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The map label for this gene is eif6

Identifier: 148642764

GI number: 148642764

Start: 677136

End: 677807

Strand: Reverse

Name: eif6

Synonym: Msm_0704

Alternate gene names: 148642764

Gene position: 677807-677136 (Counterclockwise)

Preceding gene: 148642765

Following gene: 148642763

Centisome position: 36.58

GC content: 34.82

Gene sequence:

>672_bases
ATGTTAAGAAGAATAAACATTGTAGATAATCCTAATATAGGAGTATTTATTTTAGCAACTGATGATTTGGCTGTTGTTCC
TTACAATCTTCTTGACGAAAAGGTTAAGCTGATTGAAGAAACACTAGAAGTTGATGCTGTAAAATCTTCTATTTCCGGAT
GTAACCTTATTGGATCTTTAGCTGTAGCTAATTCAAACGGTATTGTTGTTTCCCCACATGTATTAGATAGAGAAGTTAAA
CAGTTTGAAGAATTAGGTTTAAATGTAGCTACAATTCCCGGAAATTATACTGCAGTAGGTAATATTGTTGCAGCTAATGA
TACTGGTGCTATTGTAAGTCCGTTTTTATCTGATGAGGCAGTTAAAGTCATTGAAGATACTTTAGATGTAAATGTTGAAT
CAACTTCCATGGTCGGAAGCGATATTATCGGTTCACTGATTACAGTTACCAACAAAGGATTTTTAATGGATAAAAATGCT
ACTGAAACTGAAGTAGACTTTGCTCGTGATGTATTTGGTGTTGAAGGAGATATTGGTACTGTAGGCAGAGGTATTTCTTT
AGTTGGGGCATGCTCTCTTGCAAATTCAAGTGGAGCTATTGTAGCTAAAGAAAGTACAGGTCCTGAAATGGCTAGAGTTG
AAGAAGCATTAGGCTTTTTAGACGATTTATAA

Upstream 100 bases:

>100_bases
AAATTACTGTAAAAGCAGTTAAAGATGATGATGGCGTAGTAGAAGCTACTTTAGCAGAATAGCTATATAATACTACTTCA
ATACTACGTGAGGTAACAAT

Downstream 100 bases:

>100_bases
ATAATATCCTGAGGAGTTAATATGATAACAAAAATTTACAGAGTTAAAGGTACTTTTGTAATGGGCGATTCATATCATAA
ATTTACTAAAGAATACAAAG

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MLRRINIVDNPNIGVFILATDDLAVVPYNLLDEKVKLIEETLEVDAVKSSISGCNLIGSLAVANSNGIVVSPHVLDREVK
QFEELGLNVATIPGNYTAVGNIVAANDTGAIVSPFLSDEAVKVIEDTLDVNVESTSMVGSDIIGSLITVTNKGFLMDKNA
TETEVDFARDVFGVEGDIGTVGRGISLVGACSLANSSGAIVAKESTGPEMARVEEALGFLDDL

Sequences:

>Translated_223_residues
MLRRINIVDNPNIGVFILATDDLAVVPYNLLDEKVKLIEETLEVDAVKSSISGCNLIGSLAVANSNGIVVSPHVLDREVK
QFEELGLNVATIPGNYTAVGNIVAANDTGAIVSPFLSDEAVKVIEDTLDVNVESTSMVGSDIIGSLITVTNKGFLMDKNA
TETEVDFARDVFGVEGDIGTVGRGISLVGACSLANSSGAIVAKESTGPEMARVEEALGFLDDL
>Mature_223_residues
MLRRINIVDNPNIGVFILATDDLAVVPYNLLDEKVKLIEETLEVDAVKSSISGCNLIGSLAVANSNGIVVSPHVLDREVK
QFEELGLNVATIPGNYTAVGNIVAANDTGAIVSPFLSDEAVKVIEDTLDVNVESTSMVGSDIIGSLITVTNKGFLMDKNA
TETEVDFARDVFGVEGDIGTVGRGISLVGACSLANSSGAIVAKESTGPEMARVEEALGFLDDL

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family

Homologues:

Organism=Homo sapiens, GI4504771, Length=219, Percent_Identity=25.5707762557078, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI31563378, Length=219, Percent_Identity=25.5707762557078, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17506075, Length=220, Percent_Identity=25.4545454545455, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325273, Length=226, Percent_Identity=25.2212389380531, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21492634, Length=219, Percent_Identity=26.027397260274, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF6_METS3 (A5UL31)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001273277.1
- ProteinModelPortal:   A5UL31
- SMR:   A5UL31
- STRING:   A5UL31
- GeneID:   5217273
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_0704
- eggNOG:   arNOG10240
- HOGENOM:   HBG589638
- OMA:   AGMAVND
- ProtClustDB:   PRK04046
- HAMAP:   MF_00032
- InterPro:   IPR002769
- PANTHER:   PTHR10784
- PIRSF:   PIRSF006413
- SMART:   SM00654
- TIGRFAMs:   TIGR00323

Pfam domain/function: PF01912 eIF-6

EC number: NA

Molecular weight: Translated: 23354; Mature: 23354

Theoretical pI: Translated: 3.91; Mature: 3.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRINIVDNPNIGVFILATDDLAVVPYNLLDEKVKLIEETLEVDAVKSSISGCNLIGSL
CCEEEEEECCCCEEEEEEEECCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
AVANSNGIVVSPHVLDREVKQFEELGLNVATIPGNYTAVGNIVAANDTGAIVSPFLSDEA
EEECCCCEEECCHHHHHHHHHHHHCCCEEEECCCCEEEECEEEEECCCCCEECCHHCHHH
VKVIEDTLDVNVESTSMVGSDIIGSLITVTNKGFLMDKNATETEVDFARDVFGVEGDIGT
HHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHHCCCCCCCCC
VGRGISLVGACSLANSSGAIVAKESTGPEMARVEEALGFLDDL
CCCCEEEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRRINIVDNPNIGVFILATDDLAVVPYNLLDEKVKLIEETLEVDAVKSSISGCNLIGSL
CCEEEEEECCCCEEEEEEEECCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
AVANSNGIVVSPHVLDREVKQFEELGLNVATIPGNYTAVGNIVAANDTGAIVSPFLSDEA
EEECCCCEEECCHHHHHHHHHHHHCCCEEEECCCCEEEECEEEEECCCCCEECCHHCHHH
VKVIEDTLDVNVESTSMVGSDIIGSLITVTNKGFLMDKNATETEVDFARDVFGVEGDIGT
HHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHHCCCCCCCCC
VGRGISLVGACSLANSSGAIVAKESTGPEMARVEEALGFLDDL
CCCCEEEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA