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The map label for this gene is gcvT [H]

Identifier: 148378696

GI number: 148378696

Start: 800406

End: 801533

Strand: Direct

Name: gcvT [H]

Synonym: CBO0696

Alternate gene names: 148378696

Gene position: 800406-801533 (Clockwise)

Preceding gene: 148378694

Following gene: 148378697

Centisome position: 20.59

GC content: 30.94

Gene sequence:

>1128_bases
TTGGGGGTAAAACACATGAAAGATTTAAAAGTTACGCCTTTAAGAGGAGTGTATGAAGAGTATGGTGGGAAAATTGTAGA
TTTTGCAGGATATGAACTTCCAACACAATTTAAAGGCTTTTTACATGAGCATCATACTGTAAGAGAAAAAGCAGGTCTTT
TTGATGTTTCTCATATGGGAGAAGCTATGGTAACAGGAAAAGATGCTGGAAAATTCATTCAATACTTAATGACTAATGAC
ATAAATGTTCTTAAAGATAATGAGGTTTTGTACACATTCATGTGTAATGAAGATGGTGGAGTGATAGATGATTTATTGGT
TTATAAATTTGCAGAGGATGAGTTTTTTTTAGTTATTAATGCAAGTAATAAGGATAAAGATGTTAAGTGGATAATGGACC
ACAAAGGGGATTTTGATGTTGAAATTGTTGATGTATCAGATAGCATTGCACAACTTGCATTCCAAGGACCTTTAGCAGAA
GAAATACTTCAAAAAATAGTAGATGTAGATTTACAAGAAATAAAATTCTTTAAACTTAAAAGAGATGTTTTAGTTAATGG
GAAAAAGTGCTTAGTATCAAGAACCGGTTATACTGGAGAAGATGGTTTTGAAATTTATTGTAAACCAGAGGATGCAAAAG
GACTATGGCATGCTATATTAAATGCAGGAAAAGAAGAAGGTGCACAGCCAATAGGATTAGGTGCTAGAGATACTTTAAGA
TTTGAAGCTAGTCTTCTTTTATATGGAAATGAAATGGATGAAACAATTACACCATTAGAAGTAGGTATGGGATTCTTTGC
AAAATTAAAAATTGAAGAAGATTTTATAGGAAAAGATGCTTTAATAAAACAAAAAGCAGAAGGCGTAACTAGAAAATTGG
TAGGATTTGAACTTTTAGATAAGGGAATTCCGAGGCATGGTTATGAGGTTATTAAAGATGGAAAAGTTATAGGACATGTT
ACAACTGGATATAAATCTCCTACATTAAACAAAGCAATTGGATTAGCTTTAGTAGAAGAACAATATTCTAAAATAGGAAC
AGAGTTTAATATAAAAGTTAGAAAAAAAGAATTAAAAGCTGTTGCTATAGATAAGAGATTCTATACTAAAAAAACAAAAA
CCAAATAA

Upstream 100 bases:

>100_bases
TTTGGAATTAAAATAAACTTTACAACTTGGTTTTACACTAAATCATTTTCATAATTTTATTAAAACATATATATAAATAT
TTATGGGTAAATAATTTTAA

Downstream 100 bases:

>100_bases
TATATTAACGGTTAATTTGTAGATTATTTTTTAATATATATAAATTCACACTAATGTTTAGTTTTCAGGCTAAAATGTCA
TTGGTAATCAATATATAATA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MGVKHMKDLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEAMVTGKDAGKFIQYLMTND
INVLKDNEVLYTFMCNEDGGVIDDLLVYKFAEDEFFLVINASNKDKDVKWIMDHKGDFDVEIVDVSDSIAQLAFQGPLAE
EILQKIVDVDLQEIKFFKLKRDVLVNGKKCLVSRTGYTGEDGFEIYCKPEDAKGLWHAILNAGKEEGAQPIGLGARDTLR
FEASLLLYGNEMDETITPLEVGMGFFAKLKIEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPRHGYEVIKDGKVIGHV
TTGYKSPTLNKAIGLALVEEQYSKIGTEFNIKVRKKELKAVAIDKRFYTKKTKTK

Sequences:

>Translated_375_residues
MGVKHMKDLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEAMVTGKDAGKFIQYLMTND
INVLKDNEVLYTFMCNEDGGVIDDLLVYKFAEDEFFLVINASNKDKDVKWIMDHKGDFDVEIVDVSDSIAQLAFQGPLAE
EILQKIVDVDLQEIKFFKLKRDVLVNGKKCLVSRTGYTGEDGFEIYCKPEDAKGLWHAILNAGKEEGAQPIGLGARDTLR
FEASLLLYGNEMDETITPLEVGMGFFAKLKIEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPRHGYEVIKDGKVIGHV
TTGYKSPTLNKAIGLALVEEQYSKIGTEFNIKVRKKELKAVAIDKRFYTKKTKTK
>Mature_374_residues
GVKHMKDLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEAMVTGKDAGKFIQYLMTNDI
NVLKDNEVLYTFMCNEDGGVIDDLLVYKFAEDEFFLVINASNKDKDVKWIMDHKGDFDVEIVDVSDSIAQLAFQGPLAEE
ILQKIVDVDLQEIKFFKLKRDVLVNGKKCLVSRTGYTGEDGFEIYCKPEDAKGLWHAILNAGKEEGAQPIGLGARDTLRF
EASLLLYGNEMDETITPLEVGMGFFAKLKIEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPRHGYEVIKDGKVIGHVT
TGYKSPTLNKAIGLALVEEQYSKIGTEFNIKVRKKELKAVAIDKRFYTKKTKTK

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=376, Percent_Identity=35.3723404255319, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI257796258, Length=353, Percent_Identity=35.4107648725212, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI24797151, Length=345, Percent_Identity=32.463768115942, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI257796254, Length=373, Percent_Identity=32.7077747989276, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI257796256, Length=320, Percent_Identity=34.375, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI197927446, Length=325, Percent_Identity=28, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI21361378, Length=325, Percent_Identity=28, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI194306651, Length=376, Percent_Identity=25.531914893617, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=39.945652173913, Blast_Score=241, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17560118, Length=354, Percent_Identity=38.135593220339, Blast_Score=220, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI32563613, Length=327, Percent_Identity=27.217125382263, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71994045, Length=331, Percent_Identity=26.8882175226586, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71994052, Length=331, Percent_Identity=26.8882175226586, Blast_Score=114, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6320222, Length=371, Percent_Identity=35.0404312668464, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI20129441, Length=374, Percent_Identity=33.6898395721925, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI28571104, Length=286, Percent_Identity=29.020979020979, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI20130091, Length=319, Percent_Identity=24.4514106583072, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 42182; Mature: 42051

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVKHMKDLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMG
CCCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCC
EAMVTGKDAGKFIQYLMTNDINVLKDNEVLYTFMCNEDGGVIDDLLVYKFAEDEFFLVIN
CEEEECCCHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCCHHHHHEEEECCCCEEEEEE
ASNKDKDVKWIMDHKGDFDVEIVDVSDSIAQLAFQGPLAEEILQKIVDVDLQEIKFFKLK
CCCCCCCEEEEECCCCCCCEEEEECCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHH
RDVLVNGKKCLVSRTGYTGEDGFEIYCKPEDAKGLWHAILNAGKEEGAQPIGLGARDTLR
HHHHCCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHCCHHHCCCCCCCCCCCEEE
FEASLLLYGNEMDETITPLEVGMGFFAKLKIEEDFIGKDALIKQKAEGVTRKLVGFELLD
EEEEEEEECCCCCCCCCHHHHCCCEEEEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHH
KGIPRHGYEVIKDGKVIGHVTTGYKSPTLNKAIGLALVEEQYSKIGTEFNIKVRKKELKA
CCCCCCCHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEE
VAIDKRFYTKKTKTK
EEECHHHHCCCCCCC
>Mature Secondary Structure 
GVKHMKDLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMG
CCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCC
EAMVTGKDAGKFIQYLMTNDINVLKDNEVLYTFMCNEDGGVIDDLLVYKFAEDEFFLVIN
CEEEECCCHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCCHHHHHEEEECCCCEEEEEE
ASNKDKDVKWIMDHKGDFDVEIVDVSDSIAQLAFQGPLAEEILQKIVDVDLQEIKFFKLK
CCCCCCCEEEEECCCCCCCEEEEECCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHH
RDVLVNGKKCLVSRTGYTGEDGFEIYCKPEDAKGLWHAILNAGKEEGAQPIGLGARDTLR
HHHHCCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHCCHHHCCCCCCCCCCCEEE
FEASLLLYGNEMDETITPLEVGMGFFAKLKIEEDFIGKDALIKQKAEGVTRKLVGFELLD
EEEEEEEECCCCCCCCCHHHHCCCEEEEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHH
KGIPRHGYEVIKDGKVIGHVTTGYKSPTLNKAIGLALVEEQYSKIGTEFNIKVRKKELKA
CCCCCCCHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEE
VAIDKRFYTKKTKTK
EEECHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA