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The map label for this gene is coxB [H]

Identifier: 148361222

GI number: 148361222

Start: 3454598

End: 3455803

Strand: Reverse

Name: coxB [H]

Synonym: LPC_3196

Alternate gene names: 148361222

Gene position: 3455803-3454598 (Counterclockwise)

Preceding gene: 148361223

Following gene: 148361221

Centisome position: 96.63

GC content: 43.2

Gene sequence:

>1206_bases
ATGTTAAACAGGTTAAAAATCTGTAAATTAATTGCGTTACTTAGTGCCTGGACTTCCGCGCAGTCGCTGTGGGCTGCTGC
GGATGAGTGGCAGTTAAACATGTACAAAGGGGTGACTCCTTTAAGTAACGATATGTATTACCTTCACATGGTCGCTATGG
CTGTTTGTGCAGTAATAGGAGTGGTTGTTTTTGGTGTGATGATCTACTCATTAATTCATCACAGAAAATCAAAAGGATAC
CAGCCTGCATCTTTTCATGATAATCCAAAATTGGAAATCATCTGGACTATTATCCCGTTTCTAATTCTTGTCGGGCTCGC
AGTTCCAGCTACCCGAGTACTAATCCGTATGGATGATACGCAGTTGTCCGATGTGACGGTCAAGGTGGTCGGCTATCAGT
GGAAATGGCAATACCAGTATCTTGATCAGGGTATTAGCTACTTCAGCAGCCTATCGACACCCTATGAGCAAATTGAAAAC
AAGCAAAAGAAAAATCAGTGGTACTTGCTGGAAGTAGATAATCCTTTAGTCGTACCAGTCAACAAAAAAATTCGATTTTT
AGTGACATCGAACGATGTAGTCCACTCATGGTGGGTGCCTGAGCTGGGCGTCAAGCGAGACGCTATCCCGGGATTTATGC
ATGAGGCATGGGCCAGAATTGAAAAGCCTGGTGTATACAGAGGTCAATGCGCCGAGCTTTGCGGAATTAATCATGGTTTT
ATGCCTATCGTAGTGAAAGCAGTTAGTGAAGAAGAATTCGATCGATGGGTTAGTGAGCAAACCAAAGTAGAAGATATTTA
TGCTGAAAAGTCGGATAAACCGCGTGAACAAAAAACAATGACCCGTGATCAGTTAATGACGCTTGGCAAGCAAAAATACG
ATCTGATTTGCTCAGCTTGTCATCAGCCTAATGGCACTGGCTTGCCACCAATGTACCCTCCTCTCAAGGGTAGTTCTGTT
GCCGTTGGAAAGCCAATTTCACGACACATTGAATTACTCCTCAATGGTGTTCCTGGCTCAGCAATGCAGTCTTATAAAGA
TCAACTGACTGATGAGGAAATAGCAGCCATTGTTACGTATGAGCGTAATGCTTGGGGAAATAATACTAATGATTTAATTC
AACCCGCAGATGTTGCGGCACTGCGACATGGTACCGATACTAAACCTACCATGGTTAATAAAGCTAAAGCTGGAGGTTTG
CAATGA

Upstream 100 bases:

>100_bases
GTAATTATTCTTTGTGGTAGGGTTACCAGCAACATTTGAATAAATGAACTAGCTTAAACATTAGTCGGTTTCCGGCTACT
TGAAGAGATGAGGGATTGGG

Downstream 100 bases:

>100_bases
AATACGCAATAGCGCATTCAGAAGATTCTCATGAAGATCATGGTCCCGAACAAGGCAAAGGCTTTATGGGATTTGTCAAA
AGGTGGCTATTTACAACCAA

Product: cytochrome c oxidase subunit II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MLNRLKICKLIALLSAWTSAQSLWAAADEWQLNMYKGVTPLSNDMYYLHMVAMAVCAVIGVVVFGVMIYSLIHHRKSKGY
QPASFHDNPKLEIIWTIIPFLILVGLAVPATRVLIRMDDTQLSDVTVKVVGYQWKWQYQYLDQGISYFSSLSTPYEQIEN
KQKKNQWYLLEVDNPLVVPVNKKIRFLVTSNDVVHSWWVPELGVKRDAIPGFMHEAWARIEKPGVYRGQCAELCGINHGF
MPIVVKAVSEEEFDRWVSEQTKVEDIYAEKSDKPREQKTMTRDQLMTLGKQKYDLICSACHQPNGTGLPPMYPPLKGSSV
AVGKPISRHIELLLNGVPGSAMQSYKDQLTDEEIAAIVTYERNAWGNNTNDLIQPADVAALRHGTDTKPTMVNKAKAGGL
Q

Sequences:

>Translated_401_residues
MLNRLKICKLIALLSAWTSAQSLWAAADEWQLNMYKGVTPLSNDMYYLHMVAMAVCAVIGVVVFGVMIYSLIHHRKSKGY
QPASFHDNPKLEIIWTIIPFLILVGLAVPATRVLIRMDDTQLSDVTVKVVGYQWKWQYQYLDQGISYFSSLSTPYEQIEN
KQKKNQWYLLEVDNPLVVPVNKKIRFLVTSNDVVHSWWVPELGVKRDAIPGFMHEAWARIEKPGVYRGQCAELCGINHGF
MPIVVKAVSEEEFDRWVSEQTKVEDIYAEKSDKPREQKTMTRDQLMTLGKQKYDLICSACHQPNGTGLPPMYPPLKGSSV
AVGKPISRHIELLLNGVPGSAMQSYKDQLTDEEIAAIVTYERNAWGNNTNDLIQPADVAALRHGTDTKPTMVNKAKAGGL
Q
>Mature_401_residues
MLNRLKICKLIALLSAWTSAQSLWAAADEWQLNMYKGVTPLSNDMYYLHMVAMAVCAVIGVVVFGVMIYSLIHHRKSKGY
QPASFHDNPKLEIIWTIIPFLILVGLAVPATRVLIRMDDTQLSDVTVKVVGYQWKWQYQYLDQGISYFSSLSTPYEQIEN
KQKKNQWYLLEVDNPLVVPVNKKIRFLVTSNDVVHSWWVPELGVKRDAIPGFMHEAWARIEKPGVYRGQCAELCGINHGF
MPIVVKAVSEEEFDRWVSEQTKVEDIYAEKSDKPREQKTMTRDQLMTLGKQKYDLICSACHQPNGTGLPPMYPPLKGSSV
AVGKPISRHIELLLNGVPGSAMQSYKDQLTDEEIAAIVTYERNAWGNNTNDLIQPADVAALRHGTDTKPTMVNKAKAGGL
Q

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=168, Percent_Identity=42.8571428571429, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1786635, Length=236, Percent_Identity=23.728813559322, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6226540, Length=223, Percent_Identity=36.322869955157, Blast_Score=144, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 45284; Mature: 45284

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA ; PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNRLKICKLIALLSAWTSAQSLWAAADEWQLNMYKGVTPLSNDMYYLHMVAMAVCAVIG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCCCHHHHHHHHHHHHHHHH
VVVFGVMIYSLIHHRKSKGYQPASFHDNPKLEIIWTIIPFLILVGLAVPATRVLIRMDDT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCHHEEEEEECCC
QLSDVTVKVVGYQWKWQYQYLDQGISYFSSLSTPYEQIENKQKKNQWYLLEVDNPLVVPV
CCCCEEEEEEEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCEEEEC
NKKIRFLVTSNDVVHSWWVPELGVKRDAIPGFMHEAWARIEKPGVYRGQCAELCGINHGF
CCCEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCCCH
MPIVVKAVSEEEFDRWVSEQTKVEDIYAEKSDKPREQKTMTRDQLMTLGKQKYDLICSAC
HHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
HQPNGTGLPPMYPPLKGSSVAVGKPISRHIELLLNGVPGSAMQSYKDQLTDEEIAAIVTY
CCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEE
ERNAWGNNTNDLIQPADVAALRHGTDTKPTMVNKAKAGGLQ
ECCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHCCCCCCCCC
>Mature Secondary Structure
MLNRLKICKLIALLSAWTSAQSLWAAADEWQLNMYKGVTPLSNDMYYLHMVAMAVCAVIG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCCCHHHHHHHHHHHHHHHH
VVVFGVMIYSLIHHRKSKGYQPASFHDNPKLEIIWTIIPFLILVGLAVPATRVLIRMDDT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCHHEEEEEECCC
QLSDVTVKVVGYQWKWQYQYLDQGISYFSSLSTPYEQIENKQKKNQWYLLEVDNPLVVPV
CCCCEEEEEEEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCEEEEC
NKKIRFLVTSNDVVHSWWVPELGVKRDAIPGFMHEAWARIEKPGVYRGQCAELCGINHGF
CCCEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCCCH
MPIVVKAVSEEEFDRWVSEQTKVEDIYAEKSDKPREQKTMTRDQLMTLGKQKYDLICSAC
HHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
HQPNGTGLPPMYPPLKGSSVAVGKPISRHIELLLNGVPGSAMQSYKDQLTDEEIAAIVTY
CCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEE
ERNAWGNNTNDLIQPADVAALRHGTDTKPTMVNKAKAGGLQ
ECCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA