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The map label for this gene is ydgK [H]

Identifier: 148652201

GI number: 148652201

Start: 470331

End: 471545

Strand: Direct

Name: ydgK [H]

Synonym: PsycPRwf_0389

Alternate gene names: 148652201

Gene position: 470331-471545 (Clockwise)

Preceding gene: 148652200

Following gene: 148652203

Centisome position: 15.79

GC content: 45.6

Gene sequence:

>1215_bases
ATGTCAAATACTCAAAATTCTACGCCAAAACTGCCTGTAGCATGGATTATGATGCTGGGGCTTATCGTGGCCATCGGCCC
ATTATCTATCGACATGTACCTACCTGCGCTGCCAACAATGGCTGAGGATTTTGGGGTCAGTACCGCTCAGATTTCAAACT
CAGTACCGGCATATTTTGCCGGCTTGGTCTTCGGCCAGCTGATATATGGGCCGTTAAGTGACCGCGTTGGCCGAGTCAAG
CCGCTGTATTTTGGTATGACCTTGTATGTCATTGCTTCGCTGATTTGTGCCACCACCGACAGTCAATATGTGCTGTTTGC
AGCACGTACCTTGCAAGCTTTAGGGGCGTGTGTTGGGGCGGTGGTTACCCGAGCCGCCATTCGTGATACCTTGCCGCCCA
AACAAATGGCCAAAGCCTTCTCTATTATGGTATTGGTGATGGGACTGGCGCCAATTTTAGCGCCTTCACTGGGTGCCGCA
TTTTTACGCTTTTTTGATTGGCATGTGATTTTTTGGTTCTTGGCAGGTTTTGGGGTACTAAACTTGCTACTGACCAAGTT
CTTTTTTAAAGAAACCTTGACTGAAGAAAACCGAAATTACAAACCTTTGAATACCATTTTAAGTCAATATCTAGACTTAC
TAAAAGATCCCTCTTTTGGGTTTCCGGCTATTGGTGCCGGTCTATTAATGGGCTCAATGTTCGTTTATATCAGTGCAGCG
CCCGAGCTGTTAATGGATGGCTATGGGCTAACGGAGAACCAGTTTAGTTTAATATTTGGTATGAATGCCGCAGGCTTTGT
GGCACTTACTCAGGTGAATCAGTTTTTAACCAATAGGTTTCGTCTGATTAGCTTACTGCGTTTTGGGGCAGTTATGCAGG
CAGTTGCTGCGATAGGACTGTTGTTGTTAGGTGGGATTTATGGTGCAGAGGCTTGGTTGCCATTGGTACTTATCTGTATT
TTCTTCTGTATTGCCGGTTTGGGGTTAACTCAGCCGAATGCCTCAGCAATTGCCTTGGCGTTTCAAAAACACCGCGCCGG
TATGGCCAGTGCCTTACAAGGCTCATTAATGTTTTGTGTGGGTATTTTTGGCGGCTTATTGCTCAACTTATTTCCGGTAA
ACCCTGTGTTTAAGCTTGGGGCCACCATGTCAATTTTAATGTGTTTGGGCACCTTTTTGATTTATCGCATGGATAAGAAT
TTAAACCTAGAGTAG

Upstream 100 bases:

>100_bases
AGGTTGCTTTTTGATATTGGTGATATCAAGTGTATTAATAACATCACAATAAAATAAATAGGTAATACCTATATTAAACC
TTTAGCTCTGTGTGAGATTT

Downstream 100 bases:

>100_bases
AGGTAAGACACGGGGTCACGCCAGCAACATGCAGCCATCAGCAGCTGCTTTGACGCAAAAAATACGTTTTGTAGATAGCG
CCTAAATTGGCGGTGCTATG

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSNTQNSTPKLPVAWIMMLGLIVAIGPLSIDMYLPALPTMAEDFGVSTAQISNSVPAYFAGLVFGQLIYGPLSDRVGRVK
PLYFGMTLYVIASLICATTDSQYVLFAARTLQALGACVGAVVTRAAIRDTLPPKQMAKAFSIMVLVMGLAPILAPSLGAA
FLRFFDWHVIFWFLAGFGVLNLLLTKFFFKETLTEENRNYKPLNTILSQYLDLLKDPSFGFPAIGAGLLMGSMFVYISAA
PELLMDGYGLTENQFSLIFGMNAAGFVALTQVNQFLTNRFRLISLLRFGAVMQAVAAIGLLLLGGIYGAEAWLPLVLICI
FFCIAGLGLTQPNASAIALAFQKHRAGMASALQGSLMFCVGIFGGLLLNLFPVNPVFKLGATMSILMCLGTFLIYRMDKN
LNLE

Sequences:

>Translated_404_residues
MSNTQNSTPKLPVAWIMMLGLIVAIGPLSIDMYLPALPTMAEDFGVSTAQISNSVPAYFAGLVFGQLIYGPLSDRVGRVK
PLYFGMTLYVIASLICATTDSQYVLFAARTLQALGACVGAVVTRAAIRDTLPPKQMAKAFSIMVLVMGLAPILAPSLGAA
FLRFFDWHVIFWFLAGFGVLNLLLTKFFFKETLTEENRNYKPLNTILSQYLDLLKDPSFGFPAIGAGLLMGSMFVYISAA
PELLMDGYGLTENQFSLIFGMNAAGFVALTQVNQFLTNRFRLISLLRFGAVMQAVAAIGLLLLGGIYGAEAWLPLVLICI
FFCIAGLGLTQPNASAIALAFQKHRAGMASALQGSLMFCVGIFGGLLLNLFPVNPVFKLGATMSILMCLGTFLIYRMDKN
LNLE
>Mature_403_residues
SNTQNSTPKLPVAWIMMLGLIVAIGPLSIDMYLPALPTMAEDFGVSTAQISNSVPAYFAGLVFGQLIYGPLSDRVGRVKP
LYFGMTLYVIASLICATTDSQYVLFAARTLQALGACVGAVVTRAAIRDTLPPKQMAKAFSIMVLVMGLAPILAPSLGAAF
LRFFDWHVIFWFLAGFGVLNLLLTKFFFKETLTEENRNYKPLNTILSQYLDLLKDPSFGFPAIGAGLLMGSMFVYISAAP
ELLMDGYGLTENQFSLIFGMNAAGFVALTQVNQFLTNRFRLISLLRFGAVMQAVAAIGLLLLGGIYGAEAWLPLVLICIF
FCIAGLGLTQPNASAIALAFQKHRAGMASALQGSLMFCVGIFGGLLLNLFPVNPVFKLGATMSILMCLGTFLIYRMDKNL
NLE

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=396, Percent_Identity=31.0606060606061, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1790146, Length=339, Percent_Identity=28.9085545722714, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI48994889, Length=349, Percent_Identity=30.3724928366762, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790794, Length=330, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082312, Length=194, Percent_Identity=31.4432989690722, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1787065, Length=267, Percent_Identity=27.7153558052434, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081983, Length=204, Percent_Identity=26.4705882352941, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43726; Mature: 43595

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SNTQNSTPKLPVAWIMMLGLIVAIGPLSIDMYLPALPTMAEDFGVSTAQISNSVPAYFA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHCCCCHHHHH
GLVFGQLIYGPLSDRVGRVKPLYFGMTLYVIASLICATTDSQYVLFAARTLQALGACVGA
HHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VVTRAAIRDTLPPKQMAKAFSIMVLVMGLAPILAPSLGAAFLRFFDWHVIFWFLAGFGVL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLLLTKFFFKETLTEENRNYKPLNTILSQYLDLLKDPSFGFPAIGAGLLMGSMFVYISAA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
PELLMDGYGLTENQFSLIFGMNAAGFVALTQVNQFLTNRFRLISLLRFGAVMQAVAAIGL
HHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLGGIYGAEAWLPLVLICIFFCIAGLGLTQPNASAIALAFQKHRAGMASALQGSLMFCV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GIFGGLLLNLFPVNPVFKLGATMSILMCLGTFLIYRMDKNLNLE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]