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The map label for this gene is xdhA1 [H]

Identifier: 148378260

GI number: 148378260

Start: 305551

End: 307881

Strand: Direct

Name: xdhA1 [H]

Synonym: CBO0258

Alternate gene names: 148378260

Gene position: 305551-307881 (Clockwise)

Preceding gene: 148378258

Following gene: 148378261

Centisome position: 7.86

GC content: 37.54

Gene sequence:

>2331_bases
ATGTATGATTTAAATATTATAGGTAAAAATGTACCAAGAAAAGAGTCCATAGACAAAGTAACAGGTGCAGCAAAGTATAC
AAATGATTATGAAGCCACTGGACTTTTATATGCCAGAATGGTAACAAGTCCCTATGCTCATGCAAAAATAAAGGCTATCG
AATATGAAAATTCACTAAAGACTTCCGGAGTTAGGGCCGTGATAACAGGAGAATACTTTCCTCAGCTTGTTGGGTCCACT
ATTGTTGATAGACCTCCCATTGCTATAGATAAAGTAAGATACAATGGTGAACCAGTGGCAGTGGTAGTAGCTGATAGCGA
GATTGAAGCTAAAAAAGCTGCTCAGATGATAAAGATAGAATATGAACCTCTACCGGTAGTGAATTCTCCAAGTGAAGCAA
TAAAAAAAGATTCACCGTTGGTTCATGAAAAGCTTGGTGATTATGAGATTATTGATGAAGTTTTTCCGGAACCTAACACA
AATATCGCTAACAGAACTAAGATTAGAAAAGGTGATATAAAGAAAGGGTGGCATGAAAGTGAGGTAACTGTGGAGGCAAG
TTTTTCATTTCCACCTTCTGATCATGCTGCTATGGAGACAAGGTCCGTAACAGCAAGGATATTACCAGATGGAAGAGTTA
TTATATACTCTTGCTCTCAGGCTCCATTTGCCATAAAAAAACTTATAAGTCATTTCTTTAATATCGATCCTGGCAAGGTT
ATTGTCCATGTACCTCTTGTAGGTGGAGCCTATGGAGGGAAAACAGCTGTGCAGCTAGAGTTCATTGCTTATTTATGCTC
AAAAGCTGTTGGGGGAAGACAGGTCAAACTCACCAATACAAGAGAAGAAGATTTTATTACATCTCCCGTTCATATAGGTC
TTGATGCGAAAATAAAACTTGGATCTACAAAAGCTGGAAGGCTTACTGCTACGGAGATAACCTATTTATTTGATGGTGGC
TCATATTCTGATAAAGCTGTAATTATAAGCAGAGCAGCGGGAATAGATTGTACAGGACCTTATAATATTGAAAATGTATG
GTGTGACTCATTATGCATGTATACTAATCATCCTTATGCTGCAGCCTTTAGAGGATTCGGTCATCCTGAACTTACCTTTG
TAATAGAAAGATCGATGGACATTTTAGCAGATAAGCTAGGAATGGATCCCTTAGAATTAAGGTTAAGAAATGCAATTTTA
CCAGGGGATACTAGTGCTACTCAGATCTTGCTTAATAAAAGCAATTTAGGCAATTTACCACAGTGTATACAAAAGCTAAT
TGAATTAATAAATTGGGGAGAAGTAGATGAAGCTGAAACTGAGGACGGTAAAGTTAGGGCTAAAGGTGTAAGCTGCTTCT
GGAAAAATTCAAATACATCTTTAAATGCAGGGGGAGGAGCGGTTCTTACATTTAATTTAGATGGGAGTATTAATCTTATC
TGCGCTGCAGTTGAAATAGGTCAGGGAATTAAAACAGCTTTAGCACAAATATTAGCAGAAAAAATGAAAATGGATGTAGA
TCAAATTCATGTAACAATGGAAGTTAATACTAAGACCAATCCTGAACACTGGAAAACAGCTGCGAGTAGAACTACTTTGC
TAGTTGGAAGAGCAGTTTTAAGGGCAGCAGAGGATGCAATTAATCAACTATGCGATATTGCCGCTGTTGTTCTGGGACGT
TCACCAGTTGAACTGGAGGTTGGTAGAGGAAGAGTATTTTTAAAAGATAACCCTCAAATAGGAATAGAAATTAGTAAAAT
TGCATTCGGGTATATCTTGCCTAATGGGAATTCAATTGGTGCACAAGTTATTGGAAGAGGGAGTTATGCTTTTAATAATC
TAACAACATTAGATCCTAAAACCGGCAAAGGCAATCCAGGGCCTGAATGGACTGTTGGAGCAGCAGCTGTAGAGATAGAG
CTTGATAAAAAAGAATATACTTACAAAATTATAAAAGCTGCTTGTGTTATAGATGCAGGTAAAGTTATTAATGCTGGAGG
AGCAAGAGGTCAAATATCCGGTGGCATGAACTTAGGTTTAAGCTTTGCCAGTCGTGAAGCATTTTTGTTTACAAATAAGG
GCATTGTTCAAAATAAGCAGCTAAGAACATATAATATTATGAGATTAGGAGAAAATCCAGAATATCTTGTAGATTTTGTA
GAAACTCCAAATTTGGATGGTCCATATGGTGCAAGAGGAATTGGAGAATATGGCGTAATTGGAATGCCTGCAGCACTTGG
AAATAGCTTATCCTGTGCAGCAGAAGTACCTCTTAATCAATTGCCGTTGATCCCTGAATTTATATGGAAAGTAAAAGAGG
GAGGACATTAA

