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The map label for this gene is xdhAC [H]

Identifier: 148380837

GI number: 148380837

Start: 3063646

End: 3066216

Strand: Reverse

Name: xdhAC [H]

Synonym: CBO2881

Alternate gene names: 148380837

Gene position: 3066216-3063646 (Counterclockwise)

Preceding gene: 148380838

Following gene: 148380836

Centisome position: 78.89

GC content: 34.42

Gene sequence:

>2571_bases
ATGGGGGTAATAAATGTGTATGAATTTATATTAAATGAAAGAAATGTATCTGTTTCAGAGGATATTAATTTACTTGAATA
TTTGAGGGATAATGAGGATTTAACTTCAGTAAAAAATGGGTGTGCAGAAGGAGCCTGTGGAGCCTGTATGATACTTGTTA
ATGGTAAGGCGCTTAGAGCCTGTATATGTACAACTGCAAAGGTGAATGGAAAAGATGTTAAGACTGTAGAGGGGTTAACA
GAATTTGAAAAGGATGTTTTTACTTGGGCTTTTTCTAAAGCTGGAGCAGTACAGTGTGGATATTGTATTCCAGGGATGAT
AATAAGTGCAAAGGCACTTTTAGATAAAAATCTAAATCCAAATAAGAAAGAAATTAAAACTGCTATTAGAGGAAATGTAT
GTAGATGTACTGGATATGTGAAAATAATAAAAGCCATTGAAATGGCAGCAGGGGCATTTAGAAATGGTAAACTTCCATTT
GCGAAAGAATATAAAGGGAAAATAGGTGAAAATATTCCAAGAATAGATGCAAAAGATAAAATTTTAGGTATAGGAAAATA
TGTAGATGACATGAAGATAGAAGGAATGGTTTATGGTTCTGCTTTAAGATCAAAATATCCTAGAGCTTTAGTAAAAAGCA
TTGATATAAGTGTAGCTTTAAAACATCCAGAAGTTGAAGCTATTCTTACAGCAGAAGATGTCCCAGGAAATAGGCTTATA
GGACATATTGTAAAGGATTGGCCAGCAATGATAGCCGTAGGAGAAGGAACAAGGTATGTTGGTGATGCAGTGGCTTTAGT
GGCAGCAAAAAGCAAGAAGGCTTTAAAAGAAATACTTAATTTAATAAAGGTAGAATATGAAGAATTAGAACCTATTTCTA
ATCCTAATATTGCAATAGCTGAAGATGCTCCTAAAATTCATCCTAAGGGAAATATTTTAACAGTGGAAAAAGTTAATAGA
GGAGATGTAGATGAGGCAATAGCCAATTCTAAGTATGTGGTTACTAATCATTATTCTACTCCCTTTACTGAACATGCTTT
TTTAGAGCCTGAAAGTGCTTTAGCTATGCCAGATGGGGATGGAGTTATTATTTATACAGGAAGCCAAGGTATATATGATG
AGCAGAGAGAGATTTCTGAGCTTTTAGGGCTTCCTAAAGAAAAAGTAAGGACTATTAGCAAATATGTGGGTGGAGGCTTT
GGTGGAAAAGAAGATATGAGTGTACAACATCATGCCGCTCTTCTTGCATGGACTATTAAAAAGCCCGTTAAAATAACTTT
AAGTCGTAAGGAAAGTATAAAGATTCATCCTAAAAGACATGCTATGGAAATGACAATTACTACTGCATGTGATGAAAAAG
GAAATTTAACTGCTTTTAAAGCAGATATTATATCAGATACTGGTGCCTATGCATCATTAGGAGGACCTGTACTCCAAAGA
GCTTGTACTCATGCAGCTGGCCCATATAAATGTCCTAATGTGAAAATAAAAGGTACCGCTGTATATACTAACAATCCCCC
AGGAGGAGCTTTTAGGGGATTTGGAGTAACACAATCAGTTTTTGGATCAGAGTGCAACTTAAATCTTTTAGCTGAAAAAG
TTGGTATATCTCCTTGGGAAATAAGATTTAAAAACGCAGTAGAACCTGGAGATGCACTACCTAATGGACAAATTGCTGAT
AAAGGAACTGCAATTAAAGAAACTATATTAGCTGTGAAAGATGTATATAAAAAGAGTAAATGTGCAGGAATAGCCTGTTG
TATGAAAAATTCAGGAGTTGGTGTTGGAATACCGGATATTGGAAGATGTAACTTAATAGTAATAGATGGAAAGGTTCATA
TAAGAACTAGTGCAGCTTGCATAGGTCAAGGTCTTGGAACAATTCTTACACAAATAATATGTGAAACAATAGGTTTATTA
CCAGAACAGATAATTTTAGATTTACCAGATACAAAATTTGCACCAGATTCAGGGACAACTACAGCATCAAGACAAACAGT
ATTTACTGGAGAAGCCACAAGAATGGCATCATTAAAGCTTAAGGAAAAATTATTAACTACATCATTAGAAGAGTGTGAAG
GTGAAGAATTTTATGGGGAATATCAAAGTATTACAGATCCTATTAATTCTGATAAAAAGAATCCAGTAAGTCACGTGGCT
TATGGCTATGCAACACAAGTTGTTATTCTTGATGATGATGGAAAAGTAGAAAGAGTAGTTGCAGCACATGATGTGGGAAA
AGCTATAAATTTAACTAATGTAGAAGGACAAATTGAAGGTGGAATAGTTATGGGACTTGGGTATGCATTTACAGAAGATT
ATCCATTAAATAAATCTATCCCAACTGCTAAGTTTGGCACATTAGGTTTGTTTAGAGCTACTGATATACCAGAAATTGAA
ACAACAATAATTGAAAAGAATACTAATGATTTAGCTTATGGTGCAAAAGGAATAGGAGAAATTACAACCATACCAACAGC
CCCAGCAGCTCAAGGTGCTTACTATAAATTTGATGGAAACTTTAGAAAAAAGCTTCCACTTGAGGATACTGCTTATAGAA
GAAAAAAATAA

Upstream 100 bases:

>100_bases
GAGAGTATTAGAGGTAGTAGTCATCGTATAAAGTTCATTTATAGTTTTATACATTTAGACATATAAAGAGAAAATAATAG
GCTTATTGATACATAAATAT

Downstream 100 bases:

>100_bases
TTATCTTAGATAGTAATATTTTAAAATAGATTTAATTTTAACCATGCAAATATAAAAAATACATGTATAGATAGATAACT
TACTTGACTAGGAATCTCAA

Product: xanthine dehydrogenase family protein, molybdopterin-binding subunit

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 856; Mature: 855

Protein sequence:

>856_residues
MGVINVYEFILNERNVSVSEDINLLEYLRDNEDLTSVKNGCAEGACGACMILVNGKALRACICTTAKVNGKDVKTVEGLT
EFEKDVFTWAFSKAGAVQCGYCIPGMIISAKALLDKNLNPNKKEIKTAIRGNVCRCTGYVKIIKAIEMAAGAFRNGKLPF
AKEYKGKIGENIPRIDAKDKILGIGKYVDDMKIEGMVYGSALRSKYPRALVKSIDISVALKHPEVEAILTAEDVPGNRLI
GHIVKDWPAMIAVGEGTRYVGDAVALVAAKSKKALKEILNLIKVEYEELEPISNPNIAIAEDAPKIHPKGNILTVEKVNR
GDVDEAIANSKYVVTNHYSTPFTEHAFLEPESALAMPDGDGVIIYTGSQGIYDEQREISELLGLPKEKVRTISKYVGGGF
GGKEDMSVQHHAALLAWTIKKPVKITLSRKESIKIHPKRHAMEMTITTACDEKGNLTAFKADIISDTGAYASLGGPVLQR
ACTHAAGPYKCPNVKIKGTAVYTNNPPGGAFRGFGVTQSVFGSECNLNLLAEKVGISPWEIRFKNAVEPGDALPNGQIAD
KGTAIKETILAVKDVYKKSKCAGIACCMKNSGVGVGIPDIGRCNLIVIDGKVHIRTSAACIGQGLGTILTQIICETIGLL
PEQIILDLPDTKFAPDSGTTTASRQTVFTGEATRMASLKLKEKLLTTSLEECEGEEFYGEYQSITDPINSDKKNPVSHVA
YGYATQVVILDDDGKVERVVAAHDVGKAINLTNVEGQIEGGIVMGLGYAFTEDYPLNKSIPTAKFGTLGLFRATDIPEIE
TTIIEKNTNDLAYGAKGIGEITTIPTAPAAQGAYYKFDGNFRKKLPLEDTAYRRKK

Sequences:

>Translated_856_residues
MGVINVYEFILNERNVSVSEDINLLEYLRDNEDLTSVKNGCAEGACGACMILVNGKALRACICTTAKVNGKDVKTVEGLT
EFEKDVFTWAFSKAGAVQCGYCIPGMIISAKALLDKNLNPNKKEIKTAIRGNVCRCTGYVKIIKAIEMAAGAFRNGKLPF
AKEYKGKIGENIPRIDAKDKILGIGKYVDDMKIEGMVYGSALRSKYPRALVKSIDISVALKHPEVEAILTAEDVPGNRLI
GHIVKDWPAMIAVGEGTRYVGDAVALVAAKSKKALKEILNLIKVEYEELEPISNPNIAIAEDAPKIHPKGNILTVEKVNR
GDVDEAIANSKYVVTNHYSTPFTEHAFLEPESALAMPDGDGVIIYTGSQGIYDEQREISELLGLPKEKVRTISKYVGGGF
GGKEDMSVQHHAALLAWTIKKPVKITLSRKESIKIHPKRHAMEMTITTACDEKGNLTAFKADIISDTGAYASLGGPVLQR
ACTHAAGPYKCPNVKIKGTAVYTNNPPGGAFRGFGVTQSVFGSECNLNLLAEKVGISPWEIRFKNAVEPGDALPNGQIAD
KGTAIKETILAVKDVYKKSKCAGIACCMKNSGVGVGIPDIGRCNLIVIDGKVHIRTSAACIGQGLGTILTQIICETIGLL
PEQIILDLPDTKFAPDSGTTTASRQTVFTGEATRMASLKLKEKLLTTSLEECEGEEFYGEYQSITDPINSDKKNPVSHVA
YGYATQVVILDDDGKVERVVAAHDVGKAINLTNVEGQIEGGIVMGLGYAFTEDYPLNKSIPTAKFGTLGLFRATDIPEIE
TTIIEKNTNDLAYGAKGIGEITTIPTAPAAQGAYYKFDGNFRKKLPLEDTAYRRKK
>Mature_855_residues
GVINVYEFILNERNVSVSEDINLLEYLRDNEDLTSVKNGCAEGACGACMILVNGKALRACICTTAKVNGKDVKTVEGLTE
FEKDVFTWAFSKAGAVQCGYCIPGMIISAKALLDKNLNPNKKEIKTAIRGNVCRCTGYVKIIKAIEMAAGAFRNGKLPFA
KEYKGKIGENIPRIDAKDKILGIGKYVDDMKIEGMVYGSALRSKYPRALVKSIDISVALKHPEVEAILTAEDVPGNRLIG
HIVKDWPAMIAVGEGTRYVGDAVALVAAKSKKALKEILNLIKVEYEELEPISNPNIAIAEDAPKIHPKGNILTVEKVNRG
DVDEAIANSKYVVTNHYSTPFTEHAFLEPESALAMPDGDGVIIYTGSQGIYDEQREISELLGLPKEKVRTISKYVGGGFG
GKEDMSVQHHAALLAWTIKKPVKITLSRKESIKIHPKRHAMEMTITTACDEKGNLTAFKADIISDTGAYASLGGPVLQRA
CTHAAGPYKCPNVKIKGTAVYTNNPPGGAFRGFGVTQSVFGSECNLNLLAEKVGISPWEIRFKNAVEPGDALPNGQIADK
GTAIKETILAVKDVYKKSKCAGIACCMKNSGVGVGIPDIGRCNLIVIDGKVHIRTSAACIGQGLGTILTQIICETIGLLP
EQIILDLPDTKFAPDSGTTTASRQTVFTGEATRMASLKLKEKLLTTSLEECEGEEFYGEYQSITDPINSDKKNPVSHVAY
GYATQVVILDDDGKVERVVAAHDVGKAINLTNVEGQIEGGIVMGLGYAFTEDYPLNKSIPTAKFGTLGLFRATDIPEIET
TIIEKNTNDLAYGAKGIGEITTIPTAPAAQGAYYKFDGNFRKKLPLEDTAYRRKK

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=711, Percent_Identity=26.5822784810127, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI71773480, Length=712, Percent_Identity=25.4213483146067, Blast_Score=148, Evalue=2e-35,
Organism=Escherichia coli, GI1789230, Length=736, Percent_Identity=29.6195652173913, Blast_Score=289, Evalue=4e-79,
Organism=Escherichia coli, GI1789246, Length=950, Percent_Identity=26, Blast_Score=253, Evalue=3e-68,
Organism=Escherichia coli, GI1786478, Length=732, Percent_Identity=24.0437158469945, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789232, Length=129, Percent_Identity=42.6356589147287, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1786480, Length=157, Percent_Identity=35.031847133758, Blast_Score=96, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17540638, Length=716, Percent_Identity=25.5586592178771, Blast_Score=172, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI32566215, Length=715, Percent_Identity=24.1958041958042, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17539860, Length=735, Percent_Identity=22.9931972789116, Blast_Score=112, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17737937, Length=686, Percent_Identity=27.2594752186589, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24647193, Length=691, Percent_Identity=23.8784370477569, Blast_Score=119, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24647199, Length=645, Percent_Identity=22.7906976744186, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24647201, Length=657, Percent_Identity=23.1354642313546, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24647197, Length=165, Percent_Identity=27.8787878787879, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24647195, Length=165, Percent_Identity=27.8787878787879, Blast_Score=73, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 92413; Mature: 92282

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVINVYEFILNERNVSVSEDINLLEYLRDNEDLTSVKNGCAEGACGACMILVNGKALRA
CCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEECCCEEEE
CICTTAKVNGKDVKTVEGLTEFEKDVFTWAFSKAGAVQCGYCIPGMIISAKALLDKNLNP
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCC
NKKEIKTAIRGNVCRCTGYVKIIKAIEMAAGAFRNGKLPFAKEYKGKIGENIPRIDAKDK
CHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHCCCCCCCCCCCC
ILGIGKYVDDMKIEGMVYGSALRSKYPRALVKSIDISVALKHPEVEAILTAEDVPGNRLI
EEECCCCCCCEEECEEEECHHHHHHHHHHHHHHCCEEEEEECCCEEEEEEECCCCCCHHH
GHIVKDWPAMIAVGEGTRYVGDAVALVAAKSKKALKEILNLIKVEYEELEPISNPNIAIA
HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
EDAPKIHPKGNILTVEKVNRGDVDEAIANSKYVVTNHYSTPFTEHAFLEPESALAMPDGD
CCCCCCCCCCCEEEEEECCCCCHHHHHCCCCEEEEECCCCCCCCCEEECCCCCEECCCCC
GVIIYTGSQGIYDEQREISELLGLPKEKVRTISKYVGGGFGGKEDMSVQHHAALLAWTIK
EEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHEEEEEEEC
KPVKITLSRKESIKIHPKRHAMEMTITTACDEKGNLTAFKADIISDTGAYASLGGPVLQR
CCEEEEEECCCCEEECCCCCEEEEEEEEECCCCCCEEEEEEEHHCCCCCCHHCCHHHHHH
ACTHAAGPYKCPNVKIKGTAVYTNNPPGGAFRGFGVTQSVFGSECNLNLLAEKVGISPWE
HHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHCCCCCCCEEHHHHHCCCCEE
IRFKNAVEPGDALPNGQIADKGTAIKETILAVKDVYKKSKCAGIACCMKNSGVGVGIPDI
EEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCC
GRCNLIVIDGKVHIRTSAACIGQGLGTILTQIICETIGLLPEQIILDLPDTKFAPDSGTT
CCEEEEEECCEEEEEEHHHHHHCCHHHHHHHHHHHHHCCCCHHHEEECCCCCCCCCCCCC
TASRQTVFTGEATRMASLKLKEKLLTTSLEECEGEEFYGEYQSITDPINSDKKNPVSHVA
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHEE
YGYATQVVILDDDGKVERVVAAHDVGKAINLTNVEGQIEGGIVMGLGYAFTEDYPLNKSI
ECEEEEEEEECCCCCEEEEEEHHHCCCEEEEECCCCEECCCEEEEECEEECCCCCCCCCC
PTAKFGTLGLFRATDIPEIETTIIEKNTNDLAYGAKGIGEITTIPTAPAAQGAYYKFDGN
CCCCCCCEEEEECCCCCCCEEEEEECCCCCHHCCCCCCCCEEECCCCCCCCCCEEEECCC
FRKKLPLEDTAYRRKK
CCCCCCCCCCHHHCCC
>Mature Secondary Structure 
GVINVYEFILNERNVSVSEDINLLEYLRDNEDLTSVKNGCAEGACGACMILVNGKALRA
CHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEECCCEEEE
CICTTAKVNGKDVKTVEGLTEFEKDVFTWAFSKAGAVQCGYCIPGMIISAKALLDKNLNP
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCC
NKKEIKTAIRGNVCRCTGYVKIIKAIEMAAGAFRNGKLPFAKEYKGKIGENIPRIDAKDK
CHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHCCCCCCCCCCCC
ILGIGKYVDDMKIEGMVYGSALRSKYPRALVKSIDISVALKHPEVEAILTAEDVPGNRLI
EEECCCCCCCEEECEEEECHHHHHHHHHHHHHHCCEEEEEECCCEEEEEEECCCCCCHHH
GHIVKDWPAMIAVGEGTRYVGDAVALVAAKSKKALKEILNLIKVEYEELEPISNPNIAIA
HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
EDAPKIHPKGNILTVEKVNRGDVDEAIANSKYVVTNHYSTPFTEHAFLEPESALAMPDGD
CCCCCCCCCCCEEEEEECCCCCHHHHHCCCCEEEEECCCCCCCCCEEECCCCCEECCCCC
GVIIYTGSQGIYDEQREISELLGLPKEKVRTISKYVGGGFGGKEDMSVQHHAALLAWTIK
EEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHEEEEEEEC
KPVKITLSRKESIKIHPKRHAMEMTITTACDEKGNLTAFKADIISDTGAYASLGGPVLQR
CCEEEEEECCCCEEECCCCCEEEEEEEEECCCCCCEEEEEEEHHCCCCCCHHCCHHHHHH
ACTHAAGPYKCPNVKIKGTAVYTNNPPGGAFRGFGVTQSVFGSECNLNLLAEKVGISPWE
HHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHCCCCCCCEEHHHHHCCCCEE
IRFKNAVEPGDALPNGQIADKGTAIKETILAVKDVYKKSKCAGIACCMKNSGVGVGIPDI
EEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCC
GRCNLIVIDGKVHIRTSAACIGQGLGTILTQIICETIGLLPEQIILDLPDTKFAPDSGTT
CCEEEEEECCEEEEEEHHHHHHCCHHHHHHHHHHHHHCCCCHHHEEECCCCCCCCCCCCC
TASRQTVFTGEATRMASLKLKEKLLTTSLEECEGEEFYGEYQSITDPINSDKKNPVSHVA
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHEE
YGYATQVVILDDDGKVERVVAAHDVGKAINLTNVEGQIEGGIVMGLGYAFTEDYPLNKSI
ECEEEEEEEECCCCCEEEEEEHHHCCCEEEEECCCCEECCCEEEEECEEECCCCCCCCCC
PTAKFGTLGLFRATDIPEIETTIIEKNTNDLAYGAKGIGEITTIPTAPAAQGAYYKFDGN
CCCCCCCEEEEECCCCCCCEEEEEECCCCCHHCCCCCCCCEEECCCCCCCCCCEEEECCC
FRKKLPLEDTAYRRKK
CCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]