Click here to switch to the map view.

The map label for this gene is purO

Identifier: 148643036

GI number: 148643036

Start: 937645

End: 938271

Strand: Reverse

Name: purO

Synonym: Msm_0976

Alternate gene names: 148643036

Gene position: 938271-937645 (Counterclockwise)

Preceding gene: 148643037

Following gene: 148643035

Centisome position: 50.63

GC content: 33.01

Gene sequence:

>627_bases
ATGTATACGGGAAGAATTTTATCAATTGGTATGAATTGTGAAGGTAAACCTTTTGTGGCATATAGGGTGTCTAGCAGATC
ATTTCCTAATAGGCAATGCTTAAAATTTGATAATAGGGCATCTATTGTGCCGAAAGAAGGTTTCGAAAAAGATATTTTTG
AAAATACTTACATTACATATAATTGTATACGTATTGTAAAAGATATGGCTATTGTGTCTAATGGTTCACATACAGATGTA
ATAGCTGATAAAATAGCTTTGGGGATGAATATTAAAGATGCAATAGCTTATTCATTGCTTACTTTGGATTATGAAAAAGA
TGATTATCATACTCCACGTATTGCAGGAGTTGTTACATCTACAAATAAAAAGGATGATTATGTTTGCTATGTGGGGATAG
CTAATGATGAAAAATTATTGGTTGACAAAATCCCATACGGCGAAGCCGTATTTATTTCCACATATGGAAGTCAATTCTAC
GACCCTGTAGATTTTGATGCAAAAACAGCTGATGATGCTGCAAAATTTATTTTTGATGGAGGTATTTTTGCCAATTACAA
AAAAGCAGTAACTGCTGGTGCGGCTGTTTTTGATGGGGAATGGAATATAGGTAATTTCAATCCTTAA

Upstream 100 bases:

>100_bases
AATACAAATAAAACCTGGAGAGATTATTATAACTACTCCTGCAGGTGTGTCTCCTGAAGAAGCTGTCAGAAGTCCAAATA
CTACTTAAAGAGGTTGAAAA

Downstream 100 bases:

>100_bases
TTTTTTTTATTTTTTTTTAAAAGATGATTAATATGTCAATAGAATTAATTGGTTTAGACAATATTCCATTAGTTGAACCT
AATGACGATGTTTGTCAAAT

Product: IMP cyclohydrolase

Products: NA

Alternate protein names: IMP synthase; Inosinicase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MYTGRILSIGMNCEGKPFVAYRVSSRSFPNRQCLKFDNRASIVPKEGFEKDIFENTYITYNCIRIVKDMAIVSNGSHTDV
IADKIALGMNIKDAIAYSLLTLDYEKDDYHTPRIAGVVTSTNKKDDYVCYVGIANDEKLLVDKIPYGEAVFISTYGSQFY
DPVDFDAKTADDAAKFIFDGGIFANYKKAVTAGAAVFDGEWNIGNFNP

Sequences:

>Translated_208_residues
MYTGRILSIGMNCEGKPFVAYRVSSRSFPNRQCLKFDNRASIVPKEGFEKDIFENTYITYNCIRIVKDMAIVSNGSHTDV
IADKIALGMNIKDAIAYSLLTLDYEKDDYHTPRIAGVVTSTNKKDDYVCYVGIANDEKLLVDKIPYGEAVFISTYGSQFY
DPVDFDAKTADDAAKFIFDGGIFANYKKAVTAGAAVFDGEWNIGNFNP
>Mature_208_residues
MYTGRILSIGMNCEGKPFVAYRVSSRSFPNRQCLKFDNRASIVPKEGFEKDIFENTYITYNCIRIVKDMAIVSNGSHTDV
IADKIALGMNIKDAIAYSLLTLDYEKDDYHTPRIAGVVTSTNKKDDYVCYVGIANDEKLLVDKIPYGEAVFISTYGSQFY
DPVDFDAKTADDAAKFIFDGGIFANYKKAVTAGAAVFDGEWNIGNFNP

Specific function: Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP

COG id: COG3363

COG function: function code F; Archaeal IMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal IMP cyclohydrolase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURO_METS3 (A5ULV3)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001273549.1
- ProteinModelPortal:   A5ULV3
- SMR:   A5ULV3
- STRING:   A5ULV3
- GeneID:   5216946
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_0976
- eggNOG:   arNOG08037
- HOGENOM:   HBG539724
- OMA:   YIGRFLV
- ProtClustDB:   PRK04151
- HAMAP:   MF_00705
- InterPro:   IPR010191
- InterPro:   IPR020600
- Gene3D:   G3DSA:3.60.20.20
- PIRSF:   PIRSF004866
- TIGRFAMs:   TIGR01922

Pfam domain/function: PF07826 IMP_cyclohyd; SSF75569 PurO_cyclohydro

EC number: =3.5.4.10

Molecular weight: Translated: 23167; Mature: 23167

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTGRILSIGMNCEGKPFVAYRVSSRSFPNRQCLKFDNRASIVPKEGFEKDIFENTYITY
CCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHEEECCCCCCCCCCCCCCHHHCCCEEEH
NCIRIVKDMAIVSNGSHTDVIADKIALGMNIKDAIAYSLLTLDYEKDDYHTPRIAGVVTS
HHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHEEEEEEEECCCCCCCCCEEEEEEEC
TNKKDDYVCYVGIANDEKLLVDKIPYGEAVFISTYGSQFYDPVDFDAKTADDAAKFIFDG
CCCCCCEEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHEEECC
GIFANYKKAVTAGAAVFDGEWNIGNFNP
CEEECCHHHHHCCCEEECCCCCCCCCCC
>Mature Secondary Structure
MYTGRILSIGMNCEGKPFVAYRVSSRSFPNRQCLKFDNRASIVPKEGFEKDIFENTYITY
CCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHEEECCCCCCCCCCCCCCHHHCCCEEEH
NCIRIVKDMAIVSNGSHTDVIADKIALGMNIKDAIAYSLLTLDYEKDDYHTPRIAGVVTS
HHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHEEEEEEEECCCCCCCCCEEEEEEEC
TNKKDDYVCYVGIANDEKLLVDKIPYGEAVFISTYGSQFYDPVDFDAKTADDAAKFIFDG
CCCCCCEEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHEEECC
GIFANYKKAVTAGAAVFDGEWNIGNFNP
CEEECCHHHHHCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA