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The map label for this gene is nrdD [C]

Identifier: 148643443

GI number: 148643443

Start: 1399295

End: 1401625

Strand: Reverse

Name: nrdD [C]

Synonym: Msm_1383

Alternate gene names: 148643443

Gene position: 1401625-1399295 (Counterclockwise)

Preceding gene: 148643444

Following gene: 148643442

Centisome position: 75.63

GC content: 35.48

Gene sequence:

>2331_bases
ATGGTGACATATATGGAAAAGACTTCCGAAATAATGAAAGAACTTGCTAACTCCAAGAAAATCAACGTTGAAAAAAACAA
CGGTATTAAAGAAAGATTTAGCTATGAAAAATTATTAAAATCCTTAGTAATGGTTGAAACTCCTTTCTTTGAATCTGATA
AAATTGTAGCTCAGGTTGTTTCTTCACTTTATGATGGCATTAAAACCAAAGAAATTAAAAAAATCGTATATGAATGTTTA
GAAGATATTGATGGTGAAATAGCTAACAAATACTTAGCCAGTACCCAATTAAAAGTACGTACTTCCAGAGATACCATTGA
AGCATTTGATTTATCCAAAATCGCAAATACTTTAATTGAAGAAACAGGTGCATCCCAAGAAACCGCATTTGAAATAGCTA
CTGAAGTCTGGAAAGAGCTTAAAAAATTAAATGTGGAATACTTAACCGCGCCAATGATTAGGGAAATGGTAAACACCAAA
CTTGTAGAATATGGATTAGAAGACTTAAGAAGCCGTTACACTCGTTTAGGTATCCCTGTATACAACATCACTTCATTAAT
TGAAAACGGTAACAGGGACAATGCAAATATGATTCACAACCCTGAAAGTATCCACAAACATGTAGCTGATGAAGCATTAA
AACAATATGCTCTTTTACAAATGCTTCCGTCACATTTAGCTGATGCACATATGTCCGGAGATATCCATATTCACGATTTA
GAATTCTTTGCAGGAAGACCTCTAAACTGTATGCAGCACGATATAAGAACTTTCATCAAATACGGACTTAAAGTAGACGG
AACCGGAGATCATACATCTGTTGCAGGTGCTCCAAACCACATGGAAACCTTAATGAACCATACTGGAGAAATTATGCTTG
CATCACAACAAAACATGTCCGGAGGACAAGCTATGTCCTTATGGAACGTATTTGTAGCACCATTTGCAAGAGGCAGAACC
TATGAAGAAATCAAACAATCTGTCCAAATGCTTATTTATAATTTAAATATGGCTTATGCAGCTAGAGGTTCCCAGGTACC
GTTTACAAGTATGGTTTTAGAATTCGGAGTTCCAAAGTTCTTACAGGATGTAACTGCATACGGTCCGAAAGGTCAAGTCG
TCGGAACCTATGGTGATTTTGAAGAAGAAACCAGATTAATCCAAAAAGCATTTACTGAAACATTACTTGCCGGTGACCAA
GAAGGAAAACCTCATCTTTTCCCAAATACTATTTACACACTCCGTGAAGAAACATTAAAAGGAGATTATGAAGAAGACTT
ACATTTAGTCCATGAATTATCTGCAAAATACGGATCATCATATTTCATCAATATGTTGCCGGATTACAGGGGCAAAATGG
CAAATTATATGGGATGTAGAACCTGTTTACAAGATAACTGGACTGGTGACTGGGAACAAGACTGTTTAAGAACAGGTAAC
CTTGCATATGTAACTTTAAACCTTCCAAGGATAGGATACCAATCTAAAGACGAATCTCAAGTATTCGAGTATTTGGATGA
ATACATGGATTTAGCTGCAGAAACATTAATGCTTAGAAGAGAACAAGGATTAAAATGTTTAAATGACTTCCATATATTAC
CATTCCTTAAACAAAAAGTTGGAGAAGACAGCTATTACAGAATCCAAAATTCAACATTATCTTTTGGTTTTGTTGGTCTT
AACGAAATGTTATTATCCTTATTTGGAAAAGGTATCGAAGATAAAGACGCAAACAAATTTGGTGTCAAATGTATTGAATA
CTTAAATGAAAGAGCTGACAAATTAAAAGAGGAAACTGGTCTTAGATGGTCTGTTCTCCAAACTCCTGCAGAATCCACCG
CATACAGATTTGCAACTCTTGATAAAGAGCAATTCGGAGATCAAGCTATCGTACAAGGTGACGGAAGTGCTAATTACTAC
ACCAACTCATCACATGTTCCAGTAAACACAGATGTCTCCCTTATTGACAAAATAAAAATCGAAGAACAATACCACAGTTT
AACTCCTGGTGGACATATCTTCCATGCATTTATGGGAGAATCCTACTCCGATCCAGATTCATTAATGAGTTTAACTAACA
AAATAGCTAAAAAATCAGATATTGGTTTCTGGGCTTACAGTTCTGCATTAAGTTTCTGTCTTAATTGTAAAACTTTAATG
AAAGGTTTAAACAACAAATGTCCAACCTGTGGAGAAAGTGAAGATGTTGAATGGTATGACAGAATTACCGGATACGTACA
ACAAGTAGGACGTGCAAAATCATCATCAGGTGGTTGGAACCCTGGAAAACGTCAAGAGTTAATTGACAGAAGAAGATTTG
AAGATGAATAA

Upstream 100 bases:

>100_bases
TGAAGTATACATTGTTCGTATCAAAGCGAACATAATATATACAAGTAAGAATATATAATTAATACAACTGAGAGAAAACT
CTCTCGTCAAAATTTATAGG

Downstream 100 bases:

>100_bases
TCTTCTTCCAAACACCATCCTTTAAAAAAAAACTATCACCCCCATCCTATTTTTATCAGAACATTATTATATGAAATCTT
CCAGAAATAATACATATTGT

Product: anaerobic ribonucleoside-triphosphate reductase, NrdD

Products: ribonucleoside triphosphate; thioredoxin

Alternate protein names: NA

Number of amino acids: Translated: 776; Mature: 776

Protein sequence:

>776_residues
MVTYMEKTSEIMKELANSKKINVEKNNGIKERFSYEKLLKSLVMVETPFFESDKIVAQVVSSLYDGIKTKEIKKIVYECL
EDIDGEIANKYLASTQLKVRTSRDTIEAFDLSKIANTLIEETGASQETAFEIATEVWKELKKLNVEYLTAPMIREMVNTK
LVEYGLEDLRSRYTRLGIPVYNITSLIENGNRDNANMIHNPESIHKHVADEALKQYALLQMLPSHLADAHMSGDIHIHDL
EFFAGRPLNCMQHDIRTFIKYGLKVDGTGDHTSVAGAPNHMETLMNHTGEIMLASQQNMSGGQAMSLWNVFVAPFARGRT
YEEIKQSVQMLIYNLNMAYAARGSQVPFTSMVLEFGVPKFLQDVTAYGPKGQVVGTYGDFEEETRLIQKAFTETLLAGDQ
EGKPHLFPNTIYTLREETLKGDYEEDLHLVHELSAKYGSSYFINMLPDYRGKMANYMGCRTCLQDNWTGDWEQDCLRTGN
LAYVTLNLPRIGYQSKDESQVFEYLDEYMDLAAETLMLRREQGLKCLNDFHILPFLKQKVGEDSYYRIQNSTLSFGFVGL
NEMLLSLFGKGIEDKDANKFGVKCIEYLNERADKLKEETGLRWSVLQTPAESTAYRFATLDKEQFGDQAIVQGDGSANYY
TNSSHVPVNTDVSLIDKIKIEEQYHSLTPGGHIFHAFMGESYSDPDSLMSLTNKIAKKSDIGFWAYSSALSFCLNCKTLM
KGLNNKCPTCGESEDVEWYDRITGYVQQVGRAKSSSGGWNPGKRQELIDRRRFEDE

Sequences:

>Translated_776_residues
MVTYMEKTSEIMKELANSKKINVEKNNGIKERFSYEKLLKSLVMVETPFFESDKIVAQVVSSLYDGIKTKEIKKIVYECL
EDIDGEIANKYLASTQLKVRTSRDTIEAFDLSKIANTLIEETGASQETAFEIATEVWKELKKLNVEYLTAPMIREMVNTK
LVEYGLEDLRSRYTRLGIPVYNITSLIENGNRDNANMIHNPESIHKHVADEALKQYALLQMLPSHLADAHMSGDIHIHDL
EFFAGRPLNCMQHDIRTFIKYGLKVDGTGDHTSVAGAPNHMETLMNHTGEIMLASQQNMSGGQAMSLWNVFVAPFARGRT
YEEIKQSVQMLIYNLNMAYAARGSQVPFTSMVLEFGVPKFLQDVTAYGPKGQVVGTYGDFEEETRLIQKAFTETLLAGDQ
EGKPHLFPNTIYTLREETLKGDYEEDLHLVHELSAKYGSSYFINMLPDYRGKMANYMGCRTCLQDNWTGDWEQDCLRTGN
LAYVTLNLPRIGYQSKDESQVFEYLDEYMDLAAETLMLRREQGLKCLNDFHILPFLKQKVGEDSYYRIQNSTLSFGFVGL
NEMLLSLFGKGIEDKDANKFGVKCIEYLNERADKLKEETGLRWSVLQTPAESTAYRFATLDKEQFGDQAIVQGDGSANYY
TNSSHVPVNTDVSLIDKIKIEEQYHSLTPGGHIFHAFMGESYSDPDSLMSLTNKIAKKSDIGFWAYSSALSFCLNCKTLM
KGLNNKCPTCGESEDVEWYDRITGYVQQVGRAKSSSGGWNPGKRQELIDRRRFEDE
>Mature_776_residues
MVTYMEKTSEIMKELANSKKINVEKNNGIKERFSYEKLLKSLVMVETPFFESDKIVAQVVSSLYDGIKTKEIKKIVYECL
EDIDGEIANKYLASTQLKVRTSRDTIEAFDLSKIANTLIEETGASQETAFEIATEVWKELKKLNVEYLTAPMIREMVNTK
LVEYGLEDLRSRYTRLGIPVYNITSLIENGNRDNANMIHNPESIHKHVADEALKQYALLQMLPSHLADAHMSGDIHIHDL
EFFAGRPLNCMQHDIRTFIKYGLKVDGTGDHTSVAGAPNHMETLMNHTGEIMLASQQNMSGGQAMSLWNVFVAPFARGRT
YEEIKQSVQMLIYNLNMAYAARGSQVPFTSMVLEFGVPKFLQDVTAYGPKGQVVGTYGDFEEETRLIQKAFTETLLAGDQ
EGKPHLFPNTIYTLREETLKGDYEEDLHLVHELSAKYGSSYFINMLPDYRGKMANYMGCRTCLQDNWTGDWEQDCLRTGN
LAYVTLNLPRIGYQSKDESQVFEYLDEYMDLAAETLMLRREQGLKCLNDFHILPFLKQKVGEDSYYRIQNSTLSFGFVGL
NEMLLSLFGKGIEDKDANKFGVKCIEYLNERADKLKEETGLRWSVLQTPAESTAYRFATLDKEQFGDQAIVQGDGSANYY
TNSSHVPVNTDVSLIDKIKIEEQYHSLTPGGHIFHAFMGESYSDPDSLMSLTNKIAKKSDIGFWAYSSALSFCLNCKTLM
KGLNNKCPTCGESEDVEWYDRITGYVQQVGRAKSSSGGWNPGKRQELIDRRRFEDE

Specific function: Unknown

COG id: COG1328

COG function: function code F; Oxygen-sensitive ribonucleoside-triphosphate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 DOD-type homing endonuclease domains [H]

Homologues:

Organism=Escherichia coli, GI1790686, Length=648, Percent_Identity=26.8518518518519, Blast_Score=172, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR003586
- InterPro:   IPR003587
- InterPro:   IPR007869
- InterPro:   IPR006142
- InterPro:   IPR004042
- InterPro:   IPR006141
- InterPro:   IPR012833 [H]

Pfam domain/function: PF03477 ATP-cone; PF05204 Hom_end [H]

EC number: 1.17.4.2

Molecular weight: Translated: 88146; Mature: 88146

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTYMEKTSEIMKELANSKKINVEKNNGIKERFSYEKLLKSLVMVETPFFESDKIVAQVV
CCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
SSLYDGIKTKEIKKIVYECLEDIDGEIANKYLASTQLKVRTSRDTIEAFDLSKIANTLIE
HHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHH
ETGASQETAFEIATEVWKELKKLNVEYLTAPMIREMVNTKLVEYGLEDLRSRYTRLGIPV
HCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
YNITSLIENGNRDNANMIHNPESIHKHVADEALKQYALLQMLPSHLADAHMSGDIHIHDL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
EFFAGRPLNCMQHDIRTFIKYGLKVDGTGDHTSVAGAPNHMETLMNHTGEIMLASQQNMS
HHHCCCCHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCC
GGQAMSLWNVFVAPFARGRTYEEIKQSVQMLIYNLNMAYAARGSQVPFTSMVLEFGVPKF
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHCCHHH
LQDVTAYGPKGQVVGTYGDFEEETRLIQKAFTETLLAGDQEGKPHLFPNTIYTLREETLK
HHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHC
GDYEEDLHLVHELSAKYGSSYFINMLPDYRGKMANYMGCRTCLQDNWTGDWEQDCLRTGN
CCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
LAYVTLNLPRIGYQSKDESQVFEYLDEYMDLAAETLMLRREQGLKCLNDFHILPFLKQKV
EEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
GEDSYYRIQNSTLSFGFVGLNEMLLSLFGKGIEDKDANKFGVKCIEYLNERADKLKEETG
CCCCEEEEECCCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
LRWSVLQTPAESTAYRFATLDKEQFGDQAIVQGDGSANYYTNSSHVPVNTDVSLIDKIKI
CEEEEECCCCHHHHHHHHCCCHHHCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
EEQYHSLTPGGHIFHAFMGESYSDPDSLMSLTNKIAKKSDIGFWAYSSALSFCLNCKTLM
HHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KGLNNKCPTCGESEDVEWYDRITGYVQQVGRAKSSSGGWNPGKRQELIDRRRFEDE
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MVTYMEKTSEIMKELANSKKINVEKNNGIKERFSYEKLLKSLVMVETPFFESDKIVAQVV
CCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
SSLYDGIKTKEIKKIVYECLEDIDGEIANKYLASTQLKVRTSRDTIEAFDLSKIANTLIE
HHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHH
ETGASQETAFEIATEVWKELKKLNVEYLTAPMIREMVNTKLVEYGLEDLRSRYTRLGIPV
HCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
YNITSLIENGNRDNANMIHNPESIHKHVADEALKQYALLQMLPSHLADAHMSGDIHIHDL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
EFFAGRPLNCMQHDIRTFIKYGLKVDGTGDHTSVAGAPNHMETLMNHTGEIMLASQQNMS
HHHCCCCHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCC
GGQAMSLWNVFVAPFARGRTYEEIKQSVQMLIYNLNMAYAARGSQVPFTSMVLEFGVPKF
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHCCHHH
LQDVTAYGPKGQVVGTYGDFEEETRLIQKAFTETLLAGDQEGKPHLFPNTIYTLREETLK
HHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHC
GDYEEDLHLVHELSAKYGSSYFINMLPDYRGKMANYMGCRTCLQDNWTGDWEQDCLRTGN
CCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
LAYVTLNLPRIGYQSKDESQVFEYLDEYMDLAAETLMLRREQGLKCLNDFHILPFLKQKV
EEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
GEDSYYRIQNSTLSFGFVGLNEMLLSLFGKGIEDKDANKFGVKCIEYLNERADKLKEETG
CCCCEEEEECCCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
LRWSVLQTPAESTAYRFATLDKEQFGDQAIVQGDGSANYYTNSSHVPVNTDVSLIDKIKI
CEEEEECCCCHHHHHHHHCCCHHHCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
EEQYHSLTPGGHIFHAFMGESYSDPDSLMSLTNKIAKKSDIGFWAYSSALSFCLNCKTLM
HHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KGLNNKCPTCGESEDVEWYDRITGYVQQVGRAKSSSGGWNPGKRQELIDRRRFEDE
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2'-deoxyribonucleoside triphosphate; thioredoxin disulfide; H2O

Specific reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]