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The map label for this gene is pla [H]

Identifier: 148360161

GI number: 148360161

Start: 2876972

End: 2877898

Strand: Reverse

Name: pla [H]

Synonym: LPC_2092

Alternate gene names: 148360161

Gene position: 2877898-2876972 (Counterclockwise)

Preceding gene: 148360160

Following gene: 148360163

Centisome position: 80.47

GC content: 37.76

Gene sequence:

>927_bases
ATGAAAAATAAAATAGTTTTGTTGGCTCCAGTCTCTTTATCCTTTCTTTTCTCATGCTCTACTTATGCTGCGGATTACGA
ATTTAATGGTTTGTCATTAAGTGCTTCTCTAGGCATTCTGTCAGGTAAAGCTCATGAATATGTTTACCATCCAGAGACAG
ACACTAAGTTAAGCCAGCTGGATTGGCGCATAAAAAATGCTCCGATAATAAAAGGGGAATTAAATTATGATTTCCTGGAT
TGGCTTAGCATGAACAGTAGAGGCTGGACAACTTTGGTAAAAAATAAAGCTGCTATGGATGATTATGATTGGCTCAATCC
TTATCAAGATACCTGGACTCACTGGTCTCATCATGAAGATACGTATCTCAATTATGCAAATGAGTTAGATATGAGCTTAA
GGGCTTGGTTGATGCAAAAACAAAATTACAAGTTAGGCCTGGCTACTGGTTATCAATGGAATTCCTTTGACTGGAAAGCT
ACTGGAGGTTGTTACCAATATTACGGAGGGCTCTATGCCGGTTGTTTTCCAGGAGATCAACCAGGAATAGGATACCAACA
AAAATTTAGAACTCCTTATATTGGTCTGGCAGGGAAGTATTTTATTAATAATTTTGAGTTTAGTGGTCTTTTAAAATTTA
GTGATTGGGTTTCAGCTCGAGATCATGATGAGCATTATGCCCGCAACTTAACATTCAATGAGCGGGGAAATAGCTCCAGA
TATTATGCGGCAACGATTCATTCTGGCTACTTTTTGAAACCTAATACGAAAATTTTTGTTGAGGCTTCTTACAATCATTA
TTCTAATGGGAGAGCGGATACTGAAATCATTGACAATGACACGGGTGAGCGCAGTTATTTCGGTGATTCAGCAGGGCTAT
CCAATAAACACTATACTGTTGCACTTGGTTTACAATATCTTTTTTAA

Upstream 100 bases:

>100_bases
CAATGTTGATCTTGACAAGATCATTATGGATCACAATAATGCGATTGGTTTTTTAAAGTCACTTTGCTGCAAGGATTGCC
AGCCTTAACTAGGAAAAAAT

Downstream 100 bases:

>100_bases
AAGGTCAAATTCTCTAATCCCAACTGGCAAGTGGCAACTGTCTTAAGTCCTAACTTCAAGACAGTTGCTACATAAGTTCT
TTATTTCAACCATATCTGGA

Product: outer membrane protease

Products: NA

Alternate protein names: Plasminogen activator [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MKNKIVLLAPVSLSFLFSCSTYAADYEFNGLSLSASLGILSGKAHEYVYHPETDTKLSQLDWRIKNAPIIKGELNYDFLD
WLSMNSRGWTTLVKNKAAMDDYDWLNPYQDTWTHWSHHEDTYLNYANELDMSLRAWLMQKQNYKLGLATGYQWNSFDWKA
TGGCYQYYGGLYAGCFPGDQPGIGYQQKFRTPYIGLAGKYFINNFEFSGLLKFSDWVSARDHDEHYARNLTFNERGNSSR
YYAATIHSGYFLKPNTKIFVEASYNHYSNGRADTEIIDNDTGERSYFGDSAGLSNKHYTVALGLQYLF

Sequences:

>Translated_308_residues
MKNKIVLLAPVSLSFLFSCSTYAADYEFNGLSLSASLGILSGKAHEYVYHPETDTKLSQLDWRIKNAPIIKGELNYDFLD
WLSMNSRGWTTLVKNKAAMDDYDWLNPYQDTWTHWSHHEDTYLNYANELDMSLRAWLMQKQNYKLGLATGYQWNSFDWKA
TGGCYQYYGGLYAGCFPGDQPGIGYQQKFRTPYIGLAGKYFINNFEFSGLLKFSDWVSARDHDEHYARNLTFNERGNSSR
YYAATIHSGYFLKPNTKIFVEASYNHYSNGRADTEIIDNDTGERSYFGDSAGLSNKHYTVALGLQYLF
>Mature_308_residues
MKNKIVLLAPVSLSFLFSCSTYAADYEFNGLSLSASLGILSGKAHEYVYHPETDTKLSQLDWRIKNAPIIKGELNYDFLD
WLSMNSRGWTTLVKNKAAMDDYDWLNPYQDTWTHWSHHEDTYLNYANELDMSLRAWLMQKQNYKLGLATGYQWNSFDWKA
TGGCYQYYGGLYAGCFPGDQPGIGYQQKFRTPYIGLAGKYFINNFEFSGLLKFSDWVSARDHDEHYARNLTFNERGNSSR
YYAATIHSGYFLKPNTKIFVEASYNHYSNGRADTEIIDNDTGERSYFGDSAGLSNKHYTVALGLQYLF

Specific function: Seems to play an essential role in plague transmission by mediating flea blockage in a temperature-dependent fashion. Fibrinolytic activity prevails at 37 degrees Celsius whereas coagulase expression predominates at lower temperatures (<30 degrees Celsius

COG id: COG4571

COG function: function code M; Outer membrane protease

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A26 family [H]

Homologues:

Organism=Escherichia coli, GI1786777, Length=314, Percent_Identity=39.171974522293, Blast_Score=234, Evalue=7e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020080
- InterPro:   IPR000036
- InterPro:   IPR020079 [H]

Pfam domain/function: PF01278 Omptin [H]

EC number: =3.4.23.48 [H]

Molecular weight: Translated: 35470; Mature: 35470

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00037 MYB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKIVLLAPVSLSFLFSCSTYAADYEFNGLSLSASLGILSGKAHEYVYHPETDTKLSQL
CCCCEEEEECCCEEEEEEHHHEECCEEECCEEEEEEEEEECCCCEEEEECCCCCCCHHHH
DWRIKNAPIIKGELNYDFLDWLSMNSRGWTTLVKNKAAMDDYDWLNPYQDTWTHWSHHED
CEEECCCCEEEECCCCCHHHHEECCCCCCEEEECCCCCCCCCCCCCCCHHHCCCCCCCCC
TYLNYANELDMSLRAWLMQKQNYKLGLATGYQWNSFDWKATGGCYQYYGGLYAGCFPGDQ
HHHHHHHHCCHHHHHHHHHCCCCEEEEEECCEECCCCEEECCCHHHHCCCEEEECCCCCC
PGIGYQQKFRTPYIGLAGKYFINNFEFSGLLKFSDWVSARDHDEHYARNLTFNERGNSSR
CCCCHHHHCCCCEEECCCEEEEECCCEEEEEEEHHHCCCCCCCHHHHHCCEECCCCCCCE
YYAATIHSGYFLKPNTKIFVEASYNHYSNGRADTEIIDNDTGERSYFGDSAGLSNKHYTV
EEEEEECCCEEECCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEE
ALGLQYLF
EEEEEECC
>Mature Secondary Structure
MKNKIVLLAPVSLSFLFSCSTYAADYEFNGLSLSASLGILSGKAHEYVYHPETDTKLSQL
CCCCEEEEECCCEEEEEEHHHEECCEEECCEEEEEEEEEECCCCEEEEECCCCCCCHHHH
DWRIKNAPIIKGELNYDFLDWLSMNSRGWTTLVKNKAAMDDYDWLNPYQDTWTHWSHHED
CEEECCCCEEEECCCCCHHHHEECCCCCCEEEECCCCCCCCCCCCCCCHHHCCCCCCCCC
TYLNYANELDMSLRAWLMQKQNYKLGLATGYQWNSFDWKATGGCYQYYGGLYAGCFPGDQ
HHHHHHHHCCHHHHHHHHHCCCCEEEEEECCEECCCCEEECCCHHHHCCCEEEECCCCCC
PGIGYQQKFRTPYIGLAGKYFINNFEFSGLLKFSDWVSARDHDEHYARNLTFNERGNSSR
CCCCHHHHCCCCEEECCCEEEEECCCEEEEEEEHHHCCCCCCCHHHHHCCEECCCCCCCE
YYAATIHSGYFLKPNTKIFVEASYNHYSNGRADTEIIDNDTGERSYFGDSAGLSNKHYTV
EEEEEECCCEEECCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEE
ALGLQYLF
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2526282; 2651310; 9748454; 11586360 [H]