Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 148360485

GI number: 148360485

Start: 1047334

End: 1048488

Strand: Direct

Name: acdA [H]

Synonym: LPC_2425

Alternate gene names: 148360485

Gene position: 1047334-1048488 (Clockwise)

Preceding gene: 148360488

Following gene: 148360484

Centisome position: 29.28

GC content: 41.9

Gene sequence:

>1155_bases
ATGCATTTTAATTTCACTGATGAACATTTGGCATTTCGAGAAATGGCCTCCGAGTTTGCTCGTAACAAACTGGCTCCAAT
GGCAGATTTCTGGGATGAACAAGGTTACTTTCCAATCGAAATTTTAAGAGAAGCGGCGCAATTAGGTATGGCGGGAATGG
TAGTCCGCGAAGACATAGGAGGTGCTCAGCTCTCTCGTCTGGATGCAGCACTCATCTTTGAACAACTCGCTACGGGCTGT
ATTCCAACAAGTGCATATCTCTCCATCCATAATATGGTCGCTTCATTGGTCGACCGCTATGGCAGCCAAGAGATTCGCAA
GAAATGGGGACCAAAATTAACCAGTATGGAAGTGATAGCCAGTTATTGTCTTACAGAGCCAGAATCAGGATCTGATGCAG
CCTCTTTAAAAACTCGCGCGGTAAAAGAGGGTGAATATTATGTTCTTAATGGTGCGAAAGCATTCATATCGGGTGGAAGT
GTTAGTGATGTGTATTTATGTATGGTACGTACAGGTGATGAGTCTCATCATGGCATCAGTTGTTTGTTAATTGAAAAGAA
TACTCCTGGTCTGACATTTGGCAAACTGGAGAAAAAATTAGGTTGGCGAAATCAGCCAACTTGTATGCTATATTTTGAAA
ATTGTCGTGTGCCCATTGCCAATCGTGTTGGTGAAGAAGGTATGGGTTTTAAAATTGCACTGAATGCCTTAAACGGAGGG
AGAGTGAATATTGCTTCCTGCTCATTAGGAGGGGCCCTTGCTTGCCTGCGAATGAGCCAATCTTATATGCATGAGCGCAA
ACAGTTTGGAAAACCTTTAACTCAGATGCAAGCTCTTCGTTTTTATTTTGCGGATATGTTAACAGATTATGAAGCGGCAA
GGCTGATGGTTTATAGGGCTGCAGCAGCAATGGATAATGATGATCCCAATGCGCCAATGTATTGTGCTATGGGCAAGCGC
TTGGCTACAGATGTCGCATTTCGTATTAGTGATAAAGCCATGCAATTGCATGGAGGTTATGGCTACCTGCGAGATTATCA
AATTGAAAGAATATTTAGAGATTTAAGAGTTCATCAAATTCTTGAAGGCACTAATGAAATCATGCGTGAAATTATAGCGA
AAGCAAGTTTGGATGAAGAGTATTTTATAGAGTAA

Upstream 100 bases:

>100_bases
TTATCTTTCCTGGGCGCTAAAAATTCGCAATAATATCATTTTTTAAGAAAGCGTCATAAATAAATCCAATGACTAAAATC
AATAAATCTAAGGATGGTCT

Downstream 100 bases:

>100_bases
TCATAGGGGATTATTGATGAATTTAATTGAACAGGATATAGATAATAACGGAATCTTAACTTTAACCTTGAATAGGCCAG
AGAAGCTCAATGCTTTAAGC

Product: short chain-specific acyl CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MHFNFTDEHLAFREMASEFARNKLAPMADFWDEQGYFPIEILREAAQLGMAGMVVREDIGGAQLSRLDAALIFEQLATGC
IPTSAYLSIHNMVASLVDRYGSQEIRKKWGPKLTSMEVIASYCLTEPESGSDAASLKTRAVKEGEYYVLNGAKAFISGGS
VSDVYLCMVRTGDESHHGISCLLIEKNTPGLTFGKLEKKLGWRNQPTCMLYFENCRVPIANRVGEEGMGFKIALNALNGG
RVNIASCSLGGALACLRMSQSYMHERKQFGKPLTQMQALRFYFADMLTDYEAARLMVYRAAAAMDNDDPNAPMYCAMGKR
LATDVAFRISDKAMQLHGGYGYLRDYQIERIFRDLRVHQILEGTNEIMREIIAKASLDEEYFIE

Sequences:

>Translated_384_residues
MHFNFTDEHLAFREMASEFARNKLAPMADFWDEQGYFPIEILREAAQLGMAGMVVREDIGGAQLSRLDAALIFEQLATGC
IPTSAYLSIHNMVASLVDRYGSQEIRKKWGPKLTSMEVIASYCLTEPESGSDAASLKTRAVKEGEYYVLNGAKAFISGGS
VSDVYLCMVRTGDESHHGISCLLIEKNTPGLTFGKLEKKLGWRNQPTCMLYFENCRVPIANRVGEEGMGFKIALNALNGG
RVNIASCSLGGALACLRMSQSYMHERKQFGKPLTQMQALRFYFADMLTDYEAARLMVYRAAAAMDNDDPNAPMYCAMGKR
LATDVAFRISDKAMQLHGGYGYLRDYQIERIFRDLRVHQILEGTNEIMREIIAKASLDEEYFIE
>Mature_384_residues
MHFNFTDEHLAFREMASEFARNKLAPMADFWDEQGYFPIEILREAAQLGMAGMVVREDIGGAQLSRLDAALIFEQLATGC
IPTSAYLSIHNMVASLVDRYGSQEIRKKWGPKLTSMEVIASYCLTEPESGSDAASLKTRAVKEGEYYVLNGAKAFISGGS
VSDVYLCMVRTGDESHHGISCLLIEKNTPGLTFGKLEKKLGWRNQPTCMLYFENCRVPIANRVGEEGMGFKIALNALNGG
RVNIASCSLGGALACLRMSQSYMHERKQFGKPLTQMQALRFYFADMLTDYEAARLMVYRAAAAMDNDDPNAPMYCAMGKR
LATDVAFRISDKAMQLHGGYGYLRDYQIERIFRDLRVHQILEGTNEIMREIIAKASLDEEYFIE

