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The map label for this gene is pdp [H]

Identifier: 148379823

GI number: 148379823

Start: 1986119

End: 1987423

Strand: Reverse

Name: pdp [H]

Synonym: CBO1863

Alternate gene names: 148379823

Gene position: 1987423-1986119 (Counterclockwise)

Preceding gene: 148379824

Following gene: 148379822

Centisome position: 51.13

GC content: 30.65

Gene sequence:

>1305_bases
ATGAGAATGTATGATTTGATCCTAAAGAAAAGAAATGGAGGAGAGCTAAGCAAAGAAGAAATAGATTATTTTATTTTAGA
ATATACTAATGGTAATGTCCCAGATTATCAAGCTTCAGCTCTTTTAATGGCTATATACTTTCAAAAAATGAAAAGAAGAG
AAACTGTAGATTTGACTATGGCTATGGTTAACTCTGGAGATATATTGGATTTATCAAAAATACAGGGTATAAAAGTTGAT
AAACATAGTACTGGTGGAGTTGGAGATACTACTACCTTAGTTTTGGCGCCTATGGTAGCAGCCTTAGGTATACCTGTAGC
TAAAATGTCTGGTAGAGGTTTAGGTCATACTGGTGGAACTATAGATAAATTAGAATCTTTTAAAGGTTTTTCAGTAAATA
TGACAGAGGATAAATTTATAAATAACGTTAACAATATTAAAATAGCTGTAGGAGCTCAAACAGCAGATTTAGCTCCAGCG
GATAAAAAATTATATGCATTAAGAGATGTTACTGCTACAGTAGACAATATTTCTTTAATAGCTTCTAGTATAATGAGCAA
AAAAATAGCTGCAGGAGCTAATGCCATAATTTTAGATGTAAAGGTTGGAGAAGGAGCCTTCATGAAAACTCCGGAAACTG
CAAAAGAGTTAGCGGAAGAAATGGTTAATATAGGTAAAAGTGTAGGCAGAAATACTGTGGCTATATTATCAGATATGGAT
CAACCTTTAGGTTATGCTATAGGAAATGCTTTAGAAGTAAAAGAAGCTATAGATACACTAAAAGGTAAAGGTCCTAAGGA
TTTATTAGAATTATGTTTAACCTTAGGAAGTAATATGGTTATTTTATCACAAAAAGCAAATACTATAGAGGAAGCAAGAA
AGATGCTTTTAAGTACTATAGAAAAAGGATTAGCTATAGAAAAATTAAAAGAATTTATTAGATCTCAAGGCGGAGATGGT
ACTTTAGTAGACAATACAGAAAAATTACCTAAGGCAGAATATATAATTCCTGTAATTTGTGATAGAAATGGATATATAAA
TAAAATTCATGCCCAAAATATAGGGATAATAGCATCAGAGTTAGGAGCAGGAAGGGTTACAAAGGATAGCATTATAGATT
TAGCAGTAGGTATAGTTTTGAACAAGAAGAGATCAGATAAAGTTAAAAAAGGAGATATAATAGCTTATATTCATGCTAAT
GATAAAATAAAAGGAGAAAAGGCTGCAAAAGATATATTAAATAATTATGTTATAGAAGAAGAGTTAAAAGAAGAATTACC
TTTAATATATGGTACAGTAAAATAG

Upstream 100 bases:

>100_bases
ATTTCGCTAACAAGTTATAAATGTGTATACATTAAAACTAAATCTATTTGGAGGCAATCCTTATATTATATAATAATTGC
TTTGTAGGGAGGAATAAATT

Downstream 100 bases:

>100_bases
CATAGTTAAAGCATTCATAAAAGCATATTTAATTTTTAAAGTAGGTTTAAATTAAAGCTATAATTATAAAAAGTTATAAT
CATATAAGCATAGAGGAGGA

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRMYDLILKKRNGGELSKEEIDYFILEYTNGNVPDYQASALLMAIYFQKMKRRETVDLTMAMVNSGDILDLSKIQGIKVD
KHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGTIDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPA
DKKLYALRDVTATVDNISLIASSIMSKKIAAGANAIILDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
QPLGYAIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILSQKANTIEEARKMLLSTIEKGLAIEKLKEFIRSQGGDG
TLVDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASELGAGRVTKDSIIDLAVGIVLNKKRSDKVKKGDIIAYIHAN
DKIKGEKAAKDILNNYVIEEELKEELPLIYGTVK

Sequences:

>Translated_434_residues
MRMYDLILKKRNGGELSKEEIDYFILEYTNGNVPDYQASALLMAIYFQKMKRRETVDLTMAMVNSGDILDLSKIQGIKVD
KHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGTIDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPA
DKKLYALRDVTATVDNISLIASSIMSKKIAAGANAIILDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
QPLGYAIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILSQKANTIEEARKMLLSTIEKGLAIEKLKEFIRSQGGDG
TLVDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASELGAGRVTKDSIIDLAVGIVLNKKRSDKVKKGDIIAYIHAN
DKIKGEKAAKDILNNYVIEEELKEELPLIYGTVK
>Mature_434_residues
MRMYDLILKKRNGGELSKEEIDYFILEYTNGNVPDYQASALLMAIYFQKMKRRETVDLTMAMVNSGDILDLSKIQGIKVD
KHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGTIDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPA
DKKLYALRDVTATVDNISLIASSIMSKKIAAGANAIILDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
QPLGYAIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILSQKANTIEEARKMLLSTIEKGLAIEKLKEFIRSQGGDG
TLVDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASELGAGRVTKDSIIDLAVGIVLNKKRSDKVKKGDIIAYIHAN
DKIKGEKAAKDILNNYVIEEELKEELPLIYGTVK

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=407, Percent_Identity=38.0835380835381, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI4503445, Length=407, Percent_Identity=38.0835380835381, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI166158922, Length=407, Percent_Identity=38.0835380835381, Blast_Score=271, Evalue=1e-72,
Organism=Escherichia coli, GI1790842, Length=431, Percent_Identity=40.6032482598608, Blast_Score=304, Evalue=6e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 47002; Mature: 47002

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMYDLILKKRNGGELSKEEIDYFILEYTNGNVPDYQASALLMAIYFQKMKRRETVDLTM
CCHHHHHHCCCCCCCCCHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHEEEE
AMVNSGDILDLSKIQGIKVDKHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGT
EEECCCCEEEHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPADKKLYALRDVTATVDNISLI
HHHHHHCCCCEEECCHHHHHCCCCCEEEEEECCCCCCCCCCHHHEEHHHHHHHHHHHHHH
ASSIMSKKIAAGANAIILDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHCC
QPLGYAIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILSQKANTIEEARKMLLSTI
CHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHH
EKGLAIEKLKEFIRSQGGDGTLVDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASE
HHCHHHHHHHHHHHCCCCCCCEECCHHCCCCCCEEEEEEECCCCCEEEEECCCCCEEECC
LGAGRVTKDSIIDLAVGIVLNKKRSDKVKKGDIIAYIHANDKIKGEKAAKDILNNYVIEE
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
ELKEELPLIYGTVK
HHHHCCCEEEECCC
>Mature Secondary Structure
MRMYDLILKKRNGGELSKEEIDYFILEYTNGNVPDYQASALLMAIYFQKMKRRETVDLTM
CCHHHHHHCCCCCCCCCHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHEEEE
AMVNSGDILDLSKIQGIKVDKHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGT
EEECCCCEEEHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPADKKLYALRDVTATVDNISLI
HHHHHHCCCCEEECCHHHHHCCCCCEEEEEECCCCCCCCCCHHHEEHHHHHHHHHHHHHH
ASSIMSKKIAAGANAIILDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHCC
QPLGYAIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILSQKANTIEEARKMLLSTI
CHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHH
EKGLAIEKLKEFIRSQGGDGTLVDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASE
HHCHHHHHHHHHHHCCCCCCCEECCHHCCCCCCEEEEEEECCCCCEEEEECCCCCEEECC
LGAGRVTKDSIIDLAVGIVLNKKRSDKVKKGDIIAYIHANDKIKGEKAAKDILNNYVIEE
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
ELKEELPLIYGTVK
HHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377; 10568751 [H]