGAGGACGCGCTGAATGCTTATTTGGCATGCTGCGGCAGGCATGTGCGTAATGGCT
TAGGTGATAAAGTGGCCTTGGTACATGAAGATACTAAGCAAAAAATTACTCAGCTTAGCTTCAATGAGCTAGATCAAAGA
AGCGCCCAAGTGGCCAACTTGCTCAAAGCCTATGGCGTCAAAGCTGGTGATAGAGTAGCGACCATGCTACCGCGCACCCC
AGAGCTGCTTATTGTGGTGTTGGCCACCTGGCGTGTCGGGGCAATTTATCAGCCTCTATTCACCGCCTTTGGGGTGGAGT
CTATCGCTTATCGACTCGATAAAGCGGACACCAAGGTGGTATTTACCAATTTGGACAACCGCTCAAAATTTGATGAGATT
GAAAACTTGCCTACGATGGTGTTGATTGAAGCGCAAGCCGCCGCGGATGCTAGTGGTTACAGCGATGATATCTTTTCCAA
AGCCGAGCAGTATTCTGAGGTGTGTGAGCCGGTACTACTGACCCCCGATGCGCCATTTTTACAAATGTTTACCTCAGGTA
CTGTGGGCAAGTCAAAAGGTGTTAGTGTGCCTTTGGCCGCTTTGCCAACTTTTTATCTGTACATGCGCTATGCCATTGAC
CTGCAACAAACAGATCACTACTGGAACATGGCCGATCCTGGCTGGGCTTATGGCTTGTATTATGCCATTACTGGTCCGTT
ATTGATGGGCATTACCACTTACTTTAATGAGATGGGTTTTGATGCCCAGAACACCCTTGATTTCCTAGTCCGACATAAAA
TTAGCAACATAGCTTCCTCGCCAACTGCATTTAGAATGATGAAATCCAGTGGGGTCTTTGAAGGTGTGGCGGACCAATTG
TCGTTACGTGTGGCCAATTCAGCAGGTGAGACACTCAATACCGAAGTGGTGGGCTGGGTGAGCGAAAACCTAGGCTGTAA
GGTCTGCGATCAGTATGGTCAGACTGAGACGGGTATGACCTGCTGCATGCATCATGCGTTGCAGCATGAGGCGCCCACAG
GCAGCATGGGAATGCCACTACCAGGACATAAACTGGTGGTATTAGATGCCGATATGCAACTGGTAGAAGATGGGGTGCAA
GGGCAATTGGCAGTGGTGGTTAGTCAGTCGCCAGCCTTTTATTTTAATGGCTACAGCTGGAATGAAAAACAGGCCTTTTT
CGATGACTATTATTTGACTGGTGATGTGGTTGAGCGTCATCAAGATGGCACGTTCTGGTTTGCCGGTCGTGATGATGATA
TTATCATTACCGCAGGCTACCGCATAGGGCCCACCGATGTGGAAAACTGTGTGATGGAGCACGAAGCTGTGGCAGAATCG
GCTGCTGTGGGAGTTCCGGATGAGACGCGTGGCCATGTCATCAAATCTTATGTGGTGTTAAAAGAGGGCATTGATGGCTC
AGAAGATTTGGTCAATCAAATAAAGTCTTTGGTACAAAAGCGGCTGTCAGCTCATGCTTATCCGCGTTATGTGGAGTTTG
TGACGGCATTGCCGAAAACACCCAGTGGCAAAATACAGCGTTTTTTATTGCGTCAATCAAATTGA

Upstream 100 bases:

>100_bases
AAATCGGTTAATAATAGACAGGTTAATAGGATGTTAACTTAACTCTTATCCCCCAGCGCCCAATATAGGGCATGCTAGAA
GATGCTAAAGGAATAGCGAC

Downstream 100 bases:

