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The map label for this gene is hslU [H]

Identifier: 148360705

GI number: 148360705

Start: 776208

End: 777551

Strand: Direct

Name: hslU [H]

Synonym: LPC_2652

Alternate gene names: 148360705

Gene position: 776208-777551 (Clockwise)

Preceding gene: 148360706

Following gene: 148360704

Centisome position: 21.7

GC content: 41.59

Gene sequence:

>1344_bases
ATGATGAAGGCAAATAATATGGTCATGACCCCTCGAGAGATAGTTCAAGAATTAGATAAGCACATTATTGGTCAAGATGA
TGCAAAACGTGCCGTAGCCATTGCATTACGAAATCGTTGGCGTCGAATGAAAATCAAAGATCCAGTATTGCGCAACGAGA
TAATGCCTAAAAATATTTTGATGATAGGCCCTACCGGTGTTGGTAAGACGGAGATTGCAAGACGTTTGGCTAATTTGGCT
AAAGCTCCATTTATTAAAGTAGAAGCAACCAAATTCACGGAAGTGGGATATGTGGGGCGTGATGTTGATTCGATCATTCG
TGACTTAACAGATATGGCAATCAAGCAAGAGCGTGAATTTGCCATGAAAAAAGTGGAGCACCTGGCAGAAGATGCGGCTG
AAGAACGAATCCTGGATGTTTTACTCCCTCCTGCTCGAGGAACATTAACTCCTGGTGAGAAAAACACGACAGCTCGTCAA
GTGTTTCGTAAGCAATTACGCGAAGGTGAGCTTAATGATAATGAAATTGAAATTGAAGTAGCAGCAACGCCTGTTGGCAT
TGAAATTATGGCTCCTCCAGGTATGGAAGAGATGACTAGCCAATTGCAGTCTATGTTTCAACAAGTTGGAAGCTACAGAA
CGAAAACTCGAAAAATGACCGTTGCCAAGGCAATGAAAATTTTGAGAGAGGAAGAAGCGGCAAAATTAATTAACGAAGAA
GATATCAAGTTAAAAGCGATTGAAAGTGTTGAGCAAAATGGAATAGTGTTCATTGATGAGTTGGATAAAATTGCCAAACG
CTCCGATACTGTAAGTGGGGGAGATGTATCACGTGAGGGTGTTCAGCGAGATTTATTGCCATTAGTTGAAGGAACTACCG
TTTCAACAAAATACGGCATGGTAAAATCCGATCATATTTTATTCATTGCTTCAGGTGCTTTTCATGTAGCTAAACCTTCT
GACTTGATTGCTGAATTGCAAGGGCGTCTGCCGATACGTGTCGAGTTGTCAGCCCTCTCTGTGGAAGATTTTGTACGAAT
CCTTACTGAGCCAAGCGCCTCTTTAACTTTACAGTATTCCGCTTTGATGGAAACCGAAGGATTGACTCTTACCTTTGATG
AAACAGGAATTCGACGTATTGCTGAAGTAGCCTGGCAAGTGAATGAGCGTACGGAAAATATCGGAGCAAGAAGATTATAT
ACCGTCATGGAACGCTTACTGGAAGTGGTTTCATTTGAAGCGACTGATAAAGCTGGCGAAACAGTGCATGTTGATAAAGC
CTATGTCGATAAGAATTTAGGCCAACTAATCGCTGATGAGGATTTGGCTCGCTATATTTTGTAA

Upstream 100 bases:

>100_bases
AACACACAGTTATCTGCCAAGGAGATTGTCCAGAAAGCTTTAACAATCGCTGGCGACATTTGTATTTATACTAACAATAA
TTTAACCATAGAAGAATTAA

Downstream 100 bases:

>100_bases
TCCAGAATAGTTAAACTGAAATCAAGAATGAAATCTTTTTAACAGATCAACTTTTTGTGGGGGATATTTCTCGAAAAAGA
GATATCCCTCATGTGATTCT

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MMKANNMVMTPREIVQELDKHIIGQDDAKRAVAIALRNRWRRMKIKDPVLRNEIMPKNILMIGPTGVGKTEIARRLANLA
KAPFIKVEATKFTEVGYVGRDVDSIIRDLTDMAIKQEREFAMKKVEHLAEDAAEERILDVLLPPARGTLTPGEKNTTARQ
VFRKQLREGELNDNEIEIEVAATPVGIEIMAPPGMEEMTSQLQSMFQQVGSYRTKTRKMTVAKAMKILREEEAAKLINEE
DIKLKAIESVEQNGIVFIDELDKIAKRSDTVSGGDVSREGVQRDLLPLVEGTTVSTKYGMVKSDHILFIASGAFHVAKPS
DLIAELQGRLPIRVELSALSVEDFVRILTEPSASLTLQYSALMETEGLTLTFDETGIRRIAEVAWQVNERTENIGARRLY
TVMERLLEVVSFEATDKAGETVHVDKAYVDKNLGQLIADEDLARYIL

Sequences:

>Translated_447_residues
MMKANNMVMTPREIVQELDKHIIGQDDAKRAVAIALRNRWRRMKIKDPVLRNEIMPKNILMIGPTGVGKTEIARRLANLA
KAPFIKVEATKFTEVGYVGRDVDSIIRDLTDMAIKQEREFAMKKVEHLAEDAAEERILDVLLPPARGTLTPGEKNTTARQ
VFRKQLREGELNDNEIEIEVAATPVGIEIMAPPGMEEMTSQLQSMFQQVGSYRTKTRKMTVAKAMKILREEEAAKLINEE
DIKLKAIESVEQNGIVFIDELDKIAKRSDTVSGGDVSREGVQRDLLPLVEGTTVSTKYGMVKSDHILFIASGAFHVAKPS
DLIAELQGRLPIRVELSALSVEDFVRILTEPSASLTLQYSALMETEGLTLTFDETGIRRIAEVAWQVNERTENIGARRLY
TVMERLLEVVSFEATDKAGETVHVDKAYVDKNLGQLIADEDLARYIL
>Mature_447_residues
MMKANNMVMTPREIVQELDKHIIGQDDAKRAVAIALRNRWRRMKIKDPVLRNEIMPKNILMIGPTGVGKTEIARRLANLA
KAPFIKVEATKFTEVGYVGRDVDSIIRDLTDMAIKQEREFAMKKVEHLAEDAAEERILDVLLPPARGTLTPGEKNTTARQ
VFRKQLREGELNDNEIEIEVAATPVGIEIMAPPGMEEMTSQLQSMFQQVGSYRTKTRKMTVAKAMKILREEEAAKLINEE
DIKLKAIESVEQNGIVFIDELDKIAKRSDTVSGGDVSREGVQRDLLPLVEGTTVSTKYGMVKSDHILFIASGAFHVAKPS
DLIAELQGRLPIRVELSALSVEDFVRILTEPSASLTLQYSALMETEGLTLTFDETGIRRIAEVAWQVNERTENIGARRLY
TVMERLLEVVSFEATDKAGETVHVDKAYVDKNLGQLIADEDLARYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=442, Percent_Identity=69.4570135746606, Blast_Score=626, Evalue=1e-180,
Organism=Escherichia coli, GI1786642, Length=100, Percent_Identity=47, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 50116; Mature: 50116

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKANNMVMTPREIVQELDKHIIGQDDAKRAVAIALRNRWRRMKIKDPVLRNEIMPKNIL
CCCCCCEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEE
MIGPTGVGKTEIARRLANLAKAPFIKVEATKFTEVGYVGRDVDSIIRDLTDMAIKQEREF
EECCCCCCHHHHHHHHHHHHHCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
AMKKVEHLAEDAAEERILDVLLPPARGTLTPGEKNTTARQVFRKQLREGELNDNEIEIEV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
AATPVGIEIMAPPGMEEMTSQLQSMFQQVGSYRTKTRKMTVAKAMKILREEEAAKLINEE
EECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DIKLKAIESVEQNGIVFIDELDKIAKRSDTVSGGDVSREGVQRDLLPLVEGTTVSTKYGM
CCCHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCC
VKSDHILFIASGAFHVAKPSDLIAELQGRLPIRVELSALSVEDFVRILTEPSASLTLQYS
EECCCEEEEECCCEECCCHHHHHHHHHCCCCEEEEEHHHCHHHHHHHHCCCCCCEEEEEH
ALMETEGLTLTFDETGIRRIAEVAWQVNERTENIGARRLYTVMERLLEVVSFEATDKAGE
HHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TVHVDKAYVDKNLGQLIADEDLARYIL
EEEEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMKANNMVMTPREIVQELDKHIIGQDDAKRAVAIALRNRWRRMKIKDPVLRNEIMPKNIL
CCCCCCEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEE
MIGPTGVGKTEIARRLANLAKAPFIKVEATKFTEVGYVGRDVDSIIRDLTDMAIKQEREF
EECCCCCCHHHHHHHHHHHHHCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
AMKKVEHLAEDAAEERILDVLLPPARGTLTPGEKNTTARQVFRKQLREGELNDNEIEIEV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
AATPVGIEIMAPPGMEEMTSQLQSMFQQVGSYRTKTRKMTVAKAMKILREEEAAKLINEE
EECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DIKLKAIESVEQNGIVFIDELDKIAKRSDTVSGGDVSREGVQRDLLPLVEGTTVSTKYGM
CCCHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCC
VKSDHILFIASGAFHVAKPSDLIAELQGRLPIRVELSALSVEDFVRILTEPSASLTLQYS
EECCCEEEEECCCEECCCHHHHHHHHHCCCCEEEEEHHHCHHHHHHHHCCCCCCEEEEEH
ALMETEGLTLTFDETGIRRIAEVAWQVNERTENIGARRLYTVMERLLEVVSFEATDKAGE
HHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TVHVDKAYVDKNLGQLIADEDLARYIL
EEEEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA