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The map label for this gene is appC [H]

Identifier: 148360387

GI number: 148360387

Start: 1156845

End: 1158191

Strand: Direct

Name: appC [H]

Synonym: LPC_2326

Alternate gene names: 148360387

Gene position: 1156845-1158191 (Clockwise)

Preceding gene: 148360388

Following gene: 148360386

Centisome position: 32.35

GC content: 39.27

Gene sequence:

>1347_bases
ATGACATTTGAATTGCTTTGGACTGACAAATGTTTTCTTACTTTACTGGCGGTGGTTTTATTTACCGTTTTGCTGAGCCT
TAGAAAACAACACATCAAATTGTCATTTGCAATCATTTTACAAAGGCCGTTAGCAATCAGTGCTGGAATTGTGTTGTTGC
TGTTTTTAGCCATCGGTGTTTTGGACTCCATTCATATTAAATTCATCAATGATAAAACAGAAAAAACCCAGTCTCTATTA
GATAGAGTCCTTGCACCTATAGGGAGTACCTATGAGAAAACTTATTCAGCTCCTTTGGCTTTAAATCAATTTATGAGTGA
AACGAAGTTGATTAATGGAGTCATAACTCAGGTTTACCCTCGCTTAAAATATCCACCAGCCTCTATTAAGAATGAAAAGG
ACAAATCCCTTATCATCAAGTCTGTGCTTATGAAAGGTATAACATATAGTGCTTTAGTCATTTTGGGTGGGTGGTTATTA
CTTGCTTTAATAAAGTTTAGTCTTGGATATAAAAATATTTTCATTTTAAATTCTACTCAAATCAGCGCTATAGCGACTGT
AGCTGTACTTACTTTTGCGGTCGTCATTGGTTACGGATTATCAAGATCCTTTCATGTCTTGGGCACAGGGCAAATCGGGC
AAGATATTTTTTATTTCAGTTTGAAAAGTGTGCGAACGGGTCTAATCATTGGTTTTTTAACAACCCTCTTCATGTTGCCA
CTGGCTTTATTTCTGGGGATTGCAGCAGGGTATTTTGGTGGGCTTGTGGATGATATTATCCAGTATGTTTATACTACTTT
AAGCTCCATTCCAGGTGTTTTGCTAATTACGGCTTCCGTATTGTCATTGCAAACTTATATTGCAAACCACCCAGAGCAAT
TTACTACTTTGGCCAAGAGTGCCGATGCACGTTTATTAGCTCTTTGCTTGATACTGGGTGTGACCAGTTGGACAAGCCTG
TGCCGTCTTTTGCGAGCAGAAACTTTAAAATTGCGAGAAATAGATTATGTCCTGGCCGCACGTGCCTTAGGCAGTAGTTG
GTTTACCATCGTACGCAAACATTTGGTGCCCAATGTCATGCATATTGTTATCATCACCCTGGTATTGGATTTCAGTTTTT
TAGTCTTGGCAGAAGCTGTATTGACCTATGTAGGGGTAGGGGTTTCACCCATGACTATTAGTTGGGGAAATATGATTAAT
GGGGCGCGCCTTGAATTAGCACGTGACCCTGTTGTATGGTGGCCTATGTTTGCAGCCTTTCTGTTAATGTTTTTATTGGT
TTTGGCAATGAACTTGTTTGCAGACGCAGTACGGGATGCTTTTGACCCACATCAATCTCATTTATAG

Upstream 100 bases:

>100_bases
CAGTTCTTTACATCATAGGCCTGGTTCTGACTGATTTTTCTTACATCCTAGTTGATCCCCGAGTGCGATTATCCTGATAA
CCAAGGAGTATGTGGCAAAA

Downstream 100 bases:

>100_bases
TCAATATCTGTTAGTTTCCTATTTCCGGGATTTAGGTTAAAGTTTCGAAATTATCGTGAATGGGTTAATTCTCTATGCGA
CAACGTTTTGTTCATTTAAG

Product: peptide ABC transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTFELLWTDKCFLTLLAVVLFTVLLSLRKQHIKLSFAIILQRPLAISAGIVLLLFLAIGVLDSIHIKFINDKTEKTQSLL
DRVLAPIGSTYEKTYSAPLALNQFMSETKLINGVITQVYPRLKYPPASIKNEKDKSLIIKSVLMKGITYSALVILGGWLL
LALIKFSLGYKNIFILNSTQISAIATVAVLTFAVVIGYGLSRSFHVLGTGQIGQDIFYFSLKSVRTGLIIGFLTTLFMLP
LALFLGIAAGYFGGLVDDIIQYVYTTLSSIPGVLLITASVLSLQTYIANHPEQFTTLAKSADARLLALCLILGVTSWTSL
CRLLRAETLKLREIDYVLAARALGSSWFTIVRKHLVPNVMHIVIITLVLDFSFLVLAEAVLTYVGVGVSPMTISWGNMIN
GARLELARDPVVWWPMFAAFLLMFLLVLAMNLFADAVRDAFDPHQSHL

Sequences:

>Translated_448_residues
MTFELLWTDKCFLTLLAVVLFTVLLSLRKQHIKLSFAIILQRPLAISAGIVLLLFLAIGVLDSIHIKFINDKTEKTQSLL
DRVLAPIGSTYEKTYSAPLALNQFMSETKLINGVITQVYPRLKYPPASIKNEKDKSLIIKSVLMKGITYSALVILGGWLL
LALIKFSLGYKNIFILNSTQISAIATVAVLTFAVVIGYGLSRSFHVLGTGQIGQDIFYFSLKSVRTGLIIGFLTTLFMLP
LALFLGIAAGYFGGLVDDIIQYVYTTLSSIPGVLLITASVLSLQTYIANHPEQFTTLAKSADARLLALCLILGVTSWTSL
CRLLRAETLKLREIDYVLAARALGSSWFTIVRKHLVPNVMHIVIITLVLDFSFLVLAEAVLTYVGVGVSPMTISWGNMIN
GARLELARDPVVWWPMFAAFLLMFLLVLAMNLFADAVRDAFDPHQSHL
>Mature_447_residues
TFELLWTDKCFLTLLAVVLFTVLLSLRKQHIKLSFAIILQRPLAISAGIVLLLFLAIGVLDSIHIKFINDKTEKTQSLLD
RVLAPIGSTYEKTYSAPLALNQFMSETKLINGVITQVYPRLKYPPASIKNEKDKSLIIKSVLMKGITYSALVILGGWLLL
ALIKFSLGYKNIFILNSTQISAIATVAVLTFAVVIGYGLSRSFHVLGTGQIGQDIFYFSLKSVRTGLIIGFLTTLFMLPL
ALFLGIAAGYFGGLVDDIIQYVYTTLSSIPGVLLITASVLSLQTYIANHPEQFTTLAKSADARLLALCLILGVTSWTSLC
RLLRAETLKLREIDYVLAARALGSSWFTIVRKHLVPNVMHIVIITLVLDFSFLVLAEAVLTYVGVGVSPMTISWGNMING
ARLELARDPVVWWPMFAAFLLMFLLVLAMNLFADAVRDAFDPHQSHL

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787054, Length=239, Percent_Identity=30.1255230125523, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789889, Length=240, Percent_Identity=30, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1789964, Length=240, Percent_Identity=32.0833333333333, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1787760, Length=243, Percent_Identity=27.1604938271605, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788505, Length=242, Percent_Identity=27.6859504132231, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787498, Length=244, Percent_Identity=27.0491803278689, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 49481; Mature: 49350

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFELLWTDKCFLTLLAVVLFTVLLSLRKQHIKLSFAIILQRPLAISAGIVLLLFLAIGV
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LDSIHIKFINDKTEKTQSLLDRVLAPIGSTYEKTYSAPLALNQFMSETKLINGVITQVYP
HHHHHEEEECCHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RLKYPPASIKNEKDKSLIIKSVLMKGITYSALVILGGWLLLALIKFSLGYKNIFILNSTQ
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCH
ISAIATVAVLTFAVVIGYGLSRSFHVLGTGQIGQDIFYFSLKSVRTGLIIGFLTTLFMLP
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALFLGIAAGYFGGLVDDIIQYVYTTLSSIPGVLLITASVLSLQTYIANHPEQFTTLAKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ADARLLALCLILGVTSWTSLCRLLRAETLKLREIDYVLAARALGSSWFTIVRKHLVPNVM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HIVIITLVLDFSFLVLAEAVLTYVGVGVSPMTISWGNMINGARLELARDPVVWWPMFAAF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHCCCCCHHHHHHHHH
LLMFLLVLAMNLFADAVRDAFDPHQSHL
HHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TFELLWTDKCFLTLLAVVLFTVLLSLRKQHIKLSFAIILQRPLAISAGIVLLLFLAIGV
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LDSIHIKFINDKTEKTQSLLDRVLAPIGSTYEKTYSAPLALNQFMSETKLINGVITQVYP
HHHHHEEEECCHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RLKYPPASIKNEKDKSLIIKSVLMKGITYSALVILGGWLLLALIKFSLGYKNIFILNSTQ
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCH
ISAIATVAVLTFAVVIGYGLSRSFHVLGTGQIGQDIFYFSLKSVRTGLIIGFLTTLFMLP
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALFLGIAAGYFGGLVDDIIQYVYTTLSSIPGVLLITASVLSLQTYIANHPEQFTTLAKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ADARLLALCLILGVTSWTSLCRLLRAETLKLREIDYVLAARALGSSWFTIVRKHLVPNVM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HIVIITLVLDFSFLVLAEAVLTYVGVGVSPMTISWGNMINGARLELARDPVVWWPMFAAF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHCCCCCHHHHHHHHH
LLMFLLVLAMNLFADAVRDAFDPHQSHL
HHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]