| Definition | Legionella pneumophila str. Corby chromosome, complete genome. |
|---|---|
| Accession | NC_009494 |
| Length | 3,576,470 |
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The map label for this gene is clpA [H]
Identifier: 148360535
GI number: 148360535
Start: 1002644
End: 1004911
Strand: Direct
Name: clpA [H]
Synonym: LPC_2477
Alternate gene names: 148360535
Gene position: 1002644-1004911 (Clockwise)
Preceding gene: 148360536
Following gene: 148360534
Centisome position: 28.03
GC content: 40.04
Gene sequence:
>2268_bases ATGTTAAATAAAGAACTAGAATTCACCTTGAATCTAGCTTTCAAGGAAGCAAAAGAAAAGCGTCATGAGTTCATGACTGT TGAACATTTGCTGTTGTCTTTGCTTGATAATCCAGCAGCAGGAAATGTATTACAGGCTTGTGATGCTAACATCGAGGCAT TACGTCGTGATTTAATCGAATTTATTGATGAAACAACCCCAAGAATTCCTGAGGATGAACTGGACAGGGAAACTCAACCA ACATTAGGTTTTCAAAGGGTTTTACAGCGTGCAGTATTTCATGTGCAGTCAGCAGGTAAAACAGAAGTCACTGGAGCTAA TGTATTAGCCGCAATTTTTAGTGAGCAAGAAAGTCAGGCTGTATATTTTTTGCGACGTGAAAATATTACTCGCCTTGATG TCATTAATTATATTTCTCATGGAGTGTCAAAATATCAAAACAACGATATGCATGAAAACATGAATTCGTCTATGGAAGAA GACATGATGACCCCTGAGGGTAATGAATCTCCACTTGATAGTTATTGCACCAATCTCAACAGACGCGCAAAACAGGGCAA GATAGATCCGTTGATAGGGCGGCATGAAGAGATACAAAGAACTATACAAGTGCTTTGCAGACGCCGTAAAAATAATCCTT TATTAGTTGGCGAGGCAGGTGTAGGTAAAACGGCTATCGCAGAAGGTTTGGCCAGACGCATTGTGGATGGTGAAATCCCA GATTCCATAAGAGGCTGCGTAGTCTACTCTCTTGACTTGGGCGCCTTATTGGCAGGAACGAAATACAGAGGGGATTTTGA AAAACGATTGAAAGCTGTGCTGAAACAGTTGGGGCAGCAAGAAGGAGCCATTTTATTCATAGATGAAATTCACACCATTA TTGGCGCAGGCGCTGCATCTGGAGGAGTCATGGATGCTTCCAACCTGGTTAAGCCATTATTGGCAAATGGTGAATTGAAA TGTATTGGCTCAACCACTTATCAGGAATATCGTGGAATATTTGAAAAAGACAGGGCCTTGGCAAGACGATTCCAAAAAAT TGATATTTCAGAACCAACAATCGATGAAACTTTTGAAATATTAAAAGGATTAAAAGGCAAATTGGAAGCTCACCATGGAG TAAAATTTTCAATTGCTTCATTAAAAGCAGCAGCAGAATTATCTGCAAAATACATCAATGATCGGTTTTTGCCTGACAAA GCGATTGATGTGGTGGATGAAGCAGGCGCTTATCAGAATTTACTGACAGCAAATAAACGTAAAAAAATTATTAGCGTGAC TGAAATAGAGAGTGTTGTCGCAAAAATCGCTAGAATCCCAATTAAAAAAGTATCTGCACGCGATAAAGATACTCTGCGTA ACCTGGAGCGTGATTTAAAATTATTAGTCTATGGGCAAGACCAGGCAATTACTGCCTTGGCTTCAGCAATCAAACTGGGT AGATCCGGACTTAGAGAACCTCAGAAGCCAGTAGGTTGTTTCTTGTTTGCCGGACCAACTGGTGTAGGAAAGACAGAGGT AACAAGGCAACTGGCTAATGTGTTAGGCATAGAGTTGCTGCGTTTTGATATGTCAGAGTACATGGAAAAACACACTGTTT CACGTTTGATTGGAGCACCTCCTGGCTATGTAGGATACGATCAAGGTGGTTTACTGACTGAAGCCGTGACTAAGAATCCA CATGCTGTTCTGCTACTTGATGAAATAGAAAAAGCACATCCTGATGTTTTTAATTTATTGTTGCAGATAATGGATCATGG CACTTTAACTGATACTAACGGTCGTCAAGCTGATTTCAGACATATCATACTTGTAATGACCAGTAACGCAGGAGCCAGTG AAATTGTTCGTAACTCCATAGGTTTTTCAACGCAAGACAATACCAATGATGGGTTGGAAGTAATTAAAAAGCAATTCAGT CCTGAGTTTAGGAACCGTTTGGATGCTATTATCAATTTTGCTCCGTTAGATACACAGACTATAGGACTAGTCGTTGATAA ATTCATTATGGAGTTGGATGAACAATTAAGTCATAAAGGTGTTACTTTTACAGTTGATAAGTCAGCCAGGGAATGGCTGA TGGAGCATGGTTATGATAAAGCCATGGGAGCAAGACCTATGGCCAGATTGATTCAGGAAAACATCAAAAAGCCTCTTGCT GATGAACTGTTGTTTGGTAAATTAATGCATGGCGGTCATGTCACTTTGCGAGTGAAAGACGGTAAACTGCATTTTGACAG TCATGATCATAGAGAAGGTGTTTGTTAA
Upstream 100 bases:
>100_bases GTCGCCCTGGTAAATGAATACGCCAGAATGAATCAACATCCATTATTATCTAGTATGGAACCGGAGTAAACTGGTGGTGG GTTGGTAAGGAGCAATGACA
Downstream 100 bases:
>100_bases ACGGGAACCATCTTCAGTTCTGTGCATGACAAATTTTTTGTTATGCACAGACAAAATCACAATAATCCTGAGATAGTAAT TGTCATTAACTTGTTAGTTG
Product: ATP binding protease component ClpA
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 755; Mature: 755
Protein sequence:
>755_residues MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIEFIDETTPRIPEDELDRETQP TLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMEE DMMTPEGNESPLDSYCTNLNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAASGGVMDASNLVKPLLANGELK CIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEILKGLKGKLEAHHGVKFSIASLKAAAELSAKYINDRFLPDK AIDVVDEAGAYQNLLTANKRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAPPGYVGYDQGGLLTEAVTKNP HAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFRHIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQFS PEFRNRLDAIINFAPLDTQTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC
Sequences:
>Translated_755_residues MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIEFIDETTPRIPEDELDRETQP TLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMEE DMMTPEGNESPLDSYCTNLNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAASGGVMDASNLVKPLLANGELK CIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEILKGLKGKLEAHHGVKFSIASLKAAAELSAKYINDRFLPDK AIDVVDEAGAYQNLLTANKRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAPPGYVGYDQGGLLTEAVTKNP HAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFRHIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQFS PEFRNRLDAIINFAPLDTQTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC >Mature_755_residues MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIEFIDETTPRIPEDELDRETQP TLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMEE DMMTPEGNESPLDSYCTNLNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAASGGVMDASNLVKPLLANGELK CIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEILKGLKGKLEAHHGVKFSIASLKAAAELSAKYINDRFLPDK AIDVVDEAGAYQNLLTANKRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAPPGYVGYDQGGLLTEAVTKNP HAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFRHIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQFS PEFRNRLDAIINFAPLDTQTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC
Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]
COG id: COG0542
COG function: function code O; ATPases with chaperone activity, ATP-binding subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the clpA/clpB family [H]
Homologues:
Organism=Homo sapiens, GI13540606, Length=317, Percent_Identity=31.8611987381703, Blast_Score=157, Evalue=5e-38, Organism=Escherichia coli, GI1787109, Length=739, Percent_Identity=66.5764546684709, Blast_Score=1016, Evalue=0.0, Organism=Escherichia coli, GI1788943, Length=411, Percent_Identity=44.5255474452555, Blast_Score=301, Evalue=9e-83, Organism=Saccharomyces cerevisiae, GI6320464, Length=327, Percent_Identity=45.565749235474, Blast_Score=280, Evalue=5e-76, Organism=Saccharomyces cerevisiae, GI6323002, Length=419, Percent_Identity=39.3794749403341, Blast_Score=266, Evalue=1e-71,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR013093 - InterPro: IPR003959 - InterPro: IPR018368 - InterPro: IPR001270 - InterPro: IPR019489 - InterPro: IPR004176 - InterPro: IPR013461 - InterPro: IPR023150 [H]
Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]
EC number: NA
Molecular weight: Translated: 84036; Mature: 84036
Theoretical pI: Translated: 6.64; Mature: 6.64
Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIE CCCCCEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHH FIDETTPRIPEDELDRETQPTLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQA HHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCE VYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMEEDMMTPEGNESPLDSYCTNLN EEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHH RRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCC DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAAS CCCCCEEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCC GGVMDASNLVKPLLANGELKCIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEI CCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH LKGLKGKLEAHHGVKFSIASLKAAAELSAKYINDRFLPDKAIDVVDEAGAYQNLLTANKR HHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHH KKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG HHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHH RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAP HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC PGYVGYDQGGLLTEAVTKNPHAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFR CCCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCE HIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQFSPEFRNRLDAIINFAPLDTQT EEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHH IGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA HHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCHHH DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC HHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCC >Mature Secondary Structure MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIE CCCCCEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHH FIDETTPRIPEDELDRETQPTLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQA HHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCE VYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMEEDMMTPEGNESPLDSYCTNLN EEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHH RRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCC DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAAS CCCCCEEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCC GGVMDASNLVKPLLANGELKCIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEI CCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH LKGLKGKLEAHHGVKFSIASLKAAAELSAKYINDRFLPDKAIDVVDEAGAYQNLLTANKR HHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHH KKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG HHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHH RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAP HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC PGYVGYDQGGLLTEAVTKNPHAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFR CCCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCE HIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQFSPEFRNRLDAIINFAPLDTQT EEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHH IGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA HHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCHHH DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC HHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]