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The map label for this gene is aqpM [H]

Identifier: 148643145

GI number: 148643145

Start: 1037265

End: 1038035

Strand: Reverse

Name: aqpM [H]

Synonym: Msm_1085

Alternate gene names: 148643145

Gene position: 1038035-1037265 (Counterclockwise)

Preceding gene: 148643146

Following gene: 148643143

Centisome position: 56.01

GC content: 34.89

Gene sequence:

>771_bases
ATGGCGCCATGCGGTATTGGAAAAAAATTCATTGCTGAATTGCTTGGAACATTTTTCTTAGTATTTTTTGGAACAGGTTC
TGCAGTTATCACATTGATGATATCAGAATCAGTTAATCCAAATAATGTGGGCATTGGAATTTTAGGCGGTTTGGGAGATT
GGATAGCTATTGCACTGGCATTTGGTTTAACTGTAATGGTTTGTATCTATCTTTTTGGAAGAATTTCAGGAGCTCATTTA
AATCCTGCAGTTACAATTGGATTGCTGCTTAGTAAAAATATTTCTTTAGCAGATTCTGTGTATTATATTGTAGCTCAGAT
AATCGGAGCTTGTTTCGGAAGTTTAGCAGTATTTTTATGTTTAGGAATGCCTTCAGTAGTTGTTGGAGGTTTAGGTGCAA
CTGCTCCTGGCATGGGTGTAAGTTATTTACAAACAATATTTGCGGAATTTATTGGAACTTTCTTTTTAGTGCTTGTAATA
ATGGGTGTTGCTGTTGATAAAAAAGCTACTCCTAATTTTGCAGGTTTATCTATTGGTTTTACAGTAACTGCAGTTATTAT
CTTTTTAGGACCATTTACTGGAGGTTCTATAAATCCTGCACGTACATTTGCTCCTTATTTGATGGATTATTTGGTTGGCG
GAATAAATCTTTGGATATATTTCCCAATTTATTTAATAGGTCCAATTGCAGGAGCTATTGCTGCAGCATTGGTATATACT
TATCTGGCTAAAGACAATGATGTTTGTGAAATACCTGGACCATTTAATTAG

Upstream 100 bases:

>100_bases
CTCCAGTTAAAGGTTGTAAGAATTGTGCGTCTGCTTCATTAATTGATTTCAGACATGATTTCTGTCAGTGGAAAGATGCA
GTATAAAGTAGGTGTGTTAT

Downstream 100 bases:

>100_bases
TTGCTATTAGTTGATAGTAACTAATTTTTATTTTTTTTTAAAAAAAGTAATTTAAGATAGCTGTTTAAGCTATCTGTTAA
GTTTTTGATAGTTTGCAGCC

Product: AraC family regulator

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MAPCGIGKKFIAELLGTFFLVFFGTGSAVITLMISESVNPNNVGIGILGGLGDWIAIALAFGLTVMVCIYLFGRISGAHL
NPAVTIGLLLSKNISLADSVYYIVAQIIGACFGSLAVFLCLGMPSVVVGGLGATAPGMGVSYLQTIFAEFIGTFFLVLVI
MGVAVDKKATPNFAGLSIGFTVTAVIIFLGPFTGGSINPARTFAPYLMDYLVGGINLWIYFPIYLIGPIAGAIAAALVYT
YLAKDNDVCEIPGPFN

Sequences:

>Translated_256_residues
MAPCGIGKKFIAELLGTFFLVFFGTGSAVITLMISESVNPNNVGIGILGGLGDWIAIALAFGLTVMVCIYLFGRISGAHL
NPAVTIGLLLSKNISLADSVYYIVAQIIGACFGSLAVFLCLGMPSVVVGGLGATAPGMGVSYLQTIFAEFIGTFFLVLVI
MGVAVDKKATPNFAGLSIGFTVTAVIIFLGPFTGGSINPARTFAPYLMDYLVGGINLWIYFPIYLIGPIAGAIAAALVYT
YLAKDNDVCEIPGPFN
>Mature_255_residues
APCGIGKKFIAELLGTFFLVFFGTGSAVITLMISESVNPNNVGIGILGGLGDWIAIALAFGLTVMVCIYLFGRISGAHLN
PAVTIGLLLSKNISLADSVYYIVAQIIGACFGSLAVFLCLGMPSVVVGGLGATAPGMGVSYLQTIFAEFIGTFFLVLVIM
GVAVDKKATPNFAGLSIGFTVTAVIIFLGPFTGGSINPARTFAPYLMDYLVGGINLWIYFPIYLIGPIAGAIAAALVYTY
LAKDNDVCEIPGPFN

Specific function: Channel that permits osmotically driven movement of water in both directions [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502181, Length=192, Percent_Identity=38.5416666666667, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4755125, Length=192, Percent_Identity=38.5416666666667, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4502179, Length=236, Percent_Identity=32.6271186440678, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI37694062, Length=238, Percent_Identity=34.453781512605, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI4502183, Length=243, Percent_Identity=33.7448559670782, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI6912506, Length=237, Percent_Identity=31.2236286919831, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4826645, Length=274, Percent_Identity=31.3868613138686, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI86792455, Length=238, Percent_Identity=31.5126050420168, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI157266307, Length=257, Percent_Identity=25.6809338521401, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI45446752, Length=217, Percent_Identity=30.8755760368664, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787101, Length=205, Percent_Identity=37.5609756097561, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790362, Length=268, Percent_Identity=32.089552238806, Blast_Score=95, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17558372, Length=199, Percent_Identity=38.6934673366834, Blast_Score=113, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71993722, Length=242, Percent_Identity=29.3388429752066, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994009, Length=253, Percent_Identity=30.0395256916996, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17544068, Length=259, Percent_Identity=31.2741312741313, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17531431, Length=253, Percent_Identity=24.1106719367589, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17531429, Length=253, Percent_Identity=24.1106719367589, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321054, Length=221, Percent_Identity=33.4841628959276, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325450, Length=195, Percent_Identity=32.8205128205128, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24652747, Length=240, Percent_Identity=32.5, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45551084, Length=240, Percent_Identity=32.5, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24762344, Length=241, Percent_Identity=33.6099585062241, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24762346, Length=241, Percent_Identity=33.6099585062241, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24762348, Length=241, Percent_Identity=33.6099585062241, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20130305, Length=241, Percent_Identity=33.6099585062241, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24652751, Length=245, Percent_Identity=31.8367346938775, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19922038, Length=245, Percent_Identity=31.8367346938775, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45550503, Length=195, Percent_Identity=31.7948717948718, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24762342, Length=198, Percent_Identity=31.8181818181818, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136672, Length=190, Percent_Identity=33.1578947368421, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 26648; Mature: 26517

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCCEECCCCCCC
>Mature Secondary Structure 
APCGIGKKFIAELLGTFFLVFFGTGSAVITLMISESVNPNNVGIGILGGLGDWIAIALA
CCCCCCHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCCCEEEECCHHHHHHHHHH
FGLTVMVCIYLFGRISGAHLNPAVTIGLLLSKNISLADSVYYIVAQIIGACFGSLAVFLC
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGMPSVVVGGLGATAPGMGVSYLQTIFAEFIGTFFLVLVIMGVAVDKKATPNFAGLSIGF
HCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHH
TVTAVIIFLGPFTGGSINPARTFAPYLMDYLVGGINLWIYFPIYLIGPIAGAIAAALVYT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLAKDNDVCEIPGPFN
HHHCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]