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The map label for this gene is uvrC

Identifier: 148381321

GI number: 148381321

Start: 3617404

End: 3619260

Strand: Reverse

Name: uvrC

Synonym: CBO3380

Alternate gene names: 148381321

Gene position: 3619260-3617404 (Counterclockwise)

Preceding gene: 148381322

Following gene: 148381320

Centisome position: 93.11

GC content: 26.87

Gene sequence:

>1857_bases
GTGTTTGATTTAGAATACCAATTAAAAAACCTACCAGATAAACCTGGAGTATATTTAATGAAAAATAATTTAGGGGAAAT
TATTTATGTAGGGAAAGCAAAAATATTAAAAAATAGAGTAAGGCAATATTTTCAAAAATCACAAAAACATTCTGAAAAGG
TTAAGGCTATGGTGAAAAATATAGAAGAGTTTGAGTATATAATTACAGACTCAGAAATAGAAGCTTTAATATTAGAATGT
AATTTAATAAAAAAATATAGACCAAAATATAATATTCTTTTAAAGGATGATAAACATTATCCCTTTATAAAAGTTACATT
AGCTGAGGACTTTCCAAGGGTAATTTCTACAAGAAAGGTTACAAAGGATGGAAGTAAATATTTTGGGCCTTATGTAGATG
GAAGTTCTGTAAAAGATATTATAGAATTAATAAAAAAGACTTTCCCAATAAGAACTTGCAAGAAAAATATAGTAGAGGAA
GCTAAGGCTATAAGACCTTGTCTAAATTATCAAATAGGACTATGCAAAGCTCCTTGTGCTCAGTATATAAAAAAAAGTGA
GTATAGAGAAACTATAGATGATGTTATAAAATTATTATCAGGAAAACATCTAGATATAGTAGAAAATTTTAAATTAAACA
TGGAAAAAGCAGCGGAAAATTTAGAATTTGAAAAAGCAGCTATGTTAAGAGACAAAATAAATATAATAGAAAAAATAGGT
GAAAAACAAAAAATAATTTTAAATAATTTTGACAATGAAGATTACATATCATTATATAGTGATGGAAAGGATACATGTTT
TCAAGTATTCTTTTTAAGAAATGGAAAAATAGTTGGAAGGGAACATTTTATTATAGAAGATACTTTTGATACTAATTCTT
CTACATTGATTTCTAATTTTTTAAAAGAATTTTATGGAGGCACCGCTTATATTCCTAAAACGATATATGTGCCTAACATA
GAAGATGAAGCATTACTAGAGCAGTGGCTTACATTAAAAAAGGAAAGTAAATCTACAATTAAAATTCCTATAAAAGGGGA
AAAGAAGAATATATTAGTTTTAGTAGAAAAAAATGCTAAAACCACATTAGAAAATTTTAAATTAAAATATTTACAAGAAA
AGGCTTTATATGATAATGTTTTGAAGGATTTAAAAAATATATTAAGATTACAAGAAGAACCTATAAGAATTGAAGCCTTT
GATATATCTAATATACAAGGATTTGATTCTGTAGGCAGTATGGTAGTCTTTGAAAAAGGAAGAGCGAAACCTAGTGATTA
TAGAAGATTTAAGATAAACACGGTAAAGGGTGCTGATGATTACAAAAGCATGAAGGAAATATTAACCAGAAGGTTTCAGC
ATGGTTTAAGTGAAATAAAGTCTATACAGGATAGAAAGTTAGAGTTTAGTTCAGGAAAGTTTTCTGTTTTCCCAGATTTA
ATATTAATGGATGGCGGAAAGGGACAAATAAATATTGCACTTGAGGTTCTAAATGCCTTTAATATAGATATACCCGTTTG
TGGTATGGTTAAAGATAATAAACATAGAACTAGAGGTTTAATTTATAACGGAGAGGAAATAATTATAAATAAATATGGAA
GTGTTATGAAGTTTATTACTAGGGTACAAGATGAAGTTCATAGGTTTGCTATAAGTTATCATAGGAGTTTAAGGGGAAAA
AATAGTTTTCACTCTTTGTTAGATGATATTCCAAATATAGGAGAAAAAAGAAAAAAAGATTTGCTTTTTAATTTTAAAAG
TATAGATAACATAAAAAAAGCAACCTATGAAGAACTTTTAAGCATACCATCTATGGATAAGAAGTCAGCTGAGTGTGTGC
TTGAATTTTTTAAATAA

Upstream 100 bases:

>100_bases
AAAATAGCGACATTAATAGAAACTATACTAACTACTTCAGTTTTAATATTTACAATATATAAATTACCAATAATTTTTCC
CAAATAATAGGAGTGATTAA

Downstream 100 bases:

>100_bases
AAATTGTTTTTTACTAGAAAGTATAAAATTATTGAGAGAAGGGTTAAAGTGAGATATTTAGTAGATACACATACACATAC
AATAGTAAGTGGGCATGCAT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MFDLEYQLKNLPDKPGVYLMKNNLGEIIYVGKAKILKNRVRQYFQKSQKHSEKVKAMVKNIEEFEYIITDSEIEALILEC
NLIKKYRPKYNILLKDDKHYPFIKVTLAEDFPRVISTRKVTKDGSKYFGPYVDGSSVKDIIELIKKTFPIRTCKKNIVEE
AKAIRPCLNYQIGLCKAPCAQYIKKSEYRETIDDVIKLLSGKHLDIVENFKLNMEKAAENLEFEKAAMLRDKINIIEKIG
EKQKIILNNFDNEDYISLYSDGKDTCFQVFFLRNGKIVGREHFIIEDTFDTNSSTLISNFLKEFYGGTAYIPKTIYVPNI
EDEALLEQWLTLKKESKSTIKIPIKGEKKNILVLVEKNAKTTLENFKLKYLQEKALYDNVLKDLKNILRLQEEPIRIEAF
DISNIQGFDSVGSMVVFEKGRAKPSDYRRFKINTVKGADDYKSMKEILTRRFQHGLSEIKSIQDRKLEFSSGKFSVFPDL
ILMDGGKGQINIALEVLNAFNIDIPVCGMVKDNKHRTRGLIYNGEEIIINKYGSVMKFITRVQDEVHRFAISYHRSLRGK
NSFHSLLDDIPNIGEKRKKDLLFNFKSIDNIKKATYEELLSIPSMDKKSAECVLEFFK

Sequences:

>Translated_618_residues
MFDLEYQLKNLPDKPGVYLMKNNLGEIIYVGKAKILKNRVRQYFQKSQKHSEKVKAMVKNIEEFEYIITDSEIEALILEC
NLIKKYRPKYNILLKDDKHYPFIKVTLAEDFPRVISTRKVTKDGSKYFGPYVDGSSVKDIIELIKKTFPIRTCKKNIVEE
AKAIRPCLNYQIGLCKAPCAQYIKKSEYRETIDDVIKLLSGKHLDIVENFKLNMEKAAENLEFEKAAMLRDKINIIEKIG
EKQKIILNNFDNEDYISLYSDGKDTCFQVFFLRNGKIVGREHFIIEDTFDTNSSTLISNFLKEFYGGTAYIPKTIYVPNI
EDEALLEQWLTLKKESKSTIKIPIKGEKKNILVLVEKNAKTTLENFKLKYLQEKALYDNVLKDLKNILRLQEEPIRIEAF
DISNIQGFDSVGSMVVFEKGRAKPSDYRRFKINTVKGADDYKSMKEILTRRFQHGLSEIKSIQDRKLEFSSGKFSVFPDL
ILMDGGKGQINIALEVLNAFNIDIPVCGMVKDNKHRTRGLIYNGEEIIINKYGSVMKFITRVQDEVHRFAISYHRSLRGK
NSFHSLLDDIPNIGEKRKKDLLFNFKSIDNIKKATYEELLSIPSMDKKSAECVLEFFK
>Mature_618_residues
MFDLEYQLKNLPDKPGVYLMKNNLGEIIYVGKAKILKNRVRQYFQKSQKHSEKVKAMVKNIEEFEYIITDSEIEALILEC
NLIKKYRPKYNILLKDDKHYPFIKVTLAEDFPRVISTRKVTKDGSKYFGPYVDGSSVKDIIELIKKTFPIRTCKKNIVEE
AKAIRPCLNYQIGLCKAPCAQYIKKSEYRETIDDVIKLLSGKHLDIVENFKLNMEKAAENLEFEKAAMLRDKINIIEKIG
EKQKIILNNFDNEDYISLYSDGKDTCFQVFFLRNGKIVGREHFIIEDTFDTNSSTLISNFLKEFYGGTAYIPKTIYVPNI
EDEALLEQWLTLKKESKSTIKIPIKGEKKNILVLVEKNAKTTLENFKLKYLQEKALYDNVLKDLKNILRLQEEPIRIEAF
DISNIQGFDSVGSMVVFEKGRAKPSDYRRFKINTVKGADDYKSMKEILTRRFQHGLSEIKSIQDRKLEFSSGKFSVFPDL
ILMDGGKGQINIALEVLNAFNIDIPVCGMVKDNKHRTRGLIYNGEEIIINKYGSVMKFITRVQDEVHRFAISYHRSLRGK
NSFHSLLDDIPNIGEKRKKDLLFNFKSIDNIKKATYEELLSIPSMDKKSAECVLEFFK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=631, Percent_Identity=33.2805071315372, Blast_Score=339, Evalue=3e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_CLOB1 (A7FYX4)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385697.1
- ProteinModelPortal:   A7FYX4
- STRING:   A7FYX4
- GeneID:   5396982
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3436
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   CBOT441770:CLB_3436-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 71686; Mature: 71686

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDLEYQLKNLPDKPGVYLMKNNLGEIIYVGKAKILKNRVRQYFQKSQKHSEKVKAMVKN
CCCCCCHHHCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEEFEYIITDSEIEALILECNLIKKYRPKYNILLKDDKHYPFIKVTLAEDFPRVISTRKV
HHHHHEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECHHHHHHHHHHHC
TKDGSKYFGPYVDGSSVKDIIELIKKTFPIRTCKKNIVEEAKAIRPCLNYQIGLCKAPCA
CCCCCHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
QYIKKSEYRETIDDVIKLLSGKHLDIVENFKLNMEKAAENLEFEKAAMLRDKINIIEKIG
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCC
EKQKIILNNFDNEDYISLYSDGKDTCFQVFFLRNGKIVGREHFIIEDTFDTNSSTLISNF
CCCEEEEECCCCCCEEEEECCCCCCEEEEEEEECCEEECCEEEEEEECCCCCCHHHHHHH
LKEFYGGTAYIPKTIYVPNIEDEALLEQWLTLKKESKSTIKIPIKGEKKNILVLVEKNAK
HHHHCCCCEECCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCH
TTLENFKLKYLQEKALYDNVLKDLKNILRLQEEPIRIEAFDISNIQGFDSVGSMVVFEKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHCCEEEEECC
RAKPSDYRRFKINTVKGADDYKSMKEILTRRFQHGLSEIKSIQDRKLEFSSGKFSVFPDL
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEECCCE
ILMDGGKGQINIALEVLNAFNIDIPVCGMVKDNKHRTRGLIYNGEEIIINKYGSVMKFIT
EEEECCCCEEEEEEEEHHHCCCCCCEECCEECCCCCCCCEEECCCEEEEEHHHHHHHHHH
RVQDEVHRFAISYHRSLRGKNSFHSLLDDIPNIGEKRKKDLLFNFKSIDNIKKATYEELL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHEEHHHHHHHHHHHHHHHH
SIPSMDKKSAECVLEFFK
CCCCCCCHHHHHHHHHHC
>Mature Secondary Structure
MFDLEYQLKNLPDKPGVYLMKNNLGEIIYVGKAKILKNRVRQYFQKSQKHSEKVKAMVKN
CCCCCCHHHCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEEFEYIITDSEIEALILECNLIKKYRPKYNILLKDDKHYPFIKVTLAEDFPRVISTRKV
HHHHHEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECHHHHHHHHHHHC
TKDGSKYFGPYVDGSSVKDIIELIKKTFPIRTCKKNIVEEAKAIRPCLNYQIGLCKAPCA
CCCCCHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
QYIKKSEYRETIDDVIKLLSGKHLDIVENFKLNMEKAAENLEFEKAAMLRDKINIIEKIG
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCC
EKQKIILNNFDNEDYISLYSDGKDTCFQVFFLRNGKIVGREHFIIEDTFDTNSSTLISNF
CCCEEEEECCCCCCEEEEECCCCCCEEEEEEEECCEEECCEEEEEEECCCCCCHHHHHHH
LKEFYGGTAYIPKTIYVPNIEDEALLEQWLTLKKESKSTIKIPIKGEKKNILVLVEKNAK
HHHHCCCCEECCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCH
TTLENFKLKYLQEKALYDNVLKDLKNILRLQEEPIRIEAFDISNIQGFDSVGSMVVFEKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHCCEEEEECC
RAKPSDYRRFKINTVKGADDYKSMKEILTRRFQHGLSEIKSIQDRKLEFSSGKFSVFPDL
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEECCCE
ILMDGGKGQINIALEVLNAFNIDIPVCGMVKDNKHRTRGLIYNGEEIIINKYGSVMKFIT
EEEECCCCEEEEEEEEHHHCCCCCCEECCEECCCCCCCCEEECCCEEEEEHHHHHHHHHH
RVQDEVHRFAISYHRSLRGKNSFHSLLDDIPNIGEKRKKDLLFNFKSIDNIKKATYEELL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHEEHHHHHHHHHHHHHHHH
SIPSMDKKSAECVLEFFK
CCCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA