Click here to switch to the map view.

The map label for this gene is patB [H]

Identifier: 148379376

GI number: 148379376

Start: 1527112

End: 1528290

Strand: Direct

Name: patB [H]

Synonym: CBO1400

Alternate gene names: 148379376

Gene position: 1527112-1528290 (Clockwise)

Preceding gene: 148379375

Following gene: 148379377

Centisome position: 39.29

GC content: 30.11

Gene sequence:

>1179_bases
ATGAAGTATAATTTTGACAAAGTAGTAAATAGGGATAATACAAATTGTAGTAAATGGAATTTTAATAAAGAAACCTTTGG
GTATGAAGATATTATATCTATGTGGATAGCTGATATGGATTTTGAAACAGTTCCAGAGGTAAAAGAAGAAATAATAAATA
GGGCTCATCATGGTATTTATGGATATACTGCTACGGCAGAATCCTATTATAAAGAAGTTGTAAATTGGATGAAAAAACGT
CATGGATGGAATATAAAAAAAGAATGGATAACTAATACTCCTGGAATAGTTATGGCTGTAAATACTATAGTTAGAACTTT
TACTCATTCAGGGGACAAGGTACTACTCCAAAGACCTATATATTATCCATTTTTTAAGGCTATAAACAATAATGGATGTC
ATATAGTAAACAATCCATTAAAGTTTGATGGGAAAAGATATGAAATGGATTTTGAGGACTTAGATAACAAACTTTCAGAC
CCTAGAGTAAAGATAATGATATTATGTAGTCCCCATAATCCTACAGGAAGAGTCTGGACTAAAGAAGAGCTCGTAAAGGT
AGGTAATCTTTGTTTAAAACATAATGTATTAGTAATCTCAGATGAAATACATTCAGACTTAATATATAAACCTAATAAAC
ATATTCCTTTTGCAGCTATATGTAAAGAATTTGCAGATATAAGTATAACTTGTACAGCACCAAGTAAAACCTTTAATTTA
GCAGGACTTCAAGGTTCAAATATAATAATATCTAATGAAATATTGATGAATGAATTTAAAATAGCTATGGAAAATATAGG
ATTGTCAAGATTGAATATTTTTGCATCTATAGCCTGTGAAGCAGCCTATAAATATGGAGAACAATGGGTAGAAGAATTAA
TAGATTATTTACAAGAGAATAAAGAATTTGCAAAGAAATTTATTAAAGAAAAAGTGCCTATGTTAAAGGTAATAGAGCCA
GAGGGAACATATCTTTTATGGATAGATTGCAGAGAATTAAAAATGTCAAAGGAGGAACTTGAGGAATTTATGCTAAAAGA
AGCAGGAGTAGCCTTTGATGAAGGTTATATATTTGGAGAAGAAGCTATAGGTTTTGAAAGAATGAATATAGCTTGCCCTA
GAGAGGTACTAAAGGGGGCTCTAGAGAAAATTGAAAAAGCTATAAGCAATAAAATGTAG

Upstream 100 bases:

>100_bases
GGATATTTATAATAAAATAATTAATTTAATATAAAGTAAGAAATTCTTTATGTTATTAAGAATGTAAATATTTAAAATGA
TTTTATATGGAGTGATAATT

Downstream 100 bases:

>100_bases
GATATGATGGCTGGTGGTACAATGAGTAAACTATCACAAAAGTGGTTTAAACTTGATATAACTAAGAAGGAATAGGTGTG
GTAGTATATGATTTTTGACC

Product: aminotransferase, classes I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKYNFDKVVNRDNTNCSKWNFNKETFGYEDIISMWIADMDFETVPEVKEEIINRAHHGIYGYTATAESYYKEVVNWMKKR
HGWNIKKEWITNTPGIVMAVNTIVRTFTHSGDKVLLQRPIYYPFFKAINNNGCHIVNNPLKFDGKRYEMDFEDLDNKLSD
PRVKIMILCSPHNPTGRVWTKEELVKVGNLCLKHNVLVISDEIHSDLIYKPNKHIPFAAICKEFADISITCTAPSKTFNL
AGLQGSNIIISNEILMNEFKIAMENIGLSRLNIFASIACEAAYKYGEQWVEELIDYLQENKEFAKKFIKEKVPMLKVIEP
EGTYLLWIDCRELKMSKEELEEFMLKEAGVAFDEGYIFGEEAIGFERMNIACPREVLKGALEKIEKAISNKM

Sequences:

>Translated_392_residues
MKYNFDKVVNRDNTNCSKWNFNKETFGYEDIISMWIADMDFETVPEVKEEIINRAHHGIYGYTATAESYYKEVVNWMKKR
HGWNIKKEWITNTPGIVMAVNTIVRTFTHSGDKVLLQRPIYYPFFKAINNNGCHIVNNPLKFDGKRYEMDFEDLDNKLSD
PRVKIMILCSPHNPTGRVWTKEELVKVGNLCLKHNVLVISDEIHSDLIYKPNKHIPFAAICKEFADISITCTAPSKTFNL
AGLQGSNIIISNEILMNEFKIAMENIGLSRLNIFASIACEAAYKYGEQWVEELIDYLQENKEFAKKFIKEKVPMLKVIEP
EGTYLLWIDCRELKMSKEELEEFMLKEAGVAFDEGYIFGEEAIGFERMNIACPREVLKGALEKIEKAISNKM
>Mature_392_residues
MKYNFDKVVNRDNTNCSKWNFNKETFGYEDIISMWIADMDFETVPEVKEEIINRAHHGIYGYTATAESYYKEVVNWMKKR
HGWNIKKEWITNTPGIVMAVNTIVRTFTHSGDKVLLQRPIYYPFFKAINNNGCHIVNNPLKFDGKRYEMDFEDLDNKLSD
PRVKIMILCSPHNPTGRVWTKEELVKVGNLCLKHNVLVISDEIHSDLIYKPNKHIPFAAICKEFADISITCTAPSKTFNL
AGLQGSNIIISNEILMNEFKIAMENIGLSRLNIFASIACEAAYKYGEQWVEELIDYLQENKEFAKKFIKEKVPMLKVIEP
EGTYLLWIDCRELKMSKEELEEFMLKEAGVAFDEGYIFGEEAIGFERMNIACPREVLKGALEKIEKAISNKM

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=161, Percent_Identity=31.6770186335404, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI56713256, Length=161, Percent_Identity=31.6770186335404, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI95147551, Length=260, Percent_Identity=22.6923076923077, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI169881279, Length=260, Percent_Identity=22.6923076923077, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI169881281, Length=197, Percent_Identity=24.3654822335025, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787909, Length=388, Percent_Identity=33.2474226804124, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1788627, Length=301, Percent_Identity=23.9202657807309, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786816, Length=353, Percent_Identity=20.1133144475921, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788722, Length=375, Percent_Identity=23.2, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=155, Percent_Identity=26.4516129032258, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71994472, Length=155, Percent_Identity=26.4516129032258, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17567663, Length=299, Percent_Identity=21.7391304347826, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17567369, Length=154, Percent_Identity=24.6753246753247, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=292, Percent_Identity=25.6849315068493, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573069, Length=279, Percent_Identity=25.4480286738351, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646114, Length=279, Percent_Identity=25.4480286738351, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573067, Length=279, Percent_Identity=25.4480286738351, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573065, Length=279, Percent_Identity=25.4480286738351, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45383; Mature: 45383

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYNFDKVVNRDNTNCSKWNFNKETFGYEDIISMWIADMDFETVPEVKEEIINRAHHGIY
CCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
GYTATAESYYKEVVNWMKKRHGWNIKKEWITNTPGIVMAVNTIVRTFTHSGDKVLLQRPI
EEECCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
YYPFFKAINNNGCHIVNNPLKFDGKRYEMDFEDLDNKLSDPRVKIMILCSPHNPTGRVWT
HHHHHHHHCCCCCEEECCCCCCCCCEEEECHHHHHHCCCCCCEEEEEEECCCCCCCCEEC
KEELVKVGNLCLKHNVLVISDEIHSDLIYKPNKHIPFAAICKEFADISITCTAPSKTFNL
HHHHHHHHHHHHHCCEEEEECCCCCCCEECCCCCCCHHHHHHHHCCEEEEEECCCCEEEE
AGLQGSNIIISNEILMNEFKIAMENIGLSRLNIFASIACEAAYKYGEQWVEELIDYLQEN
ECCCCCCEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KEFAKKFIKEKVPMLKVIEPEGTYLLWIDCRELKMSKEELEEFMLKEAGVAFDEGYIFGE
HHHHHHHHHHCCCEEEEECCCCCEEEEEEHHHHHCCHHHHHHHHHHHCCCEECCCEEECC
EAIGFERMNIACPREVLKGALEKIEKAISNKM
HHCCEECCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKYNFDKVVNRDNTNCSKWNFNKETFGYEDIISMWIADMDFETVPEVKEEIINRAHHGIY
CCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
GYTATAESYYKEVVNWMKKRHGWNIKKEWITNTPGIVMAVNTIVRTFTHSGDKVLLQRPI
EEECCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
YYPFFKAINNNGCHIVNNPLKFDGKRYEMDFEDLDNKLSDPRVKIMILCSPHNPTGRVWT
HHHHHHHHCCCCCEEECCCCCCCCCEEEECHHHHHHCCCCCCEEEEEEECCCCCCCCEEC
KEELVKVGNLCLKHNVLVISDEIHSDLIYKPNKHIPFAAICKEFADISITCTAPSKTFNL
HHHHHHHHHHHHHCCEEEEECCCCCCCEECCCCCCCHHHHHHHHCCEEEEEECCCCEEEE
AGLQGSNIIISNEILMNEFKIAMENIGLSRLNIFASIACEAAYKYGEQWVEELIDYLQEN
ECCCCCCEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KEFAKKFIKEKVPMLKVIEPEGTYLLWIDCRELKMSKEELEEFMLKEAGVAFDEGYIFGE
HHHHHHHHHHCCCEEEEECCCCCEEEEEEHHHHHCCHHHHHHHHHHHCCCEECCCEEECC
EAIGFERMNIACPREVLKGALEKIEKAISNKM
HHCCEECCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]