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The map label for this gene is aroK

Identifier: 148360419

GI number: 148360419

Start: 1114698

End: 1115225

Strand: Direct

Name: aroK

Synonym: LPC_2358

Alternate gene names: 148360419

Gene position: 1114698-1115225 (Clockwise)

Preceding gene: 148360420

Following gene: 148360418

Centisome position: 31.17

GC content: 40.53

Gene sequence:

>528_bases
ATGAGCATAGTTAAAGTACGAAATATTTTTCTCATTGGTCCGATGGGTGCTGGTAAAAGTACTATAGGACGTGCTTTGGC
AAAGGAGCTCAAACTAGAATTCTATGACTCAGATGAAGTAATTGAAGAGCGTGCGGGCGCAGATATATCGTGGATCTTTG
ATATAGAAGGTGAGGAGGGATTTAGACGTCGAGAGCAAAAGGTCATTGATGAATTGACTCAAAAAACCAATATAGTATTG
GCAACGGGTGGCGGAGTCGTTATTACTCCTGAAAACAGGAATGCCCTGGCAGGCCGTGGCACAGTGATTTATCTCAAAAC
ATCTTTGCAACAGCAATTTGAAAGAACAAAGCGTGATACCAAACGTCCTTTATTACAAACAGAAGATCTTGAGGGACGCC
TGGAGTCACTCAGAGATGAGCGAGAACCTTTTTATGACGAATTGGCAGATGTCAGTTTTGAAACAGATAAACTGACTGTA
AAAGCTGTTGCAAACAATATAATAAAATACTTATATGGCGAAGTTTGA

Upstream 100 bases:

>100_bases
GTAGTAAATATCATGAAATCAACTAAGACGTGTATCTAATTTGTTGTTATAATAGCACGGCTAATTATGACAATTCAGTA
GAAGAGGTAAGTAAAAAAAA

Downstream 100 bases:

>100_bases
ACTTTATGCCGAGGTTGATGTTTCGATTTCAGGGCATCAATATCCAATAATTATTTGCCGCAATGGTTTAATTGATCCTG
AATTAATTAATCGCTTTATC

Product: shikimate kinase I

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MSIVKVRNIFLIGPMGAGKSTIGRALAKELKLEFYDSDEVIEERAGADISWIFDIEGEEGFRRREQKVIDELTQKTNIVL
ATGGGVVITPENRNALAGRGTVIYLKTSLQQQFERTKRDTKRPLLQTEDLEGRLESLRDEREPFYDELADVSFETDKLTV
KAVANNIIKYLYGEV

Sequences:

>Translated_175_residues
MSIVKVRNIFLIGPMGAGKSTIGRALAKELKLEFYDSDEVIEERAGADISWIFDIEGEEGFRRREQKVIDELTQKTNIVL
ATGGGVVITPENRNALAGRGTVIYLKTSLQQQFERTKRDTKRPLLQTEDLEGRLESLRDEREPFYDELADVSFETDKLTV
KAVANNIIKYLYGEV
>Mature_174_residues
SIVKVRNIFLIGPMGAGKSTIGRALAKELKLEFYDSDEVIEERAGADISWIFDIEGEEGFRRREQKVIDELTQKTNIVLA
TGGGVVITPENRNALAGRGTVIYLKTSLQQQFERTKRDTKRPLLQTEDLEGRLESLRDEREPFYDELADVSFETDKLTVK
AVANNIIKYLYGEV

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family

Homologues:

Organism=Escherichia coli, GI87082255, Length=166, Percent_Identity=60.8433734939759, Blast_Score=209, Evalue=7e-56,
Organism=Escherichia coli, GI1786587, Length=146, Percent_Identity=32.8767123287671, Blast_Score=88, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320332, Length=155, Percent_Identity=29.0322580645161, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): AROK_LEGPA (Q5X6H1)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123322.1
- ProteinModelPortal:   Q5X6H1
- SMR:   Q5X6H1
- STRING:   Q5X6H1
- GeneID:   3117779
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp0994
- LegioList:   lpp0994
- eggNOG:   COG0703
- HOGENOM:   HBG335815
- OMA:   VIYLRAN
- ProtClustDB:   PRK05057
- BioCyc:   LPNE297246:LPP0994-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00109
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 19829; Mature: 19698

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 38-38 BINDING 62-62 BINDING 84-84 BINDING 122-122 BINDING 141-141

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVKVRNIFLIGPMGAGKSTIGRALAKELKLEFYDSDEVIEERAGADISWIFDIEGEEG
CCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHEECCCHHHHHHHCCCCEEEEEEECCCHH
FRRREQKVIDELTQKTNIVLATGGGVVITPENRNALAGRGTVIYLKTSLQQQFERTKRDT
HHHHHHHHHHHHHHHCCEEEEECCCEEEECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
KRPLLQTEDLEGRLESLRDEREPFYDELADVSFETDKLTVKAVANNIIKYLYGEV
HCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIVKVRNIFLIGPMGAGKSTIGRALAKELKLEFYDSDEVIEERAGADISWIFDIEGEEG
CEEEEEEEEEEECCCCCHHHHHHHHHHHHHHEECCCHHHHHHHCCCCEEEEEEECCCHH
FRRREQKVIDELTQKTNIVLATGGGVVITPENRNALAGRGTVIYLKTSLQQQFERTKRDT
HHHHHHHHHHHHHHHCCEEEEECCCEEEECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
KRPLLQTEDLEGRLESLRDEREPFYDELADVSFETDKLTVKAVANNIIKYLYGEV
HCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA