Click here to switch to the map view.

The map label for this gene is argG [H]

Identifier: 148360892

GI number: 148360892

Start: 582909

End: 584126

Strand: Direct

Name: argG [H]

Synonym: LPC_2852

Alternate gene names: 148360892

Gene position: 582909-584126 (Clockwise)

Preceding gene: 148360893

Following gene: 148360891

Centisome position: 16.3

GC content: 40.48

Gene sequence:

>1218_bases
ATGAAAAAGGTTATTAAAAAAATCGCATTAGCTTATTCAGGTGGCTTGGATACCTCCATCATGATCCCTTGGCTTAAAGA
GCATTATGAGCATGCTGAAGTAATCGCTGTGATTTGTGATTTAGGGCAACAGGAAGATCTCGATACCATAAAAAATAAAG
CACTAAAAAGCGGCGCTTCCAAAGCGTATGTAGTCGATGTGAAGAATGAGTTTGCCATTCAATATCTTTGGCCTTTGGTA
AAATCAGGTGCTTTATATGAAGATCAATACATTTTGGGCACTATTTCAAGGCCACTAATTGCTCAAAAACTTGTTGAAAT
TGCTTTGACGGAGCAAGTAAATGCCGTTGCACATGGAGCCACCGGTAAAGGGAATGATCAAGTGCGTTTTGAATATTCGA
TTAAGGCACTTGCACCTCAGCTTGAAATTATTGCTCCCTGGAGAACTTGGGATATTAAATCAAGACAGGAAGCAATTGTG
TATGCTAAAGCGCATGGCATTGAGGTACCAGTGACTCCCAAAGCGCCTTATTCTAGAGATCATAACATTTGGTATATTTC
TCATGAAGGTGGTGTGCTCGAAGATCCTTCTCAGGAAATGCCGGATGACGTGTTATTAATGACTGCTCCTGTATCACAGA
CTCCTGATGAAGAGGAAGTGGTTGTTCTTGATTTCAAAAAGGGGGTTCCAGTCGCCTTAAATGGACAAGAACTTTCTCCA
GTGGATCTCTTAAATTCATTAAATCAAAAAGCAGGGCAGCATGGTATTGGAGTGGCGGACATTGTTGAAAATCGATTAGT
TGGAATGAAAATTCGAGGGATTTATGAAGCACCTGCTGCTGCCGTGCTTTATAAGGCACATAAACTTTTGGAGAGTTTAT
GTCTCACTCGTTCTACGTTACATCTGAAGCAATCTTTGCAGCAAACTTATGCCAATTTGGTTTATGAAGGAAGATGGTTT
TCTCAAACCAAACAGGCTTTGGATGCATTCATTGATGTGACGCAGCAGCATGTCACAGGCTGTGTTAAGTTAAAGTTATT
CAAAGGAAACATTATCCCTGCCGGTATGCATTCTCCCTATAGCTTGCATCATCCCGAATTGGCTACTTTTGAAGAGGATA
ATGTATACAACCAAAAGGACGCTGAAGGATTCATTAACCTCTTTTCTTTATCCGCTAAAATCTATAGCCAGGTACATCAG
GAGGGGAATTATGACTAA

Upstream 100 bases:

>100_bases
TGTTGGTTGTAAAGCAAGGGCAACTAATTGCTGACTTTAAAACCCAAGAGGTGTCTGATCCTATTTTATATCTACAGCAG
TTTTACCAGGGGGAAATATT

Downstream 100 bases:

>100_bases
TAAGACATGGGGAGGGCGATTTAAGAAATCTTTGGATAGCGGTGTCAACCAGTTTAATGCGTCATTGTCTTTTGATCATG
TGCTTTTTGACCAAGACATT

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKKVIKKIALAYSGGLDTSIMIPWLKEHYEHAEVIAVICDLGQQEDLDTIKNKALKSGASKAYVVDVKNEFAIQYLWPLV
KSGALYEDQYILGTISRPLIAQKLVEIALTEQVNAVAHGATGKGNDQVRFEYSIKALAPQLEIIAPWRTWDIKSRQEAIV
YAKAHGIEVPVTPKAPYSRDHNIWYISHEGGVLEDPSQEMPDDVLLMTAPVSQTPDEEEVVVLDFKKGVPVALNGQELSP
VDLLNSLNQKAGQHGIGVADIVENRLVGMKIRGIYEAPAAAVLYKAHKLLESLCLTRSTLHLKQSLQQTYANLVYEGRWF
SQTKQALDAFIDVTQQHVTGCVKLKLFKGNIIPAGMHSPYSLHHPELATFEEDNVYNQKDAEGFINLFSLSAKIYSQVHQ
EGNYD

Sequences:

>Translated_405_residues
MKKVIKKIALAYSGGLDTSIMIPWLKEHYEHAEVIAVICDLGQQEDLDTIKNKALKSGASKAYVVDVKNEFAIQYLWPLV
KSGALYEDQYILGTISRPLIAQKLVEIALTEQVNAVAHGATGKGNDQVRFEYSIKALAPQLEIIAPWRTWDIKSRQEAIV
YAKAHGIEVPVTPKAPYSRDHNIWYISHEGGVLEDPSQEMPDDVLLMTAPVSQTPDEEEVVVLDFKKGVPVALNGQELSP
VDLLNSLNQKAGQHGIGVADIVENRLVGMKIRGIYEAPAAAVLYKAHKLLESLCLTRSTLHLKQSLQQTYANLVYEGRWF
SQTKQALDAFIDVTQQHVTGCVKLKLFKGNIIPAGMHSPYSLHHPELATFEEDNVYNQKDAEGFINLFSLSAKIYSQVHQ
EGNYD
>Mature_405_residues
MKKVIKKIALAYSGGLDTSIMIPWLKEHYEHAEVIAVICDLGQQEDLDTIKNKALKSGASKAYVVDVKNEFAIQYLWPLV
KSGALYEDQYILGTISRPLIAQKLVEIALTEQVNAVAHGATGKGNDQVRFEYSIKALAPQLEIIAPWRTWDIKSRQEAIV
YAKAHGIEVPVTPKAPYSRDHNIWYISHEGGVLEDPSQEMPDDVLLMTAPVSQTPDEEEVVVLDFKKGVPVALNGQELSP
VDLLNSLNQKAGQHGIGVADIVENRLVGMKIRGIYEAPAAAVLYKAHKLLESLCLTRSTLHLKQSLQQTYANLVYEGRWF
SQTKQALDAFIDVTQQHVTGCVKLKLFKGNIIPAGMHSPYSLHHPELATFEEDNVYNQKDAEGFINLFSLSAKIYSQVHQ
EGNYD

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=404, Percent_Identity=44.0594059405941, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI16950633, Length=404, Percent_Identity=44.0594059405941, Blast_Score=332, Evalue=4e-91,
Organism=Escherichia coli, GI1789563, Length=404, Percent_Identity=29.7029702970297, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324514, Length=407, Percent_Identity=37.3464373464373, Blast_Score=268, Evalue=1e-72,
Organism=Drosophila melanogaster, GI21358151, Length=412, Percent_Identity=41.504854368932, Blast_Score=303, Evalue=2e-82,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 45101; Mature: 45101

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVIKKIALAYSGGLDTSIMIPWLKEHYEHAEVIAVICDLGQQEDLDTIKNKALKSGAS
CHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
KAYVVDVKNEFAIQYLWPLVKSGALYEDQYILGTISRPLIAQKLVEIALTEQVNAVAHGA
CEEEEECCCCHHHHHHHHHHHCCCEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
TGKGNDQVRFEYSIKALAPQLEIIAPWRTWDIKSRQEAIVYAKAHGIEVPVTPKAPYSRD
CCCCCCEEEEEEEEEHHCCCEEEEECCCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCC
HNIWYISHEGGVLEDPSQEMPDDVLLMTAPVSQTPDEEEVVVLDFKKGVPVALNGQELSP
CCEEEEECCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEECCCCCCH
VDLLNSLNQKAGQHGIGVADIVENRLVGMKIRGIYEAPAAAVLYKAHKLLESLCLTRSTL
HHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
HLKQSLQQTYANLVYEGRWFSQTKQALDAFIDVTQQHVTGCVKLKLFKGNIIPAGMHSPY
HHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCEEECCCCCCC
SLHHPELATFEEDNVYNQKDAEGFINLFSLSAKIYSQVHQEGNYD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKVIKKIALAYSGGLDTSIMIPWLKEHYEHAEVIAVICDLGQQEDLDTIKNKALKSGAS
CHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
KAYVVDVKNEFAIQYLWPLVKSGALYEDQYILGTISRPLIAQKLVEIALTEQVNAVAHGA
CEEEEECCCCHHHHHHHHHHHCCCEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
TGKGNDQVRFEYSIKALAPQLEIIAPWRTWDIKSRQEAIVYAKAHGIEVPVTPKAPYSRD
CCCCCCEEEEEEEEEHHCCCEEEEECCCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCC
HNIWYISHEGGVLEDPSQEMPDDVLLMTAPVSQTPDEEEVVVLDFKKGVPVALNGQELSP
CCEEEEECCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEECCCCCCH
VDLLNSLNQKAGQHGIGVADIVENRLVGMKIRGIYEAPAAAVLYKAHKLLESLCLTRSTL
HHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
HLKQSLQQTYANLVYEGRWFSQTKQALDAFIDVTQQHVTGCVKLKLFKGNIIPAGMHSPY
HHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCEEECCCCCCC
SLHHPELATFEEDNVYNQKDAEGFINLFSLSAKIYSQVHQEGNYD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA