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The map label for this gene is hpt [H]

Identifier: 148381032

GI number: 148381032

Start: 3267789

End: 3268334

Strand: Direct

Name: hpt [H]

Synonym: CBO3081

Alternate gene names: 148381032

Gene position: 3267789-3268334 (Clockwise)

Preceding gene: 148381004

Following gene: 148381034

Centisome position: 84.07

GC content: 29.49

Gene sequence:

>546_bases
ATGTATGCATTGGAGGATTATCATGGAAGAAAAAACAGAAATATATTAATAAGTAAAGAAGAAATAGAAGAAAAAATTAC
AGAAATTGGCGAAAAAATTTCAAAAGATTATAAAGATAAAAACTTATACATATTATCTCTTTTAAGGGGAAGCTTCATAT
TTGCTGCAGATATTGTAAGAAAAATAAACGTTCCTACAAAAATAGGATTTATGACTACTTCTAGTTATGGTCATAAAGAA
CAATCCTCTGGAAATGTTAAAATAGTAAATGATATCCCTGATGACATAAAAGGCTATGATGTTATTGTGGTAGATGACAT
CGTTGATACAGGGATAACCATGGAATTTGTTATGAACCACGTAAAATCTCTTGGTGCTAATTCTGTAAAATCCTGTGTTC
TTCTTGATAAGCCCGAAAGAAGAAAAGTAAATTTAGATCCGGATTATTCATGCTTTACCATCCCAGATGTATTTGTTGTT
GGATATGGGTTAAATTATGGAGACTATTATAGAAATATACCTTATGTTTTTAACTGGAAAGAATAA

Upstream 100 bases:

>100_bases
ACAAATTATAATAAAAAGATTTATTAGGCTTTACTCTATACCTTGACAACTTTCATATAATTTTATACTATAAAAACAAT
ATTGTAAATATACATAATCT

Downstream 100 bases:

>100_bases
TAAAAATGTAAAGCTTATAAGGCTTTACATTTTTGTTTAATCTCCACTATTTAATTTGAAGCCTGCATCTTTTAGTTTCA
TGTCAATAGCAGTATTAGGT

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MYALEDYHGRKNRNILISKEEIEEKITEIGEKISKDYKDKNLYILSLLRGSFIFAADIVRKINVPTKIGFMTTSSYGHKE
QSSGNVKIVNDIPDDIKGYDVIVVDDIVDTGITMEFVMNHVKSLGANSVKSCVLLDKPERRKVNLDPDYSCFTIPDVFVV
GYGLNYGDYYRNIPYVFNWKE

Sequences:

>Translated_181_residues
MYALEDYHGRKNRNILISKEEIEEKITEIGEKISKDYKDKNLYILSLLRGSFIFAADIVRKINVPTKIGFMTTSSYGHKE
QSSGNVKIVNDIPDDIKGYDVIVVDDIVDTGITMEFVMNHVKSLGANSVKSCVLLDKPERRKVNLDPDYSCFTIPDVFVV
GYGLNYGDYYRNIPYVFNWKE
>Mature_181_residues
MYALEDYHGRKNRNILISKEEIEEKITEIGEKISKDYKDKNLYILSLLRGSFIFAADIVRKINVPTKIGFMTTSSYGHKE
QSSGNVKIVNDIPDDIKGYDVIVVDDIVDTGITMEFVMNHVKSLGANSVKSCVLLDKPERRKVNLDPDYSCFTIPDVFVV
GYGLNYGDYYRNIPYVFNWKE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI9910262, Length=172, Percent_Identity=31.3953488372093, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI4504483, Length=186, Percent_Identity=28.494623655914, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI87081689, Length=165, Percent_Identity=42.4242424242424, Blast_Score=149, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17510817, Length=171, Percent_Identity=28.0701754385965, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20751; Mature: 20751

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYALEDYHGRKNRNILISKEEIEEKITEIGEKISKDYKDKNLYILSLLRGSFIFAADIVR
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHH
KINVPTKIGFMTTSSYGHKEQSSGNVKIVNDIPDDIKGYDVIVVDDIVDTGITMEFVMNH
HCCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHH
VKSLGANSVKSCVLLDKPERRKVNLDPDYSCFTIPDVFVVGYGLNYGDYYRNIPYVFNWK
HHHCCCCCCCEEEEECCCCCCEECCCCCCCEEECCCEEEEECCCCCCHHHCCCCEEEECC
E
C
>Mature Secondary Structure
MYALEDYHGRKNRNILISKEEIEEKITEIGEKISKDYKDKNLYILSLLRGSFIFAADIVR
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHH
KINVPTKIGFMTTSSYGHKEQSSGNVKIVNDIPDDIKGYDVIVVDDIVDTGITMEFVMNH
HCCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHH
VKSLGANSVKSCVLLDKPERRKVNLDPDYSCFTIPDVFVVGYGLNYGDYYRNIPYVFNWK
HHHCCCCCCCEEEEECCCCCCEECCCCCCCEEECCCEEEEECCCCCCHHHCCCCEEEECC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]