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The map label for this gene is fabH

Identifier: 148381542

GI number: 148381542

Start: 3846386

End: 3847366

Strand: Reverse

Name: fabH

Synonym: CBO3604

Alternate gene names: 148381542

Gene position: 3847366-3846386 (Counterclockwise)

Preceding gene: 148381543

Following gene: 148381541

Centisome position: 98.98

GC content: 30.89

Gene sequence:

>981_bases
ATGAGTAATATTAGTGTTATTGGAACTGGAAGTTATGTACCTAATAATATTATTACTAATGATTTTTTATCAACTATAGT
AGATACTAGCGATGAATGGATAAGAACTAGAACAGGTATATTAGAGAGAAGGATTTCTAAGGGAGAAAACACTATTTATA
TGGCAACAGAATCTGCAAAAGAAGCAATTAAAAATGCTAATATAGAGGCTAATGATTTAGATTTAATAATTGTAGCTACA
TTGACTCCAGACAATTTCATGCCTTCTACTGCCTGTAGTGTTCAAAAGGAAATAGGAGCTATGAACGCTTTATGCTTTGA
TATATCTGCAGCTTGTTCAGGGTTTATATATGGACTTGAGATAGCCTGTTCTATGTTAAAAAATAGCTTTAGAAATAAAG
CTTTAATAATAGGTGCTGAGAATCTATCTAAAATAGTTGACTGGGAAGATAGAAATACCTGTGTATTGTTTGGAGATGGA
GCAGGGTCAGCTATATTAAGTAAAACTAAGGAAGAAGGAATTTTAGAGTTCCATTCTGGATCAAATGGATTAAAAGGAGA
ACATCTTACTTGTGGAGTTTTAAAAGCTAATAATACTCCCAATAAGAATGATAGCTTAGAAAAGAATAATTTTATAAAGA
TGAATGGTAAAGAAATATTTAGGTTTGCAGTAGGGGCAATGAATGAAACTATTTACAATATACAAGAAAAGACTAAGTGG
GATTTAAATGAAGTTAAGTATATTATATCTCATCAAGCTAACTCTAGAATAATAGAGTATACAGCTAAAAAGCTTAATAC
TGAGAAAGATAAATTTTATATGAACCTAGACAAATATGGAAACACATCCGCAGCAAGTATACCTATAGCATTAGATGAAA
TGAACAAAAGAGGCCTATTAAATAAACAAGATAAAATTATATTAGTAGGCTTTGGTGGTGGTTTAACCTTTGGGGGAGTT
GCCATTGTATGGAGTATTTAA

Upstream 100 bases:

>100_bases
ACAGAAGAAGAAGAAAAAGTACTTATAAAATCTTTGGATAAACTAAATAATTTTTTTAAGGAAAAGTATAATTTAAATAA
AGTTAATAAGGAGAAAAATG

Downstream 100 bases:

>100_bases
TAAAAAATAAAATAAATATAAATTTTAGGAGGAAAAGATTATGGTATTTGAAAAAGTTAAAAACATTATAGTAGAACAAT
TAGGTTTAGATGAAGGAGAA

Product: 3-oxoacyl-(acyl-carrier-protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSNISVIGTGSYVPNNIITNDFLSTIVDTSDEWIRTRTGILERRISKGENTIYMATESAKEAIKNANIEANDLDLIIVAT
LTPDNFMPSTACSVQKEIGAMNALCFDISAACSGFIYGLEIACSMLKNSFRNKALIIGAENLSKIVDWEDRNTCVLFGDG
AGSAILSKTKEEGILEFHSGSNGLKGEHLTCGVLKANNTPNKNDSLEKNNFIKMNGKEIFRFAVGAMNETIYNIQEKTKW
DLNEVKYIISHQANSRIIEYTAKKLNTEKDKFYMNLDKYGNTSAASIPIALDEMNKRGLLNKQDKIILVGFGGGLTFGGV
AIVWSI

Sequences:

>Translated_326_residues
MSNISVIGTGSYVPNNIITNDFLSTIVDTSDEWIRTRTGILERRISKGENTIYMATESAKEAIKNANIEANDLDLIIVAT
LTPDNFMPSTACSVQKEIGAMNALCFDISAACSGFIYGLEIACSMLKNSFRNKALIIGAENLSKIVDWEDRNTCVLFGDG
AGSAILSKTKEEGILEFHSGSNGLKGEHLTCGVLKANNTPNKNDSLEKNNFIKMNGKEIFRFAVGAMNETIYNIQEKTKW
DLNEVKYIISHQANSRIIEYTAKKLNTEKDKFYMNLDKYGNTSAASIPIALDEMNKRGLLNKQDKIILVGFGGGLTFGGV
AIVWSI
>Mature_325_residues
SNISVIGTGSYVPNNIITNDFLSTIVDTSDEWIRTRTGILERRISKGENTIYMATESAKEAIKNANIEANDLDLIIVATL
TPDNFMPSTACSVQKEIGAMNALCFDISAACSGFIYGLEIACSMLKNSFRNKALIIGAENLSKIVDWEDRNTCVLFGDGA
GSAILSKTKEEGILEFHSGSNGLKGEHLTCGVLKANNTPNKNDSLEKNNFIKMNGKEIFRFAVGAMNETIYNIQEKTKWD
LNEVKYIISHQANSRIIEYTAKKLNTEKDKFYMNLDKYGNTSAASIPIALDEMNKRGLLNKQDKIILVGFGGGLTFGGVA
IVWSI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=315, Percent_Identity=40.3174603174603, Blast_Score=242, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_CLOB1 (A7FPM6)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385916.1
- ProteinModelPortal:   A7FPM6
- SMR:   A7FPM6
- STRING:   A7FPM6
- GeneID:   5395624
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3684
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   YIVPHQA
- ProtClustDB:   CLSK972443
- BioCyc:   CBOT441770:CLB_3684-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 35813; Mature: 35682

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 251-251 ACT_SITE 281-281

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNISVIGTGSYVPNNIITNDFLSTIVDTSDEWIRTRTGILERRISKGENTIYMATESAK
CCCEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHH
EAIKNANIEANDLDLIIVATLTPDNFMPSTACSVQKEIGAMNALCFDISAACSGFIYGLE
HHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IACSMLKNSFRNKALIIGAENLSKIVDWEDRNTCVLFGDGAGSAILSKTKEEGILEFHSG
HHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCEEEEEECCCCCHHHHHCCCCCEEEEECC
SNGLKGEHLTCGVLKANNTPNKNDSLEKNNFIKMNGKEIFRFAVGAMNETIYNIQEKTKW
CCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCC
DLNEVKYIISHQANSRIIEYTAKKLNTEKDKFYMNLDKYGNTSAASIPIALDEMNKRGLL
CHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHEEEEECCCCCCCCCEEEEEEECCCCCCCC
NKQDKIILVGFGGGLTFGGVAIVWSI
CCCCCEEEEEECCCCCCCCEEEEEEC
>Mature Secondary Structure 
SNISVIGTGSYVPNNIITNDFLSTIVDTSDEWIRTRTGILERRISKGENTIYMATESAK
CCEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHH
EAIKNANIEANDLDLIIVATLTPDNFMPSTACSVQKEIGAMNALCFDISAACSGFIYGLE
HHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IACSMLKNSFRNKALIIGAENLSKIVDWEDRNTCVLFGDGAGSAILSKTKEEGILEFHSG
HHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCEEEEEECCCCCHHHHHCCCCCEEEEECC
SNGLKGEHLTCGVLKANNTPNKNDSLEKNNFIKMNGKEIFRFAVGAMNETIYNIQEKTKW
CCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCC
DLNEVKYIISHQANSRIIEYTAKKLNTEKDKFYMNLDKYGNTSAASIPIALDEMNKRGLL
CHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHEEEEECCCCCCCCCEEEEEEECCCCCCCC
NKQDKIILVGFGGGLTFGGVAIVWSI
CCCCCEEEEEECCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA