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The map label for this gene is patB [H]

Identifier: 148642104

GI number: 148642104

Start: 32058

End: 33221

Strand: Reverse

Name: patB [H]

Synonym: Msm_0044

Alternate gene names: 148642104

Gene position: 33221-32058 (Counterclockwise)

Preceding gene: 148642105

Following gene: 148642102

Centisome position: 1.79

GC content: 32.9

Gene sequence:

>1164_bases
ATGATTTACATGAAATATGATTTTGACAGCATTATTAACCGTAAAAACACTAACTGCTTAAAATGGGATTTATTTGACAC
TGAACTCCCTATGTGGGTAGCTGACATGGATTTTAAGGTTGCTCCGGAAATATCTGATGAAATTATAAAAAAAGCTGATG
AAAGTCTCTACGGATATGCTGTAATTCCTGATGAATGGTATGATGCATATGCTGACTGGTGGAAAGATTACGGATTGGAA
ATGGATAAAGATTATCTGAAATTTGCCAATGGAGTAATGCCTGCAATAGCTACCATTATCCGTAAATTAACTGATGAAAA
TGATAAAATATTAATCCAAACACCGGTTTATCATGTATTTTTCCATGTAATTGAAGACAATAACAGGGAAGTTGTGGAAA
ATCAGCTGATGTACAGAAATGGAAAGTATGAAATTGATTTTGAGGATTTGGAAGAAAAATTAGCTGAAGCAGATGTAACT
TTGATGATGCTGTGCAATCCCCATAATCCCATTGGTAAAATATGGTCCAGAACAGAACTGAAAAAAATAGCTGATTTATG
TGCCAAATATGATGTAACTATAATATCTGACGAGATTCATTGTGATTTAACTGATCCCGATAAAAAATACATTCCATTTG
CAGGTATAAGCAACCATGATTCCATTACAACAATTTCTCCTACCAAATCATTTAATATAGCGGGATTAAATACTGCTGCG
GTTTATATTGTGGGAGATAAATTGAAGGAAGATGTTTTCAACGCTCTTGATGTTGAATGGGTCAGCAGAGCCAATATTTT
TGCTATAAATGCCGCAATAGCAGCATATAATAACGGCAGACCATGGCTTGATGAACTGAGGCAGTATTTATATGACAACA
AGAAATTTGCAGCTGATTTTATAAAAAAGGAAATTCCTGAAATTAAGTTAACTGATGCAGATGCTACTTATTTATTATGG
CTTGACTGTTCTGATTTGGATATATCTTCAGAGGAATTCATCAAGTTTTTAAATGAAAAAACAGGGGTTTTATTATCTGC
AGGTGTTGATTTTGGTAAAAACAGTGATGAATTTTTAAGATTAAATATTGCCTGTCCAAGACAGTTACTTGAAAAGGGTT
TAAAAGCTATTAAAAAAGGAGTAGCTATTTATAAACAAATTTAA

Upstream 100 bases:

>100_bases
ATGCAATAAAAATATAATTCTGCTGATAATTTAGACAAACTTTTTAAAGTCAATTTAGTTGGCTGTTGGCATCAGGCAAA
AGTTATAAAAGAAATTAAAA

Downstream 100 bases:

>100_bases
GTGCAGCAGAATTTATTTCATAGTAATCTCTTTTTTTATAACCTAAATGTATTCCGCTTTTTTGAGCTCTGATTTCCAAT
CTGACCATTCCGTATGAGAA

Product: PLP dependent aminotransferase (aspartate)

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MIYMKYDFDSIINRKNTNCLKWDLFDTELPMWVADMDFKVAPEISDEIIKKADESLYGYAVIPDEWYDAYADWWKDYGLE
MDKDYLKFANGVMPAIATIIRKLTDENDKILIQTPVYHVFFHVIEDNNREVVENQLMYRNGKYEIDFEDLEEKLAEADVT
LMMLCNPHNPIGKIWSRTELKKIADLCAKYDVTIISDEIHCDLTDPDKKYIPFAGISNHDSITTISPTKSFNIAGLNTAA
VYIVGDKLKEDVFNALDVEWVSRANIFAINAAIAAYNNGRPWLDELRQYLYDNKKFAADFIKKEIPEIKLTDADATYLLW
LDCSDLDISSEEFIKFLNEKTGVLLSAGVDFGKNSDEFLRLNIACPRQLLEKGLKAIKKGVAIYKQI

Sequences:

>Translated_387_residues
MIYMKYDFDSIINRKNTNCLKWDLFDTELPMWVADMDFKVAPEISDEIIKKADESLYGYAVIPDEWYDAYADWWKDYGLE
MDKDYLKFANGVMPAIATIIRKLTDENDKILIQTPVYHVFFHVIEDNNREVVENQLMYRNGKYEIDFEDLEEKLAEADVT
LMMLCNPHNPIGKIWSRTELKKIADLCAKYDVTIISDEIHCDLTDPDKKYIPFAGISNHDSITTISPTKSFNIAGLNTAA
VYIVGDKLKEDVFNALDVEWVSRANIFAINAAIAAYNNGRPWLDELRQYLYDNKKFAADFIKKEIPEIKLTDADATYLLW
LDCSDLDISSEEFIKFLNEKTGVLLSAGVDFGKNSDEFLRLNIACPRQLLEKGLKAIKKGVAIYKQI
>Mature_387_residues
MIYMKYDFDSIINRKNTNCLKWDLFDTELPMWVADMDFKVAPEISDEIIKKADESLYGYAVIPDEWYDAYADWWKDYGLE
MDKDYLKFANGVMPAIATIIRKLTDENDKILIQTPVYHVFFHVIEDNNREVVENQLMYRNGKYEIDFEDLEEKLAEADVT
LMMLCNPHNPIGKIWSRTELKKIADLCAKYDVTIISDEIHCDLTDPDKKYIPFAGISNHDSITTISPTKSFNIAGLNTAA
VYIVGDKLKEDVFNALDVEWVSRANIFAINAAIAAYNNGRPWLDELRQYLYDNKKFAADFIKKEIPEIKLTDADATYLLW
LDCSDLDISSEEFIKFLNEKTGVLLSAGVDFGKNSDEFLRLNIACPRQLLEKGLKAIKKGVAIYKQI

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=155, Percent_Identity=29.0322580645161, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI56713256, Length=155, Percent_Identity=29.0322580645161, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787909, Length=381, Percent_Identity=33.8582677165354, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1787710, Length=320, Percent_Identity=20.9375, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17567369, Length=138, Percent_Identity=27.536231884058, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=267, Percent_Identity=25.0936329588015, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44588; Mature: 44588

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYMKYDFDSIINRKNTNCLKWDLFDTELPMWVADMDFKVAPEISDEIIKKADESLYGYA
CEEEEECHHHHHCCCCCCEEEEEEECCCCCEEEECCCCEECCCHHHHHHHHHCCCCEEEE
VIPDEWYDAYADWWKDYGLEMDKDYLKFANGVMPAIATIIRKLTDENDKILIQTPVYHVF
ECCHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCHHHEE
FHVIEDNNREVVENQLMYRNGKYEIDFEDLEEKLAEADVTLMMLCNPHNPIGKIWSRTEL
EEEEECCCHHHHHHHHHHCCCCEEECHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHH
KKIADLCAKYDVTIISDEIHCDLTDPDKKYIPFAGISNHDSITTISPTKSFNIAGLNTAA
HHHHHHHHHCCEEEEECEEEECCCCCCCCEECCCCCCCCCCEEEECCCCCEEEECCCEEE
VYIVGDKLKEDVFNALDVEWVSRANIFAINAAIAAYNNGRPWLDELRQYLYDNKKFAADF
EEEECCHHHHHHHHHHCHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHH
IKKEIPEIKLTDADATYLLWLDCSDLDISSEEFIKFLNEKTGVLLSAGVDFGKNSDEFLR
HHHHCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCEEE
LNIACPRQLLEKGLKAIKKGVAIYKQI
EEECCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIYMKYDFDSIINRKNTNCLKWDLFDTELPMWVADMDFKVAPEISDEIIKKADESLYGYA
CEEEEECHHHHHCCCCCCEEEEEEECCCCCEEEECCCCEECCCHHHHHHHHHCCCCEEEE
VIPDEWYDAYADWWKDYGLEMDKDYLKFANGVMPAIATIIRKLTDENDKILIQTPVYHVF
ECCHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCHHHEE
FHVIEDNNREVVENQLMYRNGKYEIDFEDLEEKLAEADVTLMMLCNPHNPIGKIWSRTEL
EEEEECCCHHHHHHHHHHCCCCEEECHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHH
KKIADLCAKYDVTIISDEIHCDLTDPDKKYIPFAGISNHDSITTISPTKSFNIAGLNTAA
HHHHHHHHHCCEEEEECEEEECCCCCCCCEECCCCCCCCCCEEEECCCCCEEEECCCEEE
VYIVGDKLKEDVFNALDVEWVSRANIFAINAAIAAYNNGRPWLDELRQYLYDNKKFAADF
EEEECCHHHHHHHHHHCHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHH
IKKEIPEIKLTDADATYLLWLDCSDLDISSEEFIKFLNEKTGVLLSAGVDFGKNSDEFLR
HHHHCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCEEE
LNIACPRQLLEKGLKAIKKGVAIYKQI
EEECCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]