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The map label for this gene is dnaZX [H]

Identifier: 148361067

GI number: 148361067

Start: 3281333

End: 3283003

Strand: Direct

Name: dnaZX [H]

Synonym: LPC_3037

Alternate gene names: 148361067

Gene position: 3281333-3283003 (Clockwise)

Preceding gene: 148358517

Following gene: 148361068

Centisome position: 91.75

GC content: 41.41

Gene sequence:

>1671_bases
ATGAGCTATCTGGCACTTGCCCGTAAATGGCGACCACGCACATTTTCCCAACTGGTTGGCCAAGAGCATATTAATAAAGC
ACTGATCAACGCGCTGAATCAACAACGTTTGCATCATGCTTATCTATTTACTGGTACTCGCGGGGTCGGGAAAACCAGCG
TCGCCCGTATTTTAGCTAAAGCCCTCAATTGTGAAAAAGGCATCACCTCAGAACCATGCCTTCATTGCGATACCTGTGTT
GCCATTGAGCAAGGCCGTTATATTGATCTCATTGAAATAGACGGAGCCTCCAAAACCAGAGTTGAAGACACGCGAGATTT
ACTTGACAACATACAATATGCACCGACAAATGGCCGTTTTAAAATTTATCTAATTGATGAAGTGCATATGCTATCCCAGC
ATAGCTTTAATGCTTTACTAAAAACATTAGAAGAACCGCCTTCGCATGTGAAATTTATTCTGGCAACGACTGACCCACAA
AAATTACCTGTTACTGTCTTATCGCGTTGTTTGCAATTTAATCTAAAACACTTGCCTGCTGAGTTGATAAATCAACAATT
GCAATTAATTCTCCAAGAGGAGCGCTTGGATTTTGAAATACAAGCGCTAGACATATTGGCTCAGGCTGCCCGCGGAAGCA
TGCGCGATGCATTAAGTTTATTGGATCAGGCCATTACCAGTTGTGAAACGAAATTGCTGGCAAGTGATGTAAAAATGCTC
TTGGGACATACCCAACAAGATTACGCGTTGCTGCTCTTGCAAGCCCTGGCCAAGCAAGAAGCGCCAATCATGCTTGTATT
AAGTCAGCAAATTATTGCCGAAGGAGGGAATTTTCAATACGTTCTTGATGAAATGCTTAACTATCTGCATCAAATTACCG
TATATCAATGCCTGGGCGACAACAATCCATTAATTAGTCCAAAAGCTGAAATTAAAGAATTAGCAAAACAGTTTTCGGCC
GAGGACACACAATTATTCTATCAAATAGGTATTAAGGGACGTGAGGAGATGCATCTCGCCCCTACGCTGGCCATTGGCTT
TAATATGACCATGCTGCGCATGTATACCTTTAAACCAGCTTCTCATGTAACAACACCTCCATTAGCATTCGAGCAAAATA
ATAAAACATGCTCACTAATTGTTGATGATAATACACCAGCCCAAAACCCTATTGGAATTGAACCAATACCCGTTACTAAA
GCGACGGACAACACCGTTGCCTATCATCAGACCCAATCATTATCAACAGACGATAAAAAATCTGCCAACTCTGGTGAGTC
CATGAACTGTGACTGGAACGACATAATACCACAGTTAAAATTATCGGGTTTAGCACTTAATGCCATAGAAAATGCAGAAT
TTCTTGGTAAAAAAGAGCGAGAAATTACATTGGGAGTACAGAAAGGGCACCAGTCCTTATTCACTCCCACAGCGATTAAC
CGAATTGAAACCGCATTGGCCGGGTATTATAAAAGTCCCGTAAAAATTATTTTAAACAGTCAAGATGCCGTGCATGCCTC
TCCAGCTCAACAGAAAGAGAAAGCGACCCAAGAAAAGCAAGAACAAGCAGAGGCAGCATTACACGCTGACCCGGTATTTC
AACAGTTAAAACAAGAATTTTCAGCAGAATTGGTCAAAAATTCTATTGTCCTGTTAAAAGATGACTTATAA

Upstream 100 bases:

>100_bases
GATTGTGAACCCCGTCAGGCCCGGAAGGGAGCAGCGGTAGCAATTGATGCGGGCGCCGGGGTGTGGCTCTTAGAGTCGCC
GCCCAACTTGTGAAACACGT

Downstream 100 bases:

>100_bases
TACTTAAACTAACCATAAATAGACGAGGCTGTAATGGATATTAATCAAAATTTAGGCAATTTAATGAAAGAAGCGCAAAA
AATGCAACAACGTATGCAAG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MSYLALARKWRPRTFSQLVGQEHINKALINALNQQRLHHAYLFTGTRGVGKTSVARILAKALNCEKGITSEPCLHCDTCV
AIEQGRYIDLIEIDGASKTRVEDTRDLLDNIQYAPTNGRFKIYLIDEVHMLSQHSFNALLKTLEEPPSHVKFILATTDPQ
KLPVTVLSRCLQFNLKHLPAELINQQLQLILQEERLDFEIQALDILAQAARGSMRDALSLLDQAITSCETKLLASDVKML
LGHTQQDYALLLLQALAKQEAPIMLVLSQQIIAEGGNFQYVLDEMLNYLHQITVYQCLGDNNPLISPKAEIKELAKQFSA
EDTQLFYQIGIKGREEMHLAPTLAIGFNMTMLRMYTFKPASHVTTPPLAFEQNNKTCSLIVDDNTPAQNPIGIEPIPVTK
ATDNTVAYHQTQSLSTDDKKSANSGESMNCDWNDIIPQLKLSGLALNAIENAEFLGKKEREITLGVQKGHQSLFTPTAIN
RIETALAGYYKSPVKIILNSQDAVHASPAQQKEKATQEKQEQAEAALHADPVFQQLKQEFSAELVKNSIVLLKDDL

Sequences:

>Translated_556_residues
MSYLALARKWRPRTFSQLVGQEHINKALINALNQQRLHHAYLFTGTRGVGKTSVARILAKALNCEKGITSEPCLHCDTCV
AIEQGRYIDLIEIDGASKTRVEDTRDLLDNIQYAPTNGRFKIYLIDEVHMLSQHSFNALLKTLEEPPSHVKFILATTDPQ
KLPVTVLSRCLQFNLKHLPAELINQQLQLILQEERLDFEIQALDILAQAARGSMRDALSLLDQAITSCETKLLASDVKML
LGHTQQDYALLLLQALAKQEAPIMLVLSQQIIAEGGNFQYVLDEMLNYLHQITVYQCLGDNNPLISPKAEIKELAKQFSA
EDTQLFYQIGIKGREEMHLAPTLAIGFNMTMLRMYTFKPASHVTTPPLAFEQNNKTCSLIVDDNTPAQNPIGIEPIPVTK
ATDNTVAYHQTQSLSTDDKKSANSGESMNCDWNDIIPQLKLSGLALNAIENAEFLGKKEREITLGVQKGHQSLFTPTAIN
RIETALAGYYKSPVKIILNSQDAVHASPAQQKEKATQEKQEQAEAALHADPVFQQLKQEFSAELVKNSIVLLKDDL
>Mature_555_residues
SYLALARKWRPRTFSQLVGQEHINKALINALNQQRLHHAYLFTGTRGVGKTSVARILAKALNCEKGITSEPCLHCDTCVA
IEQGRYIDLIEIDGASKTRVEDTRDLLDNIQYAPTNGRFKIYLIDEVHMLSQHSFNALLKTLEEPPSHVKFILATTDPQK
LPVTVLSRCLQFNLKHLPAELINQQLQLILQEERLDFEIQALDILAQAARGSMRDALSLLDQAITSCETKLLASDVKMLL
GHTQQDYALLLLQALAKQEAPIMLVLSQQIIAEGGNFQYVLDEMLNYLHQITVYQCLGDNNPLISPKAEIKELAKQFSAE
DTQLFYQIGIKGREEMHLAPTLAIGFNMTMLRMYTFKPASHVTTPPLAFEQNNKTCSLIVDDNTPAQNPIGIEPIPVTKA
TDNTVAYHQTQSLSTDDKKSANSGESMNCDWNDIIPQLKLSGLALNAIENAEFLGKKEREITLGVQKGHQSLFTPTAINR
IETALAGYYKSPVKIILNSQDAVHASPAQQKEKATQEKQEQAEAALHADPVFQQLKQEFSAELVKNSIVLLKDDL

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=261, Percent_Identity=24.5210727969349, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194306571, Length=251, Percent_Identity=24.3027888446215, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI194306567, Length=251, Percent_Identity=24.3027888446215, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786676, Length=370, Percent_Identity=55.9459459459459, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1787341, Length=146, Percent_Identity=30.1369863013699, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71986063, Length=328, Percent_Identity=23.1707317073171, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17554730, Length=220, Percent_Identity=28.1818181818182, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324039, Length=232, Percent_Identity=26.2931034482759, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 62074; Mature: 61943

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLALARKWRPRTFSQLVGQEHINKALINALNQQRLHHAYLFTGTRGVGKTSVARILAK
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHH
ALNCEKGITSEPCLHCDTCVAIEQGRYIDLIEIDGASKTRVEDTRDLLDNIQYAPTNGRF
HHCCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCEECCCCCCE
KIYLIDEVHMLSQHSFNALLKTLEEPPSHVKFILATTDPQKLPVTVLSRCLQFNLKHLPA
EEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCH
ELINQQLQLILQEERLDFEIQALDILAQAARGSMRDALSLLDQAITSCETKLLASDVKML
HHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGHTQQDYALLLLQALAKQEAPIMLVLSQQIIAEGGNFQYVLDEMLNYLHQITVYQCLGD
HCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECC
NNPLISPKAEIKELAKQFSAEDTQLFYQIGIKGREEMHLAPTLAIGFNMTMLRMYTFKPA
CCCCCCCHHHHHHHHHHHCCCHHEEEEEECCCCCCCEEECEEEEECCCEEEEEEEEECCC
SHVTTPPLAFEQNNKTCSLIVDDNTPAQNPIGIEPIPVTKATDNTVAYHQTQSLSTDDKK
CCCCCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
SANSGESMNCDWNDIIPQLKLSGLALNAIENAEFLGKKEREITLGVQKGHQSLFTPTAIN
CCCCCCCCCCCHHHHCHHHHHCCEEEHHHHCHHHCCCCCCEEEEEHHHCCCHHCCHHHHH
RIETALAGYYKSPVKIILNSQDAVHASPAQQKEKATQEKQEQAEAALHADPVFQQLKQEF
HHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SAELVKNSIVLLKDDL
HHHHHHCCEEEEECCC
>Mature Secondary Structure 
SYLALARKWRPRTFSQLVGQEHINKALINALNQQRLHHAYLFTGTRGVGKTSVARILAK
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHH
ALNCEKGITSEPCLHCDTCVAIEQGRYIDLIEIDGASKTRVEDTRDLLDNIQYAPTNGRF
HHCCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCEECCCCCCE
KIYLIDEVHMLSQHSFNALLKTLEEPPSHVKFILATTDPQKLPVTVLSRCLQFNLKHLPA
EEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCH
ELINQQLQLILQEERLDFEIQALDILAQAARGSMRDALSLLDQAITSCETKLLASDVKML
HHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGHTQQDYALLLLQALAKQEAPIMLVLSQQIIAEGGNFQYVLDEMLNYLHQITVYQCLGD
HCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECC
NNPLISPKAEIKELAKQFSAEDTQLFYQIGIKGREEMHLAPTLAIGFNMTMLRMYTFKPA
CCCCCCCHHHHHHHHHHHCCCHHEEEEEECCCCCCCEEECEEEEECCCEEEEEEEEECCC
SHVTTPPLAFEQNNKTCSLIVDDNTPAQNPIGIEPIPVTKATDNTVAYHQTQSLSTDDKK
CCCCCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
SANSGESMNCDWNDIIPQLKLSGLALNAIENAEFLGKKEREITLGVQKGHQSLFTPTAIN
CCCCCCCCCCCHHHHCHHHHHCCEEEHHHHCHHHCCCCCCEEEEEHHHCCCHHCCHHHHH
RIETALAGYYKSPVKIILNSQDAVHASPAQQKEKATQEKQEQAEAALHADPVFQQLKQEF
HHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SAELVKNSIVLLKDDL
HHHHHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]