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The map label for this gene is fhs

Identifier: 148381464

GI number: 148381464

Start: 3765668

End: 3767341

Strand: Reverse

Name: fhs

Synonym: CBO3523

Alternate gene names: 148381464

Gene position: 3767341-3765668 (Counterclockwise)

Preceding gene: 148381465

Following gene: 148381463

Centisome position: 96.92

GC content: 31.12

Gene sequence:

>1674_bases
ATGTTTAAATCCGATATAGAAATAGCACAAGAATCTAAAATGAAAAATATAAAAAATATAGCTGAGAAGATAGGGTTAAC
AGAAGAAGATATAGATTTATATGGAAAATATAAATGTAAAATTTCATTAGATGTTTTAAAGAGAAATAAAGATAAAAAAG
ATGGAAAACTAATTTTAGTTACAGCTATAAATCCTACTCCAGCAGGAGAAGGAAAATCCACAGTTACAGTAGGTTTAGGG
CAAGCCTTATGGAAGAAAAATAAAAAAGCGGTTATAGCATTAAGAGAACCTTCTTTGGGACCTGTATTTGGTATAAAAGG
AGGTGCAGCTGGAGGAGGATACTCTCAAGTTGTACCTATGGAAGATATAAATCTTCATTTTACAGGTGATATGCATGCTA
TTACTTCAGCTAATAATTTATTAGCTGCTGCTATAGATAACCATATTCATCAAGGGAATATTTTGAAGATTGATCAAAGA
AGAATTCTCTTTAAAAGAGTTATGGATATGAATGATAGAGCTTTAAGAAATGTAATTGTAGCCTTAGGTGGAAAAATAAA
TGGATTTCCAAGAGAAGATGGATTTATGATAACTGTAGCTTCAGAGATTATGGCTATATTATGTTTAGCAGAAGATCTTA
TGGATCTTAAGAATAAAATGGGAGAAATATTAGTAGCTTATAGTACAGAGGGGAAACCTATATACTGCGAAGATTTAGAG
GTTCAGGGAGCTATGGCATTATTAATGAAAGATGCTATAAAACCTAATTTAGTTCAAACTTTAGAAAATACTCCGGCTAT
TATACATGGTGGACCTTTCGCTAATATAGCTCATGGATGTAATAGTATATTGGGAACAAAGATGGCCTTAAAATTAGGAG
ATTATGTAATAACAGAGGCAGGCTTTGGAGCAGATCTAGGAGCAGAAAAGTTTTTTGATATTAAATGTAGAAAAGCTAAT
TTAAAACCAAATTGTGTAGTTATAGTAGCTACAGTAAGAGCTTTAAAATATAATGGTGGCATTCCTAAGGAAAATCTAAA
GGAACAAAATATGGAAGCCCTATCAAAGGGTATAAAAAATCTAGGGAAACATATAGAGAATGTTAATAAGTTTGGTGTAC
CAGCAGTAGTTGCTATAAATAAATTTATATCAGATACAGAAGAAGAAATAGAATTTATAAAAAAATATTGTAAAGAATTA
GGTGCAGAAGTGTCTATAGCAGAGGTATGGGAAAAAGGTGGAAATGGTGGCTTAGAATTAGCTGATAAAGTTTTAGATAC
CATAGAAAATAAAGAAAGTAAATTTAATCCTATATACGAGGAAACTCTTAGTATAAAACAAAAAATAGAAACAATTGCCG
AGGAAATATATGGAGCAGAAGGGGTAGATTATTCTAAAGAGGCAGAAAAGCAAATATCTGAAATAGAAAAATTAGATTTA
GATAAAAAGCCTGTATGTATGGCAAAAACTCAGTATTCTTTATCAGATGATGCTAAACTATTAGGAAGACCATGTGGATT
TAGAATTAATGTCAAAGAAGTTAGAATATCCAATGGAGCTGGATTTATAGTTGTGTTAACAGGAAATGTTATGACTATGC
CAGGTTTACCTAAGAAACCTGCAGCTAACAATATGAATGTATTATCAGATGGCAATATAGTTGGACTATTCTAA

Upstream 100 bases:

>100_bases
AGAGTAGAATTAAAAAATTATTAAACAGCGAATAAATAATTATTCAATTACACAAAAATAATTAATAGGGTCCGTATTAT
AACTAAGGGGGAATATATAA

Downstream 100 bases:

>100_bases
CATTAATATAATAGAAGTATTAACTTGACAAAATAATTTGAACTGATAAAATAAAATTATTAAATTGACATTAAATCAAG
CATAAAGGGCAGCGGCAAGG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLKRNKDKKDGKLILVTAINPTPAGEGKSTVTVGLG
QALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPMEDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQR
RILFKRVMDMNDRALRNVIVALGGKINGFPREDGFMITVASEIMAILCLAEDLMDLKNKMGEILVAYSTEGKPIYCEDLE
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEAGFGADLGAEKFFDIKCRKAN
LKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKNLGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKEL
GAEVSIAEVWEKGGNGGLELADKVLDTIENKESKFNPIYEETLSIKQKIETIAEEIYGAEGVDYSKEAEKQISEIEKLDL
DKKPVCMAKTQYSLSDDAKLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKPAANNMNVLSDGNIVGLF

Sequences:

>Translated_557_residues
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLKRNKDKKDGKLILVTAINPTPAGEGKSTVTVGLG
QALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPMEDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQR
RILFKRVMDMNDRALRNVIVALGGKINGFPREDGFMITVASEIMAILCLAEDLMDLKNKMGEILVAYSTEGKPIYCEDLE
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEAGFGADLGAEKFFDIKCRKAN
LKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKNLGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKEL
GAEVSIAEVWEKGGNGGLELADKVLDTIENKESKFNPIYEETLSIKQKIETIAEEIYGAEGVDYSKEAEKQISEIEKLDL
DKKPVCMAKTQYSLSDDAKLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKPAANNMNVLSDGNIVGLF
>Mature_557_residues
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLKRNKDKKDGKLILVTAINPTPAGEGKSTVTVGLG
QALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPMEDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQR
RILFKRVMDMNDRALRNVIVALGGKINGFPREDGFMITVASEIMAILCLAEDLMDLKNKMGEILVAYSTEGKPIYCEDLE
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEAGFGADLGAEKFFDIKCRKAN
LKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKNLGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKEL
GAEVSIAEVWEKGGNGGLELADKVLDTIENKESKFNPIYEETLSIKQKIETIAEEIYGAEGVDYSKEAEKQISEIEKLDL
DKKPVCMAKTQYSLSDDAKLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKPAANNMNVLSDGNIVGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=620, Percent_Identity=44.0322580645161, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=44.7495961227787, Blast_Score=460, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=44.3729903536978, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=44.3729903536978, Blast_Score=471, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6319558, Length=633, Percent_Identity=42.8120063191153, Blast_Score=455, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=42.8115015974441, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=42.9725363489499, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=42.9725363489499, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=42.9725363489499, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=42.9725363489499, Blast_Score=463, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_CLOB1 (A7FZB0)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385839.1
- ProteinModelPortal:   A7FZB0
- SMR:   A7FZB0
- STRING:   A7FZB0
- GeneID:   5397945
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3598
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- ProtClustDB:   PRK13505
- BioCyc:   CBOT441770:CLB_3598-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 60744; Mature: 60744

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLKRNKDKKDGKLILV
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEHHHCCCCCCCCCEEEE
TAINPTPAGEGKSTVTVGLGQALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPM
EEECCCCCCCCCCEEEEECCHHHHCCCCCEEEEEECCCCCCEEECCCCCCCCCCCEECCC
EDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQRRILFKRVMDMNDRALRNVIV
CCCEEEECCCCCEECCCCCCHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHH
ALGGKINGFPREDGFMITVASEIMAILCLAEDLMDLKNKMGEILVAYSTEGKPIYCEDLE
HHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCC
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEA
HHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEECC
GFGADLGAEKFFDIKCRKANLKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKN
CCCCCCCCCCEEEEEEEECCCCCCEEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKELGAEVSIAEVWEKGGNGGLEL
HHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHH
ADKVLDTIENKESKFNPIYEETLSIKQKIETIAEEIYGAEGVDYSKEAEKQISEIEKLDL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC
DKKPVCMAKTQYSLSDDAKLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKP
CCCCEEEEECCCCCCCCHHHHCCCCCCEEEEEEEEEECCCCEEEEEECCEEECCCCCCCC
AANNMNVLSDGNIVGLF
CCCCCEEECCCCEEEEC
>Mature Secondary Structure
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLKRNKDKKDGKLILV
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEHHHCCCCCCCCCEEEE
TAINPTPAGEGKSTVTVGLGQALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPM
EEECCCCCCCCCCEEEEECCHHHHCCCCCEEEEEECCCCCCEEECCCCCCCCCCCEECCC
EDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQRRILFKRVMDMNDRALRNVIV
CCCEEEECCCCCEECCCCCCHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHH
ALGGKINGFPREDGFMITVASEIMAILCLAEDLMDLKNKMGEILVAYSTEGKPIYCEDLE
HHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCC
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEA
HHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEECC
GFGADLGAEKFFDIKCRKANLKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKN
CCCCCCCCCCEEEEEEEECCCCCCEEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKELGAEVSIAEVWEKGGNGGLEL
HHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHH
ADKVLDTIENKESKFNPIYEETLSIKQKIETIAEEIYGAEGVDYSKEAEKQISEIEKLDL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC
DKKPVCMAKTQYSLSDDAKLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKP
CCCCEEEEECCCCCCCCHHHHCCCCCCEEEEEEEEEECCCCEEEEEECCEEECCCCCCCC
AANNMNVLSDGNIVGLF
CCCCCEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA