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The map label for this gene is neuB

Identifier: 148360594

GI number: 148360594

Start: 931669

End: 932691

Strand: Direct

Name: neuB

Synonym: LPC_2540

Alternate gene names: NA

Gene position: 931669-932691 (Clockwise)

Preceding gene: 148360595

Following gene: 148360593

Centisome position: 26.05

GC content: 39.2

Gene sequence:

>1023_bases
ATGACTTGTTTTATTATTGCTGAAGCAGGAGTAAACCATAATGGTGATCTTCAACTGGCTAAAGAATTAGTTTATGCAGC
CAAAGAGTCAGGAGCTGATGCAGTAAAGTTTCAGACTTTCAAAGCGGACACCTTGGTCAATAAAACAGTAGAAAAAGCGG
AATACCAAAAAAATAATGCCCCGGAATCCTCTACCCAGTACGAGATGCTCAAGGCACTGGAGCTTTCAGAAGAGGACCAT
TATTTACTAAGTGAATTAGCCAATTCACTCGGCATTGAATTTATGTCAACTGGTTTTGATGAACAAAGCATTGATTTTCT
TATTTCTTTAGGGGTAAAGCGATTAAAAATCCCTTCTGGCGAAATTACTAATGTACCTTATTTACAACATTGTGCCAGTA
AGAAGTTACCATTAATCATCTCAACAGGGATGTGCGATCTACAAGACGTAAGAGTAGCCATAGATACAGTAAAACCCTAC
TATGGAAACTCTTTATCCGATTATCTGGTTTTGTTGCATTGTACCTCTAATTATCCGGCAGCTTATCAGGACGTGAATTT
GAAAGCCATGCAGACATTAGCTGACGAATTTCAATTGCCAGTAGGTTATTCTGATCATACTTTAGGTATTTTGGTGCCAA
CATTAGCAGTAGGAATGGGGGCGTGCGTTATCGAAAAGCACTTTACAATGGATAAATCTCTTCCTGGTCCAGATCATCTT
GCTTCTATGAATCCAGAGGAAATGAAGAATTTAGTGCAGTCCATCAGAGACGCTGAAACTGTTTTGGGAAGTGGTGAAAA
AAAACCGTCGGATAATGAGCTGCCGATAAGAGCTCTGGTTAGAAGAAGTATTACTTTAAGACGTGATTTGGTGAAAGGAG
CACAAATCAGTAAGGAAGATTTGATCTTGCTAAGACCTGGTACTGGGATAGCGCCCTCTGAAATATCAAATATTGTAGGC
TCTCGATTAAGTATGAATTTGTCTGCGGGTACTACTTTGTTATGGGAACATATTGAAGCGTAA

Upstream 100 bases:

>100_bases
CTTTATTGTTAAATAGTATTAGTGAATCCATCGACATCGATACGCCAATCGATTGGGCTCTAACAGAAAAATTAATGGAA
TTAAACCAAGAGGCTCTAGT

Downstream 100 bases:

>100_bases
TGATCAGAAAAATAATTTATGTTACAGGTACTCGTGCCGATTATGGACTGATGAGAGAAGTACTAAAAAGATTACACCAG
TCAGAAGACATTGACTTATC

Product: N-acetylneuraminic acid synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTCFIIAEAGVNHNGDLQLAKELVYAAKESGADAVKFQTFKADTLVNKTVEKAEYQKNNAPESSTQYEMLKALELSEEDH
YLLSELANSLGIEFMSTGFDEQSIDFLISLGVKRLKIPSGEITNVPYLQHCASKKLPLIISTGMCDLQDVRVAIDTVKPY
YGNSLSDYLVLLHCTSNYPAAYQDVNLKAMQTLADEFQLPVGYSDHTLGILVPTLAVGMGACVIEKHFTMDKSLPGPDHL
ASMNPEEMKNLVQSIRDAETVLGSGEKKPSDNELPIRALVRRSITLRRDLVKGAQISKEDLILLRPGTGIAPSEISNIVG
SRLSMNLSAGTTLLWEHIEA

Sequences:

>Translated_340_residues
MTCFIIAEAGVNHNGDLQLAKELVYAAKESGADAVKFQTFKADTLVNKTVEKAEYQKNNAPESSTQYEMLKALELSEEDH
YLLSELANSLGIEFMSTGFDEQSIDFLISLGVKRLKIPSGEITNVPYLQHCASKKLPLIISTGMCDLQDVRVAIDTVKPY
YGNSLSDYLVLLHCTSNYPAAYQDVNLKAMQTLADEFQLPVGYSDHTLGILVPTLAVGMGACVIEKHFTMDKSLPGPDHL
ASMNPEEMKNLVQSIRDAETVLGSGEKKPSDNELPIRALVRRSITLRRDLVKGAQISKEDLILLRPGTGIAPSEISNIVG
SRLSMNLSAGTTLLWEHIEA
>Mature_339_residues
TCFIIAEAGVNHNGDLQLAKELVYAAKESGADAVKFQTFKADTLVNKTVEKAEYQKNNAPESSTQYEMLKALELSEEDHY
LLSELANSLGIEFMSTGFDEQSIDFLISLGVKRLKIPSGEITNVPYLQHCASKKLPLIISTGMCDLQDVRVAIDTVKPYY
GNSLSDYLVLLHCTSNYPAAYQDVNLKAMQTLADEFQLPVGYSDHTLGILVPTLAVGMGACVIEKHFTMDKSLPGPDHLA
SMNPEEMKNLVQSIRDAETVLGSGEKKPSDNELPIRALVRRSITLRRDLVKGAQISKEDLILLRPGTGIAPSEISNIVGS
RLSMNLSAGTTLLWEHIEA

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=340, Percent_Identity=34.4117647058824, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI21357081, Length=364, Percent_Identity=31.8681318681319, Blast_Score=175, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 37276; Mature: 37145

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCFIIAEAGVNHNGDLQLAKELVYAAKESGADAVKFQTFKADTLVNKTVEKAEYQKNNA
CEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCC
PESSTQYEMLKALELSEEDHYLLSELANSLGIEFMSTGFDEQSIDFLISLGVKRLKIPSG
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCHHEEECCCC
EITNVPYLQHCASKKLPLIISTGMCDLQDVRVAIDTVKPYYGNSLSDYLVLLHCTSNYPA
CCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCHHHEEEEEEECCCCCC
AYQDVNLKAMQTLADEFQLPVGYSDHTLGILVPTLAVGMGACVIEKHFTMDKSLPGPDHL
CHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
ASMNPEEMKNLVQSIRDAETVLGSGEKKPSDNELPIRALVRRSITLRRDLVKGAQISKED
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
LILLRPGTGIAPSEISNIVGSRLSMNLSAGTTLLWEHIEA
EEEECCCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHCC
>Mature Secondary Structure 
TCFIIAEAGVNHNGDLQLAKELVYAAKESGADAVKFQTFKADTLVNKTVEKAEYQKNNA
EEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCC
PESSTQYEMLKALELSEEDHYLLSELANSLGIEFMSTGFDEQSIDFLISLGVKRLKIPSG
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCHHEEECCCC
EITNVPYLQHCASKKLPLIISTGMCDLQDVRVAIDTVKPYYGNSLSDYLVLLHCTSNYPA
CCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCHHHEEEEEEECCCCCC
AYQDVNLKAMQTLADEFQLPVGYSDHTLGILVPTLAVGMGACVIEKHFTMDKSLPGPDHL
CHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
ASMNPEEMKNLVQSIRDAETVLGSGEKKPSDNELPIRALVRRSITLRRDLVKGAQISKED
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
LILLRPGTGIAPSEISNIVGSRLSMNLSAGTTLLWEHIEA
EEEECCCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]