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The map label for this gene is ilvC

Identifier: 148643282

GI number: 148643282

Start: 1222282

End: 1223274

Strand: Reverse

Name: ilvC

Synonym: Msm_1222

Alternate gene names: 148643282

Gene position: 1223274-1222282 (Counterclockwise)

Preceding gene: 148643283

Following gene: 148643281

Centisome position: 66.01

GC content: 34.94

Gene sequence:

>993_bases
ATGAAAATGTATTACGAATCAGATGTAAATACTGATGCTCTTGAAGGTAAAACCGTAGCTGTAATGGGTTATGGAAGCCA
AGGTAGAGCACAATCTAGAAACATGGCTGACAGTGGTGTCAATGTTATTGTTGGACTTAGAGAAAATGGTAATTCTTGGA
ATTTAGCTAAAGAAGATGGTATGACTGTAAAAACCTTCTCTGATGCAGCTAAAGAAGCAGATATCATCCATATTTTACTT
CCTGATGAAATCCAAGAAAAAGTTTACAATGAACAAATTGCACCTTATGTTGAAGCTGGAAATACCATTTCCTTCTCTCA
CGGATATAACATTCACTTTGGATTAATCAAACCTGATGAAGATGTTAATATTGTAATGTTTGCTCCTAAAGGACCAGGTT
CTAGAGTAAGAACTACTTACTTAGACGGTTTTGGAATTCCTGGATTAGTAGCTATTGAACAAGACGCTACTGGAGATGCA
TTACAACTTGCATTAGGTATGGCAAAAGCTTGTGGTTTCACTAAAGCTGGTGTAATTGAAACTACTTTTAAAGAAGAAAC
TGAAACTGATTTATTTGGTGAACAAGCTGTTTTATGTGGTGGACTTACTGCATTAATTAATGCTGGTTTCCAAACTTTAG
TAGAAGCTGGTTACCAACCTGAAATTGCTTACTTTGAAACCTGTCACGAAGTAAAACTTATTGTTGATGATATTTATGAA
CATGGTTTCGGCGGAATGTGGAAAGATGTAAGTAATACTGCAGAATATGGTGGATTAACCAGAAGGGACTATGTCATAAC
TGAAGAAACTAAAAAAGGTATGAAAAAAGTTTTATCTGAAATTCAAGATGGTACTTTCAAAAAACAATTTGCTGATGAAA
ATGCAACTGATGCAGCAAACTTAAAAGAAATGAGGGCTGCTGAAGACCAAGAAACTATTGAAGTTGTTGGAGAAAGACTC
AGAAAAGCTTGTGGATTACAAAAAGATGATTAA

Upstream 100 bases:

>100_bases
ACATTAGTTACTTTTATAAGTAGAAAAAATAATATATACTACTTGATATTTGAAGTACTTTAAATATCTCACATTTATCA
ATTATATAGGAGAAGTTAAA

Downstream 100 bases:

>100_bases
ATAATTTAATCATTATTTCTCTTTTTTCTCTTTTTTTTATAATTATTTTTTTGGATGCAATTATTATGGTTTTTATAGGA
ATGGATCATGGAACTACTGG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MKMYYESDVNTDALEGKTVAVMGYGSQGRAQSRNMADSGVNVIVGLRENGNSWNLAKEDGMTVKTFSDAAKEADIIHILL
PDEIQEKVYNEQIAPYVEAGNTISFSHGYNIHFGLIKPDEDVNIVMFAPKGPGSRVRTTYLDGFGIPGLVAIEQDATGDA
LQLALGMAKACGFTKAGVIETTFKEETETDLFGEQAVLCGGLTALINAGFQTLVEAGYQPEIAYFETCHEVKLIVDDIYE
HGFGGMWKDVSNTAEYGGLTRRDYVITEETKKGMKKVLSEIQDGTFKKQFADENATDAANLKEMRAAEDQETIEVVGERL
RKACGLQKDD

