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The map label for this gene is saeR [H]

Identifier: 148379888

GI number: 148379888

Start: 2050602

End: 2051288

Strand: Reverse

Name: saeR [H]

Synonym: CBO1926

Alternate gene names: 148379888

Gene position: 2051288-2050602 (Counterclockwise)

Preceding gene: 148379889

Following gene: 148379887

Centisome position: 52.77

GC content: 30.28

Gene sequence:

>687_bases
ATGCAGGAAAAAATATTAATAGTAGATGATGAAGATGATATAGTATCTTTTATAAAGGATTATTTTGAGGATCAAGGTTA
CCGCGTTATTACAGCTAGTAATGGTAGAGAAGCTATAGAATACTGTGATAAAGATATAGATATTATTTTACTTGATATAA
TGATGCCTAATATTGATGGTTTTCAGGTTTGCCAAAAGATAAGGGACAAAGTATCCTGTCCTATAATATTTTTAAGTGCT
AGGCAAAGTGAGGTTGATAAAATTAAAGGTCTTTCAGTAGGTGGAGATGATTATATAGTAAAGCCCTTTAGCATAAAAGA
ATTAAAAGCAAGAGTTGAGGCTCATCTTAGAAGAGAAAAAAGAGTTCCTTTAAATAATAGATCTAAGATAATCTTTGGAA
AACTTACTTTAGATCTTAATAGTCGTAAAGTTCATTATGAAGAGGAGGAAATACTTTTTACAGCTAAAGAATTTGATATA
GTAGAACTTTTAGCATTACATCCAGAACAGATATTTTCTAAAGAACAAATCTATGAAAAAGTTTGGGGATATGATGCAGA
AGGGGATGCAAATACAGTAGCAGAGCATATAAAAAAGATAAGAGCAAAGTTTATAAAAATAAGTGTATCTCTTAATCATA
TAGCTACGGTATGGGGAGTAGGTTATAGATGGGAGAGAAAAAAATGA

Upstream 100 bases:

>100_bases
TTTATATCTAATTTAATTTGTAAAGTATAAAACTTGAAAAATGTTACATTTTAATGTACATGCTATAATATTATTAAAAT
GCAAAAATAGAGGTGTTTAT

Downstream 100 bases:

>100_bases
TGGAAAAAGCATCCTTAAAAACACAAACTATAAGTACTTTTTTATTAATTATATTTTTAAGTATAGTATGTACAATAGCT
ACTCTAGGAACTTATTTATT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: Staphylococcus exoprotein expression protein R [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MQEKILIVDDEDDIVSFIKDYFEDQGYRVITASNGREAIEYCDKDIDIILLDIMMPNIDGFQVCQKIRDKVSCPIIFLSA
RQSEVDKIKGLSVGGDDYIVKPFSIKELKARVEAHLRREKRVPLNNRSKIIFGKLTLDLNSRKVHYEEEEILFTAKEFDI
VELLALHPEQIFSKEQIYEKVWGYDAEGDANTVAEHIKKIRAKFIKISVSLNHIATVWGVGYRWERKK

Sequences:

>Translated_228_residues
MQEKILIVDDEDDIVSFIKDYFEDQGYRVITASNGREAIEYCDKDIDIILLDIMMPNIDGFQVCQKIRDKVSCPIIFLSA
RQSEVDKIKGLSVGGDDYIVKPFSIKELKARVEAHLRREKRVPLNNRSKIIFGKLTLDLNSRKVHYEEEEILFTAKEFDI
VELLALHPEQIFSKEQIYEKVWGYDAEGDANTVAEHIKKIRAKFIKISVSLNHIATVWGVGYRWERKK
>Mature_228_residues
MQEKILIVDDEDDIVSFIKDYFEDQGYRVITASNGREAIEYCDKDIDIILLDIMMPNIDGFQVCQKIRDKVSCPIIFLSA
RQSEVDKIKGLSVGGDDYIVKPFSIKELKARVEAHLRREKRVPLNNRSKIIFGKLTLDLNSRKVHYEEEEILFTAKEFDI
VELLALHPEQIFSKEQIYEKVWGYDAEGDANTVAEHIKKIRAKFIKISVSLNHIATVWGVGYRWERKK

Specific function: Member of the two-component regulatory system saeR/saeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs n

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=32.6086956521739, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=36.3636363636364, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=33.7662337662338, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=33.7777777777778, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=34.3891402714932, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=31.6964285714286, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=33.9285714285714, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=33.9285714285714, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=33.0396475770925, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=30.7692307692308, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=32.7433628318584, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=28.2608695652174, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI145693140, Length=228, Percent_Identity=28.5087719298246, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=34.4827586206897, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI145693157, Length=119, Percent_Identity=31.0924369747899, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26496; Mature: 26496

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEKILIVDDEDDIVSFIKDYFEDQGYRVITASNGREAIEYCDKDIDIILLDIMMPNIDG
CCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCEEEEEEECCCCCH
FQVCQKIRDKVSCPIIFLSARQSEVDKIKGLSVGGDDYIVKPFSIKELKARVEAHLRREK
HHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHC
RVPLNNRSKIIFGKLTLDLNSRKVHYEEEEILFTAKEFDIVELLALHPEQIFSKEQIYEK
CCCCCCCCEEEEEEEEEEECCCEEEECCHHEEEEECCCCHHHHHHCCHHHHHHHHHHHHH
VWGYDAEGDANTVAEHIKKIRAKFIKISVSLNHIATVWGVGYRWERKK
HCCCCCCCCHHHHHHHHHHHHHHHEEEEEEHHHHHHHHCCCEEECCCC
>Mature Secondary Structure
MQEKILIVDDEDDIVSFIKDYFEDQGYRVITASNGREAIEYCDKDIDIILLDIMMPNIDG
CCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCEEEEEEECCCCCH
FQVCQKIRDKVSCPIIFLSARQSEVDKIKGLSVGGDDYIVKPFSIKELKARVEAHLRREK
HHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHC
RVPLNNRSKIIFGKLTLDLNSRKVHYEEEEILFTAKEFDIVELLALHPEQIFSKEQIYEK
CCCCCCCCEEEEEEEEEEECCCEEEECCHHEEEEECCCCHHHHHHCCHHHHHHHHHHHHH
VWGYDAEGDANTVAEHIKKIRAKFIKISVSLNHIATVWGVGYRWERKK
HCCCCCCCCHHHHHHHHHHHHHHHEEEEEEHHHHHHHHCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA