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The map label for this gene is hdrA [H]

Identifier: 148642142

GI number: 148642142

Start: 79936

End: 82242

Strand: Reverse

Name: hdrA [H]

Synonym: Msm_0082

Alternate gene names: 148642142

Gene position: 82242-79936 (Counterclockwise)

Preceding gene: 148642143

Following gene: 148642139

Centisome position: 4.44

GC content: 34.89

Gene sequence:

>2307_bases
ATGCCTGAAGATTTAAAAGTGGGAGTTTTCATCTGTGAATGCGGTGGAAATATCTCTGATACTGTTGATATTCAAAAAGT
TAAGGATTCACTGAATGTGGAAGTTGTAGAGCAATTTGTAAATTTATGTTCTTTAAATGGAAGAAAAATCATTAGGGATG
CAATTTTTGATCATCATTTGGACCGTGTTGTAATTGCGGCATGTTCTCCAATAAGTCATGAAAAAACTTTTCAGGATTAT
GTTCAGCCATTAAATCCTTATTTGATGGATATGGCAAATATTCGTGAACAGTGTTCATGGGTTCATAATGATAAAGATGG
GGCAACCAAAAAAGCCATAACTCTTATTAATGCTTCAATAGAAAAAGTAAAAAAATCAGATGCTGTTAATCCGATATACT
GTCAAACACCAAATGAAGTGGCAGTAATTGGTGGTGGAATAGCAGGTATGAATGCTGCATTGTCACTAGCTAAACAGGGA
ACTAAAGTAACTATTATAGAAAGTTCCCCATCTATCGGCGGACATATGGCTAAAATAGGAAAAGTTTTCTCTCCTGTAAA
AATAGCTGAAGAGTGTGGAATGTGTTTACTGAATCCAATATTGAATGAAGTTGTTTGGAATGAAAATATTGAGATTATAA
CTAATGCAAAAGTCATTGAATCAGAAAGAAGGGCAGGAACCTATAATCTAATTGTTGAAAAATCTCCAAGGTATGTAGAT
ACTGAAAAATGTATAGCCTGCGGTAAGTGTGCGGAAGTCTGTGAAGTGGAAGTTCCCGATGATTGGAATGACGGACTATC
TAACAGAAAAGCTATTTATCGTCCTTTTGGTCAGTCTTATCCTGAAGCATATGTTGTGGATATGGAACATTGTGACAGGT
GTGGGGACTGTAAAAGACAATGTAGTATGAATGCTATCCGTTTTAAAGTAAAACCAGAAAAGATTCCGATTTCTGTAGGT
TCTATTATTATAGCTACAGGACATAAACTCTTTGATCCTGATTTAAGACCGGAATACGGATATTCCAGATATGATGATGT
TATAACTCAAAGTGAACTGGGCCGTATTACAGGAGTAAACGGTCCGACTAAAGGTAAACTGGTAAAATCAAACGGAGAAA
TTCCAAAAAGGGTAGTTATGATACAGTGTGTTGGATCAAGAGATGAAAAACCCGACGGACATTTGTACTGTTCCAAAGTA
TGCTGCAGTGTTGCTTTAAAAAATGCAAACATTATAAAACACAAACACCCTGAAACAGATGTTGTTATCTGTTATACTGA
TATGAGAACTCCTAGTATGTATGAAAAGTATTATAAACACACACAGGCTAATGGAGTAAGATTCATACGTGGAAGACCTG
GTGAAGTTGTTAAAAGAAATGGTAACTTTATTGTTCGTGTTGAAGACACTCTTAAAAGAGAATTTTCAGAAATTGAAGCA
GATATGGTTGTATTATCTACAGCTATGGAACCTTCTGAAGGTACCAAGGAAATTGCAGAAATCTTAAATGTTGGAACTAC
TGAAGATGAATTCATTAAAGAGGCACATCCAAAAATCAAACCTGTAACCACTGATATTCAGGGAACTTTTGTTTGTGGAA
CAGCACAGGATCCGAAAGATATTACAGAATCAATTATGCAGGCTACTGCAGCTGCTTCCAAAGTATCTGAATATAATTAT
GGCGGAATAGAAATTGAACCATTCATTGCAGAAATTGATGAAGAAAAATGTATTGTTTGCGGTGAATGTGTTGAACGTTG
TAAATTCAAATCAATGAGTATTCAGGATGATGAAATCTACATTGACCCGATGAGCTGTACAGGTTGTGGAAAATGTTTAG
TTGGATGTAAGCAGTTTGCTATTACAGTTAACGGTAATATTGATGAAAAGATAAAAGCTACAATTGATGGAGTATTGGCT
AAAAAAGAACCTGGAGAACGTATGATTTTAGTTTTCCTTGATAATATTGGTTATACTGCAGCAGATAATATTGGAGTTAA
CAGATTGTCTTATCCTGAATCCATCCATATCATTAGGGTGCTTTCTGTAAATCGTGTAAGGCCTCGCCACATTAAACATG
CTCTTGAAAATGGTGCTGATGGAATATTTATTGGTGAATTCCCTGGAGATTTGATGTATGATGAAGTTGAAAGGAAAATA
GAAAAAGTCAAAGAAAGGATTAGGGAAGTTAATCAAAATCCTGACAGGATAACATTTTCAAAAGTTTACATCCCGTATTA
TTCAGGATTGGCAAATAAGTTAAATGATTTTGATAAGAAAATTAAGGAATTAAATGAGTCTGAATAG

Upstream 100 bases:

>100_bases
TAGCTATTGCAATGGGTGGTGACTTTGATGAAGTAATCGGTGCAAAAGCACATACTGTACCAATAGATTCAGTCATTAAT
GATTTAAGGGAGGTTGACTA

Downstream 100 bases:

>100_bases
ATTCATTTAATTTATATACTTTTTATAAACCTTTTTTTAATTTCTATTGGTGTTAAATCGATAATTGGTGCTGGTGAGTT
TCCAGGTTCTGTATTGAAAC

Product: heterodisulfide reductase, subunit A, HdrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 768; Mature: 767

Protein sequence:

>768_residues
MPEDLKVGVFICECGGNISDTVDIQKVKDSLNVEVVEQFVNLCSLNGRKIIRDAIFDHHLDRVVIAACSPISHEKTFQDY
VQPLNPYLMDMANIREQCSWVHNDKDGATKKAITLINASIEKVKKSDAVNPIYCQTPNEVAVIGGGIAGMNAALSLAKQG
TKVTIIESSPSIGGHMAKIGKVFSPVKIAEECGMCLLNPILNEVVWNENIEIITNAKVIESERRAGTYNLIVEKSPRYVD
TEKCIACGKCAEVCEVEVPDDWNDGLSNRKAIYRPFGQSYPEAYVVDMEHCDRCGDCKRQCSMNAIRFKVKPEKIPISVG
SIIIATGHKLFDPDLRPEYGYSRYDDVITQSELGRITGVNGPTKGKLVKSNGEIPKRVVMIQCVGSRDEKPDGHLYCSKV
CCSVALKNANIIKHKHPETDVVICYTDMRTPSMYEKYYKHTQANGVRFIRGRPGEVVKRNGNFIVRVEDTLKREFSEIEA
DMVVLSTAMEPSEGTKEIAEILNVGTTEDEFIKEAHPKIKPVTTDIQGTFVCGTAQDPKDITESIMQATAAASKVSEYNY
GGIEIEPFIAEIDEEKCIVCGECVERCKFKSMSIQDDEIYIDPMSCTGCGKCLVGCKQFAITVNGNIDEKIKATIDGVLA
KKEPGERMILVFLDNIGYTAADNIGVNRLSYPESIHIIRVLSVNRVRPRHIKHALENGADGIFIGEFPGDLMYDEVERKI
EKVKERIREVNQNPDRITFSKVYIPYYSGLANKLNDFDKKIKELNESE

Sequences:

>Translated_768_residues
MPEDLKVGVFICECGGNISDTVDIQKVKDSLNVEVVEQFVNLCSLNGRKIIRDAIFDHHLDRVVIAACSPISHEKTFQDY
VQPLNPYLMDMANIREQCSWVHNDKDGATKKAITLINASIEKVKKSDAVNPIYCQTPNEVAVIGGGIAGMNAALSLAKQG
TKVTIIESSPSIGGHMAKIGKVFSPVKIAEECGMCLLNPILNEVVWNENIEIITNAKVIESERRAGTYNLIVEKSPRYVD
TEKCIACGKCAEVCEVEVPDDWNDGLSNRKAIYRPFGQSYPEAYVVDMEHCDRCGDCKRQCSMNAIRFKVKPEKIPISVG
SIIIATGHKLFDPDLRPEYGYSRYDDVITQSELGRITGVNGPTKGKLVKSNGEIPKRVVMIQCVGSRDEKPDGHLYCSKV
CCSVALKNANIIKHKHPETDVVICYTDMRTPSMYEKYYKHTQANGVRFIRGRPGEVVKRNGNFIVRVEDTLKREFSEIEA
DMVVLSTAMEPSEGTKEIAEILNVGTTEDEFIKEAHPKIKPVTTDIQGTFVCGTAQDPKDITESIMQATAAASKVSEYNY
GGIEIEPFIAEIDEEKCIVCGECVERCKFKSMSIQDDEIYIDPMSCTGCGKCLVGCKQFAITVNGNIDEKIKATIDGVLA
KKEPGERMILVFLDNIGYTAADNIGVNRLSYPESIHIIRVLSVNRVRPRHIKHALENGADGIFIGEFPGDLMYDEVERKI
EKVKERIREVNQNPDRITFSKVYIPYYSGLANKLNDFDKKIKELNESE
>Mature_767_residues
PEDLKVGVFICECGGNISDTVDIQKVKDSLNVEVVEQFVNLCSLNGRKIIRDAIFDHHLDRVVIAACSPISHEKTFQDYV
QPLNPYLMDMANIREQCSWVHNDKDGATKKAITLINASIEKVKKSDAVNPIYCQTPNEVAVIGGGIAGMNAALSLAKQGT
KVTIIESSPSIGGHMAKIGKVFSPVKIAEECGMCLLNPILNEVVWNENIEIITNAKVIESERRAGTYNLIVEKSPRYVDT
EKCIACGKCAEVCEVEVPDDWNDGLSNRKAIYRPFGQSYPEAYVVDMEHCDRCGDCKRQCSMNAIRFKVKPEKIPISVGS
IIIATGHKLFDPDLRPEYGYSRYDDVITQSELGRITGVNGPTKGKLVKSNGEIPKRVVMIQCVGSRDEKPDGHLYCSKVC
CSVALKNANIIKHKHPETDVVICYTDMRTPSMYEKYYKHTQANGVRFIRGRPGEVVKRNGNFIVRVEDTLKREFSEIEAD
MVVLSTAMEPSEGTKEIAEILNVGTTEDEFIKEAHPKIKPVTTDIQGTFVCGTAQDPKDITESIMQATAAASKVSEYNYG
GIEIEPFIAEIDEEKCIVCGECVERCKFKSMSIQDDEIYIDPMSCTGCGKCLVGCKQFAITVNGNIDEKIKATIDGVLAK
KEPGERMILVFLDNIGYTAADNIGVNRLSYPESIHIIRVLSVNRVRPRHIKHALENGADGIFIGEFPGDLMYDEVERKIE
KVKERIREVNQNPDRITFSKVYIPYYSGLANKLNDFDKKIKELNESE

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR003813
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4; PF02662 FlpD [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 85579; Mature: 85448

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEDLKVGVFICECGGNISDTVDIQKVKDSLNVEVVEQFVNLCSLNGRKIIRDAIFDHHL
CCCCEEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DRVVIAACSPISHEKTFQDYVQPLNPYLMDMANIREQCSWVHNDKDGATKKAITLINASI
HHEEHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EKVKKSDAVNPIYCQTPNEVAVIGGGIAGMNAALSLAKQGTKVTIIESSPSIGGHMAKIG
HHHHHHCCCCCEEECCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
KVFSPVKIAEECGMCLLNPILNEVVWNENIEIITNAKVIESERRAGTYNLIVEKSPRYVD
HHHCHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHCCCEEEEEEECCCCEEC
TEKCIACGKCAEVCEVEVPDDWNDGLSNRKAIYRPFGQSYPEAYVVDMEHCDRCGDCKRQ
HHHHHHHCCHHHHEEEECCCCCCCCCCCCCHHCCCCCCCCCCEEEEEHHHCCCHHHHHHH
CSMNAIRFKVKPEKIPISVGSIIIATGHKLFDPDLRPEYGYSRYDDVITQSELGRITGVN
CCCCEEEEEECCCCCCEEECCEEEECCCEECCCCCCCCCCCCHHHHHHHHHHCCCEECCC
GPTKGKLVKSNGEIPKRVVMIQCVGSRDEKPDGHLYCSKVCCSVALKNANIIKHKHPETD
CCCCCCEEECCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCC
VVICYTDMRTPSMYEKYYKHTQANGVRFIRGRPGEVVKRNGNFIVRVEDTLKREFSEIEA
EEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCHHEEECCCEEEEEHHHHHHHHHHHHH
DMVVLSTAMEPSEGTKEIAEILNVGTTEDEFIKEAHPKIKPVTTDIQGTFVCGTAQDPKD
HHEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCEEECCCEEEEECCCCCHHH
ITESIMQATAAASKVSEYNYGGIEIEPFIAEIDEEKCIVCGECVERCKFKSMSIQDDEIY
HHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCEEEHHHHHHHHCCCCCCCCCCEEE
IDPMSCTGCGKCLVGCKQFAITVNGNIDEKIKATIDGVLAKKEPGERMILVFLDNIGYTA
ECCCCCCCHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCC
ADNIGVNRLSYPESIHIIRVLSVNRVRPRHIKHALENGADGIFIGEFPGDLMYDEVERKI
CCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
EKVKERIREVNQNPDRITFSKVYIPYYSGLANKLNDFDKKIKELNESE
HHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PEDLKVGVFICECGGNISDTVDIQKVKDSLNVEVVEQFVNLCSLNGRKIIRDAIFDHHL
CCCEEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DRVVIAACSPISHEKTFQDYVQPLNPYLMDMANIREQCSWVHNDKDGATKKAITLINASI
HHEEHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EKVKKSDAVNPIYCQTPNEVAVIGGGIAGMNAALSLAKQGTKVTIIESSPSIGGHMAKIG
HHHHHHCCCCCEEECCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
KVFSPVKIAEECGMCLLNPILNEVVWNENIEIITNAKVIESERRAGTYNLIVEKSPRYVD
HHHCHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHCCCEEEEEEECCCCEEC
TEKCIACGKCAEVCEVEVPDDWNDGLSNRKAIYRPFGQSYPEAYVVDMEHCDRCGDCKRQ
HHHHHHHCCHHHHEEEECCCCCCCCCCCCCHHCCCCCCCCCCEEEEEHHHCCCHHHHHHH
CSMNAIRFKVKPEKIPISVGSIIIATGHKLFDPDLRPEYGYSRYDDVITQSELGRITGVN
CCCCEEEEEECCCCCCEEECCEEEECCCEECCCCCCCCCCCCHHHHHHHHHHCCCEECCC
GPTKGKLVKSNGEIPKRVVMIQCVGSRDEKPDGHLYCSKVCCSVALKNANIIKHKHPETD
CCCCCCEEECCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCC
VVICYTDMRTPSMYEKYYKHTQANGVRFIRGRPGEVVKRNGNFIVRVEDTLKREFSEIEA
EEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCHHEEECCCEEEEEHHHHHHHHHHHHH
DMVVLSTAMEPSEGTKEIAEILNVGTTEDEFIKEAHPKIKPVTTDIQGTFVCGTAQDPKD
HHEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCEEECCCEEEEECCCCCHHH
ITESIMQATAAASKVSEYNYGGIEIEPFIAEIDEEKCIVCGECVERCKFKSMSIQDDEIY
HHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCEEEHHHHHHHHCCCCCCCCCCEEE
IDPMSCTGCGKCLVGCKQFAITVNGNIDEKIKATIDGVLAKKEPGERMILVFLDNIGYTA
ECCCCCCCHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCC
ADNIGVNRLSYPESIHIIRVLSVNRVRPRHIKHALENGADGIFIGEFPGDLMYDEVERKI
CCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
EKVKERIREVNQNPDRITFSKVYIPYYSGLANKLNDFDKKIKELNESE
HHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]