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The map label for this gene is hemA

Identifier: 148643027

GI number: 148643027

Start: 929813

End: 931012

Strand: Reverse

Name: hemA

Synonym: Msm_0967

Alternate gene names: 148643027

Gene position: 931012-929813 (Counterclockwise)

Preceding gene: 148643028

Following gene: 148643024

Centisome position: 50.24

GC content: 31.5

Gene sequence:

>1200_bases
ATGATACTTAATTTAAGAGTTGACCATAAAATTGCAAATATTGATGCTATGGAAAATATTGCAAAGGAAATGGATCAGTT
ATTTTTGGAATTGCAGGAAAAGTATTCAATTGTAGAATATGTGGAAATATCTACATGTAATCGTAAGGAATATTACATTC
ATAATGACAATATAGATGCTTCTGATTCTCTTTTATCTCATGAAAATAAAAGCATTATTATTGATTATGGAGACAGTGTT
ATTAAGCATCTTTTCCGTATGACTTCAGGTCTGGAGTCTATGATTGTAGGTGAAGACCAGATTTTAGGCCAGGTTAGTGA
TGCTAAGCAAAAGGCATTTAAAGAACGTCATTGCGGAAAGATTTTGGATTCTATTTTTACTAAAGCTATTCATGTCGGTC
GTGTAGTGAGAAATAAAACCAATATTAACAAAGGATCAATTTCCATAGGTTCTGCAGCTGTTGATTTGGCTGAAAAGCAT
TTGGGGAATCTTGAAAACAAGTCTGTTTTGGTTATTGGTGCAGGGAAGATGGGTAAGCTGGTGGCTAAGGCTTTGGCTGA
GAAAAATTTAAATGCAATATTTGTTGCAAACAGAACTTATTATGTTGCAGTTGAACTGGCTAATGATTTAAACGGTCATG
CTGTTCTTTTTAACGAATTAGGCAAATATGTCCAAACAGCAGACCTGATAATAAGTGCAACAGGTGCTCCTCATTATATT
TTAAATAAAGAACGTTTGGAAAAGACTGATGGAGATTTTAAAGACTTGTTAATGATTGATATAGCTAATCCAAGAGATAT
TTGCGAAGATGTCTGCGAATTGGGAGTTAAATTATTTAACATTGATGATTTGCGTGAGATTGCAGATGAAAATACTAAAC
TCAGAAAAAAAGAATTTGCAGAAGCTGAAAATATCATCGATGAAGAGTTCAGTTTACTTAAAGAATCCTTTAAGTTAATT
GGTGTTGAAGATATTATTGCTAATTTAAGAGTATCTATGGAAAATATACGAGAAAGAGAAACTGAAAAGGCGATTGCCAA
ACTTTCTGATGTAGATGCAAATGCTAAAATAATAGATAATTTAACAAATTCTATTGTCAACAAAATATTTTTTGATATTT
CTAAAAAAATTAAACAGGCAGCTCATGAAAATGATGAAGAATTGATCAGAGCTATTGAATTTATGTTTGAAGAAAAATAA

Upstream 100 bases:

>100_bases
CTTTATGAAATTTTCAATGATGAAAATATTAAAGGATTACTTGATAACCATAAAATAGATGAAGCTAAAGAGTATATCGA
TGATTTGATAAGGGGATTTG

Downstream 100 bases:

>100_bases
TTAAAGAAGGTTTTTATTCAAACATTCCTTTTACTTCACTATTTTTAATTTTACTTGCTTTTAGAGCATATTCCACATCT
TTGTTATCTACAGTTTCTTT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MILNLRVDHKIANIDAMENIAKEMDQLFLELQEKYSIVEYVEISTCNRKEYYIHNDNIDASDSLLSHENKSIIIDYGDSV
IKHLFRMTSGLESMIVGEDQILGQVSDAKQKAFKERHCGKILDSIFTKAIHVGRVVRNKTNINKGSISIGSAAVDLAEKH
LGNLENKSVLVIGAGKMGKLVAKALAEKNLNAIFVANRTYYVAVELANDLNGHAVLFNELGKYVQTADLIISATGAPHYI
LNKERLEKTDGDFKDLLMIDIANPRDICEDVCELGVKLFNIDDLREIADENTKLRKKEFAEAENIIDEEFSLLKESFKLI
GVEDIIANLRVSMENIRERETEKAIAKLSDVDANAKIIDNLTNSIVNKIFFDISKKIKQAAHENDEELIRAIEFMFEEK

Sequences:

>Translated_399_residues
MILNLRVDHKIANIDAMENIAKEMDQLFLELQEKYSIVEYVEISTCNRKEYYIHNDNIDASDSLLSHENKSIIIDYGDSV
IKHLFRMTSGLESMIVGEDQILGQVSDAKQKAFKERHCGKILDSIFTKAIHVGRVVRNKTNINKGSISIGSAAVDLAEKH
LGNLENKSVLVIGAGKMGKLVAKALAEKNLNAIFVANRTYYVAVELANDLNGHAVLFNELGKYVQTADLIISATGAPHYI
LNKERLEKTDGDFKDLLMIDIANPRDICEDVCELGVKLFNIDDLREIADENTKLRKKEFAEAENIIDEEFSLLKESFKLI
GVEDIIANLRVSMENIRERETEKAIAKLSDVDANAKIIDNLTNSIVNKIFFDISKKIKQAAHENDEELIRAIEFMFEEK
>Mature_399_residues
MILNLRVDHKIANIDAMENIAKEMDQLFLELQEKYSIVEYVEISTCNRKEYYIHNDNIDASDSLLSHENKSIIIDYGDSV
IKHLFRMTSGLESMIVGEDQILGQVSDAKQKAFKERHCGKILDSIFTKAIHVGRVVRNKTNINKGSISIGSAAVDLAEKH
LGNLENKSVLVIGAGKMGKLVAKALAEKNLNAIFVANRTYYVAVELANDLNGHAVLFNELGKYVQTADLIISATGAPHYI
LNKERLEKTDGDFKDLLMIDIANPRDICEDVCELGVKLFNIDDLREIADENTKLRKKEFAEAENIIDEEFSLLKESFKLI
GVEDIIANLRVSMENIRERETEKAIAKLSDVDANAKIIDNLTNSIVNKIFFDISKKIKQAAHENDEELIRAIEFMFEEK

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=408, Percent_Identity=30.3921568627451, Blast_Score=172, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_METS3 (A5ULU4)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001273540.1
- ProteinModelPortal:   A5ULU4
- SMR:   A5ULU4
- STRING:   A5ULU4
- GeneID:   5217012
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_0967
- eggNOG:   arNOG04783
- HOGENOM:   HBG732626
- OMA:   GEDQIIG
- ProtClustDB:   PRK00045
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 44990; Mature: 44990

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 46-46 BINDING 93-93 BINDING 104-104

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILNLRVDHKIANIDAMENIAKEMDQLFLELQEKYSIVEYVEISTCNRKEYYIHNDNIDA
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCC
SDSLLSHENKSIIIDYGDSVIKHLFRMTSGLESMIVGEDQILGQVSDAKQKAFKERHCGK
HHHHHHCCCCEEEEECCHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ILDSIFTKAIHVGRVVRNKTNINKGSISIGSAAVDLAEKHLGNLENKSVLVIGAGKMGKL
HHHHHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHCCCCCCEEEEEECCHHHHH
VAKALAEKNLNAIFVANRTYYVAVELANDLNGHAVLFNELGKYVQTADLIISATGAPHYI
HHHHHHHCCCCEEEEECCEEEEEEEECCCCCCCEEHHHHHHHHHHHHHHEEECCCCCCCC
LNKERLEKTDGDFKDLLMIDIANPRDICEDVCELGVKLFNIDDLREIADENTKLRKKEFA
CCHHHHHHCCCCHHHEEEEECCCHHHHHHHHHHHCCEEECHHHHHHHHCCCHHHHHHHHH
EAENIIDEEFSLLKESFKLIGVEDIIANLRVSMENIRERETEKAIAKLSDVDANAKIIDN
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LTNSIVNKIFFDISKKIKQAAHENDEELIRAIEFMFEEK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MILNLRVDHKIANIDAMENIAKEMDQLFLELQEKYSIVEYVEISTCNRKEYYIHNDNIDA
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCC
SDSLLSHENKSIIIDYGDSVIKHLFRMTSGLESMIVGEDQILGQVSDAKQKAFKERHCGK
HHHHHHCCCCEEEEECCHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ILDSIFTKAIHVGRVVRNKTNINKGSISIGSAAVDLAEKHLGNLENKSVLVIGAGKMGKL
HHHHHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHCCCCCCEEEEEECCHHHHH
VAKALAEKNLNAIFVANRTYYVAVELANDLNGHAVLFNELGKYVQTADLIISATGAPHYI
HHHHHHHCCCCEEEEECCEEEEEEEECCCCCCCEEHHHHHHHHHHHHHHEEECCCCCCCC
LNKERLEKTDGDFKDLLMIDIANPRDICEDVCELGVKLFNIDDLREIADENTKLRKKEFA
CCHHHHHHCCCCHHHEEEEECCCHHHHHHHHHHHCCEEECHHHHHHHHCCCHHHHHHHHH
EAENIIDEEFSLLKESFKLIGVEDIIANLRVSMENIRERETEKAIAKLSDVDANAKIIDN
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LTNSIVNKIFFDISKKIKQAAHENDEELIRAIEFMFEEK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA