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The map label for this gene is hisB

Identifier: 148643266

GI number: 148643266

Start: 1205953

End: 1206531

Strand: Reverse

Name: hisB

Synonym: Msm_1206

Alternate gene names: 148643266

Gene position: 1206531-1205953 (Counterclockwise)

Preceding gene: 148643267

Following gene: 148643265

Centisome position: 65.11

GC content: 32.99

Gene sequence:

>579_bases
ATGGATAGAAAATCAAATGTTTCAAGAACTACATCTGAAACAGATATACAAATAGAAATGAATCTTGACGGAAAGGGAAA
ATATAATATTTCAACTGGTGTGAATTTTTTTAATCATATGCTGGAGGCATTTTCAAAACATTCAATGATTGATTTGGTTG
TTGATGCAAAAGGAGACATTGAAATTGATGACCATCACACTATTGAAGATGTCGGTATATTATTGGGTGAAGCTTTCAGG
CAAGCTATTGGAGATAAAAGGGGAATTAAAAGAATGGCTGATGCTACAGTACCTATGGATGAATCAGTAGCTAAAGTAGC
TATTGATATTAGTGGGCGCAGCTATTGCAATATGGAATTTGATTTTACTAATGAAAAAATTGGAGACATGACTTCTGAAA
TTGTTGTTCACTTTTTTGAGTCATTTGTATCTTCGGCTAAATTAAATATTTACGGGGTTTCAAAAGGAGCAAATGATCAT
CATCAGGCTGAAGCGGTCTTTAAAGCTTTTGCCAAATCATTAAAAGAAGCAATAAAGATAGAGCATGATGAGATTCCTAG
TACAAAAGGTGTTTTATAA

Upstream 100 bases:

>100_bases
GATGGCATGCCCTGAACACTGCATTAAAATTATACGTAATGCTCCGGAAGAGTGAATAATTTACTCTTCTTTTAATTTAA
CAATAGTTTGAGGAATAGCT

Downstream 100 bases:

>100_bases
GTGGCAGGTGAAGATTTCTCTCAACGGGCATCTCATGATCGTTTAAGTGCAATAACTGATGGAGTTTATGCTGTAGCTTT
GACTTTGCTTGCTTTGGAGA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MDRKSNVSRTTSETDIQIEMNLDGKGKYNISTGVNFFNHMLEAFSKHSMIDLVVDAKGDIEIDDHHTIEDVGILLGEAFR
QAIGDKRGIKRMADATVPMDESVAKVAIDISGRSYCNMEFDFTNEKIGDMTSEIVVHFFESFVSSAKLNIYGVSKGANDH
HQAEAVFKAFAKSLKEAIKIEHDEIPSTKGVL

Sequences:

>Translated_192_residues
MDRKSNVSRTTSETDIQIEMNLDGKGKYNISTGVNFFNHMLEAFSKHSMIDLVVDAKGDIEIDDHHTIEDVGILLGEAFR
QAIGDKRGIKRMADATVPMDESVAKVAIDISGRSYCNMEFDFTNEKIGDMTSEIVVHFFESFVSSAKLNIYGVSKGANDH
HQAEAVFKAFAKSLKEAIKIEHDEIPSTKGVL
>Mature_192_residues
MDRKSNVSRTTSETDIQIEMNLDGKGKYNISTGVNFFNHMLEAFSKHSMIDLVVDAKGDIEIDDHHTIEDVGILLGEAFR
QAIGDKRGIKRMADATVPMDESVAKVAIDISGRSYCNMEFDFTNEKIGDMTSEIVVHFFESFVSSAKLNIYGVSKGANDH
HQAEAVFKAFAKSLKEAIKIEHDEIPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=191, Percent_Identity=45.5497382198953, Blast_Score=194, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324776, Length=217, Percent_Identity=37.7880184331797, Blast_Score=169, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_METS3 (A5UMI3)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001273779.1
- ProteinModelPortal:   A5UMI3
- SMR:   A5UMI3
- STRING:   A5UMI3
- GeneID:   5217379
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_1206
- eggNOG:   arNOG05643
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21304; Mature: 21304

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRKSNVSRTTSETDIQIEMNLDGKGKYNISTGVNFFNHMLEAFSKHSMIDLVVDAKGDI
CCCCCCCCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEEEECCCCE
EIDDHHTIEDVGILLGEAFRQAIGDKRGIKRMADATVPMDESVAKVAIDISGRSYCNMEF
EECCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEEEE
DFTNEKIGDMTSEIVVHFFESFVSSAKLNIYGVSKGANDHHQAEAVFKAFAKSLKEAIKI
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
EHDEIPSTKGVL
CCCCCCCCCCCC
>Mature Secondary Structure
MDRKSNVSRTTSETDIQIEMNLDGKGKYNISTGVNFFNHMLEAFSKHSMIDLVVDAKGDI
CCCCCCCCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEEEECCCCE
EIDDHHTIEDVGILLGEAFRQAIGDKRGIKRMADATVPMDESVAKVAIDISGRSYCNMEF
EECCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEEEE
DFTNEKIGDMTSEIVVHFFESFVSSAKLNIYGVSKGANDHHQAEAVFKAFAKSLKEAIKI
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
EHDEIPSTKGVL
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA