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The map label for this gene is yueD [H]

Identifier: 148360637

GI number: 148360637

Start: 883983

End: 884792

Strand: Direct

Name: yueD [H]

Synonym: LPC_2583

Alternate gene names: 148360637

Gene position: 883983-884792 (Clockwise)

Preceding gene: 148360642

Following gene: 148360636

Centisome position: 24.72

GC content: 41.48

Gene sequence:

>810_bases
ATGTCTGGTATTATTTCACCTATTGTTTTCTATATTGATGAGGAAATTGTGTATCTCATTACTGGTGGTGGTAGCGGCAT
AGGAAGAGCTTTGGCGTTTGCTTTGGCAAAACGCAATAAACAGGTGTTCATAGTGGGGCGCAGGGAAAAATTACTGCAAG
AAACCGCTTCTTTGTCTGCAAACATTCATTATTTATGTGCCGATGTCTCCACTCCTCAAGGCAGAGAGTTAATCAAAGCC
AGTTTAAGTACCACACCTCAAATTGATGGTTTGATAAACAATGCAGGAACTCTGGAGCCTACACTGCTTTTAAAAGATAT
TTCTTTTGCCGAGTGGCACCAGGCATTAAACACCAATATAGATGCGGCACTTTTTCTTCCACAACTTTTGTATGATAAAT
TGTCAGGTGGCAGAGTATTGAATGTAGGTTCAGCTGCCGCTTATTTTCCTATCAAAGGATGGGGAGCTTATTGTGTATCG
AAAGCGGCCTTGGCTATGTTAACACGATGCTGGCAGATTGAGTGCGATTCACTGGCCTTTGCCAGCGTAATGCCTGGAAT
TATCGACACTCATATGCAGGCAATAGCCCGAAACGGGATTAATCTTGATCCGGAACAGGTCAATTTTTATAGGCGTTTAA
AAGATCATAATCGTTTGATATCACCCGAAACAGTAGCAGAATTTTTTATTTGGCTGCTGTTAGATATTGATAATGAAACG
TATGTATCCAAAGAGTGGGATATATATGACACGACTCACCACTCTGCCTGGTTGAAGCCGCCTCACCAGGTACTTCATTG
GGAATTTTAA

Upstream 100 bases:

>100_bases
CTAAATACTCAAGATTTTCATTTACTTTTGATAAAATTAGCCCGTTCAGTCGCTTTTTTCTTGTTCTAAAATAAAACGTG
CAGGTTATGCAAGAAGTCTA

Downstream 100 bases:

>100_bases
TGTTTGCCTGTGATGAATTATTGCTCAATGCAAGCACAATCGATGCCACAGGGTTGCAACTTTCTAATCAAGCCATTGTT
ATAAAAAAAGGCAGAATAGA

Product: sepiapterin reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MSGIISPIVFYIDEEIVYLITGGGSGIGRALAFALAKRNKQVFIVGRREKLLQETASLSANIHYLCADVSTPQGRELIKA
SLSTTPQIDGLINNAGTLEPTLLLKDISFAEWHQALNTNIDAALFLPQLLYDKLSGGRVLNVGSAAAYFPIKGWGAYCVS
KAALAMLTRCWQIECDSLAFASVMPGIIDTHMQAIARNGINLDPEQVNFYRRLKDHNRLISPETVAEFFIWLLLDIDNET
YVSKEWDIYDTTHHSAWLKPPHQVLHWEF

Sequences:

>Translated_269_residues
MSGIISPIVFYIDEEIVYLITGGGSGIGRALAFALAKRNKQVFIVGRREKLLQETASLSANIHYLCADVSTPQGRELIKA
SLSTTPQIDGLINNAGTLEPTLLLKDISFAEWHQALNTNIDAALFLPQLLYDKLSGGRVLNVGSAAAYFPIKGWGAYCVS
KAALAMLTRCWQIECDSLAFASVMPGIIDTHMQAIARNGINLDPEQVNFYRRLKDHNRLISPETVAEFFIWLLLDIDNET
YVSKEWDIYDTTHHSAWLKPPHQVLHWEF
>Mature_268_residues
SGIISPIVFYIDEEIVYLITGGGSGIGRALAFALAKRNKQVFIVGRREKLLQETASLSANIHYLCADVSTPQGRELIKAS
LSTTPQIDGLINNAGTLEPTLLLKDISFAEWHQALNTNIDAALFLPQLLYDKLSGGRVLNVGSAAAYFPIKGWGAYCVSK
AALAMLTRCWQIECDSLAFASVMPGIIDTHMQAIARNGINLDPEQVNFYRRLKDHNRLISPETVAEFFIWLLLDIDNETY
VSKEWDIYDTTHHSAWLKPPHQVLHWEF

Specific function: Reduces benzil stereospecifically to (S)-benzoin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4507185, Length=261, Percent_Identity=29.8850574712644, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI5031737, Length=214, Percent_Identity=30.3738317757009, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=32.4742268041237, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788459, Length=236, Percent_Identity=25, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787335, Length=186, Percent_Identity=29.0322580645161, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787526, Length=231, Percent_Identity=23.8095238095238, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=192, Percent_Identity=32.8125, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=235, Percent_Identity=28.5106382978723, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=258, Percent_Identity=30.6201550387597, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=28.5185185185185, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=238, Percent_Identity=28.1512605042017, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=212, Percent_Identity=31.6037735849057, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=257, Percent_Identity=27.6264591439689, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=252, Percent_Identity=28.1746031746032, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=238, Percent_Identity=30.672268907563, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=236, Percent_Identity=30.0847457627119, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17570069, Length=183, Percent_Identity=32.2404371584699, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=186, Percent_Identity=32.7956989247312, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=192, Percent_Identity=27.6041666666667, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=28.030303030303, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71997402, Length=198, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=27.9693486590038, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322226, Length=230, Percent_Identity=29.5652173913043, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322227, Length=240, Percent_Identity=28.3333333333333, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357041, Length=225, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI23397609, Length=229, Percent_Identity=33.6244541484716, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28571526, Length=224, Percent_Identity=32.1428571428571, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24643142, Length=184, Percent_Identity=32.0652173913043, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24644339, Length=212, Percent_Identity=28.3018867924528, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 30049; Mature: 29918

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGIISPIVFYIDEEIVYLITGGGSGIGRALAFALAKRNKQVFIVGRREKLLQETASLSA
CCCHHHHHHHEECCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHCCC
NIHYLCADVSTPQGRELIKASLSTTPQIDGLINNAGTLEPTLLLKDISFAEWHQALNTNI
CEEEEEEECCCCCHHHHHHHHHCCCCCCCHHHCCCCCCCHHHEEECCCHHHHHHHHCCCC
DAALFLPQLLYDKLSGGRVLNVGSAAAYFPIKGWGAYCVSKAALAMLTRCWQIECDSLAF
HHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHH
ASVMPGIIDTHMQAIARNGINLDPEQVNFYRRLKDHNRLISPETVAEFFIWLLLDIDNET
HHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEECCCCE
YVSKEWDIYDTTHHSAWLKPPHQVLHWEF
EECCCCCCEECCCCCCCCCCCHHHCCCCC
>Mature Secondary Structure 
SGIISPIVFYIDEEIVYLITGGGSGIGRALAFALAKRNKQVFIVGRREKLLQETASLSA
CCHHHHHHHEECCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHCCC
NIHYLCADVSTPQGRELIKASLSTTPQIDGLINNAGTLEPTLLLKDISFAEWHQALNTNI
CEEEEEEECCCCCHHHHHHHHHCCCCCCCHHHCCCCCCCHHHEEECCCHHHHHHHHCCCC
DAALFLPQLLYDKLSGGRVLNVGSAAAYFPIKGWGAYCVSKAALAMLTRCWQIECDSLAF
HHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHH
ASVMPGIIDTHMQAIARNGINLDPEQVNFYRRLKDHNRLISPETVAEFFIWLLLDIDNET
HHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEECCCCE
YVSKEWDIYDTTHHSAWLKPPHQVLHWEF
EECCCCCCEECCCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]