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The map label for this gene is rpiA [H]

Identifier: 148642344

GI number: 148642344

Start: 276181

End: 276846

Strand: Reverse

Name: rpiA [H]

Synonym: Msm_0284

Alternate gene names: 148642344

Gene position: 276846-276181 (Counterclockwise)

Preceding gene: 148642345

Following gene: 148642343

Centisome position: 14.94

GC content: 36.64

Gene sequence:

>666_bases
ATGAATCTTAAAAAAGAAGCAGGTTATAAAGCAGCAGAATATGTTACAGACGGAGACATTTTAGGACTTGGAACCGGATC
TACAACTCATTATTTCATTGAAGCAGTAGGCAAAAGAATAGCTGATGAAGGAATAAATGTCATGGGAATTCCTACTTCAT
TCCAGTCATTACTGCTTGCTAAACAGTGGAACATACCGGTTACCAGCTTGGAAGAGCATGACATTGATTTGGCTGTTGAC
GGTGCAGACGAAGTGGATAAAAACCTTAACCTTGTTAAAGGTGGAGGAGCAGCTCACACCAAGGAAAAAATTGTGGATTA
CTCTGCAAAACAATTTATTGTAATTGTAGATGAATCAAAATATGTTGAAGAAATTGGAAACTTTCCGGTACCTGTGGAAG
TAATTCCTGATGCATCACGTGTGGTTATACAAACTTTAGAGGACATGGGTGCAGAATGTGAAATAAGAATGGGTGAGCGT
AAGGACGGACCGGTTATAACAGATAATGGAAATTTTGTCATTGATGCCAAATTTGAAAAAATAGAAAGCCCTATGCATTT
GGAAATAGATTTAAATTCTATTCCAGGTGTTGTTGAAAATGGTATTTTTACTCAGATGGTTGATAAAGTCATAATTGGTA
CTTCTGAAGGTATAAAAGAATTGTGA

Upstream 100 bases:

>100_bases
TGAAAAATCATGGGAAACATAAAGGTGAATGCAAAAAAGGATATAAACTTAATAAACTTACATTAGGTTTTGTTATTTAA
AAAATAAGGATATGATAAAT

Downstream 100 bases:

>100_bases
AGGTGTTATAATGCCAATACCAAGTGGAATTCCATATGATTTTAGGGAAATAGCTAATAAAATGGCTATGCTTCTGGGAA
TTTTAATTGTAGTTTATGCC

Product: ribose-5-phosphate isomerase A

Products: NA

Alternate protein names: Phosphoriboisomerase A; PRI [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MNLKKEAGYKAAEYVTDGDILGLGTGSTTHYFIEAVGKRIADEGINVMGIPTSFQSLLLAKQWNIPVTSLEEHDIDLAVD
GADEVDKNLNLVKGGGAAHTKEKIVDYSAKQFIVIVDESKYVEEIGNFPVPVEVIPDASRVVIQTLEDMGAECEIRMGER
KDGPVITDNGNFVIDAKFEKIESPMHLEIDLNSIPGVVENGIFTQMVDKVIIGTSEGIKEL

Sequences:

>Translated_221_residues
MNLKKEAGYKAAEYVTDGDILGLGTGSTTHYFIEAVGKRIADEGINVMGIPTSFQSLLLAKQWNIPVTSLEEHDIDLAVD
GADEVDKNLNLVKGGGAAHTKEKIVDYSAKQFIVIVDESKYVEEIGNFPVPVEVIPDASRVVIQTLEDMGAECEIRMGER
KDGPVITDNGNFVIDAKFEKIESPMHLEIDLNSIPGVVENGIFTQMVDKVIIGTSEGIKEL
>Mature_221_residues
MNLKKEAGYKAAEYVTDGDILGLGTGSTTHYFIEAVGKRIADEGINVMGIPTSFQSLLLAKQWNIPVTSLEEHDIDLAVD
GADEVDKNLNLVKGGGAAHTKEKIVDYSAKQFIVIVDESKYVEEIGNFPVPVEVIPDASRVVIQTLEDMGAECEIRMGER
KDGPVITDNGNFVIDAKFEKIESPMHLEIDLNSIPGVVENGIFTQMVDKVIIGTSEGIKEL

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI94536842, Length=223, Percent_Identity=42.6008968609865, Blast_Score=169, Evalue=2e-42,
Organism=Escherichia coli, GI1789280, Length=222, Percent_Identity=41.8918918918919, Blast_Score=151, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17551758, Length=232, Percent_Identity=38.7931034482759, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6324669, Length=234, Percent_Identity=39.7435897435897, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281364072, Length=215, Percent_Identity=37.6744186046512, Blast_Score=136, Evalue=8e-33,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004788
- InterPro:   IPR020672 [H]

Pfam domain/function: PF06026 Rib_5-P_isom_A [H]

EC number: =5.3.1.6 [H]

Molecular weight: Translated: 24065; Mature: 24065

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKKEAGYKAAEYVTDGDILGLGTGSTTHYFIEAVGKRIADEGINVMGIPTSFQSLLLA
CCCCHHCCCCHHHEECCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHH
KQWNIPVTSLEEHDIDLAVDGADEVDKNLNLVKGGGAAHTKEKIVDYSAKQFIVIVDESK
HCCCCCCCCCCCCCCEEEECCHHHHCCCCEEEECCCCCCHHHHHHCCCCCEEEEEEECCH
YVEEIGNFPVPVEVIPDASRVVIQTLEDMGAECEIRMGERKDGPVITDNGNFVIDAKFEK
HHHHHCCCCCCEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEECCCCEEEEEEHHH
IESPMHLEIDLNSIPGVVENGIFTQMVDKVIIGTSEGIKEL
CCCCEEEEEECCCCCCHHHCCHHHHHHHHHHCCCCCHHHCC
>Mature Secondary Structure
MNLKKEAGYKAAEYVTDGDILGLGTGSTTHYFIEAVGKRIADEGINVMGIPTSFQSLLLA
CCCCHHCCCCHHHEECCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHH
KQWNIPVTSLEEHDIDLAVDGADEVDKNLNLVKGGGAAHTKEKIVDYSAKQFIVIVDESK
HCCCCCCCCCCCCCCEEEECCHHHHCCCCEEEECCCCCCHHHHHHCCCCCEEEEEEECCH
YVEEIGNFPVPVEVIPDASRVVIQTLEDMGAECEIRMGERKDGPVITDNGNFVIDAKFEK
HHHHHCCCCCCEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEECCCCEEEEEEHHH
IESPMHLEIDLNSIPGVVENGIFTQMVDKVIIGTSEGIKEL
CCCCEEEEEECCCCCCHHHCCHHHHHHHHHHCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9419225; 9371463 [H]