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=53.3333333333333, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI4501859, Length=387, Percent_Identity=37.2093023255814, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=38.544474393531, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=33.0708661417323, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=33.0708661417323, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI21361497, Length=376, Percent_Identity=34.5744680851064, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=32.2666666666667, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4557235, Length=380, Percent_Identity=30, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI76496475, Length=380, Percent_Identity=30, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=31.7460317460317, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=32.5513196480938, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI4503943, Length=379, Percent_Identity=29.023746701847, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI7669494, Length=354, Percent_Identity=29.0960451977401, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI48976061, Length=290, Percent_Identity=30.6896551724138, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI211971008, Length=290, Percent_Identity=30.6896551724138, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI38505218, Length=393, Percent_Identity=26.2086513994911, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1786223, Length=386, Percent_Identity=28.7564766839378, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI87081958, Length=340, Percent_Identity=28.5294117647059, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87082384, Length=291, Percent_Identity=29.553264604811, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17533517, Length=371, Percent_Identity=47.4393530997305, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=35.978835978836, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17569725, Length=380, Percent_Identity=35, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=31.2335958005249, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17508101, Length=380, Percent_Identity=32.8947368421053, Blast_Score=217, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17506239, Length=379, Percent_Identity=32.7176781002639, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71985184, Length=381, Percent_Identity=31.2335958005249, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17538396, Length=384, Percent_Identity=33.8541666666667, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71990804, Length=255, Percent_Identity=38.0392156862745, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17551932, Length=380, Percent_Identity=28.9473684210526, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17505929, Length=380, Percent_Identity=28.6842105263158, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71985192, Length=327, Percent_Identity=29.0519877675841, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=34.7826086956522, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=28.8321167883212, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=27.8514588859416, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=29.8611111111111, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=247, Percent_Identity=29.1497975708502, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI86563383, Length=318, Percent_Identity=27.0440251572327, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=318, Percent_Identity=27.0440251572327, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17531913, Length=182, Percent_Identity=30.2197802197802, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=34.4827586206897, Blast_Score=240, Evalue=9e-64,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=34.8404255319149, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=35.2150537634409, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24646207, Length=377, Percent_Identity=35.8090185676393, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI281363737, Length=340, Percent_Identity=34.7058823529412, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI21355753, Length=386, Percent_Identity=31.8652849740933, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI19920834, Length=383, Percent_Identity=26.6318537859008, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 43012; Mature: 43012

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFNFTDEHLAFREMASEFARNKLAPMADFWDEQGYFPIEILREAAQLGMAGMVVREDIG
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCC
GAQLSRLDAALIFEQLATGCIPTSAYLSIHNMVASLVDRYGSQEIRKKWGPKLTSMEVIA
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHH
SYCLTEPESGSDAASLKTRAVKEGEYYVLNGAKAFISGGSVSDVYLCMVRTGDESHHGIS
HHHCCCCCCCCCHHHHHHHHCCCCCEEEEECCEEEECCCCCCEEEEEEEECCCCCCCCEE
CLLIEKNTPGLTFGKLEKKLGWRNQPTCMLYFENCRVPIANRVGEEGMGFKIALNALNGG
EEEEECCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHHHCCCCCCCEEEEEEECCCC
RVNIASCSLGGALACLRMSQSYMHERKQFGKPLTQMQALRFYFADMLTDYEAARLMVYRA
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
AAAMDNDDPNAPMYCAMGKRLATDVAFRISDKAMQLHGGYGYLRDYQIERIFRDLRVHQI
HHHCCCCCCCCCEEECCCHHHHHHHHHEECCHHHEEECCCCCHHHHHHHHHHHHHHHHHH
LEGTNEIMREIIAKASLDEEYFIE
HHHHHHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MHFNFTDEHLAFREMASEFARNKLAPMADFWDEQGYFPIEILREAAQLGMAGMVVREDIG
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCC
GAQLSRLDAALIFEQLATGCIPTSAYLSIHNMVASLVDRYGSQEIRKKWGPKLTSMEVIA
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHH
SYCLTEPESGSDAASLKTRAVKEGEYYVLNGAKAFISGGSVSDVYLCMVRTGDESHHGIS
HHHCCCCCCCCCHHHHHHHHCCCCCEEEEECCEEEECCCCCCEEEEEEEECCCCCCCCEE
CLLIEKNTPGLTFGKLEKKLGWRNQPTCMLYFENCRVPIANRVGEEGMGFKIALNALNGG
EEEEECCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHHHCCCCCCCEEEEEEECCCC
RVNIASCSLGGALACLRMSQSYMHERKQFGKPLTQMQALRFYFADMLTDYEAARLMVYRA
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
AAAMDNDDPNAPMYCAMGKRLATDVAFRISDKAMQLHGGYGYLRDYQIERIFRDLRVHQI
HHHCCCCCCCCCEEECCCHHHHHHHHHEECCHHHEEECCCCCHHHHHHHHHHHHHHHHHH
LEGTNEIMREIIAKASLDEEYFIE
HHHHHHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]