Click here to switch to the map view.

The map label for this gene is fghA [H]

Identifier: 148652395

GI number: 148652395

Start: 702758

End: 703612

Strand: Direct

Name: fghA [H]

Synonym: PsycPRwf_0583

Alternate gene names: 148652395

Gene position: 702758-703612 (Clockwise)

Preceding gene: 148652394

Following gene: 148652396

Centisome position: 23.59

GC content: 46.32

Gene sequence:

>855_bases
ATGTCAACGCTCACCCTCACCAGTAAAAATCGCTGCTTTAATGGCGAGCAATATTATTATACTCACCAATCAGCAGTGAC
CCAAACTGAGATGAGCTTTAGTATTTATTTGCCCGATGAGGCATTGGCCGGCCAAACTTGCCCGGCGTTATTGTATTTAT
CCGGCTTGACCTGTAGCCCAGACAACGTCACGCACAAAGCTCATTTTCAACAAAAATGTAGCGAGCTTGGCATGATATTT
ATAGCGCCAGACACTTCACCTAAAGGCGAATCTGTGCCCAATGATGAGCGCTATTTTGTCGGTCAGGGGGCAAGCTATTA
TGTGAATGCGACTGAAGATAAGTGGTCGAAGCATTTTAATATGCACAGTTATATTATTGACGAGTTTTATGAGCTGATTC
GTAGCCAGTTTGCTATTAGCAGTGTGGGTATCACCGGTCACTCTATGGGCGGGCATGGCGCGCTGATGTTTGGCTTTAAA
TACCCCAGCAAGTTCATCAGTGTGTCTGCCATAGCGCCTATCTGTGTTGCCAGTGAGTCTGATTGGGGGCGCGCCGCCTT
TAGTGAGTACTTTGGTGCTGAGTCAGAGCAGACATGGGCACAGTTTGATGCGGTAAATATCGTTGAAAAGGCAGGCAAGC
AGTATCCGCATATTTTAGTTGATCAAGGCGCAGCAGATGACTTCTATGTAGATGGCTACCTGCGCCCAGAGGCTTTGCAA
AAAGTGTGTCAGCAGGTTGAGCAGCCATTGACCTTGCGCTACCATGCCGGCTTTGACCACAGCTACTATTTTATCCAAAG
CATCATTAATGACCATATTGAACATCATTATAACGCCGCATTAACTGCCATATAA

Upstream 100 bases:

>100_bases
ACCTTTTGACACCAGGGCTTACTTTCAAAAAATAAGGCCTATGGTAGAATCAACATAGTAATGTCAGATATCTATATAAC
CGTCTTATAAGGAAGATAAT

Downstream 100 bases:

>100_bases
TTGGTATAATAGCTGGGTTTAATGGCCATTAAGCCCAGCGACATTTCTTTTATTCTCCTCCAATTCTTAGAGAAACAGTA
TGAGCAGCACCCAATCAGCA

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MSTLTLTSKNRCFNGEQYYYTHQSAVTQTEMSFSIYLPDEALAGQTCPALLYLSGLTCSPDNVTHKAHFQQKCSELGMIF
IAPDTSPKGESVPNDERYFVGQGASYYVNATEDKWSKHFNMHSYIIDEFYELIRSQFAISSVGITGHSMGGHGALMFGFK
YPSKFISVSAIAPICVASESDWGRAAFSEYFGAESEQTWAQFDAVNIVEKAGKQYPHILVDQGAADDFYVDGYLRPEALQ
KVCQQVEQPLTLRYHAGFDHSYYFIQSIINDHIEHHYNAALTAI

Sequences:

>Translated_284_residues
MSTLTLTSKNRCFNGEQYYYTHQSAVTQTEMSFSIYLPDEALAGQTCPALLYLSGLTCSPDNVTHKAHFQQKCSELGMIF
IAPDTSPKGESVPNDERYFVGQGASYYVNATEDKWSKHFNMHSYIIDEFYELIRSQFAISSVGITGHSMGGHGALMFGFK
YPSKFISVSAIAPICVASESDWGRAAFSEYFGAESEQTWAQFDAVNIVEKAGKQYPHILVDQGAADDFYVDGYLRPEALQ
KVCQQVEQPLTLRYHAGFDHSYYFIQSIINDHIEHHYNAALTAI
>Mature_283_residues
STLTLTSKNRCFNGEQYYYTHQSAVTQTEMSFSIYLPDEALAGQTCPALLYLSGLTCSPDNVTHKAHFQQKCSELGMIFI
APDTSPKGESVPNDERYFVGQGASYYVNATEDKWSKHFNMHSYIIDEFYELIRSQFAISSVGITGHSMGGHGALMFGFKY
PSKFISVSAIAPICVASESDWGRAAFSEYFGAESEQTWAQFDAVNIVEKAGKQYPHILVDQGAADDFYVDGYLRPEALQK
VCQQVEQPLTLRYHAGFDHSYYFIQSIINDHIEHHYNAALTAI

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=276, Percent_Identity=43.4782608695652, Blast_Score=241, Evalue=5e-64,
Organism=Escherichia coli, GI1786551, Length=276, Percent_Identity=41.6666666666667, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1788477, Length=275, Percent_Identity=42.9090909090909, Blast_Score=228, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17510185, Length=276, Percent_Identity=45.2898550724638, Blast_Score=242, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6322393, Length=279, Percent_Identity=35.84229390681, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24648347, Length=285, Percent_Identity=40.7017543859649, Blast_Score=225, Evalue=2e-59,
Organism=Drosophila melanogaster, GI45551932, Length=285, Percent_Identity=40.7017543859649, Blast_Score=225, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31856; Mature: 31725

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLTLTSKNRCFNGEQYYYTHQSAVTQTEMSFSIYLPDEALAGQTCPALLYLSGLTCSP
CCEEEEECCCCCCCCCEEEEECCHHHEEEEEEEEEEECCHHHCCCCCCHHHHCCCCCCCC
DNVTHKAHFQQKCSELGMIFIAPDTSPKGESVPNDERYFVGQGASYYVNATEDKWSKHFN
CCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEECCCEEEEECCHHHHHHHCC
MHSYIIDEFYELIRSQFAISSVGITGHSMGGHGALMFGFKYPSKFISVSAIAPICVASES
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHEEHHHHCEEEEECCC
DWGRAAFSEYFGAESEQTWAQFDAVNIVEKAGKQYPHILVDQGAADDFYVDGYLRPEALQ
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCEECHHHHH
KVCQQVEQPLTLRYHAGFDHSYYFIQSIINDHIEHHYNAALTAI
HHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEECC
>Mature Secondary Structure 
STLTLTSKNRCFNGEQYYYTHQSAVTQTEMSFSIYLPDEALAGQTCPALLYLSGLTCSP
CEEEEECCCCCCCCCEEEEECCHHHEEEEEEEEEEECCHHHCCCCCCHHHHCCCCCCCC
DNVTHKAHFQQKCSELGMIFIAPDTSPKGESVPNDERYFVGQGASYYVNATEDKWSKHFN
CCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEECCCEEEEECCHHHHHHHCC
MHSYIIDEFYELIRSQFAISSVGITGHSMGGHGALMFGFKYPSKFISVSAIAPICVASES
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHEEHHHHCEEEEECCC
DWGRAAFSEYFGAESEQTWAQFDAVNIVEKAGKQYPHILVDQGAADDFYVDGYLRPEALQ
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCEECHHHHH
KVCQQVEQPLTLRYHAGFDHSYYFIQSIINDHIEHHYNAALTAI
HHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]