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The map label for this gene is aacA4 [H]

Identifier: 148360148

GI number: 148360148

Start: 2892573

End: 2893145

Strand: Reverse

Name: aacA4 [H]

Synonym: LPC_2079

Alternate gene names: 148360148

Gene position: 2893145-2892573 (Counterclockwise)

Preceding gene: 148360147

Following gene: 148360149

Centisome position: 80.89

GC content: 38.57

Gene sequence:

>573_bases
ATGGCATTGATAAGGGATTCAAAAAGCCAAGTCATGAGTGTTTTTAAATTTCAACCTCTGGGCATCAAGGATTTAAATCA
ACTGTATCAATGGTTTCAGGAGCCAATTATTAATCATTGGTATGCGAGAGACAAAAGCTGGTCACTGGATGAAATCACAG
AAAAATACGAACCAAGAATTGCAGGTATGGAGCATGTTCCAAGTTTCATTGTATATAAAGATGACTTACCTTTCGGATTC
GTCCAGTTTTATTTGATCACAGACTCTTTACCCGATGGAATTGATGGTTATGAGAGTCTTCTCTTTGAAAAATATAATCC
CCAGGATTTAGCTGGAATCGATTTGTTTATTGCTGAAAGCGAGGGACGAGGTAGAGGATTAGGGGTGGAACTCATTAATC
GTTTTATTGATAAGTTTCTTACCCGTTTCAAAGCTGTTGTTGTTGACCCCGATGTTAACAATCAACAAGCCATTCGTTGC
TACGAAAAAGCGGGCTTTCAGCAAACAGATTTCAGCCAGGATCCCAATCATCTCATCATGATAAAACCCTTGTCATTGAT
TACAGGGAATTGA

Upstream 100 bases:

>100_bases
AGAATACCCACTCAGTTTTTGCCTACAGTATAGTGAATCATGATTATCCGCAAACCTGACATATGGAAATCAATTTGGCA
TGCCTCGGATGTGAGTCGTT

Downstream 100 bases:

>100_bases
TTATGAGCCTATTGAAAATAGAACTTTGTTTTGGCAATTTACCAAGGGTTTTAAATGATAAAATCATTTCGTGTCACAAT
TTTTTTATTTCTTGTAAGTG

Product: aminoglycoside 6'-N-acetyltransferase

Products: NA

Alternate protein names: AAC(6'); Amikacin resistance protein [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MALIRDSKSQVMSVFKFQPLGIKDLNQLYQWFQEPIINHWYARDKSWSLDEITEKYEPRIAGMEHVPSFIVYKDDLPFGF
VQFYLITDSLPDGIDGYESLLFEKYNPQDLAGIDLFIAESEGRGRGLGVELINRFIDKFLTRFKAVVVDPDVNNQQAIRC
YEKAGFQQTDFSQDPNHLIMIKPLSLITGN

Sequences:

>Translated_190_residues
MALIRDSKSQVMSVFKFQPLGIKDLNQLYQWFQEPIINHWYARDKSWSLDEITEKYEPRIAGMEHVPSFIVYKDDLPFGF
VQFYLITDSLPDGIDGYESLLFEKYNPQDLAGIDLFIAESEGRGRGLGVELINRFIDKFLTRFKAVVVDPDVNNQQAIRC
YEKAGFQQTDFSQDPNHLIMIKPLSLITGN
>Mature_189_residues
ALIRDSKSQVMSVFKFQPLGIKDLNQLYQWFQEPIINHWYARDKSWSLDEITEKYEPRIAGMEHVPSFIVYKDDLPFGFV
QFYLITDSLPDGIDGYESLLFEKYNPQDLAGIDLFIAESEGRGRGLGVELINRFIDKFLTRFKAVVVDPDVNNQQAIRCY
EKAGFQQTDFSQDPNHLIMIKPLSLITGN

Specific function: Resistance to antibiotics containing the purpurosamine ring including gentamicin, kanamycin, tobramycin, and neomycin [H]

COG id: COG1670

COG function: function code J; Acetyltransferases, including N-acetylases of ribosomal proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR019432 [H]

Pfam domain/function: PF00583 Acetyltransf_1; PF10331 AlcB [H]

EC number: =2.3.1.82 [H]

Molecular weight: Translated: 21993; Mature: 21862

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIRDSKSQVMSVFKFQPLGIKDLNQLYQWFQEPIINHWYARDKSWSLDEITEKYEPRI
CCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
AGMEHVPSFIVYKDDLPFGFVQFYLITDSLPDGIDGYESLLFEKYNPQDLAGIDLFIAES
CCHHHCCCEEEEECCCCHHHEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCEEEEEECC
EGRGRGLGVELINRFIDKFLTRFKAVVVDPDVNNQQAIRCYEKAGFQQTDFSQDPNHLIM
CCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEE
IKPLSLITGN
EECHHEECCC
>Mature Secondary Structure 
ALIRDSKSQVMSVFKFQPLGIKDLNQLYQWFQEPIINHWYARDKSWSLDEITEKYEPRI
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
AGMEHVPSFIVYKDDLPFGFVQFYLITDSLPDGIDGYESLLFEKYNPQDLAGIDLFIAES
CCHHHCCCEEEEECCCCHHHEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCEEEEEECC
EGRGRGLGVELINRFIDKFLTRFKAVVVDPDVNNQQAIRCYEKAGFQQTDFSQDPNHLIM
CCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEE
IKPLSLITGN
EECHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2841303; 1963948 [H]