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The map label for this gene is pbuO [H]

Identifier: 148379619

GI number: 148379619

Start: 1804720

End: 1806021

Strand: Direct

Name: pbuO [H]

Synonym: CBO1662

Alternate gene names: 148379619

Gene position: 1804720-1806021 (Clockwise)

Preceding gene: 148379618

Following gene: 148379620

Centisome position: 46.43

GC content: 28.8

Gene sequence:

>1302_bases
GTGGAAAATAAATTTAATAGTTTATTCAATATTAAGAAGTATAATACTACAGTCAAAGGAGAAATATTAGCAGGTTTTAC
CTCATTTTTTGCAATTGTATATATAATTGCTGTAAATGCATCTATATTATCCGATGCAGGTTTGCCTTTAGAAGGAGCAA
TAATAGCTACAGTACTATCCTCATTTGTAGGATGTATATTAGTTGGAGTCATAAGTAATGCACCACTAATTTTAGTTCCA
GGCATGGGAGTTAATGCTCTTTTTTCCTATACTATTGTAGGTTCTATGGGGCTTTCATGGCAGCAAGCATTAGCAGCGGT
ATTTGTATCAGGAGTTGTATTTTCCATAATAGCTTTTACAAGGTTTTCTAAAACCCTCATAGAATCAATCCCAACTTCCT
TAAAGGAAGCTATAACTGTGGGAATTGGTGTTTTAATTACATTTATAGGATTACAAAAAAGTGGGATTGTAATAGGAAGT
ACGACAACTTTTGTTGCATTAGGAAATTTTAATAATCCACTAGTATATGTAACTTTTATTAATTTAATAATTACATTAAT
ATTATTTATAAAAAATGTGCCAGGAAATTTTTTAATAAGCATGATTGTTGGAACGATTATATCATATTTTTTGGGACTTA
TAGATATGGCAAAGCTTACTTTTTCAAATTTTTCATTAGGCGCTTATAAAGAGGTTTTCTTTAAAATGGATTTTAGTAGC
GCTACTTCCATAACCTTTTGGATAGCAGTATTTTCATTAACGCTAGTACTTGTATTTGAAAATTTAGGGCTTTTACATGC
TCATATAAATGTTATGTTAAAGGAAGAAAATAAATTTAAAACTTCTTTTAAAGCTTGTTCGCTATCTGCTATTACTTGTG
GATTTTTTGGAACGAGTCCTACAGTAGCTACTATAGAAACTGCAGCTGGGATAACTGCAGGAGGAAAAACTGGATTAACA
TCTATTTTTACAGGAATTTTATTTTTATTATCATTATTTTTACTTCCAATTATAAAAATCATACCTAATAGTGCTATTTC
ACCTATACTTATTGTTATAGGAGGATTAATGATAAAAAATATATTAAGTATTAATTTTAATGATTTTTCAGAAGGTTTTC
CTGCTTTTTTAATTATAGTTATGATTCCACTAACTTTTAGTATTGTAGATGGTATGGCTTTTGGATTTATTTGCTATCCG
ATTGTAAAGTTAGCGGGAAAAAAATCAAAAGAAATTTCTTATGCAATGTATATAATTTCACTTATGTTCTTGTTAAATTT
TATATTACATGCAGTAAGCTGA

Upstream 100 bases:

>100_bases
AATATAATTGATTATATTAATAGTTTTTAATATAATATTTAATGCATTATAAAAATATAATGTGGGTGGGAGAGGGATAA
AAGAAAAGGACGAAGGAGAA

Downstream 100 bases:

>100_bases
AGTTATAATTGTCTATTTTAAAAATAAATAATGAACCCTGTTTAATTATTGAGAAGCATAACTAAACAGGGTTTTAATTT
TGCTTCATATATATAAAGTT

Product: xanthine/uracil permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MENKFNSLFNIKKYNTTVKGEILAGFTSFFAIVYIIAVNASILSDAGLPLEGAIIATVLSSFVGCILVGVISNAPLILVP
GMGVNALFSYTIVGSMGLSWQQALAAVFVSGVVFSIIAFTRFSKTLIESIPTSLKEAITVGIGVLITFIGLQKSGIVIGS
TTTFVALGNFNNPLVYVTFINLIITLILFIKNVPGNFLISMIVGTIISYFLGLIDMAKLTFSNFSLGAYKEVFFKMDFSS
ATSITFWIAVFSLTLVLVFENLGLLHAHINVMLKEENKFKTSFKACSLSAITCGFFGTSPTVATIETAAGITAGGKTGLT
SIFTGILFLLSLFLLPIIKIIPNSAISPILIVIGGLMIKNILSINFNDFSEGFPAFLIIVMIPLTFSIVDGMAFGFICYP
IVKLAGKKSKEISYAMYIISLMFLLNFILHAVS

Sequences:

>Translated_433_residues
MENKFNSLFNIKKYNTTVKGEILAGFTSFFAIVYIIAVNASILSDAGLPLEGAIIATVLSSFVGCILVGVISNAPLILVP
GMGVNALFSYTIVGSMGLSWQQALAAVFVSGVVFSIIAFTRFSKTLIESIPTSLKEAITVGIGVLITFIGLQKSGIVIGS
TTTFVALGNFNNPLVYVTFINLIITLILFIKNVPGNFLISMIVGTIISYFLGLIDMAKLTFSNFSLGAYKEVFFKMDFSS
ATSITFWIAVFSLTLVLVFENLGLLHAHINVMLKEENKFKTSFKACSLSAITCGFFGTSPTVATIETAAGITAGGKTGLT
SIFTGILFLLSLFLLPIIKIIPNSAISPILIVIGGLMIKNILSINFNDFSEGFPAFLIIVMIPLTFSIVDGMAFGFICYP
IVKLAGKKSKEISYAMYIISLMFLLNFILHAVS
>Mature_433_residues
MENKFNSLFNIKKYNTTVKGEILAGFTSFFAIVYIIAVNASILSDAGLPLEGAIIATVLSSFVGCILVGVISNAPLILVP
GMGVNALFSYTIVGSMGLSWQQALAAVFVSGVVFSIIAFTRFSKTLIESIPTSLKEAITVGIGVLITFIGLQKSGIVIGS
TTTFVALGNFNNPLVYVTFINLIITLILFIKNVPGNFLISMIVGTIISYFLGLIDMAKLTFSNFSLGAYKEVFFKMDFSS
ATSITFWIAVFSLTLVLVFENLGLLHAHINVMLKEENKFKTSFKACSLSAITCGFFGTSPTVATIETAAGITAGGKTGLT
SIFTGILFLLSLFLLPIIKIIPNSAISPILIVIGGLMIKNILSINFNDFSEGFPAFLIIVMIPLTFSIVDGMAFGFICYP
IVKLAGKKSKEISYAMYIISLMFLLNFILHAVS

Specific function: Involved in the uptake of the purine bases hypoxanthine and guanine. May work at purine concentrations higher than 100 uM [H]

COG id: COG2252

COG function: function code R; Permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082309, Length=439, Percent_Identity=32.1184510250569, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI1790150, Length=432, Percent_Identity=32.4074074074074, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI48994909, Length=434, Percent_Identity=31.1059907834101, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1790499, Length=434, Percent_Identity=30.4147465437788, Blast_Score=175, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46531; Mature: 46531

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKFNSLFNIKKYNTTVKGEILAGFTSFFAIVYIIAVNASILSDAGLPLEGAIIATVLS
CCCHHHHHHEEHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
SFVGCILVGVISNAPLILVPGMGVNALFSYTIVGSMGLSWQQALAAVFVSGVVFSIIAFT
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
RFSKTLIESIPTSLKEAITVGIGVLITFIGLQKSGIVIGSTTTFVALGNFNNPLVYVTFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEECCCCCCEEHHHHH
NLIITLILFIKNVPGNFLISMIVGTIISYFLGLIDMAKLTFSNFSLGAYKEVFFKMDFSS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEECCCC
ATSITFWIAVFSLTLVLVFENLGLLHAHINVMLKEENKFKTSFKACSLSAITCGFFGTSP
CHHHHHHHHHHHHHHHHHHHHCCHHEEEEEEEEECCCHHHHHHHHHHHHHEEEECCCCCC
TVATIETAAGITAGGKTGLTSIFTGILFLLSLFLLPIIKIIPNSAISPILIVIGGLMIKN
CCEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ILSINFNDFSEGFPAFLIIVMIPLTFSIVDGMAFGFICYPIVKLAGKKSKEISYAMYIIS
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LMFLLNFILHAVS
HHHHHHHHHHHCC
>Mature Secondary Structure
MENKFNSLFNIKKYNTTVKGEILAGFTSFFAIVYIIAVNASILSDAGLPLEGAIIATVLS
CCCHHHHHHEEHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
SFVGCILVGVISNAPLILVPGMGVNALFSYTIVGSMGLSWQQALAAVFVSGVVFSIIAFT
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
RFSKTLIESIPTSLKEAITVGIGVLITFIGLQKSGIVIGSTTTFVALGNFNNPLVYVTFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEECCCCCCEEHHHHH
NLIITLILFIKNVPGNFLISMIVGTIISYFLGLIDMAKLTFSNFSLGAYKEVFFKMDFSS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEECCCC
ATSITFWIAVFSLTLVLVFENLGLLHAHINVMLKEENKFKTSFKACSLSAITCGFFGTSP
CHHHHHHHHHHHHHHHHHHHHCCHHEEEEEEEEECCCHHHHHHHHHHHHHEEEECCCCCC
TVATIETAAGITAGGKTGLTSIFTGILFLLSLFLLPIIKIIPNSAISPILIVIGGLMIKN
CCEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ILSINFNDFSEGFPAFLIIVMIPLTFSIVDGMAFGFICYPIVKLAGKKSKEISYAMYIIS
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LMFLLNFILHAVS
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 11591660 [H]