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The map label for this gene is fabF [H]

Identifier: 148381537

GI number: 148381537

Start: 3842082

End: 3843329

Strand: Reverse

Name: fabF [H]

Synonym: CBO3599

Alternate gene names: 148381537

Gene position: 3843329-3842082 (Counterclockwise)

Preceding gene: 148381538

Following gene: 148381536

Centisome position: 98.88

GC content: 34.13

Gene sequence:

>1248_bases
GTGAATAATATGAATAAAAGAGTAGTTATAACTGGTATGGGTGCTATTACACCTATTGGCAATAATCTTGAGGACTTTTG
GAAAGGCATAAAAGAAGAAAAAATAGGAATAGGTAATATAAAATCTTTTGACATAGAAGATTATAAAGTTAAGTTAGCAG
CAGAGGTTAAAGATTTTGATCCAGAAGAATATATGGATAAAAAAGAAGCTAGAAGATTAGATAGGTTTTGCCAATTTGCT
ATAGCAGCAGCACAGCAAGCTATTGATAATAGTAAATTAGATTTAGATAAAATAAATAAAGAAAAATTTGGAGTTATAGT
AGGATCAGGTATTGGCGGATTAGCAACTATAGAAAAGGAAGAACAAAAATTATTAGAAAAGGGACCTAATAGAGTAAGTC
CATTATTTATACCAACAATAATAAGTAATATGGCAGCGGGAAATATAGCTATTAGATTTGGAGCTAAGGCTATATGTAGT
ACTGTAGTTACAGCCTGTGCTACAGGAACTAATTGCGCAGGTGAGGCTTTTAGAGCTATAAAGAATGGAGAAGCTGACAT
AATGCTAGCAGGAGGTACAGAGGCAGCTATAACTCCTATAGCTATAGCAGGTTTTACAACTCTTACAGCTTTAAGTAAAA
GTACAGATCCTAATAGAGCGTCTATACCTTTTGATAAAGATAGAGATGGGTTTGTTATGGGTGAAGGTTCAGGATTATTA
GTATTAGAATCACTAGATCATGCACTAGAGAGAGGTGCTAAAATTTATGCAGAAGTAGTTGGATACGGATCTACTTGTGA
TGCATATCATATGACATCTCCTGCTCCAGGAGGAGAAGGAGCGGCAAGGGCTATAGAGCTTGCTATAAAGGAAGCAGGTA
TAAATAAAGAAGAAGTATCCTATATAAATGCCCATGGAACTAGTACTCCATATAATGATAAATTTGAAACAGAAGCAATT
AAAAGAGTGTTCGGAGATTATTCATCTAGTATACCTGTCAGTTCTACAAAATCTATGATAGGACATTTATTGGGAGCAGC
GGGAGCAGTTGAAGCTATAATATGTGCAAAGTCTTTAGAAGAAGGATATATACCTGCAACAGTTGGATATAAGGTTAAAG
ATGAAGAATGTGATTTGGACTATGTGACTTCAGGCGGAAGAAATAAAATAATAAATTATGCTATGTCTAATTCTTTAGGT
TTTGGAGGACATAATGCAGTAATATTATTAAAAAAATGGGGTGAGTAA

Upstream 100 bases:

>100_bases
GTAGCAGAAGCTGTAGGATTTTTAGCTTCAGATAAAGCTGCATATATAACAGGTCAAGTTATACATGTAGATGGTGGAAT
GATTATATAGGTAAAAAGGG

Downstream 100 bases:

>100_bases
TAAATGGATTTTAAAGGCATAGAAAATTTAATAAAAGCTATGAGTGAATCAAATTTATCTTCTATGGATATAGAGTATAA
TGGTATAGCTATAAAAATGA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MNNMNKRVVITGMGAITPIGNNLEDFWKGIKEEKIGIGNIKSFDIEDYKVKLAAEVKDFDPEEYMDKKEARRLDRFCQFA
IAAAQQAIDNSKLDLDKINKEKFGVIVGSGIGGLATIEKEEQKLLEKGPNRVSPLFIPTIISNMAAGNIAIRFGAKAICS
TVVTACATGTNCAGEAFRAIKNGEADIMLAGGTEAAITPIAIAGFTTLTALSKSTDPNRASIPFDKDRDGFVMGEGSGLL
VLESLDHALERGAKIYAEVVGYGSTCDAYHMTSPAPGGEGAARAIELAIKEAGINKEEVSYINAHGTSTPYNDKFETEAI
KRVFGDYSSSIPVSSTKSMIGHLLGAAGAVEAIICAKSLEEGYIPATVGYKVKDEECDLDYVTSGGRNKIINYAMSNSLG
FGGHNAVILLKKWGE

Sequences:

>Translated_415_residues
MNNMNKRVVITGMGAITPIGNNLEDFWKGIKEEKIGIGNIKSFDIEDYKVKLAAEVKDFDPEEYMDKKEARRLDRFCQFA
IAAAQQAIDNSKLDLDKINKEKFGVIVGSGIGGLATIEKEEQKLLEKGPNRVSPLFIPTIISNMAAGNIAIRFGAKAICS
TVVTACATGTNCAGEAFRAIKNGEADIMLAGGTEAAITPIAIAGFTTLTALSKSTDPNRASIPFDKDRDGFVMGEGSGLL
VLESLDHALERGAKIYAEVVGYGSTCDAYHMTSPAPGGEGAARAIELAIKEAGINKEEVSYINAHGTSTPYNDKFETEAI
KRVFGDYSSSIPVSSTKSMIGHLLGAAGAVEAIICAKSLEEGYIPATVGYKVKDEECDLDYVTSGGRNKIINYAMSNSLG
FGGHNAVILLKKWGE
>Mature_415_residues
MNNMNKRVVITGMGAITPIGNNLEDFWKGIKEEKIGIGNIKSFDIEDYKVKLAAEVKDFDPEEYMDKKEARRLDRFCQFA
IAAAQQAIDNSKLDLDKINKEKFGVIVGSGIGGLATIEKEEQKLLEKGPNRVSPLFIPTIISNMAAGNIAIRFGAKAICS
TVVTACATGTNCAGEAFRAIKNGEADIMLAGGTEAAITPIAIAGFTTLTALSKSTDPNRASIPFDKDRDGFVMGEGSGLL
VLESLDHALERGAKIYAEVVGYGSTCDAYHMTSPAPGGEGAARAIELAIKEAGINKEEVSYINAHGTSTPYNDKFETEAI
KRVFGDYSSSIPVSSTKSMIGHLLGAAGAVEAIICAKSLEEGYIPATVGYKVKDEECDLDYVTSGGRNKIINYAMSNSLG
FGGHNAVILLKKWGE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=40.0473933649289, Blast_Score=311, Evalue=9e-85,
Organism=Homo sapiens, GI223972627, Length=178, Percent_Identity=41.0112359550562, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI41872631, Length=428, Percent_Identity=25, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=46.9437652811736, Blast_Score=356, Evalue=1e-99,
Organism=Escherichia coli, GI1788663, Length=412, Percent_Identity=35.6796116504854, Blast_Score=225, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=38.3132530120482, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=44.1860465116279, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=356, Percent_Identity=26.123595505618, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=415, Percent_Identity=24.0963855421687, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=38.6160714285714, Blast_Score=287, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24644341, Length=419, Percent_Identity=41.0501193317422, Blast_Score=318, Evalue=3e-87,
Organism=Drosophila melanogaster, GI19920632, Length=439, Percent_Identity=24.1457858769932, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI221330659, Length=439, Percent_Identity=24.1457858769932, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24581345, Length=426, Percent_Identity=23.943661971831, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44261; Mature: 44261

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNMNKRVVITGMGAITPIGNNLEDFWKGIKEEKIGIGNIKSFDIEDYKVKLAAEVKDFD
CCCCCCEEEEEECCCCCCCCCCHHHHHCCHHHCCCCCCCCCCCCCCCEEEEEEEECCCCC
PEEYMDKKEARRLDRFCQFAIAAAQQAIDNSKLDLDKINKEKFGVIVGSGIGGLATIEKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEEEEEECCCCCCEECCHH
EQKLLEKGPNRVSPLFIPTIISNMAAGNIAIRFGAKAICSTVVTACATGTNCAGEAFRAI
HHHHHHCCCCCCCCEEHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHH
KNGEADIMLAGGTEAAITPIAIAGFTTLTALSKSTDPNRASIPFDKDRDGFVMGEGSGLL
HCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLESLDHALERGAKIYAEVVGYGSTCDAYHMTSPAPGGEGAARAIELAIKEAGINKEEVS
EEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHE
YINAHGTSTPYNDKFETEAIKRVFGDYSSSIPVSSTKSMIGHLLGAAGAVEAIICAKSLE
EEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EGYIPATVGYKVKDEECDLDYVTSGGRNKIINYAMSNSLGFGGHNAVILLKKWGE
CCCCCEEECEEECCCCCCCHHCCCCCCHHEEEEEHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MNNMNKRVVITGMGAITPIGNNLEDFWKGIKEEKIGIGNIKSFDIEDYKVKLAAEVKDFD
CCCCCCEEEEEECCCCCCCCCCHHHHHCCHHHCCCCCCCCCCCCCCCEEEEEEEECCCCC
PEEYMDKKEARRLDRFCQFAIAAAQQAIDNSKLDLDKINKEKFGVIVGSGIGGLATIEKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEEEEEECCCCCCEECCHH
EQKLLEKGPNRVSPLFIPTIISNMAAGNIAIRFGAKAICSTVVTACATGTNCAGEAFRAI
HHHHHHCCCCCCCCEEHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHH
KNGEADIMLAGGTEAAITPIAIAGFTTLTALSKSTDPNRASIPFDKDRDGFVMGEGSGLL
HCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLESLDHALERGAKIYAEVVGYGSTCDAYHMTSPAPGGEGAARAIELAIKEAGINKEEVS
EEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHE
YINAHGTSTPYNDKFETEAIKRVFGDYSSSIPVSSTKSMIGHLLGAAGAVEAIICAKSLE
EEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EGYIPATVGYKVKDEECDLDYVTSGGRNKIINYAMSNSLGFGGHNAVILLKKWGE
CCCCCEEECEEECCCCCCCHHCCCCCCHHEEEEEHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]