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The map label for this gene is thsA [H]

Identifier: 148642280

GI number: 148642280

Start: 209884

End: 211539

Strand: Reverse

Name: thsA [H]

Synonym: Msm_0220

Alternate gene names: 148642280

Gene position: 211539-209884 (Counterclockwise)

Preceding gene: 148642282

Following gene: 148642279

Centisome position: 11.42

GC content: 34.66

Gene sequence:

>1656_bases
ATGATGGCAAATCAACCAATATTCATTCTTCCTGAAGGTACTGAAAGGTATTCCAAAAGAGATGCTTTAAGAATGAATAT
TACAGCAGCTAAAGTTTTAAAAGATATTGTAAGAACTACTTTAGGTCCTAAAGGAATGGACAAAATGTTAACTGATTCAT
TAGGTGATGTTATTGTTACTAATGACGGTGCAACTATAATGAGAGAAATGGATATCACTCAACCTGCTGCTAGAATGCTT
GTAGAAACAGCTAAAAAACAAGAAGACATTGTTGGAGACGGAACCACTTCCGTTGTTGTAATAGCTGGTGAATTATTAGT
TAAAGCTCAAGAATTATTAGAAGATGGAATTGCAACTTCTGTTATTGTAAAAGGTTACAGAAATGCAGCAGCTAAATCTA
TTGAAATTTTAAACAATGTAGCTATGGATGCAGATGATAGGGAAACTCTTAAAAAAGTAGCTATGACTGCTATGACAGGT
AAAGGATCAGATTATGCTAAAGATAAATTAGCTGATTTAGTAGTAGATGCAGCTTTAAGAATAGCCGAAGACGGTGAAAT
AGATATTGACAACATTAATATCCAAAGAATTTCCGGAGATTCAGTTGAAGATTCCTTTTTAGCTGAAGGTATTGTTATGG
ATAAAGATCCAGTATCTAAAAACATGCCTACTGATGTTGAAGATGCTAAAATTGCTTTAATTAAATATCCTATTGAATTA
AAAGAAATCAACACTGATGCTAAAATTGATATTACAGACCCTGCACAATTTGAAGCTTTCTTAAACAATGAAGAAGAAAT
GATTAAAGATTTAGTAGATAAAGTTGTTGCATCCGGAGCAAATGTATTGTTCTGTCAAAAAGGTATTGACGATATGGCAC
AACACTACTTAAACAAAGCAGGAATCATGGCTTATAAAAGAGTTAAAAAATCAGACATGGAAAGAATCAACAAAGCTACC
GGTGCTCAGTATGTAACTGATATTGAAGATTTAACTGCTGACAAATTAGGTTCTGCAGGTCATGTATATGTTGATAAAAT
ATTCGACCACAAATTAACTTTCATTGAAGAATGTGAAAATCCAAAAGCATCTTCCATTGTACTTAGGGGAAGTACCCGTT
ATGTAACTGAACAAATTAGCAGAGCATTAGATGATGCTTTAGGTGTTGTAGCAGCTACTATTGAAGACGGCAAAGTTCTC
ATTGGTGGAGGAGCTTGTGAAATTGATTTAGTAAAAGGATTAAGAGCATATGGTGAATCTGTAAGTGGAAGAGAACAATT
AGCTATTTTAGCTTATGCAAATGCAGTTGAAGTTATTCCAAGAACTTTAATTGAAAATGCTGGTTTAGATACCATTAATT
TAATTGCAGAATTAAAAGCTGCTCATGAAGACTCTTCAAAAATCGGTATTAATGTATTTACCGGCAAACTTGTTGACATG
GAAGAAGCAGGTGTTATTGAACCACTGAGGATTAAAACACAAGCTATCAAAGCTGCTAGTGAAGCTGCTGAAATGATATT
ACGTATTGATGATATGATTGCAGCTAGAAATGCATTAAACTCTTCAGGTCCTGACGAGTCCGGAAATGATGCTAGCGGAA
TGCCTCCGATGGGTGGAATGCCTGGAGGTATGGGTGGAATGCCACCTATGATGTAA

Upstream 100 bases:

>100_bases
AATATGCTAAAGTTTTTATATAACCTCAAACTCATTATTAATATATAAAACTTTTTGATTTTATATTGTTTTTTTATAGA
AATTTATTAATTAAGGTGAT

Downstream 100 bases:

>100_bases
AATTATTTACATCTTTTTTTATTTTTTATTTTTATTGCTTATTTTTCAATTTACTAAATTTACTTGTTTGTTTTTTACTA
TAATTCCATTCAAATTTATC

Product: thermosome subunit alpha

Products: NA

Alternate protein names: Chaperonin subunit alpha; Thermosome subunit 1 [H]

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MMANQPIFILPEGTERYSKRDALRMNITAAKVLKDIVRTTLGPKGMDKMLTDSLGDVIVTNDGATIMREMDITQPAARML
VETAKKQEDIVGDGTTSVVVIAGELLVKAQELLEDGIATSVIVKGYRNAAAKSIEILNNVAMDADDRETLKKVAMTAMTG
KGSDYAKDKLADLVVDAALRIAEDGEIDIDNINIQRISGDSVEDSFLAEGIVMDKDPVSKNMPTDVEDAKIALIKYPIEL
KEINTDAKIDITDPAQFEAFLNNEEEMIKDLVDKVVASGANVLFCQKGIDDMAQHYLNKAGIMAYKRVKKSDMERINKAT
GAQYVTDIEDLTADKLGSAGHVYVDKIFDHKLTFIEECENPKASSIVLRGSTRYVTEQISRALDDALGVVAATIEDGKVL
IGGGACEIDLVKGLRAYGESVSGREQLAILAYANAVEVIPRTLIENAGLDTINLIAELKAAHEDSSKIGINVFTGKLVDM
EEAGVIEPLRIKTQAIKAASEAAEMILRIDDMIAARNALNSSGPDESGNDASGMPPMGGMPGGMGGMPPMM

Sequences:

>Translated_551_residues
MMANQPIFILPEGTERYSKRDALRMNITAAKVLKDIVRTTLGPKGMDKMLTDSLGDVIVTNDGATIMREMDITQPAARML
VETAKKQEDIVGDGTTSVVVIAGELLVKAQELLEDGIATSVIVKGYRNAAAKSIEILNNVAMDADDRETLKKVAMTAMTG
KGSDYAKDKLADLVVDAALRIAEDGEIDIDNINIQRISGDSVEDSFLAEGIVMDKDPVSKNMPTDVEDAKIALIKYPIEL
KEINTDAKIDITDPAQFEAFLNNEEEMIKDLVDKVVASGANVLFCQKGIDDMAQHYLNKAGIMAYKRVKKSDMERINKAT
GAQYVTDIEDLTADKLGSAGHVYVDKIFDHKLTFIEECENPKASSIVLRGSTRYVTEQISRALDDALGVVAATIEDGKVL
IGGGACEIDLVKGLRAYGESVSGREQLAILAYANAVEVIPRTLIENAGLDTINLIAELKAAHEDSSKIGINVFTGKLVDM
EEAGVIEPLRIKTQAIKAASEAAEMILRIDDMIAARNALNSSGPDESGNDASGMPPMGGMPGGMGGMPPMM
>Mature_551_residues
MMANQPIFILPEGTERYSKRDALRMNITAAKVLKDIVRTTLGPKGMDKMLTDSLGDVIVTNDGATIMREMDITQPAARML
VETAKKQEDIVGDGTTSVVVIAGELLVKAQELLEDGIATSVIVKGYRNAAAKSIEILNNVAMDADDRETLKKVAMTAMTG
KGSDYAKDKLADLVVDAALRIAEDGEIDIDNINIQRISGDSVEDSFLAEGIVMDKDPVSKNMPTDVEDAKIALIKYPIEL
KEINTDAKIDITDPAQFEAFLNNEEEMIKDLVDKVVASGANVLFCQKGIDDMAQHYLNKAGIMAYKRVKKSDMERINKAT
GAQYVTDIEDLTADKLGSAGHVYVDKIFDHKLTFIEECENPKASSIVLRGSTRYVTEQISRALDDALGVVAATIEDGKVL
IGGGACEIDLVKGLRAYGESVSGREQLAILAYANAVEVIPRTLIENAGLDTINLIAELKAAHEDSSKIGINVFTGKLVDM
EEAGVIEPLRIKTQAIKAASEAAEMILRIDDMIAARNALNSSGPDESGNDASGMPPMGGMPGGMGGMPPMM

Specific function: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TCP-1 chaperonin family [H]

Homologues:

Organism=Homo sapiens, GI63162572, Length=551, Percent_Identity=37.2050816696915, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI38455427, Length=517, Percent_Identity=39.8452611218569, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI57863257, Length=511, Percent_Identity=37.3776908023483, Blast_Score=322, Evalue=6e-88,
Organism=Homo sapiens, GI24307939, Length=518, Percent_Identity=37.2586872586873, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI5453607, Length=522, Percent_Identity=33.9080459770115, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI58761484, Length=551, Percent_Identity=33.3938294010889, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI4502643, Length=506, Percent_Identity=34.3873517786561, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI58331173, Length=502, Percent_Identity=33.8645418326693, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI261399877, Length=478, Percent_Identity=33.0543933054393, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI48762932, Length=527, Percent_Identity=35.2941176470588, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI5453603, Length=519, Percent_Identity=32.5626204238921, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI302058290, Length=495, Percent_Identity=33.5353535353535, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI58331171, Length=506, Percent_Identity=30.4347826086957, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI261399875, Length=434, Percent_Identity=31.7972350230415, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI302058292, Length=502, Percent_Identity=30.0796812749004, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI57863259, Length=366, Percent_Identity=35.2459016393443, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI7657253, Length=505, Percent_Identity=25.7425742574257, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI58331185, Length=320, Percent_Identity=31.875, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI25914754, Length=411, Percent_Identity=22.6277372262774, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI9055272, Length=411, Percent_Identity=22.6277372262774, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI121583483, Length=209, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI41399285, Length=559, Percent_Identity=23.2558139534884, Blast_Score=66, Evalue=9e-11,
Organism=Homo sapiens, GI31542947, Length=559, Percent_Identity=23.2558139534884, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1790586, Length=545, Percent_Identity=21.651376146789, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17532601, Length=534, Percent_Identity=36.3295880149813, Blast_Score=332, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI25148561, Length=527, Percent_Identity=35.1043643263757, Blast_Score=315, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI25144674, Length=527, Percent_Identity=34.9146110056926, Blast_Score=308, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI17532603, Length=505, Percent_Identity=38.2178217821782, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17564182, Length=549, Percent_Identity=31.1475409836066, Blast_Score=292, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI25144678, Length=513, Percent_Identity=34.5029239766082, Blast_Score=272, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI25147750, Length=521, Percent_Identity=32.8214971209213, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI32566944, Length=444, Percent_Identity=30.1801801801802, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI71998178, Length=566, Percent_Identity=30.7420494699647, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI25144680, Length=390, Percent_Identity=34.8717948717949, Blast_Score=228, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI71981457, Length=325, Percent_Identity=34.4615384615385, Blast_Score=185, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=24.1965973534972, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322446, Length=525, Percent_Identity=35.0476190476191, Blast_Score=328, Evalue=9e-91,
Organism=Saccharomyces cerevisiae, GI6320418, Length=532, Percent_Identity=36.2781954887218, Blast_Score=306, Evalue=7e-84,
Organism=Saccharomyces cerevisiae, GI6320058, Length=507, Percent_Identity=35.1084812623274, Blast_Score=289, Evalue=8e-79,
Organism=Saccharomyces cerevisiae, GI6322350, Length=551, Percent_Identity=31.7604355716878, Blast_Score=289, Evalue=8e-79,
Organism=Saccharomyces cerevisiae, GI6322524, Length=529, Percent_Identity=32.5141776937618, Blast_Score=279, Evalue=8e-76,
Organism=Saccharomyces cerevisiae, GI6322049, Length=493, Percent_Identity=32.8600405679513, Blast_Score=252, Evalue=8e-68,
Organism=Saccharomyces cerevisiae, GI6320393, Length=531, Percent_Identity=29.9435028248588, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6322452, Length=545, Percent_Identity=30.2752293577982, Blast_Score=236, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6323288, Length=546, Percent_Identity=23.2600732600733, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321131, Length=186, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24647512, Length=548, Percent_Identity=34.4890510948905, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI24647510, Length=548, Percent_Identity=34.4890510948905, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI24583944, Length=500, Percent_Identity=37.6, Blast_Score=318, Evalue=7e-87,
Organism=Drosophila melanogaster, GI24649027, Length=523, Percent_Identity=36.7112810707457, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI24649029, Length=523, Percent_Identity=36.7112810707457, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI17647245, Length=521, Percent_Identity=35.5086372360845, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24645179, Length=525, Percent_Identity=35.8095238095238, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI24652903, Length=498, Percent_Identity=35.7429718875502, Blast_Score=298, Evalue=9e-81,
Organism=Drosophila melanogaster, GI28571140, Length=534, Percent_Identity=33.3333333333333, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI18858175, Length=534, Percent_Identity=33.3333333333333, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI19921848, Length=528, Percent_Identity=33.1439393939394, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI18859933, Length=508, Percent_Identity=33.0708661417323, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI20130093, Length=197, Percent_Identity=26.3959390862944, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45552711, Length=197, Percent_Identity=26.3959390862944, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017998
- InterPro:   IPR002194
- InterPro:   IPR002423
- InterPro:   IPR012714 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 59276; Mature: 59276

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00107 PROTEIN_KINASE_ATP ; PS00750 TCP1_1 ; PS00995 TCP1_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMANQPIFILPEGTERYSKRDALRMNITAAKVLKDIVRTTLGPKGMDKMLTDSLGDVIVT
CCCCCCEEEECCCHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEE
NDGATIMREMDITQPAARMLVETAKKQEDIVGDGTTSVVVIAGELLVKAQELLEDGIATS
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCHHH
VIVKGYRNAAAKSIEILNNVAMDADDRETLKKVAMTAMTGKGSDYAKDKLADLVVDAALR
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
IAEDGEIDIDNINIQRISGDSVEDSFLAEGIVMDKDPVSKNMPTDVEDAKIALIKYPIEL
HCCCCCEEECCEEEEEECCCCCCHHHHHCCEEECCCCCCCCCCCCCCCCEEEEEECCEEE
KEINTDAKIDITDPAQFEAFLNNEEEMIKDLVDKVVASGANVLFCQKGIDDMAQHYLNKA
EECCCCCEEEECCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHH
GIMAYKRVKKSDMERINKATGAQYVTDIEDLTADKLGSAGHVYVDKIFDHKLTFIEECEN
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCC
PKASSIVLRGSTRYVTEQISRALDDALGVVAATIEDGKVLIGGGACEIDLVKGLRAYGES
CCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCHHHHHHHHHHCCC
VSGREQLAILAYANAVEVIPRTLIENAGLDTINLIAELKAAHEDSSKIGINVFTGKLVDM
CCCCHHEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEECCEECH
EEAGVIEPLRIKTQAIKAASEAAEMILRIDDMIAARNALNSSGPDESGNDASGMPPMGGM
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PGGMGGMPPMM
CCCCCCCCCCC
>Mature Secondary Structure
MMANQPIFILPEGTERYSKRDALRMNITAAKVLKDIVRTTLGPKGMDKMLTDSLGDVIVT
CCCCCCEEEECCCHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEE
NDGATIMREMDITQPAARMLVETAKKQEDIVGDGTTSVVVIAGELLVKAQELLEDGIATS
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCHHH
VIVKGYRNAAAKSIEILNNVAMDADDRETLKKVAMTAMTGKGSDYAKDKLADLVVDAALR
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
IAEDGEIDIDNINIQRISGDSVEDSFLAEGIVMDKDPVSKNMPTDVEDAKIALIKYPIEL
HCCCCCEEECCEEEEEECCCCCCHHHHHCCEEECCCCCCCCCCCCCCCCEEEEEECCEEE
KEINTDAKIDITDPAQFEAFLNNEEEMIKDLVDKVVASGANVLFCQKGIDDMAQHYLNKA
EECCCCCEEEECCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHH
GIMAYKRVKKSDMERINKATGAQYVTDIEDLTADKLGSAGHVYVDKIFDHKLTFIEECEN
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCC
PKASSIVLRGSTRYVTEQISRALDDALGVVAATIEDGKVLIGGGACEIDLVKGLRAYGES
CCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCHHHHHHHHHHCCC
VSGREQLAILAYANAVEVIPRTLIENAGLDTINLIAELKAAHEDSSKIGINVFTGKLVDM
CCCCHHEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEECCEECH
EEAGVIEPLRIKTQAIKAASEAAEMILRIDDMIAARNALNSSGPDESGNDASGMPPMGGM
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PGGMGGMPPMM
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]