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The map label for this gene is guaC [H]

Identifier: 148361153

GI number: 148361153

Start: 3385866

End: 3386879

Strand: Direct

Name: guaC [H]

Synonym: LPC_3127

Alternate gene names: 148361153

Gene position: 3385866-3386879 (Clockwise)

Preceding gene: 148361152

Following gene: 148361155

Centisome position: 94.67

GC content: 46.35

Gene sequence:

>1014_bases
ATGACTGATCAAGCGATCACTTTTGATGATGTTTTGCTCGTTCCATCGTACAACCATCATGAATCCAGGCGAGTTGTAGA
AACAACCAGTACCGACAGGTTAGGTAAACTGACTTTAAATCTTCCGGTAATCAGCGCTAATATGGATACAATTACCGAAA
GCAATATGGCTAATTTTATGCACAGTAAAGGAGCCATGGGCGCTTTACATCGCTTTATGACCATAGAAGAAAATATTCAG
GAATTTAAGAAATGCAAAGGACCTGTCTTTGTATCAGTTGGGTGCACTGAAAATGAATTACAAAGAGCAGAAGCACTACG
GGATGCAGGAGCCGATTTTTTTTGTGTTGATGTGGCACATGCCCACGCCAAATACGTCGGCAAAACATTAAAAAGCTTAC
GTCAGTTATTAGGAAGCCGCTGCATTATGGCTGGGAATGTCGCCACTTATGCCGGGGCAGATTATCTTGCGTCTTGTGGC
GCTGATATTATTAAAGCGGGTATTGGAGGAGGCTCAGTATGCAGCACCCGAATTAAAACCGGCTTTGGCGTACCCATGTT
GACCTGTATTCAGGATTGTTCACGTGCCGATCGTTCCATCGTTGCTGATGGCGGCATCAAAACATCGGGTGATATCGTCA
AAGCATTGGCCTTTGGCGCTGATTTTGTGATGATAGGCGGCATGTTAGCCGGCTCTGCCCCCACGCCAGGAGAGGTCATT
CAAAAAGATGACGGAAGCAAAGTCAAACGCTATCGAGGCATGGCATCCCGAGAAGCCCAGGAAGCATTCCTTGGACAAAT
GCATGAATGGAAAACAGCAGAAGGTGTTGCGACTGAAGTACCATTTAGAGAAAACCCTGATGGCATTATTGCTGATATAG
TGGGGGGATTGCGTTCTGGGCTTACCTATGCCGGCGCCGACTCCATCAGCGAATTGCAAAGAAAATTGAACTATGTGATT
GTCACCCAGGCTGGGCGCCTAGAAAGCTTGCCTCACAAGTTGTTGGAAGGGTAA

Upstream 100 bases:

>100_bases
TGGGAACACAGCGCTCATATGACTTTGACTCGGGGAGAGCGCTCAAGGCTGGCATTTTATGCGGCTGAGCATTTATAGTA
TTTGTTTATGAGGATTAATA

Downstream 100 bases:

>100_bases
CCAACCGACTGGTCAATCTATATTACCCTCCGCCACCAGTCATAGTTGGAGTAGTGGGCTGAACATCAGGGATTTGGCCT
GAGTCAGGGGTTTGACTATT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTDQAITFDDVLLVPSYNHHESRRVVETTSTDRLGKLTLNLPVISANMDTITESNMANFMHSKGAMGALHRFMTIEENIQ
EFKKCKGPVFVSVGCTENELQRAEALRDAGADFFCVDVAHAHAKYVGKTLKSLRQLLGSRCIMAGNVATYAGADYLASCG
ADIIKAGIGGGSVCSTRIKTGFGVPMLTCIQDCSRADRSIVADGGIKTSGDIVKALAFGADFVMIGGMLAGSAPTPGEVI
QKDDGSKVKRYRGMASREAQEAFLGQMHEWKTAEGVATEVPFRENPDGIIADIVGGLRSGLTYAGADSISELQRKLNYVI
VTQAGRLESLPHKLLEG

Sequences:

>Translated_337_residues
MTDQAITFDDVLLVPSYNHHESRRVVETTSTDRLGKLTLNLPVISANMDTITESNMANFMHSKGAMGALHRFMTIEENIQ
EFKKCKGPVFVSVGCTENELQRAEALRDAGADFFCVDVAHAHAKYVGKTLKSLRQLLGSRCIMAGNVATYAGADYLASCG
ADIIKAGIGGGSVCSTRIKTGFGVPMLTCIQDCSRADRSIVADGGIKTSGDIVKALAFGADFVMIGGMLAGSAPTPGEVI
QKDDGSKVKRYRGMASREAQEAFLGQMHEWKTAEGVATEVPFRENPDGIIADIVGGLRSGLTYAGADSISELQRKLNYVI
VTQAGRLESLPHKLLEG
>Mature_336_residues
TDQAITFDDVLLVPSYNHHESRRVVETTSTDRLGKLTLNLPVISANMDTITESNMANFMHSKGAMGALHRFMTIEENIQE
FKKCKGPVFVSVGCTENELQRAEALRDAGADFFCVDVAHAHAKYVGKTLKSLRQLLGSRCIMAGNVATYAGADYLASCGA
DIIKAGIGGGSVCSTRIKTGFGVPMLTCIQDCSRADRSIVADGGIKTSGDIVKALAFGADFVMIGGMLAGSAPTPGEVIQ
KDDGSKVKRYRGMASREAQEAFLGQMHEWKTAEGVATEVPFRENPDGIIADIVGGLRSGLTYAGADSISELQRKLNYVIV
TQAGRLESLPHKLLEG

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541954, Length=335, Percent_Identity=37.6119402985075, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI50541952, Length=335, Percent_Identity=37.6119402985075, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI50541948, Length=335, Percent_Identity=37.6119402985075, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI50541956, Length=334, Percent_Identity=37.7245508982036, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI156104880, Length=333, Percent_Identity=37.5375375375375, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI217035146, Length=238, Percent_Identity=31.9327731092437, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI217035152, Length=238, Percent_Identity=31.9327731092437, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI217035148, Length=238, Percent_Identity=31.9327731092437, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI34328930, Length=238, Percent_Identity=31.9327731092437, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI217035150, Length=238, Percent_Identity=31.9327731092437, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI34328928, Length=238, Percent_Identity=31.9327731092437, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI156616279, Length=238, Percent_Identity=31.9327731092437, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI66933016, Length=233, Percent_Identity=29.6137339055794, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1786293, Length=335, Percent_Identity=34.9253731343284, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1788855, Length=252, Percent_Identity=38.4920634920635, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17560440, Length=335, Percent_Identity=33.134328358209, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71994385, Length=226, Percent_Identity=32.7433628318584, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71994389, Length=171, Percent_Identity=36.2573099415205, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323585, Length=263, Percent_Identity=30.0380228136882, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6323464, Length=263, Percent_Identity=29.6577946768061, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6322012, Length=263, Percent_Identity=29.6577946768061, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28571163, Length=267, Percent_Identity=29.9625468164794, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24641071, Length=267, Percent_Identity=29.9625468164794, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24641073, Length=267, Percent_Identity=29.9625468164794, Blast_Score=111, Evalue=7e-25,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 36058; Mature: 35926

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQAITFDDVLLVPSYNHHESRRVVETTSTDRLGKLTLNLPVISANMDTITESNMANFM
CCCCEEEECCEEEECCCCCCCCCEEEECCCCCCCEEEEEECEEEECCCHHHHHHHHHHHH
HSKGAMGALHRFMTIEENIQEFKKCKGPVFVSVGCTENELQRAEALRDAGADFFCVDVAH
HCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEHHHH
AHAKYVGKTLKSLRQLLGSRCIMAGNVATYAGADYLASCGADIIKAGIGGGSVCSTRIKT
HHHHHHHHHHHHHHHHHHCCCEEECCCHHHCCHHHHHHCCHHHHHHCCCCCHHHHHHHHC
GFGVPMLTCIQDCSRADRSIVADGGIKTSGDIVKALAFGADFVMIGGMLAGSAPTPGEVI
CCCCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
QKDDGSKVKRYRGMASREAQEAFLGQMHEWKTAEGVATEVPFRENPDGIIADIVGGLRSG
CCCCCHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHHHHHHC
LTYAGADSISELQRKLNYVIVTQAGRLESLPHKLLEG
CCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHCC
>Mature Secondary Structure 
TDQAITFDDVLLVPSYNHHESRRVVETTSTDRLGKLTLNLPVISANMDTITESNMANFM
CCCEEEECCEEEECCCCCCCCCEEEECCCCCCCEEEEEECEEEECCCHHHHHHHHHHHH
HSKGAMGALHRFMTIEENIQEFKKCKGPVFVSVGCTENELQRAEALRDAGADFFCVDVAH
HCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEHHHH
AHAKYVGKTLKSLRQLLGSRCIMAGNVATYAGADYLASCGADIIKAGIGGGSVCSTRIKT
HHHHHHHHHHHHHHHHHHCCCEEECCCHHHCCHHHHHHCCHHHHHHCCCCCHHHHHHHHC
GFGVPMLTCIQDCSRADRSIVADGGIKTSGDIVKALAFGADFVMIGGMLAGSAPTPGEVI
CCCCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
QKDDGSKVKRYRGMASREAQEAFLGQMHEWKTAEGVATEVPFRENPDGIIADIVGGLRSG
CCCCCHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHHHHHHC
LTYAGADSISELQRKLNYVIVTQAGRLESLPHKLLEG
CCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA