Click here to switch to the map view.

The map label for this gene is bcd [H]

Identifier: 148381147

GI number: 148381147

Start: 3407583

End: 3408722

Strand: Reverse

Name: bcd [H]

Synonym: CBO3199

Alternate gene names: 148381147

Gene position: 3408722-3407583 (Counterclockwise)

Preceding gene: 148381148

Following gene: 148381146

Centisome position: 87.7

GC content: 33.42

Gene sequence:

>1140_bases
ATGGAATTTGGTTTATCACAAGAACAAAAGCTTGTTAAGCAGATGCTAATGGAATTTGTAGAAAATGAAGTGGAACCAAT
AGCTGCTGATATAGATAAAACAGAGAGATATCCAATTGAAACAGTAGAAAAAATGGCTAAGTATGGAATAATGGGAATGC
CATTTCCAAAGGAATACGGTGGAGCTGGTACTGATTATTTAAGCTATGTTATAGCAGTAGAAGAACTTGCAAAAGAATGT
GCAACTACATCTGTTATTTTATCAGCACATACATCTTTATGTTGCGCTCCAATATTTGAATTTGGGACAGAAGAGCAAAA
GAAAAAATATTTACCAGATCTTTTAAGCGGTAAAAAAATAGGTGCTTTTGGTTTAACAGAACCTAATGCTGGCACAGATG
CATCTGCTCAACAAAGTGTAGCTGTTTTAGAAGGAGATCATTATATATTAAATGGATCAAAAATATTTATAACTAATGGT
GGAGCAGCAGATACATTTGTAATATTTGCTATGACAGATAGAAGTAAGGGCGTTAAAGGAATTTCCGCATTTATATTAGA
AAAGGGAATGCCCGGATTTAGCATTGGCAAGACAGAGGATAAAATGGGAATAAGAGCATCATCAACTACTGAACTTATAT
TTGAAGATGTAAAAGTTCCAAAACAAAATTTACTTGGTAAAGAAGGAAAAGGATTTGGTATAGCCATGAAAACTTTAGAT
GGCGGAAGAATTGGAATAGCAGCTCAAGCATTAGGAATAGCAGAAGGCGCTTTAGATCACGCTATTGCATATATGAAAGA
AAGAAAACAATTCGGTAAAAATCTTACTAAATTTCAAGGATTGCAATGGTATATAGCAGATATGAAAGTGAGAGTAGATG
CTGCTAAATATCTTGTTTATAAATCAGCATGGAAAAAATCTGCAGGAAAAAATTACACAGTTGATGCAGCTGAGGCTAAA
CTGTATGCAGCTGAAACAGCTATGTATGTAACAAATAAATCTCTACAAGTATTGGGTGGATATGGATACACTAAAGATTA
TCCATTAGAAAGAATGTTAAGAGATGCTAGAATAACTGAAATATATGAAGGAACTTCAGAAGTACAAAAAATGGTTATAG
CTAATAACTTATTACACTAG

Upstream 100 bases:

>100_bases
TTAATGATGCAATTAAATATAATACAAATTTTTTATTATGATTTTAATATTAAAGCTTTATAGCTAAAATAAAGTTTCGG
AAATAATAGGGGGATTAAAT

Downstream 100 bases:

>100_bases
GAGGAGTTTATATGAATATAGTTGTTTGTTTAAAACAAGTACCAGATACAAATGAAGTTAAAATAGATCCTGTAAAAGGA
ACTCTAATAAGAGACGGAGT

Product: butyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MEFGLSQEQKLVKQMLMEFVENEVEPIAADIDKTERYPIETVEKMAKYGIMGMPFPKEYGGAGTDYLSYVIAVEELAKEC
ATTSVILSAHTSLCCAPIFEFGTEEQKKKYLPDLLSGKKIGAFGLTEPNAGTDASAQQSVAVLEGDHYILNGSKIFITNG
GAADTFVIFAMTDRSKGVKGISAFILEKGMPGFSIGKTEDKMGIRASSTTELIFEDVKVPKQNLLGKEGKGFGIAMKTLD
GGRIGIAAQALGIAEGALDHAIAYMKERKQFGKNLTKFQGLQWYIADMKVRVDAAKYLVYKSAWKKSAGKNYTVDAAEAK
LYAAETAMYVTNKSLQVLGGYGYTKDYPLERMLRDARITEIYEGTSEVQKMVIANNLLH

Sequences:

>Translated_379_residues
MEFGLSQEQKLVKQMLMEFVENEVEPIAADIDKTERYPIETVEKMAKYGIMGMPFPKEYGGAGTDYLSYVIAVEELAKEC
ATTSVILSAHTSLCCAPIFEFGTEEQKKKYLPDLLSGKKIGAFGLTEPNAGTDASAQQSVAVLEGDHYILNGSKIFITNG
GAADTFVIFAMTDRSKGVKGISAFILEKGMPGFSIGKTEDKMGIRASSTTELIFEDVKVPKQNLLGKEGKGFGIAMKTLD
GGRIGIAAQALGIAEGALDHAIAYMKERKQFGKNLTKFQGLQWYIADMKVRVDAAKYLVYKSAWKKSAGKNYTVDAAEAK
LYAAETAMYVTNKSLQVLGGYGYTKDYPLERMLRDARITEIYEGTSEVQKMVIANNLLH
>Mature_379_residues
MEFGLSQEQKLVKQMLMEFVENEVEPIAADIDKTERYPIETVEKMAKYGIMGMPFPKEYGGAGTDYLSYVIAVEELAKEC
ATTSVILSAHTSLCCAPIFEFGTEEQKKKYLPDLLSGKKIGAFGLTEPNAGTDASAQQSVAVLEGDHYILNGSKIFITNG
GAADTFVIFAMTDRSKGVKGISAFILEKGMPGFSIGKTEDKMGIRASSTTELIFEDVKVPKQNLLGKEGKGFGIAMKTLD
GGRIGIAAQALGIAEGALDHAIAYMKERKQFGKNLTKFQGLQWYIADMKVRVDAAKYLVYKSAWKKSAGKNYTVDAAEAK
LYAAETAMYVTNKSLQVLGGYGYTKDYPLERMLRDARITEIYEGTSEVQKMVIANNLLH

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=49.0666666666667, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=42.627345844504, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI226958412, Length=374, Percent_Identity=41.7112299465241, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI226958414, Length=336, Percent_Identity=43.1547619047619, Blast_Score=288, Evalue=5e-78,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=38.8888888888889, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=37.3333333333333, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=37.3333333333333, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI21361497, Length=365, Percent_Identity=41.3698630136986, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI76496475, Length=374, Percent_Identity=36.6310160427808, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI4557235, Length=374, Percent_Identity=36.6310160427808, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=34.7480106100796, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI4503943, Length=375, Percent_Identity=30.4, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI7669494, Length=365, Percent_Identity=30.6849315068493, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI48976061, Length=398, Percent_Identity=27.6381909547739, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI211971008, Length=398, Percent_Identity=27.6381909547739, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI38505218, Length=357, Percent_Identity=27.4509803921569, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786223, Length=379, Percent_Identity=29.287598944591, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI87081958, Length=381, Percent_Identity=30.4461942257218, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI87082384, Length=289, Percent_Identity=25.2595155709343, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87081702, Length=264, Percent_Identity=24.6212121212121, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508101, Length=370, Percent_Identity=40.8108108108108, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17506239, Length=370, Percent_Identity=41.0810810810811, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=39.3139841688654, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=39.2670157068063, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=37.7952755905512, Blast_Score=278, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=38.3202099737533, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=37.6657824933687, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=42.1768707482993, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI71985184, Length=383, Percent_Identity=38.3812010443864, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=44.5414847161572, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17534353, Length=372, Percent_Identity=32.5268817204301, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=38.2352941176471, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71985192, Length=330, Percent_Identity=37.5757575757576, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17505929, Length=366, Percent_Identity=31.4207650273224, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17551932, Length=368, Percent_Identity=30.7065217391304, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17531909, Length=237, Percent_Identity=35.4430379746835, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17562446, Length=336, Percent_Identity=29.1666666666667, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=32.9545454545455, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI86563381, Length=265, Percent_Identity=27.9245283018868, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI86563383, Length=265, Percent_Identity=27.9245283018868, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540912, Length=338, Percent_Identity=24.8520710059172, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=46.7914438502674, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=44.1176470588235, Blast_Score=335, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24666513, Length=370, Percent_Identity=38.3783783783784, Blast_Score=288, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=37.8306878306878, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=38.7434554973822, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI281363737, Length=385, Percent_Identity=37.1428571428571, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI19920834, Length=378, Percent_Identity=29.1005291005291, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24652780, Length=352, Percent_Identity=22.4431818181818, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 41512; Mature: 41512

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFGLSQEQKLVKQMLMEFVENEVEPIAADIDKTERYPIETVEKMAKYGIMGMPFPKEYG
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHC
GAGTDYLSYVIAVEELAKECATTSVILSAHTSLCCAPIFEFGTEEQKKKYLPDLLSGKKI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHCCCCC
GAFGLTEPNAGTDASAQQSVAVLEGDHYILNGSKIFITNGGAADTFVIFAMTDRSKGVKG
CCCCCCCCCCCCCCCHHCCEEEEECCEEEEECCEEEEECCCCCCEEEEEEEECCCCCCHH
ISAFILEKGMPGFSIGKTEDKMGIRASSTTELIFEDVKVPKQNLLGKEGKGFGIAMKTLD
HHHHHHHCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCEEEEEECC
GGRIGIAAQALGIAEGALDHAIAYMKERKQFGKNLTKFQGLQWYIADMKVRVDAAKYLVY
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEEEEEEHHHHHHHH
KSAWKKSAGKNYTVDAAEAKLYAAETAMYVTNKSLQVLGGYGYTKDYPLERMLRDARITE
HHHHHHCCCCCEEEEHHHHHHHHHHEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHH
IYEGTSEVQKMVIANNLLH
HHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEFGLSQEQKLVKQMLMEFVENEVEPIAADIDKTERYPIETVEKMAKYGIMGMPFPKEYG
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHC
GAGTDYLSYVIAVEELAKECATTSVILSAHTSLCCAPIFEFGTEEQKKKYLPDLLSGKKI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHCCCCC
GAFGLTEPNAGTDASAQQSVAVLEGDHYILNGSKIFITNGGAADTFVIFAMTDRSKGVKG
CCCCCCCCCCCCCCCHHCCEEEEECCEEEEECCEEEEECCCCCCEEEEEEEECCCCCCHH
ISAFILEKGMPGFSIGKTEDKMGIRASSTTELIFEDVKVPKQNLLGKEGKGFGIAMKTLD
HHHHHHHCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCEEEEEECC
GGRIGIAAQALGIAEGALDHAIAYMKERKQFGKNLTKFQGLQWYIADMKVRVDAAKYLVY
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEEEEEEHHHHHHHH
KSAWKKSAGKNYTVDAAEAKLYAAETAMYVTNKSLQVLGGYGYTKDYPLERMLRDARITE
HHHHHHCCCCCEEEEHHHHHHHHHHEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHH
IYEGTSEVQKMVIANNLLH
HHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]