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The map label for this gene is hssS [H]

Identifier: 148378897

GI number: 148378897

Start: 1010534

End: 1011565

Strand: Direct

Name: hssS [H]

Synonym: CBO0906

Alternate gene names: 148378897

Gene position: 1010534-1011565 (Clockwise)

Preceding gene: 148378896

Following gene: 148378898

Centisome position: 26.0

GC content: 29.46

Gene sequence:

>1032_bases
GTGATGAATAATAAAATATCCGTTAAAATGGTAGTTGCTTTTTCTTTAATAGTTTTTTTTATTGTTACTTCGGCTGTTGT
TATTAGTGGCTTAGTAGTGGTATTTCTTTCGCGTTTTAATGTATTTACTCAACCTAATCCTTTAATTTTATTAGGCTGGT
TAGGTATTATCAGTATAATGGTAAGCACAGCGATTGCTCAAATTATAGGAAAAAAAGTACTATCCCCAATTTCTGATCTT
AACAAAGCAACTAAAGAAGTTGCTAAGGGAAATTTTAATACTAGACTTTCAGAAAATAGCTGGACAGATGAAATAAGAGA
AATGGCACATAGCGTTAATATAATGACTCATGAACTAGGTAATATTGAAACCTTAAGAGATGATTTCATTAGCAATGTTT
CTCATGAATTTAAGACTCCTATTTCAGCTATTGAAGGCTATGCTACATTACTGCAAGATGATGAATTGTCTGATGAAGAA
CGTAGAGAATATATTCATAAAATACTTATAAGTACAAAAAGATTATCTTCTCTTTCAGGGAATATTTTGCAAATAACAGA
ACTTGAAAATCAAAAGATTTTACCTTTAGAACAAAAATATTATTTAGATGAACAAATCAGACAAACTATTTTATTATTTG
AATATGAGTGGACAAAAAAAAATATAATTTTAGATATTAATCTAGACAATATTACTTACATTGGAAGTAAAGAGTTGTTA
GCTCAAGTATGGCAAAATATTTTAGGGAATGCTATTAAATTTTCTCACCAGAATGGAACAATACAGGTAACATTAACACA
AACAAATGAGGAAGTTTTAATTACAATAAAGGATAATGGTATAGGTATGTCTGAAGAGGTTAAGAACCGAGTGTTTGAAA
AGTTTTATCAGGGAGATAGTTCACATTATTCAGATGGGAATGGATTAGGTTTAGCACTTGTGAAAAGGATTATAGATATT
TGTGAAGGAACTATAGAAATCTCAAGTCATGAAGCAGTAGGTACAGAATTTACTGTTAAACTTCCTAAGTAG

Upstream 100 bases:

>100_bases
CAGTTGACGTTCATATAAATAGATTACGGGATCGGTTTAAAGACAATAAAGACTTCAATATTATTACAATTAGAGGACTA
GGTTATAAGGTGGTTAAACA

Downstream 100 bases:

>100_bases
GATATTTAATTAAAATAAAAATCATTAATATCATAAGTTCCATTTATAAAATCAAATGTTGCCAAATTACTTTTGTATTT
GTAAAGTAGGAGGATTCTTA

Product: two component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MMNNKISVKMVVAFSLIVFFIVTSAVVISGLVVVFLSRFNVFTQPNPLILLGWLGIISIMVSTAIAQIIGKKVLSPISDL
NKATKEVAKGNFNTRLSENSWTDEIREMAHSVNIMTHELGNIETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEE
RREYIHKILISTKRLSSLSGNILQITELENQKILPLEQKYYLDEQIRQTILLFEYEWTKKNIILDINLDNITYIGSKELL
AQVWQNILGNAIKFSHQNGTIQVTLTQTNEEVLITIKDNGIGMSEEVKNRVFEKFYQGDSSHYSDGNGLGLALVKRIIDI
CEGTIEISSHEAVGTEFTVKLPK

Sequences:

>Translated_343_residues
MMNNKISVKMVVAFSLIVFFIVTSAVVISGLVVVFLSRFNVFTQPNPLILLGWLGIISIMVSTAIAQIIGKKVLSPISDL
NKATKEVAKGNFNTRLSENSWTDEIREMAHSVNIMTHELGNIETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEE
RREYIHKILISTKRLSSLSGNILQITELENQKILPLEQKYYLDEQIRQTILLFEYEWTKKNIILDINLDNITYIGSKELL
AQVWQNILGNAIKFSHQNGTIQVTLTQTNEEVLITIKDNGIGMSEEVKNRVFEKFYQGDSSHYSDGNGLGLALVKRIIDI
CEGTIEISSHEAVGTEFTVKLPK
>Mature_343_residues
MMNNKISVKMVVAFSLIVFFIVTSAVVISGLVVVFLSRFNVFTQPNPLILLGWLGIISIMVSTAIAQIIGKKVLSPISDL
NKATKEVAKGNFNTRLSENSWTDEIREMAHSVNIMTHELGNIETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEE
RREYIHKILISTKRLSSLSGNILQITELENQKILPLEQKYYLDEQIRQTILLFEYEWTKKNIILDINLDNITYIGSKELL
AQVWQNILGNAIKFSHQNGTIQVTLTQTNEEVLITIKDNGIGMSEEVKNRVFEKFYQGDSSHYSDGNGLGLALVKRIIDI
CEGTIEISSHEAVGTEFTVKLPK

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=286, Percent_Identity=27.2727272727273, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786783, Length=270, Percent_Identity=22.962962962963, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788713, Length=252, Percent_Identity=28.1746031746032, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=28.4444444444444, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790346, Length=292, Percent_Identity=25.6849315068493, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788549, Length=240, Percent_Identity=30.4166666666667, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=25.9574468085106, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=28.3842794759825, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=27.8884462151394, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=304, Percent_Identity=21.0526315789474, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788279, Length=273, Percent_Identity=25.2747252747253, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790861, Length=240, Percent_Identity=24.1666666666667, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1789403, Length=292, Percent_Identity=23.2876712328767, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=214, Percent_Identity=26.1682242990654, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=26.5486725663717, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081816, Length=339, Percent_Identity=21.8289085545723, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790551, Length=299, Percent_Identity=24.0802675585284, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38697; Mature: 38697

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNNKISVKMVVAFSLIVFFIVTSAVVISGLVVVFLSRFNVFTQPNPLILLGWLGIISIM
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHH
VSTAIAQIIGKKVLSPISDLNKATKEVAKGNFNTRLSENSWTDEIREMAHSVNIMTHELG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
NIETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEERREYIHKILISTKRLSSLSG
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
NILQITELENQKILPLEQKYYLDEQIRQTILLFEYEWTKKNIILDINLDNITYIGSKELL
CEEEEEECCCCCCCCCHHHHHHHHHHHHHEEEEEEEECCCCEEEEEECCCEEEECCHHHH
AQVWQNILGNAIKFSHQNGTIQVTLTQTNEEVLITIKDNGIGMSEEVKNRVFEKFYQGDS
HHHHHHHHCHHEEEECCCCEEEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCC
SHYSDGNGLGLALVKRIIDICEGTIEISSHEAVGTEFTVKLPK
CCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCC
>Mature Secondary Structure
MMNNKISVKMVVAFSLIVFFIVTSAVVISGLVVVFLSRFNVFTQPNPLILLGWLGIISIM
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHH
VSTAIAQIIGKKVLSPISDLNKATKEVAKGNFNTRLSENSWTDEIREMAHSVNIMTHELG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
NIETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEERREYIHKILISTKRLSSLSG
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
NILQITELENQKILPLEQKYYLDEQIRQTILLFEYEWTKKNIILDINLDNITYIGSKELL
CEEEEEECCCCCCCCCHHHHHHHHHHHHHEEEEEEEECCCCEEEEEECCCEEEECCHHHH
AQVWQNILGNAIKFSHQNGTIQVTLTQTNEEVLITIKDNGIGMSEEVKNRVFEKFYQGDS
HHHHHHHHCHHEEEECCCCEEEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCC
SHYSDGNGLGLALVKRIIDICEGTIEISSHEAVGTEFTVKLPK
CCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA