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The map label for this gene is mutL [H]

Identifier: 148379758

GI number: 148379758

Start: 1914748

End: 1916517

Strand: Reverse

Name: mutL [H]

Synonym: CBO1799

Alternate gene names: 148379758

Gene position: 1916517-1914748 (Counterclockwise)

Preceding gene: 148379759

Following gene: 148379757

Centisome position: 49.31

GC content: 25.08

Gene sequence:

>1770_bases
ATGAGGAAAATAAATTTATTAGATTTAGAAACTACAAATAAAATAGCTGCAGGAGAAGTTATAGAAAGACCCTTTTCTGT
AGTAAAAGAATTAGTAGAAAATAGTATAGACGCCGGTGCCAAAAATATAACCATAGAAATAGAAGATGGAGGACAAAAGC
TTATAAAAATAATAGATGATGGAGAAGGTATTTATCCTATTGATATAAAAAATGCTTTTCTTCCTCATGCTACAAGTAAA
ATAAATTCTATAGAGGATATATACAAAATAAGTACTATGGGCTTTAGAGGTGAAGCACTAGCTAGCATTTCTTCCGTATC
AAAAACTAAACTTAAAAGTAGAGTTGACTCTTATAATTTTGGAAAAGAAATATATATAGAGGGTGGCAAAATAGAGTACT
TAAAAGATACAGGTTGCAATGTTGGCACTACTATAGAAGTTTCTGATTTATTTTATAATGTACCTGCAAGACTTAAATTT
TTGAAAAGTGCAAGAAGTGATAGTAGTTCTATATCAGATATTGTGAATAGGTTTATATTATCCCATCCAGATATATCTTT
TAATTTAATAAATAAGGGAAAGCAAAGTATAAAGAGTTATGGTACCGGAAATTTAAAGGACTCTATACGATGTGTATACA
ATAAAACAATAAGTGAAAACCTTATAAACTTCGAAAGTCATAAAGATATAATATCTGTATATGGATTTATAGGTAAGCCT
GAAATAAGCCGTAAAAGCAGAACAAATCAAAGTATATTTGTAAACAAGCGATATGTTAAAAGTAAATTTATAACTGCTGC
AGTAGAAAATGCTTTTAAATCCTTTTTAACAGTAAATAGCTATCCTTTCTTTGTAATATTTATAGATATTTTTCCGGAAT
ATATTGATGTAAATGTACATCCTACTAAATCAGAAGTTAAATTTAAAGATGAGAGAGCTATGTTTAAAACTATATTTGAT
GCAGTTCATGAAGCCATAAAAGGAGAATTAAAAGAATCCTTTACAAACTTCTTTAATAAAGAAGATATTAATATATATGA
TTCTGAAAAATCTATAACTGAACCCATAAAACTAGAGAAAGAAGAAGTACAAATACCAATAGATTTAAATAGTAATAATA
AAATTGATATTTTTGGTAATAATATAAATAAACTACCTAACAATACAGAACTTCTTAAAAATATAGGTATTAAAGAAAAA
AATACACTTGAAAATAATAATGATTTCTATACTTCTAAACAAAATGAAATATACTATGCTAATAAAAATGATGAATGTTT
AAATTCATGTAATAAAGATAACTATAGCAAAATAGAAAAGTCATTACAAAAAGATAATAAAAATCCAGATATCTTATATC
TAAATGAGCACAATAGAAATTCTTCACCTATAAATATTAAAGAAAATAAATCTAATAATTTTTATGTAGATATGAAAATA
ATAGGACAGTTTAATAATACATATATATTAATAGAAAAGGATAAAGAACTTTATATAATAGATCAACATGCGGCTCATGA
AAAAGTGTTATTTGAGAAATTCAAATGCGAAATAGAAAAGGGATATGTAATAAGTCAGATTTTATTATCTCCTGTAGTTA
TAGAACTTTCAGAAGATGAATTTAATATATACGAAGAAAACAAGGATATTTTTAAATTAATAGAAGACATGCTTATATTA
AATAATCCATATACTTGTCCCCATGGAAGACCTACTATGATTAAATTTACATTAAAAGATTTAGAAAAAAAATTTAAAAG
AATACAATGA

Upstream 100 bases:

>100_bases
ATATTAATACATACAAAATCCTATAATTTTTATTGACCTAGTACCACTTATAAGTGGTGCTAACCTATATAATAAAATTA
TAAGCTATGTGGTGATTTAA

Downstream 100 bases:

>100_bases
GGGGGATAAGGAAAAATGATAGATTTATTAATAATTGCAGGTCCTACAGCAGTAGGGAAAACAGATATTTCCATAAAACT
TGCAGAAAAACTAAATGGAG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDDGEGIYPIDIKNAFLPHATSK
INSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKF
LKSARSDSSSISDIVNRFILSHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFD
AVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEKEEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGIKEK
NTLENNNDFYTSKQNEIYYANKNDECLNSCNKDNYSKIEKSLQKDNKNPDILYLNEHNRNSSPINIKENKSNNFYVDMKI
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKCEIEKGYVISQILLSPVVIELSEDEFNIYEENKDIFKLIEDMLIL
NNPYTCPHGRPTMIKFTLKDLEKKFKRIQ

Sequences:

>Translated_589_residues
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDDGEGIYPIDIKNAFLPHATSK
INSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKF
LKSARSDSSSISDIVNRFILSHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFD
AVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEKEEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGIKEK
NTLENNNDFYTSKQNEIYYANKNDECLNSCNKDNYSKIEKSLQKDNKNPDILYLNEHNRNSSPINIKENKSNNFYVDMKI
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKCEIEKGYVISQILLSPVVIELSEDEFNIYEENKDIFKLIEDMLIL
NNPYTCPHGRPTMIKFTLKDLEKKFKRIQ
>Mature_589_residues
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDDGEGIYPIDIKNAFLPHATSK
INSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKF
LKSARSDSSSISDIVNRFILSHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFD
AVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEKEEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGIKEK
NTLENNNDFYTSKQNEIYYANKNDECLNSCNKDNYSKIEKSLQKDNKNPDILYLNEHNRNSSPINIKENKSNNFYVDMKI
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKCEIEKGYVISQILLSPVVIELSEDEFNIYEENKDIFKLIEDMLIL
NNPYTCPHGRPTMIKFTLKDLEKKFKRIQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=34.2424242424242, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4505911, Length=355, Percent_Identity=28.4507042253521, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI189458898, Length=355, Percent_Identity=28.4507042253521, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI4505913, Length=344, Percent_Identity=26.453488372093, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI310128478, Length=344, Percent_Identity=26.453488372093, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI189458896, Length=348, Percent_Identity=28.735632183908, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI263191589, Length=241, Percent_Identity=29.4605809128631, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI310128480, Length=299, Percent_Identity=24.0802675585284, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI91992162, Length=464, Percent_Identity=25.8620689655172, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI91992160, Length=464, Percent_Identity=25.8620689655172, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790612, Length=336, Percent_Identity=38.6904761904762, Blast_Score=235, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=32.5, Blast_Score=169, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17562796, Length=351, Percent_Identity=28.2051282051282, Blast_Score=138, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6323819, Length=333, Percent_Identity=36.036036036036, Blast_Score=200, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6324247, Length=353, Percent_Identity=29.7450424929178, Blast_Score=127, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6323063, Length=194, Percent_Identity=32.9896907216495, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6325093, Length=262, Percent_Identity=26.7175572519084, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136968, Length=334, Percent_Identity=33.5329341317365, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=25.2100840336134, Blast_Score=116, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67687; Mature: 67687

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1 ; PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDD
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
GEGIYPIDIKNAFLPHATSKINSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNF
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKFLKSARSDSSSISDIVNRFIL
CCEEEEECCEEEEEECCCCCCCCEEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHH
SHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
CCCCCEEEEHHHHHHHHHHCCCCCCHHHHHEEHHCHHHHHHHCCCHHHHHHHHHCCCCCC
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVH
CCCHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCCEEEEEC
PTKSEVKFKDERAMFKTIFDAVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEK
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEECC
EEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGIKEKNTLENNNDFYTSKQNEIYYA
CCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEE
NKNDECLNSCNKDNYSKIEKSLQKDNKNPDILYLNEHNRNSSPINIKENKSNNFYVDMKI
CCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEEE
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKCEIEKGYVISQILLSPVVIELSEDE
EECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHCCEEEEECCCC
FNIYEENKDIFKLIEDMLILNNPYTCPHGRPTMIKFTLKDLEKKFKRIQ
CEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHCC
>Mature Secondary Structure
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDD
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
GEGIYPIDIKNAFLPHATSKINSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNF
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKFLKSARSDSSSISDIVNRFIL
CCEEEEECCEEEEEECCCCCCCCEEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHH
SHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
CCCCCEEEEHHHHHHHHHHCCCCCCHHHHHEEHHCHHHHHHHCCCHHHHHHHHHCCCCCC
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVH
CCCHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCCEEEEEC
PTKSEVKFKDERAMFKTIFDAVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEK
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEECC
EEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGIKEKNTLENNNDFYTSKQNEIYYA
CCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEE
NKNDECLNSCNKDNYSKIEKSLQKDNKNPDILYLNEHNRNSSPINIKENKSNNFYVDMKI
CCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEEE
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKCEIEKGYVISQILLSPVVIELSEDE
EECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHCCEEEEECCCC
FNIYEENKDIFKLIEDMLILNNPYTCPHGRPTMIKFTLKDLEKKFKRIQ
CEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA