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The map label for this gene is helC [H]

Identifier: 148360333

GI number: 148360333

Start: 1208994

End: 1210196

Strand: Direct

Name: helC [H]

Synonym: LPC_2271

Alternate gene names: 148360333

Gene position: 1208994-1210196 (Clockwise)

Preceding gene: 148360335

Following gene: 148360332

Centisome position: 33.8

GC content: 40.98

Gene sequence:

>1203_bases
ATGGCTTATGAAGCTATGGCATCATCCTCTTTTACTTTCAAGGATGCTTTGGCCATTGCGTATCGAAACAATCCTGAGTT
ACAAGCAGAAATAGATAAAGCTCGGGCCATGCGTGGGTACTTTGTACAAAGCGGGCTTTACCCTAATCCACAGCTTACCT
TAACTGCCGAGAATTTTGGCGGATCTGGCAGTTATTCCAGTTACGAATCTGCTGAAACTACGGCATCAGTGACACAGCCT
ATTCCTTTAGGTAATCGTTTATCTTATTTGAAAAAAGCCAGCTATGCAGATTATTTAGCCTCATTGGCACAAATTCAAGT
CCAAAAAGCAGCGATTTATATGGCTGTTGGTGGCGCATATGTTGATGCATTGTATGCCGGACAATGGCACCAAGTAACTA
AAAAGCTTATTTCACTCAATGAGAGTATCGTTAAAGCAATTGAGCGGCGTGTTAAAGCAGGTGCGGGAGCTGAATTGGAT
TTACGTTTAGCTCAAATTCGATTGGGTGAATCGCGCATTCAAGAAAAAAAAGCGGCACGTGATGCACTGTCACAACGTGC
TAAATTGGCTCGTTTATTAGGTGTCGGGTTAAAGGTGGATCAACCATTAGTAGATAAAGGGCTACCTGATGTTACATTAA
ATTGGTCAGTGCTTTTAAAAAAATTACCTCAAAGCCCGCAATTGATACAAATGCAACAGAAACTAAAAGCCAAACGAGCA
ACCATTACAGCAGTTAAAAAATCCGTTTGGCCCGATTTAAACATTCAATTGGGCGCTCGTCATTTTTCTGATGATGGAAG
CAATGCTGCGGTGATGTCGGCTTATGCACAAGTTCCTGTTTTTGATCGCAATCAGGGGAAAATCATGACAGCGGAAGCGC
AATTCACGCAAACTGCGCGTGAATATCAGGGAACAAAGCTCGATATACGTCAAATAGCATATACTGTATTTTTACAAGCC
CAACAAAATCATTATGAAGCAGAATTAGTAACCAGTACTTTGTTACCCCTTGCTCGTAAATCAATAAAACTCGCTCAAGA
TGGCTATCAAATGGGACGCTATACCTACATTGAATTATCCACGGCCTTAAATGCTTTGTATGAAGAAGAACGACACTATC
AACAGGCACATGCAGATTATCATAAAACATTAATTCAACTTACAGGGCTTTTAGGTCTTCATCCTACCAAGGAGAGTAAA
TGA

Upstream 100 bases:

>100_bases
ACACCCAAATAAAGTTAAACTAAAAAAGTATATTTGCAAGCTAGGGGTAAGTTAAGGGATGCGTATTTATTTTTATTTAG
TTATTACATGGATGAACCTC

Downstream 100 bases:

>100_bases
ATCTATTAAAACCAGTCAGTTTCTTCCTGCAACTTGTTGTTTTCCTGCTGGGAATAAGTTCTTTTTCGCTTTGGGCGGAA
GAAACAACTCATGCTACAGA

Product: cobalt/zinc/cadmium efflux RND transporter outer membrane protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MAYEAMASSSFTFKDALAIAYRNNPELQAEIDKARAMRGYFVQSGLYPNPQLTLTAENFGGSGSYSSYESAETTASVTQP
IPLGNRLSYLKKASYADYLASLAQIQVQKAAIYMAVGGAYVDALYAGQWHQVTKKLISLNESIVKAIERRVKAGAGAELD
LRLAQIRLGESRIQEKKAARDALSQRAKLARLLGVGLKVDQPLVDKGLPDVTLNWSVLLKKLPQSPQLIQMQQKLKAKRA
TITAVKKSVWPDLNIQLGARHFSDDGSNAAVMSAYAQVPVFDRNQGKIMTAEAQFTQTAREYQGTKLDIRQIAYTVFLQA
QQNHYEAELVTSTLLPLARKSIKLAQDGYQMGRYTYIELSTALNALYEEERHYQQAHADYHKTLIQLTGLLGLHPTKESK

Sequences:

>Translated_400_residues
MAYEAMASSSFTFKDALAIAYRNNPELQAEIDKARAMRGYFVQSGLYPNPQLTLTAENFGGSGSYSSYESAETTASVTQP
IPLGNRLSYLKKASYADYLASLAQIQVQKAAIYMAVGGAYVDALYAGQWHQVTKKLISLNESIVKAIERRVKAGAGAELD
LRLAQIRLGESRIQEKKAARDALSQRAKLARLLGVGLKVDQPLVDKGLPDVTLNWSVLLKKLPQSPQLIQMQQKLKAKRA
TITAVKKSVWPDLNIQLGARHFSDDGSNAAVMSAYAQVPVFDRNQGKIMTAEAQFTQTAREYQGTKLDIRQIAYTVFLQA
QQNHYEAELVTSTLLPLARKSIKLAQDGYQMGRYTYIELSTALNALYEEERHYQQAHADYHKTLIQLTGLLGLHPTKESK
>Mature_399_residues
AYEAMASSSFTFKDALAIAYRNNPELQAEIDKARAMRGYFVQSGLYPNPQLTLTAENFGGSGSYSSYESAETTASVTQPI
PLGNRLSYLKKASYADYLASLAQIQVQKAAIYMAVGGAYVDALYAGQWHQVTKKLISLNESIVKAIERRVKAGAGAELDL
RLAQIRLGESRIQEKKAARDALSQRAKLARLLGVGLKVDQPLVDKGLPDVTLNWSVLLKKLPQSPQLIQMQQKLKAKRAT
ITAVKKSVWPDLNIQLGARHFSDDGSNAAVMSAYAQVPVFDRNQGKIMTAEAQFTQTAREYQGTKLDIRQIAYTVFLQAQ
QNHYEAELVTSTLLPLARKSIKLAQDGYQMGRYTYIELSTALNALYEEERHYQQAHADYHKTLIQLTGLLGLHPTKESK

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 44385; Mature: 44254

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYEAMASSSFTFKDALAIAYRNNPELQAEIDKARAMRGYFVQSGLYPNPQLTLTAENFG
CCCHHHCCCCCCHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
GSGSYSSYESAETTASVTQPIPLGNRLSYLKKASYADYLASLAQIQVQKAAIYMAVGGAY
CCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECHHH
VDALYAGQWHQVTKKLISLNESIVKAIERRVKAGAGAELDLRLAQIRLGESRIQEKKAAR
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHCHHHHHHHHHHH
DALSQRAKLARLLGVGLKVDQPLVDKGLPDVTLNWSVLLKKLPQSPQLIQMQQKLKAKRA
HHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEECHHHHHHHCCCCCHHHHHHHHHHHHHH
TITAVKKSVWPDLNIQLGARHFSDDGSNAAVMSAYAQVPVFDRNQGKIMTAEAQFTQTAR
HHHHHHHHHCCCCCEEECCEECCCCCCCHHHHHHHHHCCEEECCCCCEEEEHHHHHHHHH
EYQGTKLDIRQIAYTVFLQAQQNHYEAELVTSTLLPLARKSIKLAQDGYQMGRYTYIELS
HHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCEEEEEHH
TALNALYEEERHYQQAHADYHKTLIQLTGLLGLHPTKESK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AYEAMASSSFTFKDALAIAYRNNPELQAEIDKARAMRGYFVQSGLYPNPQLTLTAENFG
CCHHHCCCCCCHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
GSGSYSSYESAETTASVTQPIPLGNRLSYLKKASYADYLASLAQIQVQKAAIYMAVGGAY
CCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECHHH
VDALYAGQWHQVTKKLISLNESIVKAIERRVKAGAGAELDLRLAQIRLGESRIQEKKAAR
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHCHHHHHHHHHHH
DALSQRAKLARLLGVGLKVDQPLVDKGLPDVTLNWSVLLKKLPQSPQLIQMQQKLKAKRA
HHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEECHHHHHHHCCCCCHHHHHHHHHHHHHH
TITAVKKSVWPDLNIQLGARHFSDDGSNAAVMSAYAQVPVFDRNQGKIMTAEAQFTQTAR
HHHHHHHHHCCCCCEEECCEECCCCCCCHHHHHHHHHCCEEECCCCCEEEEHHHHHHHHH
EYQGTKLDIRQIAYTVFLQAQQNHYEAELVTSTLLPLARKSIKLAQDGYQMGRYTYIELS
HHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCEEEEEHH
TALNALYEEERHYQQAHADYHKTLIQLTGLLGLHPTKESK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]