Sequences:

>Translated_330_residues
MKMYYESDVNTDALEGKTVAVMGYGSQGRAQSRNMADSGVNVIVGLRENGNSWNLAKEDGMTVKTFSDAAKEADIIHILL
PDEIQEKVYNEQIAPYVEAGNTISFSHGYNIHFGLIKPDEDVNIVMFAPKGPGSRVRTTYLDGFGIPGLVAIEQDATGDA
LQLALGMAKACGFTKAGVIETTFKEETETDLFGEQAVLCGGLTALINAGFQTLVEAGYQPEIAYFETCHEVKLIVDDIYE
HGFGGMWKDVSNTAEYGGLTRRDYVITEETKKGMKKVLSEIQDGTFKKQFADENATDAANLKEMRAAEDQETIEVVGERL
RKACGLQKDD
>Mature_330_residues
MKMYYESDVNTDALEGKTVAVMGYGSQGRAQSRNMADSGVNVIVGLRENGNSWNLAKEDGMTVKTFSDAAKEADIIHILL
PDEIQEKVYNEQIAPYVEAGNTISFSHGYNIHFGLIKPDEDVNIVMFAPKGPGSRVRTTYLDGFGIPGLVAIEQDATGDA
LQLALGMAKACGFTKAGVIETTFKEETETDLFGEQAVLCGGLTALINAGFQTLVEAGYQPEIAYFETCHEVKLIVDDIYE
HGFGGMWKDVSNTAEYGGLTRRDYVITEETKKGMKKVLSEIQDGTFKKQFADENATDAANLKEMRAAEDQETIEVVGERL
RKACGLQKDD

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=296, Percent_Identity=34.4594594594595, Blast_Score=151, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=282, Percent_Identity=34.7517730496454, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_METS3 (A5UMJ9)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001273795.1
- ProteinModelPortal:   A5UMJ9
- SMR:   A5UMJ9
- STRING:   A5UMJ9
- GeneID:   5216052
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_1222
- eggNOG:   arNOG04335
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36106; Mature: 36106

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMYYESDVNTDALEGKTVAVMGYGSQGRAQSRNMADSGVNVIVGLRENGNSWNLAKEDG
CCEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEECCCC
MTVKTFSDAAKEADIIHILLPDEIQEKVYNEQIAPYVEAGNTISFSHGYNIHFGLIKPDE
CEEEEHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHCCCEEEECCCCEEEEEEECCCC
DVNIVMFAPKGPGSRVRTTYLDGFGIPGLVAIEQDATGDALQLALGMAKACGFTKAGVIE
CCEEEEECCCCCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEE
TTFKEETETDLFGEQAVLCGGLTALINAGFQTLVEAGYQPEIAYFETCHEVKLIVDDIYE
EHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
HGFGGMWKDVSNTAEYGGLTRRDYVITEETKKGMKKVLSEIQDGTFKKQFADENATDAAN
CCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHH
LKEMRAAEDQETIEVVGERLRKACGLQKDD
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKMYYESDVNTDALEGKTVAVMGYGSQGRAQSRNMADSGVNVIVGLRENGNSWNLAKEDG
CCEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEECCCC
MTVKTFSDAAKEADIIHILLPDEIQEKVYNEQIAPYVEAGNTISFSHGYNIHFGLIKPDE
CEEEEHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHCCCEEEECCCCEEEEEEECCCC
DVNIVMFAPKGPGSRVRTTYLDGFGIPGLVAIEQDATGDALQLALGMAKACGFTKAGVIE
CCEEEEECCCCCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEE
TTFKEETETDLFGEQAVLCGGLTALINAGFQTLVEAGYQPEIAYFETCHEVKLIVDDIYE
EHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
HGFGGMWKDVSNTAEYGGLTRRDYVITEETKKGMKKVLSEIQDGTFKKQFADENATDAAN
CCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHH
LKEMRAAEDQETIEVVGERLRKACGLQKDD
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA