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The map label for this gene is lepB [H]

Identifier: 148380401

GI number: 148380401

Start: 2577299

End: 2577823

Strand: Reverse

Name: lepB [H]

Synonym: CBO2443

Alternate gene names: 148380401

Gene position: 2577823-2577299 (Counterclockwise)

Preceding gene: 148380402

Following gene: 148380400

Centisome position: 66.32

GC content: 26.67

Gene sequence:

>525_bases
ATGTTAAAAGAATTAATAGAAGTTGTAAAATCTATAATAGTAGCTGTGATAGCAGCTTTTTTAATTATAACTTTTGTATT
TGAAACCGTAAGTGTAGAAGGTCATTCTATGGATCCAACATTAAATAATAGAGATAGACTTATAGTAGAAAAGGTAAGTT
ACTATTTTAGAAAACCTAAGGATGGAGATATCGTTGTAATTAAATATCCATCAGATACTAGAGAAAAATTTATAAAAAGA
GTTATAGCTGTTCCAGGAGATACAGTGAGTATACATGATAATAAAGTATATGTAAATGGTAAAGCTAAAGAAGAAAACTA
TATATTAGAAAAGTATATGGAAGATTTTAATGAAGTAAAAGTTCCAGAAAACTCAGTATTCGTTATGGGAGATAACAGAA
ATCATAGTAGAGATAGTAGATTCCCAGATGTTGGTTTTGTAAATTATAAATTAGTAGTAGGAAGAGCAGCAATAAGAATA
TATCCTTTTAACAAGTTTGGTAGTTTATATTCTAAAAATAAATAA

Upstream 100 bases:

>100_bases
GATAGAGTAGGTAAAGCAGCAAAAGTTAAAGAAAGAATATAATGAAACATAAGGGGCTTTAGCATAAGTCCCTTTTTTTC
ATATAAGAGGGGTGGATTTT

Downstream 100 bases:

>100_bases
AATTTTTAGTTTAAGGTGAAGTCTTAACTCTCTAACTGAAGCTAGGAATCTATTATTTATAGATATGGTGTACTTTATCC
CCCACTTTAGAAAAGCAAAT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MLKELIEVVKSIIVAVIAAFLIITFVFETVSVEGHSMDPTLNNRDRLIVEKVSYYFRKPKDGDIVVIKYPSDTREKFIKR
VIAVPGDTVSIHDNKVYVNGKAKEENYILEKYMEDFNEVKVPENSVFVMGDNRNHSRDSRFPDVGFVNYKLVVGRAAIRI
YPFNKFGSLYSKNK

Sequences:

>Translated_174_residues
MLKELIEVVKSIIVAVIAAFLIITFVFETVSVEGHSMDPTLNNRDRLIVEKVSYYFRKPKDGDIVVIKYPSDTREKFIKR
VIAVPGDTVSIHDNKVYVNGKAKEENYILEKYMEDFNEVKVPENSVFVMGDNRNHSRDSRFPDVGFVNYKLVVGRAAIRI
YPFNKFGSLYSKNK
>Mature_174_residues
MLKELIEVVKSIIVAVIAAFLIITFVFETVSVEGHSMDPTLNNRDRLIVEKVSYYFRKPKDGDIVVIKYPSDTREKFIKR
VIAVPGDTVSIHDNKVYVNGKAKEENYILEKYMEDFNEVKVPENSVFVMGDNRNHSRDSRFPDVGFVNYKLVVGRAAIRI
YPFNKFGSLYSKNK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Homo sapiens, GI21450679, Length=171, Percent_Identity=31.5789473684211, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24642241, Length=174, Percent_Identity=26.4367816091954, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 20046; Mature: 20046

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKELIEVVKSIIVAVIAAFLIITFVFETVSVEGHSMDPTLNNRDRLIVEKVSYYFRKPK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
DGDIVVIKYPSDTREKFIKRVIAVPGDTVSIHDNKVYVNGKAKEENYILEKYMEDFNEVK
CCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCHHHHHHHHHHHHHHCC
VPENSVFVMGDNRNHSRDSRFPDVGFVNYKLVVGRAAIRIYPFNKFGSLYSKNK
CCCCCEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEECHHHCCHHCCCC
>Mature Secondary Structure
MLKELIEVVKSIIVAVIAAFLIITFVFETVSVEGHSMDPTLNNRDRLIVEKVSYYFRKPK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
DGDIVVIKYPSDTREKFIKRVIAVPGDTVSIHDNKVYVNGKAKEENYILEKYMEDFNEVK
CCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCHHHHHHHHHHHHHHCC
VPENSVFVMGDNRNHSRDSRFPDVGFVNYKLVVGRAAIRIYPFNKFGSLYSKNK
CCCCCEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEECHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7865790 [H]