>100_bases
TAAATATGACTAAACCTGTTTAAATAAATGCTAAAGTTGTTTGACTGTTTGTTCGAGTAATAACTCATAATTTAACCATA
AAAAAGGATTTTAAATGAAG

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MSLTTPTSLNSISYAEFYQQFDQQDLLKQIFQDHPEDALNAYLACCGRHVRNGLGDKVALVHEDTKQKITQLSFNELDQR
SAQVANLLKAYGVKAGDRVATMLPRTPELLIVVLATWRVGAIYQPLFTAFGVESIAYRLDKADTKVVFTNLDNRSKFDEI
ENLPTMVLIEAQAAADASGYSDDIFSKAEQYSEVCEPVLLTPDAPFLQMFTSGTVGKSKGVSVPLAALPTFYLYMRYAID
LQQTDHYWNMADPGWAYGLYYAITGPLLMGITTYFNEMGFDAQNTLDFLVRHKISNIASSPTAFRMMKSSGVFEGVADQL
SLRVANSAGETLNTEVVGWVSENLGCKVCDQYGQTETGMTCCMHHALQHEAPTGSMGMPLPGHKLVVLDADMQLVEDGVQ
GQLAVVVSQSPAFYFNGYSWNEKQAFFDDYYLTGDVVERHQDGTFWFAGRDDDIIITAGYRIGPTDVENCVMEHEAVAES
AAVGVPDETRGHVIKSYVVLKEGIDGSEDLVNQIKSLVQKRLSAHAYPRYVEFVTALPKTPSGKIQRFLLRQSN

Sequences:

>Translated_554_residues
MSLTTPTSLNSISYAEFYQQFDQQDLLKQIFQDHPEDALNAYLACCGRHVRNGLGDKVALVHEDTKQKITQLSFNELDQR
SAQVANLLKAYGVKAGDRVATMLPRTPELLIVVLATWRVGAIYQPLFTAFGVESIAYRLDKADTKVVFTNLDNRSKFDEI
ENLPTMVLIEAQAAADASGYSDDIFSKAEQYSEVCEPVLLTPDAPFLQMFTSGTVGKSKGVSVPLAALPTFYLYMRYAID
LQQTDHYWNMADPGWAYGLYYAITGPLLMGITTYFNEMGFDAQNTLDFLVRHKISNIASSPTAFRMMKSSGVFEGVADQL
SLRVANSAGETLNTEVVGWVSENLGCKVCDQYGQTETGMTCCMHHALQHEAPTGSMGMPLPGHKLVVLDADMQLVEDGVQ
GQLAVVVSQSPAFYFNGYSWNEKQAFFDDYYLTGDVVERHQDGTFWFAGRDDDIIITAGYRIGPTDVENCVMEHEAVAES
AAVGVPDETRGHVIKSYVVLKEGIDGSEDLVNQIKSLVQKRLSAHAYPRYVEFVTALPKTPSGKIQRFLLRQSN
>Mature_553_residues
SLTTPTSLNSISYAEFYQQFDQQDLLKQIFQDHPEDALNAYLACCGRHVRNGLGDKVALVHEDTKQKITQLSFNELDQRS
AQVANLLKAYGVKAGDRVATMLPRTPELLIVVLATWRVGAIYQPLFTAFGVESIAYRLDKADTKVVFTNLDNRSKFDEIE
NLPTMVLIEAQAAADASGYSDDIFSKAEQYSEVCEPVLLTPDAPFLQMFTSGTVGKSKGVSVPLAALPTFYLYMRYAIDL
QQTDHYWNMADPGWAYGLYYAITGPLLMGITTYFNEMGFDAQNTLDFLVRHKISNIASSPTAFRMMKSSGVFEGVADQLS
LRVANSAGETLNTEVVGWVSENLGCKVCDQYGQTETGMTCCMHHALQHEAPTGSMGMPLPGHKLVVLDADMQLVEDGVQG
QLAVVVSQSPAFYFNGYSWNEKQAFFDDYYLTGDVVERHQDGTFWFAGRDDDIIITAGYRIGPTDVENCVMEHEAVAESA
AVGVPDETRGHVIKSYVVLKEGIDGSEDLVNQIKSLVQKRLSAHAYPRYVEFVTALPKTPSGKIQRFLLRQSN

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI122937307, Length=513, Percent_Identity=33.7231968810916, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI42544132, Length=495, Percent_Identity=31.7171717171717, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI38505220, Length=503, Percent_Identity=32.0079522862823, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI28416953, Length=548, Percent_Identity=30.6569343065693, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI58082049, Length=509, Percent_Identity=30.8447937131631, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI13375727, Length=556, Percent_Identity=29.8561151079137, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI157311624, Length=513, Percent_Identity=30.7992202729045, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI157311622, Length=513, Percent_Identity=30.7992202729045, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI8923896, Length=561, Percent_Identity=29.4117647058824, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI253970489, Length=574, Percent_Identity=29.0940766550523, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI115511026, Length=517, Percent_Identity=29.5938104448743, Blast_Score=202, Evalue=8e-52,
Organism=Homo sapiens, GI195947378, Length=428, Percent_Identity=26.6355140186916, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI156151445, Length=537, Percent_Identity=23.8361266294227, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI42544134, Length=324, Percent_Identity=27.7777777777778, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI187761345, Length=546, Percent_Identity=23.4432234432234, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI187761343, Length=546, Percent_Identity=23.4432234432234, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1790505, Length=547, Percent_Identity=29.6160877513711, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1786529, Length=529, Percent_Identity=29.6786389413989, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI145693145, Length=542, Percent_Identity=24.7232472324723, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788107, Length=530, Percent_Identity=25.2830188679245, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI221142682, Length=521, Percent_Identity=22.4568138195777, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786810, Length=571, Percent_Identity=23.9929947460595, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786801, Length=442, Percent_Identity=23.0769230769231, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71983001, Length=560, Percent_Identity=29.2857142857143, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71982997, Length=560, Percent_Identity=29.2857142857143, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17557194, Length=522, Percent_Identity=23.5632183908046, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71994694, Length=526, Percent_Identity=23.1939163498099, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71994703, Length=526, Percent_Identity=23.1939163498099, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71994690, Length=526, Percent_Identity=23.1939163498099, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71996755, Length=512, Percent_Identity=25, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17558820, Length=487, Percent_Identity=20.9445585215606, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32563687, Length=530, Percent_Identity=22.4528301886792, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17560308, Length=514, Percent_Identity=22.7626459143969, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17538037, Length=531, Percent_Identity=22.7871939736347, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17560140, Length=537, Percent_Identity=22.9050279329609, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=530, Percent_Identity=23.0188679245283, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17569507, Length=549, Percent_Identity=21.3114754098361, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531443, Length=524, Percent_Identity=20.6106870229008, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71985884, Length=397, Percent_Identity=25.1889168765743, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=560, Percent_Identity=31.0714285714286, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6319264, Length=559, Percent_Identity=30.9481216457961, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319699, Length=235, Percent_Identity=27.6595744680851, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24667955, Length=556, Percent_Identity=29.136690647482, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI62472339, Length=528, Percent_Identity=28.5984848484849, Blast_Score=195, Evalue=8e-50,
Organism=Drosophila melanogaster, GI21355225, Length=554, Percent_Identity=27.2563176895307, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24667959, Length=497, Percent_Identity=28.169014084507, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24581924, Length=546, Percent_Identity=24.9084249084249, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI19922652, Length=512, Percent_Identity=24.8046875, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24656500, Length=503, Percent_Identity=24.0556660039761, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18859661, Length=509, Percent_Identity=24.5579567779961, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355181, Length=481, Percent_Identity=21.4137214137214, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21358303, Length=462, Percent_Identity=20.995670995671, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356441, Length=517, Percent_Identity=22.0502901353965, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24648253, Length=491, Percent_Identity=21.9959266802444, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648255, Length=491, Percent_Identity=21.9959266802444, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI20130357, Length=554, Percent_Identity=21.841155234657, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21356947, Length=546, Percent_Identity=20.1465201465201, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 61420; Mature: 61289

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTTPTSLNSISYAEFYQQFDQQDLLKQIFQDHPEDALNAYLACCGRHVRNGLGDKVAL
CCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEE
VHEDTKQKITQLSFNELDQRSAQVANLLKAYGVKAGDRVATMLPRTPELLIVVLATWRVG
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHH
AIYQPLFTAFGVESIAYRLDKADTKVVFTNLDNRSKFDEIENLPTMVLIEAQAAADASGY
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCEEEEEEHHHCCCCCC
SDDIFSKAEQYSEVCEPVLLTPDAPFLQMFTSGTVGKSKGVSVPLAALPTFYLYMRYAID
CHHHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LQQTDHYWNMADPGWAYGLYYAITGPLLMGITTYFNEMGFDAQNTLDFLVRHKISNIASS
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
PTAFRMMKSSGVFEGVADQLSLRVANSAGETLNTEVVGWVSENLGCKVCDQYGQTETGMT
CHHHHHHHHCCCHHHHHHHHHEEEECCCCCCCCCCEEEEHHCCCCHHHHHHCCCCCHHHH
CCMHHALQHEAPTGSMGMPLPGHKLVVLDADMQLVEDGVQGQLAVVVSQSPAFYFNGYSW
HHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHCCCCCEEEEEEECCCEEEECCCCC
NEKQAFFDDYYLTGDVVERHQDGTFWFAGRDDDIIITAGYRIGPTDVENCVMEHEAVAES
CCCCHHHCCEEEEHHHHHHCCCCEEEEECCCCCEEEECCCEECCHHHHHHHHHHHHHHHH
AAVGVPDETRGHVIKSYVVLKEGIDGSEDLVNQIKSLVQKRLSAHAYPRYVEFVTALPKT
HCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
PSGKIQRFLLRQSN
CCHHHHHHHHHCCC
>Mature Secondary Structure 
SLTTPTSLNSISYAEFYQQFDQQDLLKQIFQDHPEDALNAYLACCGRHVRNGLGDKVAL
CCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEE
VHEDTKQKITQLSFNELDQRSAQVANLLKAYGVKAGDRVATMLPRTPELLIVVLATWRVG
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHH
AIYQPLFTAFGVESIAYRLDKADTKVVFTNLDNRSKFDEIENLPTMVLIEAQAAADASGY
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCEEEEEEHHHCCCCCC
SDDIFSKAEQYSEVCEPVLLTPDAPFLQMFTSGTVGKSKGVSVPLAALPTFYLYMRYAID
CHHHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LQQTDHYWNMADPGWAYGLYYAITGPLLMGITTYFNEMGFDAQNTLDFLVRHKISNIASS
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
PTAFRMMKSSGVFEGVADQLSLRVANSAGETLNTEVVGWVSENLGCKVCDQYGQTETGMT
CHHHHHHHHCCCHHHHHHHHHEEEECCCCCCCCCCEEEEHHCCCCHHHHHHCCCCCHHHH
CCMHHALQHEAPTGSMGMPLPGHKLVVLDADMQLVEDGVQGQLAVVVSQSPAFYFNGYSW
HHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHCCCCCEEEEEEECCCEEEECCCCC
NEKQAFFDDYYLTGDVVERHQDGTFWFAGRDDDIIITAGYRIGPTDVENCVMEHEAVAES
CCCCHHHCCEEEEHHHHHHCCCCEEEEECCCCCEEEECCCEECCHHHHHHHHHHHHHHHH
AAVGVPDETRGHVIKSYVVLKEGIDGSEDLVNQIKSLVQKRLSAHAYPRYVEFVTALPKT
HCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
PSGKIQRFLLRQSN
CCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]