Click here to switch to the map view.

The map label for this gene is dhpS [H]

Identifier: 148378820

GI number: 148378820

Start: 936659

End: 937777

Strand: Direct

Name: dhpS [H]

Synonym: CBO0828

Alternate gene names: 148378820

Gene position: 936659-937777 (Clockwise)

Preceding gene: 148378819

Following gene: 148378821

Centisome position: 24.1

GC content: 30.29

Gene sequence:

>1119_bases
ATGAATATATTTATGAATAAAAATAATATTACCCCTTTAAAAATTTTTAATGTGCTAGCTCCTGCAGCCAATATAATAAA
GCAAGAAATACTGGCTTTAGGTGGAGATTGTGCTGTAAATAAATATTGTATAAATTGCAAAGTGGAAACTTCAGATATAA
TTTTATTAGGAACCAAAAGACAGTACAAAAAATTATTGCAAAAGCTTAAATGCATGACTTTTTTTAGAATAGAAGAAATA
GTAGGGGAATTAGAAAACTATATTAAAAATAATGGAGCTGTTAAAACAGTTCTAAAGGATGAAAGAGAAATAAACTATGA
AAATTTAAAGGTTATGGGAATTATAAATTGTACTCCAGATTCTTTTTATGAGGGTTCTAGAAAAGATTCTACAGAAGAAG
CCTTAAAAACTGCAGAAAAGATGTTAAAAGAAGGTGCAGAAATTTTAGATATAGGCGGAGAATCCACAAGACCAGGTTCT
GACCCAGTAGATGAAGAGGAAGAAATAAAAAGAGTAGTTCCTGTTATAAGAGAGATAAAGAATAAATTTAAGGATGTCAT
AATTTCCATAGATACTTATAGAGCAAATACGGCAAAGTCTGCCATAGAGGCAGGTGCAGACATAGTAAATGATATAAGTG
CTATGAAGTATGATGAAAATATGGTGAAAGTAGTTAAAGAATACAATGTACCTGTAATACTTATGCATGTAAAAGGAAAA
CCAAAGGATATGCAAATAGATCCAGTTTATGAGAATTTAATGAAAGAAATTCATCTTTATTTTAATGAGAGAATAGAGTA
CTGCAAATCTCATGGTATAACAGAGGATAAAATAATATTAGATCCAGGCATAGGTTTTGGAAAAACTGTAGAGCATAATC
TAAAAATAATGAATAGAATAGAAGAATTAAAAAGCTTTAATCTTCCAGTACTTTTAGCAGCCTCAAGAAAAGCTACCATA
GGAAAAGTTTTAGGAAACTTACCTACAGAAGAAAGATTAGAAGGAACCATAGCTTTATCCTGTTTAGCGGTAGATGTAGG
AATTCAGATGGTGAGGGTACACGATGTAAAAGAAAATATAAGAGCCATAAGAATGTTAGAGGCAGTAAGAAAAATATAA

Upstream 100 bases:

>100_bases
AGAATGGTTATAAAGAAAAGGGGTGTTTAAAATAATTATAGAATTAAATAAAAATAGTTTCCCAGAAGAGTTCAATAAGA
TAGAAGTACATGAGGGTAGT

Downstream 100 bases:

>100_bases
TTATATTATAAAAAATATAATCAAAATTAAATTATAATTTAAATTGTATCTTCTGATTTTTAGGGCTGTAAGATAAATTT
ATATAATAAAAGAAAAAATT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MNIFMNKNNITPLKIFNVLAPAANIIKQEILALGGDCAVNKYCINCKVETSDIILLGTKRQYKKLLQKLKCMTFFRIEEI
VGELENYIKNNGAVKTVLKDEREINYENLKVMGIINCTPDSFYEGSRKDSTEEALKTAEKMLKEGAEILDIGGESTRPGS
DPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKSAIEAGADIVNDISAMKYDENMVKVVKEYNVPVILMHVKGK
PKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNLKIMNRIEELKSFNLPVLLAASRKATI
GKVLGNLPTEERLEGTIALSCLAVDVGIQMVRVHDVKENIRAIRMLEAVRKI

Sequences:

>Translated_372_residues
MNIFMNKNNITPLKIFNVLAPAANIIKQEILALGGDCAVNKYCINCKVETSDIILLGTKRQYKKLLQKLKCMTFFRIEEI
VGELENYIKNNGAVKTVLKDEREINYENLKVMGIINCTPDSFYEGSRKDSTEEALKTAEKMLKEGAEILDIGGESTRPGS
DPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKSAIEAGADIVNDISAMKYDENMVKVVKEYNVPVILMHVKGK
PKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNLKIMNRIEELKSFNLPVLLAASRKATI
GKVLGNLPTEERLEGTIALSCLAVDVGIQMVRVHDVKENIRAIRMLEAVRKI
>Mature_372_residues
MNIFMNKNNITPLKIFNVLAPAANIIKQEILALGGDCAVNKYCINCKVETSDIILLGTKRQYKKLLQKLKCMTFFRIEEI
VGELENYIKNNGAVKTVLKDEREINYENLKVMGIINCTPDSFYEGSRKDSTEEALKTAEKMLKEGAEILDIGGESTRPGS
DPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKSAIEAGADIVNDISAMKYDENMVKVVKEYNVPVILMHVKGK
PKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNLKIMNRIEELKSFNLPVLLAASRKATI
GKVLGNLPTEERLEGTIALSCLAVDVGIQMVRVHDVKENIRAIRMLEAVRKI

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=265, Percent_Identity=42.6415094339623, Blast_Score=236, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6324073, Length=316, Percent_Identity=33.8607594936709, Blast_Score=156, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 42020; Mature: 42020

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIFMNKNNITPLKIFNVLAPAANIIKQEILALGGDCAVNKYCINCKVETSDIILLGTKR
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECEEEEEEEEECCCEEEECCCH
QYKKLLQKLKCMTFFRIEEIVGELENYIKNNGAVKTVLKDEREINYENLKVMGIINCTPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCEEEEEEEECCCH
SFYEGSRKDSTEEALKTAEKMLKEGAEILDIGGESTRPGSDPVDEEEEIKRVVPVIREIK
HHCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
NKFKDVIISIDTYRANTAKSAIEAGADIVNDISAMKYDENMVKVVKEYNVPVILMHVKGK
HHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
PKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNLKIMNRI
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHH
EELKSFNLPVLLAASRKATIGKVLGNLPTEERLEGTIALSCLAVDVGIQMVRVHDVKENI
HHHHHCCCCEEEECCCCHHHHHHHCCCCCHHHHCHHHHHHHHHHHHCHHEEEHHHHHHHH
RAIRMLEAVRKI
HHHHHHHHHHCC
>Mature Secondary Structure
MNIFMNKNNITPLKIFNVLAPAANIIKQEILALGGDCAVNKYCINCKVETSDIILLGTKR
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECEEEEEEEEECCCEEEECCCH
QYKKLLQKLKCMTFFRIEEIVGELENYIKNNGAVKTVLKDEREINYENLKVMGIINCTPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCEEEEEEEECCCH
SFYEGSRKDSTEEALKTAEKMLKEGAEILDIGGESTRPGSDPVDEEEEIKRVVPVIREIK
HHCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
NKFKDVIISIDTYRANTAKSAIEAGADIVNDISAMKYDENMVKVVKEYNVPVILMHVKGK
HHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
PKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNLKIMNRI
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHH
EELKSFNLPVLLAASRKATIGKVLGNLPTEERLEGTIALSCLAVDVGIQMVRVHDVKENI
HHHHHCCCCEEEECCCCHHHHHHHCCCCCHHHHCHHHHHHHHHHHHCHHEEEHHHHHHHH
RAIRMLEAVRKI
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]