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The map label for this gene is glmS [C]

Identifier: 148642430

GI number: 148642430

Start: 351637

End: 352554

Strand: Reverse

Name: glmS [C]

Synonym: Msm_0370

Alternate gene names: 148642430

Gene position: 352554-351637 (Counterclockwise)

Preceding gene: 148642431

Following gene: 148642429

Centisome position: 19.02

GC content: 33.22

Gene sequence:

>918_bases
TTGTGTGGAATAGCTGGTATAGTTTATAAAGATAAAAAATTGCATTGTGCAGGTAATGACATGACCAATATGCTTCATCA
ACTTCAGCATAGAGGTCCTGATTCTGCAGGTTATTCAATTTATGGCGGAACAGGTCTTAAGGATGATGAGTACATCTTAA
AAATTCAAGTGAAAGAACAACCAAGATTACTTGAAACCGTGAAAGATACAATAAACTTTGTAACTCCAATTCAAAGTGAT
GAAGTTCTTCCGTCTGTTGGAGATTCATTTATTTACAAATGTAAAGTTCAGTTAAATAACTTTTCAGAACTTAAACCGCT
TATCTCAACTGTTGATACAATTGATGATGTTATTGTAATTAACGGAAGTCAGGATTTTGAAATGATTAAGGATGTAGGTT
CTGTATTGGACATTGCAAAAAGATACAATGTGCGTGAGGTTAAAGGAACTCATGCTATAGGTCATACAAGGTTTTCAACA
GAAAGTGGTGTGGACAGATATCATGCACACCCATTTGAAACTTACATTGTTAAAGATGTATCTGTTGTTCATAATGGTCA
GATTACAAATTATTGGAATATTAGGGATCCTTTAGAAAGAAAAGGTCATGTATTTGAAACTTTTAATGATACTGAATGTT
TGGTTCATTATATTGCAGATAAATTAGATACAGGTTATTCTTTAGAAGAAGCACTGGAACAGTCTGTAGAAGATATGGAT
GGTCCTTTTTCTTATATTATAGGAACTCCAAATGGTATTGGAATAGCTAAAGATAAATTAGGTTTACGTCCGGGAGTAAT
GGCTGAAACTGACGATGTTTTTGCAATTGCATCTGAAGAGGTATCTTTAAGGGAAGTTGTTGATACTCAAAATATTGAAC
AAATTTCTCCTGGTGAAGTAATGGTGTATGAAATTTAG

Upstream 100 bases:

>100_bases
TAATAGCTATTCAGCAAGGACATAATATAGCTATTGCATTTCATCCGGAATTAACTGATGATACTAGAATTCACGAATAT
TTTATAGAGGAGGTTTTAAA

Downstream 100 bases:

>100_bases
GAGTTGGTTTTAGTGAAAATAAAAGAATTAGATGCAGCATCACTTTCTCCACGTGAACTAAATTCACAGGTTAAAGAATC
TGCAAAAGATTATGATAAAA

Product: glutamate synthase, subunit 1

Products: L-glutamine; 5-phospho-alpha-D-ribose 1-diphosphate; H2O

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MCGIAGIVYKDKKLHCAGNDMTNMLHQLQHRGPDSAGYSIYGGTGLKDDEYILKIQVKEQPRLLETVKDTINFVTPIQSD
EVLPSVGDSFIYKCKVQLNNFSELKPLISTVDTIDDVIVINGSQDFEMIKDVGSVLDIAKRYNVREVKGTHAIGHTRFST
ESGVDRYHAHPFETYIVKDVSVVHNGQITNYWNIRDPLERKGHVFETFNDTECLVHYIADKLDTGYSLEEALEQSVEDMD
GPFSYIIGTPNGIGIAKDKLGLRPGVMAETDDVFAIASEEVSLREVVDTQNIEQISPGEVMVYEI

Sequences:

>Translated_305_residues
MCGIAGIVYKDKKLHCAGNDMTNMLHQLQHRGPDSAGYSIYGGTGLKDDEYILKIQVKEQPRLLETVKDTINFVTPIQSD
EVLPSVGDSFIYKCKVQLNNFSELKPLISTVDTIDDVIVINGSQDFEMIKDVGSVLDIAKRYNVREVKGTHAIGHTRFST
ESGVDRYHAHPFETYIVKDVSVVHNGQITNYWNIRDPLERKGHVFETFNDTECLVHYIADKLDTGYSLEEALEQSVEDMD
GPFSYIIGTPNGIGIAKDKLGLRPGVMAETDDVFAIASEEVSLREVVDTQNIEQISPGEVMVYEI
>Mature_305_residues
MCGIAGIVYKDKKLHCAGNDMTNMLHQLQHRGPDSAGYSIYGGTGLKDDEYILKIQVKEQPRLLETVKDTINFVTPIQSD
EVLPSVGDSFIYKCKVQLNNFSELKPLISTVDTIDDVIVINGSQDFEMIKDVGSVLDIAKRYNVREVKGTHAIGHTRFST
ESGVDRYHAHPFETYIVKDVSVVHNGQITNYWNIRDPLERKGHVFETFNDTECLVHYIADKLDTGYSLEEALEQSVEDMD
GPFSYIIGTPNGIGIAKDKLGLRPGVMAETDDVFAIASEEVSLREVVDTQNIEQISPGEVMVYEI

Specific function: Catalyzes The First Step In Hexosamine Metabolism, Converting Fructose-6p Into Glucosamine-6p Using Glutamine As A Nitrogen Source. [C]

COG id: COG0067

COG function: function code E; Glutamate synthase domain 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790167, Length=169, Percent_Identity=26.6272189349112, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788651, Length=202, Percent_Identity=27.2277227722772, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=184, Percent_Identity=28.2608695652174, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17532897, Length=184, Percent_Identity=28.2608695652174, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323730, Length=161, Percent_Identity=30.4347826086957, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21357745, Length=131, Percent_Identity=34.3511450381679, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005854
- InterPro:   IPR000583
- InterPro:   IPR017932 [H]

Pfam domain/function: PF00310 GATase_2 [H]

EC number: 2.4.2.14

Molecular weight: Translated: 34095; Mature: 34095

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIAGIVYKDKKLHCAGNDMTNMLHQLQHRGPDSAGYSIYGGTGLKDDEYILKIQVKEQ
CCCCCCEEEECCEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEECCC
PRLLETVKDTINFVTPIQSDEVLPSVGDSFIYKCKVQLNNFSELKPLISTVDTIDDVIVI
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHCCCEEEE
NGSQDFEMIKDVGSVLDIAKRYNVREVKGTHAIGHTRFSTESGVDRYHAHPFETYIVKDV
ECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHEEEEEE
SVVHNGQITNYWNIRDPLERKGHVFETFNDTECLVHYIADKLDTGYSLEEALEQSVEDMD
EEEECCCEEEEECCCCCHHHCCCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
GPFSYIIGTPNGIGIAKDKLGLRPGVMAETDDVFAIASEEVSLREVVDTQNIEQISPGEV
CCEEEEEECCCCCCEEHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCE
MVYEI
EEEEC
>Mature Secondary Structure
MCGIAGIVYKDKKLHCAGNDMTNMLHQLQHRGPDSAGYSIYGGTGLKDDEYILKIQVKEQ
CCCCCCEEEECCEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEECCC
PRLLETVKDTINFVTPIQSDEVLPSVGDSFIYKCKVQLNNFSELKPLISTVDTIDDVIVI
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHCCCEEEE
NGSQDFEMIKDVGSVLDIAKRYNVREVKGTHAIGHTRFSTESGVDRYHAHPFETYIVKDV
ECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHEEEEEE
SVVHNGQITNYWNIRDPLERKGHVFETFNDTECLVHYIADKLDTGYSLEEALEQSVEDMD
EEEECCCEEEEECCCCCHHHCCCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
GPFSYIIGTPNGIGIAKDKLGLRPGVMAETDDVFAIASEEVSLREVVDTQNIEQISPGEV
CCEEEEEECCCCCCEEHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCE
MVYEI
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5-phospho-beta-D-ribosylamine; diphosphate; L-glutamate

Specific reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]