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The map label for this gene is glyA [H]

Identifier: 148360621

GI number: 148360621

Start: 902839

End: 904092

Strand: Direct

Name: glyA [H]

Synonym: LPC_2567

Alternate gene names: 148360621

Gene position: 902839-904092 (Clockwise)

Preceding gene: 148360622

Following gene: 148360620

Centisome position: 25.24

GC content: 40.91

Gene sequence:

>1254_bases
ATGTTTGACGAAAGTTATACTATAAAAAATTTTGATGATGTTCTTTTTAAAGCAATTTCTGATGAAAAACGACGCCAAGA
AGAACACATTGAATTAATAGCATCTGAAAATTATGTCAGCCCGAGAGTATTGGAGGCTCAGGGTTCTGTGTTGACGAATA
AATACGCTGAAGGATATCCAGGCAAACGCTATTACGGAGGTTGTGAGTTTGTTGATGTCGCTGAAGAGTTAGCCATTTCA
AGGGCAAAATTACTTTTTGGCGCTCATTATGTCAATGTGCAACCCCATTCGGGATCACAAGCGAACGCAGCAGTCATGAT
GGCATTATTGTCCCCAGGCGATACTTTTATGGGCATGGCTTTACCTCATGGTGGGCACTTGACTCATGGGTCAAAGGTTA
ATTTTTCAGGTAAATTATACCATTCTGTCGAGTATGGTGTTGATAGCAATACGGGTTTGATTGATTATGATGCTCTGGAA
AAACTTGCGCTTCAACACAAACCAAAATTGATCATTGCCGGTTTTTCAGCTTATTCCAGGATCCTGGATTGGGCTCGATT
TAGAGAAATTGCCGATAAGGTCGGCGCTTATTTAATGGCGGACATCGCTCATGTAGCTGGTCTGGTGGCTGTAGGGTTAT
ATCCTTCTCCTGTTCCTTATGCGGATGTTGTGACAACGACAACTCATAAAACTTTAAGAGGACCTCGCGGTGGTTTAATC
CTTTGTAAGGAAAACGAAGAAATTGAGAAAAAATTAAATTCTTCTGTATTTCCTGGTATGCAAGGTGGGCCCTTAATGCA
TGTAATTGCAGCCAAGGCAGTTGCTTTTGCAGAAGCTCTGTTACCCGAATTTAAAACTTATCAGCAACAGGTTTTAGCTA
ATGCCAGAACGATGTGCAGTGTGTTACAAAGCAGAGGCTATGATATTGTTTCTGGCGGAACTGATAATCATCTTTTGCTA
GTGGATTTGATAAATAAAGGAATTACAGGTAAAGAAGCTGACGCTGCTTTAGGCAGAGCTAACATAACAGTCAATAAAAA
TTCGGTTCCCAATGATCCTCGCTCGCCTTTTGTAACGAGTGGTTTACGTTTGGGTACGCCTGCTGCAACCACAAGAGGCT
TTAAAGAAAGAGAGATTACTTTGTTATCTAACTGGGTAGCGGATGTCCTTGATAATGTTCATGATGAAACTAATATTTCA
AGAGTGAAAACCCAGGTGTTGCTACTCTGTCGTGAATTTCCGGTTTATGCCTAA

Upstream 100 bases:

>100_bases
AGCTGGGATTATTGCGGCTGGCGTAGATGGTGTAAAGAGTGTTCGTAATGACCTTATTATAAAAACAAGGTAAATATAAC
CTTCCAACCAAGGAACATTC

Downstream 100 bases:

>100_bases
TCATGTATTGTCCATTTTGTCATGCGGAAGAAACAAAGGTAGTGGATTCACGTCTGGTCGCGGATGGTGCTCAAGTTCGC
AGAAGGCGTGAATGTCTGGA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MFDESYTIKNFDDVLFKAISDEKRRQEEHIELIASENYVSPRVLEAQGSVLTNKYAEGYPGKRYYGGCEFVDVAEELAIS
RAKLLFGAHYVNVQPHSGSQANAAVMMALLSPGDTFMGMALPHGGHLTHGSKVNFSGKLYHSVEYGVDSNTGLIDYDALE
KLALQHKPKLIIAGFSAYSRILDWARFREIADKVGAYLMADIAHVAGLVAVGLYPSPVPYADVVTTTTHKTLRGPRGGLI
LCKENEEIEKKLNSSVFPGMQGGPLMHVIAAKAVAFAEALLPEFKTYQQQVLANARTMCSVLQSRGYDIVSGGTDNHLLL
VDLINKGITGKEADAALGRANITVNKNSVPNDPRSPFVTSGLRLGTPAATTRGFKEREITLLSNWVADVLDNVHDETNIS
RVKTQVLLLCREFPVYA

Sequences:

>Translated_417_residues
MFDESYTIKNFDDVLFKAISDEKRRQEEHIELIASENYVSPRVLEAQGSVLTNKYAEGYPGKRYYGGCEFVDVAEELAIS
RAKLLFGAHYVNVQPHSGSQANAAVMMALLSPGDTFMGMALPHGGHLTHGSKVNFSGKLYHSVEYGVDSNTGLIDYDALE
KLALQHKPKLIIAGFSAYSRILDWARFREIADKVGAYLMADIAHVAGLVAVGLYPSPVPYADVVTTTTHKTLRGPRGGLI
LCKENEEIEKKLNSSVFPGMQGGPLMHVIAAKAVAFAEALLPEFKTYQQQVLANARTMCSVLQSRGYDIVSGGTDNHLLL
VDLINKGITGKEADAALGRANITVNKNSVPNDPRSPFVTSGLRLGTPAATTRGFKEREITLLSNWVADVLDNVHDETNIS
RVKTQVLLLCREFPVYA
>Mature_417_residues
MFDESYTIKNFDDVLFKAISDEKRRQEEHIELIASENYVSPRVLEAQGSVLTNKYAEGYPGKRYYGGCEFVDVAEELAIS
RAKLLFGAHYVNVQPHSGSQANAAVMMALLSPGDTFMGMALPHGGHLTHGSKVNFSGKLYHSVEYGVDSNTGLIDYDALE
KLALQHKPKLIIAGFSAYSRILDWARFREIADKVGAYLMADIAHVAGLVAVGLYPSPVPYADVVTTTTHKTLRGPRGGLI
LCKENEEIEKKLNSSVFPGMQGGPLMHVIAAKAVAFAEALLPEFKTYQQQVLANARTMCSVLQSRGYDIVSGGTDNHLLL
VDLINKGITGKEADAALGRANITVNKNSVPNDPRSPFVTSGLRLGTPAATTRGFKEREITLLSNWVADVLDNVHDETNIS
RVKTQVLLLCREFPVYA

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=402, Percent_Identity=49.5024875621891, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862352, Length=402, Percent_Identity=49.5024875621891, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI261862350, Length=402, Percent_Identity=49.5024875621891, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI261862348, Length=402, Percent_Identity=49.5024875621891, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=50.6234413965087, Blast_Score=347, Evalue=9e-96,
Organism=Homo sapiens, GI261862346, Length=402, Percent_Identity=48.0099502487562, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI22547189, Length=388, Percent_Identity=47.9381443298969, Blast_Score=313, Evalue=2e-85,
Organism=Escherichia coli, GI1788902, Length=418, Percent_Identity=70.3349282296651, Blast_Score=589, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=49.5, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=49.5, Blast_Score=376, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319739, Length=397, Percent_Identity=47.6070528967254, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6323087, Length=390, Percent_Identity=47.4358974358974, Blast_Score=354, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24640005, Length=448, Percent_Identity=46.4285714285714, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI221329721, Length=448, Percent_Identity=46.4285714285714, Blast_Score=390, Evalue=1e-108,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45576; Mature: 45576

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDESYTIKNFDDVLFKAISDEKRRQEEHIELIASENYVSPRVLEAQGSVLTNKYAEGYP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCCC
GKRYYGGCEFVDVAEELAISRAKLLFGAHYVNVQPHSGSQANAAVMMALLSPGDTFMGMA
CCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCHHHEEEECCCCCCEEEEE
LPHGGHLTHGSKVNFSGKLYHSVEYGVDSNTGLIDYDALEKLALQHKPKLIIAGFSAYSR
CCCCCCCCCCCEECCCCEEEEEEEECCCCCCCEEEHHHHHHHHHHCCCCEEEECHHHHHH
ILDWARFREIADKVGAYLMADIAHVAGLVAVGLYPSPVPYADVVTTTTHKTLRGPRGGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCHHHHCCCCCCEE
LCKENEEIEKKLNSSVFPGMQGGPLMHVIAAKAVAFAEALLPEFKTYQQQVLANARTMCS
EECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLQSRGYDIVSGGTDNHLLLVDLINKGITGKEADAALGRANITVNKNSVPNDPRSPFVTS
HHHHCCCEEEECCCCCCEEEEEECCCCCCCCCHHHHCCCEEEEECCCCCCCCCCCCHHHC
GLRLGTPAATTRGFKEREITLLSNWVADVLDNVHDETNISRVKTQVLLLCREFPVYA
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFDESYTIKNFDDVLFKAISDEKRRQEEHIELIASENYVSPRVLEAQGSVLTNKYAEGYP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCCC
GKRYYGGCEFVDVAEELAISRAKLLFGAHYVNVQPHSGSQANAAVMMALLSPGDTFMGMA
CCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCHHHEEEECCCCCCEEEEE
LPHGGHLTHGSKVNFSGKLYHSVEYGVDSNTGLIDYDALEKLALQHKPKLIIAGFSAYSR
CCCCCCCCCCCEECCCCEEEEEEEECCCCCCCEEEHHHHHHHHHHCCCCEEEECHHHHHH
ILDWARFREIADKVGAYLMADIAHVAGLVAVGLYPSPVPYADVVTTTTHKTLRGPRGGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCHHHHCCCCCCEE
LCKENEEIEKKLNSSVFPGMQGGPLMHVIAAKAVAFAEALLPEFKTYQQQVLANARTMCS
EECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLQSRGYDIVSGGTDNHLLLVDLINKGITGKEADAALGRANITVNKNSVPNDPRSPFVTS
HHHHCCCEEEECCCCCCEEEEEECCCCCCCCCHHHHCCCEEEEECCCCCCCCCCCCHHHC
GLRLGTPAATTRGFKEREITLLSNWVADVLDNVHDETNISRVKTQVLLLCREFPVYA
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA