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The map label for this gene is trxA [H]

Identifier: 148361268

GI number: 148361268

Start: 3494302

End: 3494628

Strand: Reverse

Name: trxA [H]

Synonym: LPC_3242

Alternate gene names: 148361268

Gene position: 3494628-3494302 (Counterclockwise)

Preceding gene: 148361269

Following gene: 148361267

Centisome position: 97.71

GC content: 38.23

Gene sequence:

>327_bases
ATGAGTGATCATATTAAAACAGTAACCGATGCAAGCTTTGAGCAGGATGTAATTAATTCATCCAAGCCTGTTCTTGTTGA
TTTTTGGGCTGAGTGGTGTGGACCATGTCGTGCATTGACACCTATTCTGGAAGAAGTGGCAGCCACTCATAGCAAGGATA
TGACGTTTGCTAAAATCAATATCGATGAAAATCCTCAAGCTCCAGCTAAATTTGGTGTGATGAGTATCCCAACTTTGATT
CTTTTTAAAAATGGTCAGGTTGAAGCAGTTAAAATGGGTTTGCTGTCTAAATCCCAATTAAGTGCTTTTGTTGAAAGTAA
TCTGTAA

Upstream 100 bases:

>100_bases
TAAAACAAAACACACAGGATACACAGGAAAGATTTTGGATCGAATAGCATAATCTGGTCTTGGACCAGACCTTTATATTT
CTAATAACTGAGGTTTATTT

Downstream 100 bases:

>100_bases
CGGTATTAAAGATAAAAAGCCCTGAGATGAAAATTTATTTACAGGGCTTTTACTTTTTTATGGGGCTTGTGTTAAAATTA
ACCTACTTAAAGGGATTTTT

Product: hypothetical protein

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDHIKTVTDASFEQDVINSSKPVLVDFWAEWCGPCRALTPILEEVAATHSKDMTFAKINIDENPQAPAKFGVMSIPTLI
LFKNGQVEAVKMGLLSKSQLSAFVESNL

Sequences:

>Translated_108_residues
MSDHIKTVTDASFEQDVINSSKPVLVDFWAEWCGPCRALTPILEEVAATHSKDMTFAKINIDENPQAPAKFGVMSIPTLI
LFKNGQVEAVKMGLLSKSQLSAFVESNL
>Mature_107_residues
SDHIKTVTDASFEQDVINSSKPVLVDFWAEWCGPCRALTPILEEVAATHSKDMTFAKINIDENPQAPAKFGVMSIPTLIL
FKNGQVEAVKMGLLSKSQLSAFVESNL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=38.7096774193548, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=53.7037037037037, Blast_Score=134, Evalue=1e-33,
Organism=Escherichia coli, GI1788936, Length=107, Percent_Identity=37.3831775700935, Blast_Score=88, Evalue=1e-19,
Organism=Escherichia coli, GI87081747, Length=85, Percent_Identity=37.6470588235294, Blast_Score=66, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=104, Percent_Identity=43.2692307692308, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71980562, Length=83, Percent_Identity=39.7590361445783, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=83, Percent_Identity=39.7590361445783, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=85, Percent_Identity=38.8235294117647, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=88, Percent_Identity=35.2272727272727, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=36.046511627907, Blast_Score=67, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=88, Percent_Identity=37.5, Blast_Score=63, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319925, Length=83, Percent_Identity=31.3253012048193, Blast_Score=61, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=39.1752577319588, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24639826, Length=94, Percent_Identity=34.0425531914894, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=35.4838709677419, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21358065, Length=92, Percent_Identity=34.7826086956522, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24664269, Length=69, Percent_Identity=40.5797101449275, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11840; Mature: 11709

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDHIKTVTDASFEQDVINSSKPVLVDFWAEWCGPCRALTPILEEVAATHSKDMTFAKIN
CCCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEE
IDENPQAPAKFGVMSIPTLILFKNGQVEAVKMGLLSKSQLSAFVESNL
CCCCCCCCCCCCHHCCCEEEEEECCCEEEHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure 
SDHIKTVTDASFEQDVINSSKPVLVDFWAEWCGPCRALTPILEEVAATHSKDMTFAKIN
CCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEE
IDENPQAPAKFGVMSIPTLILFKNGQVEAVKMGLLSKSQLSAFVESNL
CCCCCCCCCCCCHHCCCEEEEEECCCEEEHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]