Upstream 100 bases:

>100_bases
TGATGTAGTTGTCTTAATGCAAAGATAAGATCACATTCATAATAATTAATTATGATAAATATATTATAAAAGAAAATGAT
ATTATTCCAGGGAGTAATCA

Downstream 100 bases:

>100_bases
TGATTGCATTTAATTTTGAATACTATAAACCTGATTCATTGGATGAGGCGGTAAAGATGTATAAAGAGCTTAGCAAGAGT
GGAAAAGAACCTTTATATTA

Product: xanthine dehydrogenase, molybdenum binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 776; Mature: 776

Protein sequence:

>776_residues
MYDLNIIGKNVPRKESIDKVTGAAKYTNDYEATGLLYARMVTSPYAHAKIKAIEYENSLKTSGVRAVITGEYFPQLVGST
IVDRPPIAIDKVRYNGEPVAVVVADSEIEAKKAAQMIKIEYEPLPVVNSPSEAIKKDSPLVHEKLGDYEIIDEVFPEPNT
NIANRTKIRKGDIKKGWHESEVTVEASFSFPPSDHAAMETRSVTARILPDGRVIIYSCSQAPFAIKKLISHFFNIDPGKV
IVHVPLVGGAYGGKTAVQLEFIAYLCSKAVGGRQVKLTNTREEDFITSPVHIGLDAKIKLGSTKAGRLTATEITYLFDGG
SYSDKAVIISRAAGIDCTGPYNIENVWCDSLCMYTNHPYAAAFRGFGHPELTFVIERSMDILADKLGMDPLELRLRNAIL
PGDTSATQILLNKSNLGNLPQCIQKLIELINWGEVDEAETEDGKVRAKGVSCFWKNSNTSLNAGGGAVLTFNLDGSINLI
CAAVEIGQGIKTALAQILAEKMKMDVDQIHVTMEVNTKTNPEHWKTAASRTTLLVGRAVLRAAEDAINQLCDIAAVVLGR
SPVELEVGRGRVFLKDNPQIGIEISKIAFGYILPNGNSIGAQVIGRGSYAFNNLTTLDPKTGKGNPGPEWTVGAAAVEIE
LDKKEYTYKIIKAACVIDAGKVINAGGARGQISGGMNLGLSFASREAFLFTNKGIVQNKQLRTYNIMRLGENPEYLVDFV
ETPNLDGPYGARGIGEYGVIGMPAALGNSLSCAAEVPLNQLPLIPEFIWKVKEGGH

Sequences:

>Translated_776_residues
MYDLNIIGKNVPRKESIDKVTGAAKYTNDYEATGLLYARMVTSPYAHAKIKAIEYENSLKTSGVRAVITGEYFPQLVGST
IVDRPPIAIDKVRYNGEPVAVVVADSEIEAKKAAQMIKIEYEPLPVVNSPSEAIKKDSPLVHEKLGDYEIIDEVFPEPNT
NIANRTKIRKGDIKKGWHESEVTVEASFSFPPSDHAAMETRSVTARILPDGRVIIYSCSQAPFAIKKLISHFFNIDPGKV
IVHVPLVGGAYGGKTAVQLEFIAYLCSKAVGGRQVKLTNTREEDFITSPVHIGLDAKIKLGSTKAGRLTATEITYLFDGG
SYSDKAVIISRAAGIDCTGPYNIENVWCDSLCMYTNHPYAAAFRGFGHPELTFVIERSMDILADKLGMDPLELRLRNAIL
PGDTSATQILLNKSNLGNLPQCIQKLIELINWGEVDEAETEDGKVRAKGVSCFWKNSNTSLNAGGGAVLTFNLDGSINLI
CAAVEIGQGIKTALAQILAEKMKMDVDQIHVTMEVNTKTNPEHWKTAASRTTLLVGRAVLRAAEDAINQLCDIAAVVLGR
SPVELEVGRGRVFLKDNPQIGIEISKIAFGYILPNGNSIGAQVIGRGSYAFNNLTTLDPKTGKGNPGPEWTVGAAAVEIE
LDKKEYTYKIIKAACVIDAGKVINAGGARGQISGGMNLGLSFASREAFLFTNKGIVQNKQLRTYNIMRLGENPEYLVDFV
ETPNLDGPYGARGIGEYGVIGMPAALGNSLSCAAEVPLNQLPLIPEFIWKVKEGGH
>Mature_776_residues
MYDLNIIGKNVPRKESIDKVTGAAKYTNDYEATGLLYARMVTSPYAHAKIKAIEYENSLKTSGVRAVITGEYFPQLVGST
IVDRPPIAIDKVRYNGEPVAVVVADSEIEAKKAAQMIKIEYEPLPVVNSPSEAIKKDSPLVHEKLGDYEIIDEVFPEPNT
NIANRTKIRKGDIKKGWHESEVTVEASFSFPPSDHAAMETRSVTARILPDGRVIIYSCSQAPFAIKKLISHFFNIDPGKV
IVHVPLVGGAYGGKTAVQLEFIAYLCSKAVGGRQVKLTNTREEDFITSPVHIGLDAKIKLGSTKAGRLTATEITYLFDGG
SYSDKAVIISRAAGIDCTGPYNIENVWCDSLCMYTNHPYAAAFRGFGHPELTFVIERSMDILADKLGMDPLELRLRNAIL
PGDTSATQILLNKSNLGNLPQCIQKLIELINWGEVDEAETEDGKVRAKGVSCFWKNSNTSLNAGGGAVLTFNLDGSINLI
CAAVEIGQGIKTALAQILAEKMKMDVDQIHVTMEVNTKTNPEHWKTAASRTTLLVGRAVLRAAEDAINQLCDIAAVVLGR
SPVELEVGRGRVFLKDNPQIGIEISKIAFGYILPNGNSIGAQVIGRGSYAFNNLTTLDPKTGKGNPGPEWTVGAAAVEIE
LDKKEYTYKIIKAACVIDAGKVINAGGARGQISGGMNLGLSFASREAFLFTNKGIVQNKQLRTYNIMRLGENPEYLVDFV
ETPNLDGPYGARGIGEYGVIGMPAALGNSLSCAAEVPLNQLPLIPEFIWKVKEGGH

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=759, Percent_Identity=25.5599472990777, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI91823271, Length=759, Percent_Identity=26.8774703557312, Blast_Score=203, Evalue=6e-52,
Organism=Escherichia coli, GI1789230, Length=781, Percent_Identity=29.1933418693982, Blast_Score=307, Evalue=2e-84,
Organism=Escherichia coli, GI1789246, Length=827, Percent_Identity=24.7883917775091, Blast_Score=213, Evalue=4e-56,
Organism=Escherichia coli, GI1786478, Length=773, Percent_Identity=19.9223803363519, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17540638, Length=751, Percent_Identity=23.0359520639148, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17539860, Length=734, Percent_Identity=23.0245231607629, Blast_Score=123, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI32566215, Length=745, Percent_Identity=22.8187919463087, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17737937, Length=760, Percent_Identity=24.3421052631579, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24647193, Length=797, Percent_Identity=20.2007528230866, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 84091; Mature: 84091

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDLNIIGKNVPRKESIDKVTGAAKYTNDYEATGLLYARMVTSPYAHAKIKAIEYENSLK
CEEEEEECCCCCCHHHHHHHCCCHHCCCCCCHHHEEEEHHHCCCCCCEEEEEEEECCCCC
TSGVRAVITGEYFPQLVGSTIVDRPPIAIDKVRYNGEPVAVVVADSEIEAKKAAQMIKIE
CCCEEEEEECHHHHHHHCCHHCCCCCCEEEEEEECCCEEEEEEECCCCCHHHCCEEEEEE
YEPLPVVNSPSEAIKKDSPLVHEKLGDYEIIDEVFPEPNTNIANRTKIRKGDIKKGWHES
CCCCCCCCCCHHHHHCCCCHHHHHCCCHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCC
EVTVEASFSFPPSDHAAMETRSVTARILPDGRVIIYSCSQAPFAIKKLISHFFNIDPGKV
EEEEEEEECCCCCCCHHHHHCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCE
IVHVPLVGGAYGGKTAVQLEFIAYLCSKAVGGRQVKLTNTREEDFITSPVHIGLDAKIKL
EEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCEEEEE
GSTKAGRLTATEITYLFDGGSYSDKAVIISRAAGIDCTGPYNIENVWCDSLCMYTNHPYA
CCCCCCEEEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCEECCCEEEECCCCHH
AAFRGFGHPELTFVIERSMDILADKLGMDPLELRLRNAILPGDTSATQILLNKSNLGNLP
HHHCCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCHH
QCIQKLIELINWGEVDEAETEDGKVRAKGVSCFWKNSNTSLNAGGGAVLTFNLDGSINLI
HHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEECCCCEEEEEECCCCCEEE
CAAVEIGQGIKTALAQILAEKMKMDVDQIHVTMEVNTKTNPEHWKTAASRTTLLVGRAVL
EEEEHHCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RAAEDAINQLCDIAAVVLGRSPVELEVGRGRVFLKDNPQIGIEISKIAFGYILPNGNSIG
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEEEEEEEECCCCCCC
AQVIGRGSYAFNNLTTLDPKTGKGNPGPEWTVGAAAVEIELDKKEYTYKIIKAACVIDAG
EEEEECCCEEECCEEECCCCCCCCCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHEEECC
KVINAGGARGQISGGMNLGLSFASREAFLFTNKGIVQNKQLRTYNIMRLGENPEYLVDFV
CEEECCCCCCEECCCCEECEEECCCEEEEEECCCCCCCCCEEEEEEEEECCCHHEEEEEE
ETPNLDGPYGARGIGEYGVIGMPAALGNSLSCAAEVPLNQLPLIPEFIWKVKEGGH
CCCCCCCCCCCCCCCCCCCEECCHHHCCCCCEEECCCCCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MYDLNIIGKNVPRKESIDKVTGAAKYTNDYEATGLLYARMVTSPYAHAKIKAIEYENSLK
CEEEEEECCCCCCHHHHHHHCCCHHCCCCCCHHHEEEEHHHCCCCCCEEEEEEEECCCCC
TSGVRAVITGEYFPQLVGSTIVDRPPIAIDKVRYNGEPVAVVVADSEIEAKKAAQMIKIE
CCCEEEEEECHHHHHHHCCHHCCCCCCEEEEEEECCCEEEEEEECCCCCHHHCCEEEEEE
YEPLPVVNSPSEAIKKDSPLVHEKLGDYEIIDEVFPEPNTNIANRTKIRKGDIKKGWHES
CCCCCCCCCCHHHHHCCCCHHHHHCCCHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCC
EVTVEASFSFPPSDHAAMETRSVTARILPDGRVIIYSCSQAPFAIKKLISHFFNIDPGKV
EEEEEEEECCCCCCCHHHHHCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCE
IVHVPLVGGAYGGKTAVQLEFIAYLCSKAVGGRQVKLTNTREEDFITSPVHIGLDAKIKL
EEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCEEEEE
GSTKAGRLTATEITYLFDGGSYSDKAVIISRAAGIDCTGPYNIENVWCDSLCMYTNHPYA
CCCCCCEEEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCEECCCEEEECCCCHH
AAFRGFGHPELTFVIERSMDILADKLGMDPLELRLRNAILPGDTSATQILLNKSNLGNLP
HHHCCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCHH
QCIQKLIELINWGEVDEAETEDGKVRAKGVSCFWKNSNTSLNAGGGAVLTFNLDGSINLI
HHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEECCCCEEEEEECCCCCEEE
CAAVEIGQGIKTALAQILAEKMKMDVDQIHVTMEVNTKTNPEHWKTAASRTTLLVGRAVL
EEEEHHCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RAAEDAINQLCDIAAVVLGRSPVELEVGRGRVFLKDNPQIGIEISKIAFGYILPNGNSIG
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEEEEEEEECCCCCCC
AQVIGRGSYAFNNLTTLDPKTGKGNPGPEWTVGAAAVEIELDKKEYTYKIIKAACVIDAG
EEEEECCCEEECCEEECCCCCCCCCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHEEECC
KVINAGGARGQISGGMNLGLSFASREAFLFTNKGIVQNKQLRTYNIMRLGENPEYLVDFV
CEEECCCCCCEECCCCEECEEECCCEEEEEECCCCCCCCCEEEEEEEEECCCHHEEEEEE
ETPNLDGPYGARGIGEYGVIGMPAALGNSLSCAAEVPLNQLPLIPEFIWKVKEGGH
CCCCCCCCCCCCCCCCCCCEECCHHHCCCCCEEECCCCCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]