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The map label for this gene is ispD [H]

Identifier: 148642437

GI number: 148642437

Start: 358618

End: 359328

Strand: Reverse

Name: ispD [H]

Synonym: Msm_0377

Alternate gene names: 148642437

Gene position: 359328-358618 (Counterclockwise)

Preceding gene: 148642438

Following gene: 148642436

Centisome position: 19.39

GC content: 29.54

Gene sequence:

>711_bases
ATGATTTTTGTAGCTGTTTTGGCAGGTGGAATTGGATCAAGAATGGGGGATACAGACACTCCTAAACAATTTTTAAATCT
GGGAGATCGACCTATTTTAATCCACACAATTGAAAAATTTGTGATTATGGATGAGATTGATGAAGTGATAGTTTTAACTC
CACAAAATTTTATAAATCACACAAAACATTTAATCGAAGAGTATACTCTAAACAACGATAAGATAGTTGTGATTGAAGGC
GGAAAAACCAGAAACGATACTTTAAAAAACAGTATTGACTATATTTATGAAAATTACAGTGTTGATGATGATTCAATAAT
TATAACTCATGATTCTGTCCGTCCGTTTGTAACCCATAGGATTATTCAGGATAATATTAAAGCTGCAAAAAAATATGGGG
CCTGTGATACAGTAATTCCTGCTACAGACACAATTGTGGAAAGTAGAGATGGAAAGATAATTAAAAACATTCCAATTAGG
GATTATTTTTATCAGGGTCAAACTCCACAAACCTTTAAGATAAATAAATTAAATTCTTTAATCAATGATTTAACTGATGG
TGAAAAAGAGATACTTACAGATGCTGCTAAAATATTTGTTTTAAAAGGTAAAGATGTAGCTCTTGTTGATGGAGATGTAA
CAAATATTAAAATTACATATCCTTATGATTTGAAATTAGCTAATACAATTCTAAATGATAAAAATGATTAA

Upstream 100 bases:

>100_bases
ACATGGTCTTAAAATGACTTATTTAAATGAGGAAATAGGTGAAGACATTCCTGAAGGCAAATCTCATTATTTAATAATAT
TTGAAAAAGAGTAGTTAAAA

Downstream 100 bases:

>100_bases
TATTATTTACAGATTAGTTGCTCCAAAATTCTTTGAAGAGGCTATAGAGGAAATTAACATAGATAATGTAATTGTAAGAC
CAAGTTATCTCTCAATTTGT

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MIFVAVLAGGIGSRMGDTDTPKQFLNLGDRPILIHTIEKFVIMDEIDEVIVLTPQNFINHTKHLIEEYTLNNDKIVVIEG
GKTRNDTLKNSIDYIYENYSVDDDSIIITHDSVRPFVTHRIIQDNIKAAKKYGACDTVIPATDTIVESRDGKIIKNIPIR
DYFYQGQTPQTFKINKLNSLINDLTDGEKEILTDAAKIFVLKGKDVALVDGDVTNIKITYPYDLKLANTILNDKND

Sequences:

>Translated_236_residues
MIFVAVLAGGIGSRMGDTDTPKQFLNLGDRPILIHTIEKFVIMDEIDEVIVLTPQNFINHTKHLIEEYTLNNDKIVVIEG
GKTRNDTLKNSIDYIYENYSVDDDSIIITHDSVRPFVTHRIIQDNIKAAKKYGACDTVIPATDTIVESRDGKIIKNIPIR
DYFYQGQTPQTFKINKLNSLINDLTDGEKEILTDAAKIFVLKGKDVALVDGDVTNIKITYPYDLKLANTILNDKND
>Mature_236_residues
MIFVAVLAGGIGSRMGDTDTPKQFLNLGDRPILIHTIEKFVIMDEIDEVIVLTPQNFINHTKHLIEEYTLNNDKIVVIEG
GKTRNDTLKNSIDYIYENYSVDDDSIIITHDSVRPFVTHRIIQDNIKAAKKYGACDTVIPATDTIVESRDGKIIKNIPIR
DYFYQGQTPQTFKINKLNSLINDLTDGEKEILTDAAKIFVLKGKDVALVDGDVTNIKITYPYDLKLANTILNDKND

Specific function: Provides activated ribitol phosphate for teichoic acid synthesis (Potential) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=240, Percent_Identity=29.5833333333333, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI157671913, Length=137, Percent_Identity=32.1167883211679, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1789104, Length=239, Percent_Identity=26.3598326359833, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.40 [H]

Molecular weight: Translated: 26601; Mature: 26601

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFVAVLAGGIGSRMGDTDTPKQFLNLGDRPILIHTIEKFVIMDEIDEVIVLTPQNFINH
CEEEEEECCCCCCCCCCCCCHHHHHCCCCCEEEEEHHHHHHHHHCCCCEEEECCHHHHHH
TKHLIEEYTLNNDKIVVIEGGKTRNDTLKNSIDYIYENYSVDDDSIIITHDSVRPFVTHR
HHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHH
IIQDNIKAAKKYGACDTVIPATDTIVESRDGKIIKNIPIRDYFYQGQTPQTFKINKLNSL
HHHHHHHHHHHCCCCCCCCCCCHHEEECCCCCEEECCCCHHEEECCCCCCEEEHHHHHHH
INDLTDGEKEILTDAAKIFVLKGKDVALVDGDVTNIKITYPYDLKLANTILNDKND
HHHHCCCHHHHHHHHEEEEEECCCEEEEECCCCEEEEEEECCCCHHHHHHHCCCCC
>Mature Secondary Structure
MIFVAVLAGGIGSRMGDTDTPKQFLNLGDRPILIHTIEKFVIMDEIDEVIVLTPQNFINH
CEEEEEECCCCCCCCCCCCCHHHHHCCCCCEEEEEHHHHHHHHHCCCCEEEECCHHHHHH
TKHLIEEYTLNNDKIVVIEGGKTRNDTLKNSIDYIYENYSVDDDSIIITHDSVRPFVTHR
HHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHH
IIQDNIKAAKKYGACDTVIPATDTIVESRDGKIIKNIPIRDYFYQGQTPQTFKINKLNSL
HHHHHHHHHHHCCCCCCCCCCCHHEEECCCCCEEECCCCHHEEECCCCCCEEEHHHHHHH
INDLTDGEKEILTDAAKIFVLKGKDVALVDGDVTNIKITYPYDLKLANTILNDKND
HHHHCCCHHHHHHHHEEEEEECCCEEEEECCCCEEEEEEECCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11882717 [H]